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WO2006008775A3 - Methode d'identification d'agents modulant le metabolisme de molecules steroides et agents identifies au moyen de ladite methode - Google Patents

Methode d'identification d'agents modulant le metabolisme de molecules steroides et agents identifies au moyen de ladite methode Download PDF

Info

Publication number
WO2006008775A3
WO2006008775A3 PCT/IT2005/000403 IT2005000403W WO2006008775A3 WO 2006008775 A3 WO2006008775 A3 WO 2006008775A3 IT 2005000403 W IT2005000403 W IT 2005000403W WO 2006008775 A3 WO2006008775 A3 WO 2006008775A3
Authority
WO
WIPO (PCT)
Prior art keywords
hpt
agent
metabolism
complex
verifying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IT2005/000403
Other languages
English (en)
Other versions
WO2006008775A2 (fr
Inventor
Andrea Luca D
Carlo Pedone
Paolo Abrescia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ISTITUTO BIOCHIMICO NAZIONALE SAVIO Srl
ISTITUTO BIOCHIMICO NAZ SAVIO
Original Assignee
ISTITUTO BIOCHIMICO NAZIONALE SAVIO Srl
ISTITUTO BIOCHIMICO NAZ SAVIO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ISTITUTO BIOCHIMICO NAZIONALE SAVIO Srl, ISTITUTO BIOCHIMICO NAZ SAVIO filed Critical ISTITUTO BIOCHIMICO NAZIONALE SAVIO Srl
Publication of WO2006008775A2 publication Critical patent/WO2006008775A2/fr
Publication of WO2006008775A3 publication Critical patent/WO2006008775A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne une méthode d'identification d'un agent modulant le transport inverse du cholestérol ou le métabolisme de molécules stéroïdes, ladite méthode consistant à faire incuber ledit agent avec de l'haptoglobine (Hpt), dans des conditions assurant la formation d'une liaison entre les deux molécules, de sorte qu'un complexe agent-Hpt puisse être formé; à vérifier que le complexe agent-Hpt se lie à l'hémoglobine (Hb), avec une constante d'association globalement comparable à celle de Hpt libre; à vérifier que le complexe agent-Hpt inhibe globalement Hpt, sous sa forme liée à l'agent, lors de sa liaison à HDL; à vérifier que le complexe agent-Hpt inhibe globalement l'effet négatif de Hpt sur l'enzyme LCAT.
PCT/IT2005/000403 2004-07-16 2005-07-15 Methode d'identification d'agents modulant le metabolisme de molecules steroides et agents identifies au moyen de ladite methode Ceased WO2006008775A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM2004A000357 2004-07-16
ITRM20040357 ITRM20040357A1 (it) 2004-07-16 2004-07-16 Metodo per identificare agenti modulanti del metabolismo di molecole steroidee.

Publications (2)

Publication Number Publication Date
WO2006008775A2 WO2006008775A2 (fr) 2006-01-26
WO2006008775A3 true WO2006008775A3 (fr) 2006-05-04

Family

ID=35784775

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2005/000403 Ceased WO2006008775A2 (fr) 2004-07-16 2005-07-15 Methode d'identification d'agents modulant le metabolisme de molecules steroides et agents identifies au moyen de ladite methode

Country Status (2)

Country Link
IT (1) ITRM20040357A1 (fr)
WO (1) WO2006008775A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080199398A1 (en) * 2006-06-16 2008-08-21 Brewer H Bryan Novel Peptides That Promote Lipid Efflux

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002040501A2 (fr) * 2000-11-20 2002-05-23 The Board Of Trustees Of The University Of Illinois Proteines d'echaufaudage membranaires

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002040501A2 (fr) * 2000-11-20 2002-05-23 The Board Of Trustees Of The University Of Illinois Proteines d'echaufaudage membranaires

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BALESTRIERI MARCO ET AL: "Haptoglobin inhibits lecithin-cholesterol acyltransferase in human ovarian follicular fluid", MOLECULAR REPRODUCTION AND DEVELOPMENT, vol. 59, no. 2, June 2001 (2001-06-01), pages 186 - 191, XP002369269, ISSN: 1040-452X *
CIGLIANO L ET AL: "Apolipoprotein A-I-dependent cholesterol esterification in patients with rheumatoid arthritis", LIFE SCIENCES, PERGAMON PRESS, OXFORD, GB, vol. 77, no. 1, 20 May 2005 (2005-05-20), pages 108 - 120, XP004858552, ISSN: 0024-3205 *
KARATHANAIS S K ET AL: "ISOLATION AND CHARACTERIZATION OF THE HUMAN APO LIPO PROTEIN A-I GENE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 80, no. 20, 1983, pages 6147 - 6151, XP002369899, ISSN: 0027-8424 *
SHOULDERS C C ET AL: "Gene structure of human apolipoprotein A1.", NUCLEIC ACIDS RESEARCH. 11 MAY 1983, vol. 11, no. 9, 11 May 1983 (1983-05-11), pages 2827 - 2837, XP002369898, ISSN: 0305-1048 *
SPAGNUOLO MARIA STEFANIA ET AL: "The binding of haptoglobin to apolipoprotein AI: Influence of hemoglobin and concanavalin A.", BIOLOGICAL CHEMISTRY, vol. 384, no. 12, December 2003 (2003-12-01), pages 1593 - 1596, XP009062164, ISSN: 1431-6730 *

Also Published As

Publication number Publication date
WO2006008775A2 (fr) 2006-01-26
ITRM20040357A1 (it) 2004-10-16

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