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WO2006013561A3 - Compositions et methodes de diagnostic et de traitement de trouble de stress post-traumatique - Google Patents

Compositions et methodes de diagnostic et de traitement de trouble de stress post-traumatique Download PDF

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Publication number
WO2006013561A3
WO2006013561A3 PCT/IL2005/000824 IL2005000824W WO2006013561A3 WO 2006013561 A3 WO2006013561 A3 WO 2006013561A3 IL 2005000824 W IL2005000824 W IL 2005000824W WO 2006013561 A3 WO2006013561 A3 WO 2006013561A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnosing
stress disorder
traumatic stress
compositions
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2005/000824
Other languages
English (en)
Other versions
WO2006013561A2 (fr
Inventor
Ronnen Segman
Arieh Shalev
Tania Goltser
Nir Friedman
Noa Shefi
Naftali Kaminski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Publication of WO2006013561A2 publication Critical patent/WO2006013561A2/fr
Publication of WO2006013561A3 publication Critical patent/WO2006013561A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention porte sur des gènes différentiellement exprimés chez des sujets atteints de trouble de stress post-traumatique, ces gènes pouvant être utilisés pour déterminer une prédisposition à un trouble de stress post-traumatique et/ou effectuer un diagnostic de ce trouble. Cette invention peut-être notamment utilisée dans la prévention et/ou le traitement de trouble de stress post-traumatique en régulant le taux d'expression des gènes différentiellement exprimés chez des sujets atteints de trouble de stress post-traumatique.
PCT/IL2005/000824 2004-08-02 2005-08-02 Compositions et methodes de diagnostic et de traitement de trouble de stress post-traumatique Ceased WO2006013561A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59240804P 2004-08-02 2004-08-02
US60/592,408 2004-08-02

Publications (2)

Publication Number Publication Date
WO2006013561A2 WO2006013561A2 (fr) 2006-02-09
WO2006013561A3 true WO2006013561A3 (fr) 2006-09-14

Family

ID=35787510

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2005/000824 Ceased WO2006013561A2 (fr) 2004-08-02 2005-08-02 Compositions et methodes de diagnostic et de traitement de trouble de stress post-traumatique

Country Status (1)

Country Link
WO (1) WO2006013561A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0814991A2 (pt) 2007-07-31 2015-03-31 Univ Texas Micro-rnas que controlam a expressão de miosina e identidade de miofibra.
EP2334816B1 (fr) * 2008-09-12 2013-11-20 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Gènes associés à un trouble de stress post-traumatique (ptsd)
NZ594365A (en) 2009-02-04 2013-03-28 Univ Texas Dual targeting of miR-208a or miR-208b and miR-499 in the treatment of cardiac disorders or musculoskeletal disorders
US8980860B2 (en) 2010-07-14 2015-03-17 Curna, Inc. Treatment of discs large homolog (DLG) related diseases by inhibition of natural antisense transcript to DLG
EP2756313A4 (fr) * 2011-09-14 2015-04-22 Jackson H M Found Military Med Procédés et trousses permettant la détection et la surveillance de biomarqueurs de diagnostic pour le trouble de stress post-traumatique (tspt) et permettant de distinguer la forme suicidaire et la forme non suicidaire du trouble
US9856532B2 (en) * 2012-09-07 2018-01-02 Institute For Systems Biology Markers and methods for detecting posttraumatic stress disorder (PTSD)
WO2015027116A1 (fr) * 2013-08-21 2015-02-26 The Regents Of The University Of California Motifs de métabolites pour le diagnostic et la prédiction de troubles affectant le cerveau et le système nerveux
CN106701900B (zh) * 2015-11-16 2020-03-20 上海市东方医院 长链非编码rna herc2p3基因及其在胃癌中的用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002004677A2 (fr) * 2000-07-06 2002-01-17 The Regents Of The University Of California Procede destine au diagnostic et au traitement de troubles mentaux
US20030059791A1 (en) * 2001-02-28 2003-03-27 Kazuhito Rokutan Method for evaluating DNA probes position on substrate

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002004677A2 (fr) * 2000-07-06 2002-01-17 The Regents Of The University Of California Procede destine au diagnostic et au traitement de troubles mentaux
US20030059791A1 (en) * 2001-02-28 2003-03-27 Kazuhito Rokutan Method for evaluating DNA probes position on substrate

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
CAMPBELL CATHERINE ET AL: "Assessment of normal variability in peripheral blood gene expression.", DISEASE MARKERS, vol. 18, no. 4, 2003, pages 201 - 206, XP009062691, ISSN: 0278-0240 *
CHANTARUJIKAPONG S I ET AL: "A twin study of generalized anxiety disorder symptoms, panic disorder symptoms and post-traumatic stress disorder in men.", PSYCHIATRY RESEARCH. 20 SEP 2001, vol. 103, no. 2-3, 20 September 2001 (2001-09-20), pages 133 - 145, XP002371126, ISSN: 0165-1781 *
FREEDMAN S A ET AL: "Predictors of chronic post-traumatic stress disorder. A prospective study.", THE BRITISH JOURNAL OF PSYCHIATRY : THE JOURNAL OF MENTAL SCIENCE. APR 1999, vol. 174, April 1999 (1999-04-01), pages 353 - 359, XP009062943, ISSN: 0007-1250 *
LIBERZON I ET AL: "Differential regulation of hippocampal glucocorticoid receptors mRNA and fast feedback: Relevance to post-traumatic stress disorder", JOURNAL OF NEUROENDOCRINOLOGY, vol. 11, no. 1, January 1999 (1999-01-01), pages 11 - 17, XP002371120, ISSN: 0953-8194 *
NIMGAONKAR ASHISH ET AL: "Reproducibility of gene expression across generations of Affymetrix microarrays.", BMC BIOINFORMATICS [ELECTRONIC RESOURCE]. 25 JUN 2003, vol. 4, 25 June 2003 (2003-06-25), pages 27, XP002371121, ISSN: 1471-2105 *
OPALINSKA JOANNA B ET AL: "Nucleic-acid therapeutics: basic principles and recent applications.", NATURE REVIEWS. DRUG DISCOVERY. JUL 2002, vol. 1, no. 7, July 2002 (2002-07-01), pages 503 - 514, XP009063128, ISSN: 1474-1776 *
RADICH J P ET AL: "Individual-specific variation of gene expression in peripheral blood leukocytes", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 83, no. 6, June 2004 (2004-06-01), pages 980 - 988, XP004512549, ISSN: 0888-7543 *
SEGMAN R H ET AL: "Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors", MOLECULAR PSYCHIATRY, vol. 10, no. 5, May 2005 (2005-05-01), pages 500 - 513, XP002371124, ISSN: 1359-4184 *
SEGMAN RONNEN H ET AL: "Genetics of posttraumatic stress disorder.", CNS SPECTRUMS. SEP 2003, vol. 8, no. 9, September 2003 (2003-09-01), pages 693 - 698, XP009062917, ISSN: 1092-8529 *
SEGMAN RONNEN H ET AL: "Peripheral blood mononuclear cells gene expression profiles identify emergent posttraumatic stress disorder among trauma survivors", NEUROPSYCHOPHARMACOLOGY, vol. 29, no. Suppl. 1, December 2004 (2004-12-01), & ANNUAL MEETING OF THE AMERICAN-COLLEGE-OF-NEUROPSYCHOPHARMACOLOGY; SAN JUAN, PR, USA; DECEMBER 12 -16, 2004, pages S207, XP002371123, ISSN: 0893-133X *
TANAKA T ET AL: "Expression profile of mRNAs from rat hippocampus and its application to microarray", MOLECULAR BRAIN RESEARCH, ELSEVIER SCIENCE BV, AMSTERDAM, NL, vol. 129, no. 1-2, 23 July 2004 (2004-07-23), pages 20 - 32, XP004591559, ISSN: 0169-328X *
WELLE STEPHEN ET AL: "Computational method for reducing variance with Affymetrix microarrays.", BMC BIOINFORMATICS [ELECTRONIC RESOURCE]. 30 AUG 2002, vol. 3, 30 August 2002 (2002-08-30), pages 23, XP002371122, ISSN: 1471-2105 *
WHITNEY ADELINE R ET AL: "Individuality and variation in gene expression patterns in human blood.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 100, no. 4, 18 February 2003 (2003-02-18), pages 1896 - 1901, XP002371125, ISSN: 0027-8424 *
XIAN H ET AL: "Genetic and environmental influences on posttraumatic stress disorder, alcohol and drug dependence in twin pairs.", DRUG AND ALCOHOL DEPENDENCE. 22 DEC 2000, vol. 61, no. 1, 22 December 2000 (2000-12-22), pages 95 - 102, XP002371127, ISSN: 0376-8716 *
YEHUDA RACHEL: "Post-traumatic stress disorder.", THE NEW ENGLAND JOURNAL OF MEDICINE. 10 JAN 2002, vol. 346, no. 2, 10 January 2002 (2002-01-10), pages 108 - 114, XP009062957, ISSN: 1533-4406 *

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