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WO2006007846A3 - A dressing comprising a serine protease inhibitor and an antioxidant - Google Patents

A dressing comprising a serine protease inhibitor and an antioxidant Download PDF

Info

Publication number
WO2006007846A3
WO2006007846A3 PCT/DK2005/000496 DK2005000496W WO2006007846A3 WO 2006007846 A3 WO2006007846 A3 WO 2006007846A3 DK 2005000496 W DK2005000496 W DK 2005000496W WO 2006007846 A3 WO2006007846 A3 WO 2006007846A3
Authority
WO
WIPO (PCT)
Prior art keywords
antioxidant
protease inhibitor
serine protease
dressing
spi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DK2005/000496
Other languages
French (fr)
Other versions
WO2006007846A2 (en
Inventor
Flemming Reissig Jensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Coloplast AS
Original Assignee
Coloplast AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coloplast AS filed Critical Coloplast AS
Publication of WO2006007846A2 publication Critical patent/WO2006007846A2/en
Publication of WO2006007846A3 publication Critical patent/WO2006007846A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/428—Vitamins, e.g. tocopherol, riboflavin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/432—Inhibitors, antagonists
    • A61L2300/434—Inhibitors, antagonists of enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures

Landscapes

  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides the use of a Serine Protease Inhibitor (SPI) in combination with an antioxidant, to achieve an improved and synergistic effect on the healing of wounds, especially chronic wounds, such as pressure sores or leg ulcers. The invention also includes the use of antioxidants as stabilizing entities during the production, transport, storage and sterilisation of compositions, such as pharmaceutical compositions or medical devices, containing oxidatively sensitive active pharmaceutical entities, such as SPI's.
PCT/DK2005/000496 2004-07-16 2005-07-14 A dressing comprising a serine protease inhibitor and an antioxidant Ceased WO2006007846A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200401122 2004-07-16
DKPA200401122 2004-07-16

Publications (2)

Publication Number Publication Date
WO2006007846A2 WO2006007846A2 (en) 2006-01-26
WO2006007846A3 true WO2006007846A3 (en) 2006-02-23

Family

ID=35448116

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2005/000496 Ceased WO2006007846A2 (en) 2004-07-16 2005-07-14 A dressing comprising a serine protease inhibitor and an antioxidant

Country Status (1)

Country Link
WO (1) WO2006007846A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180289836A1 (en) 2017-04-05 2018-10-11 Drexel University Complexes and methods of reducing inflammation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190917A (en) * 1986-12-24 1993-03-02 John Lezdey Treatment of psoriasis
US6174859B1 (en) * 1999-04-06 2001-01-16 J & D Sciences, Inc. Method of treatment
EP1270013A1 (en) * 2000-02-15 2003-01-02 AlphaMed Pharmaceuticals Corporation Topical wound healing compositions comprising hyaluronic acid and a serine protease inhibitor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190917A (en) * 1986-12-24 1993-03-02 John Lezdey Treatment of psoriasis
US6174859B1 (en) * 1999-04-06 2001-01-16 J & D Sciences, Inc. Method of treatment
EP1270013A1 (en) * 2000-02-15 2003-01-02 AlphaMed Pharmaceuticals Corporation Topical wound healing compositions comprising hyaluronic acid and a serine protease inhibitor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PUPPALA K C ET AL: "SERINE PROTEASE INHIBITORS PROFILES DISTINGUISH CHRONIC FROM ACUTE WOUNDS", JOURNAL OF INVESTIGATIVE DERMATOLOGY, NEW YORK, NY, US, vol. 108, no. 4, April 1997 (1997-04-01), pages 617, XP008017764, ISSN: 0022-202X *

Also Published As

Publication number Publication date
WO2006007846A2 (en) 2006-01-26

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