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WO2006007180A3 - Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia - Google Patents

Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia Download PDF

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Publication number
WO2006007180A3
WO2006007180A3 PCT/US2005/018232 US2005018232W WO2006007180A3 WO 2006007180 A3 WO2006007180 A3 WO 2006007180A3 US 2005018232 W US2005018232 W US 2005018232W WO 2006007180 A3 WO2006007180 A3 WO 2006007180A3
Authority
WO
WIPO (PCT)
Prior art keywords
exhaled breath
breath condensate
gram negative
lipopolysaccharide
negative pneumonia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/018232
Other languages
French (fr)
Other versions
WO2006007180A2 (en
Inventor
Jeffrey A Kline
Jackeline Hernandez
John Albert Watts Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Charlotte Mecklenburg Hospital
Original Assignee
Charlotte Mecklenburg Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Charlotte Mecklenburg Hospital filed Critical Charlotte Mecklenburg Hospital
Priority to JP2007527565A priority Critical patent/JP4804464B2/en
Priority to BRPI0511846-8A priority patent/BRPI0511846A/en
Priority to MXPA06014248A priority patent/MXPA06014248A/en
Priority to CA002566804A priority patent/CA2566804A1/en
Priority to AU2005262701A priority patent/AU2005262701B2/en
Priority to EP05753778A priority patent/EP1761166A4/en
Publication of WO2006007180A2 publication Critical patent/WO2006007180A2/en
Priority to IL179137A priority patent/IL179137A/en
Publication of WO2006007180A3 publication Critical patent/WO2006007180A3/en
Anticipated expiration legal-status Critical
Priority to IL218188A priority patent/IL218188A0/en
Priority to IL218189A priority patent/IL218189A0/en
Priority to IL218191A priority patent/IL218191A0/en
Priority to IL218190A priority patent/IL218190A0/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/0813—Measurement of pulmonary parameters by tracers, e.g. radioactive tracers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/412—Detecting or monitoring sepsis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/50—Lipopolysaccharides; LPS

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)

Abstract

A method for determining whether a subject has Gram negative bacterial pneumonia based on the presence of lipopolysaccharide in exhaled breath condensate collected from the subject. The collection devices utilized to collect exhaled breath condensate from both spontaneously breathing and mechanically ventilated subjects and the devices utilized to determine whether lipopolysaccharide is present in the collected exhaled breath condensate.
PCT/US2005/018232 2004-06-07 2005-05-24 Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia Ceased WO2006007180A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP2007527565A JP4804464B2 (en) 2004-06-07 2005-05-24 Diagnosis of Gram-negative bacterial pneumonia using lipopolysaccharide in exhaled breath condensate
BRPI0511846-8A BRPI0511846A (en) 2004-06-07 2005-05-24 use of exhaled breath condensate lipopolysaccharide to diagnose gram-negative pneumonia
MXPA06014248A MXPA06014248A (en) 2004-06-07 2005-05-24 Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia.
CA002566804A CA2566804A1 (en) 2004-06-07 2005-05-24 Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia
AU2005262701A AU2005262701B2 (en) 2004-06-07 2005-05-24 Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia
EP05753778A EP1761166A4 (en) 2004-06-07 2005-05-24 USE OF LIPOPOLYSACCHARIDE IN EXHAUSTED BREATHING CONDENSATION FOR THE DIAGNOSIS OF GRAM NEGATIVE PNEUMONIA
IL179137A IL179137A (en) 2004-06-07 2006-11-09 Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia
IL218188A IL218188A0 (en) 2004-06-07 2012-02-19 Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia
IL218189A IL218189A0 (en) 2004-06-07 2012-02-19 Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia
IL218191A IL218191A0 (en) 2004-06-07 2012-02-19 Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia
IL218190A IL218190A0 (en) 2004-06-07 2012-02-19 Reaction chamber assemblies for measuring the lipopolysaccharide in exhaled breath condensate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57764104P 2004-06-07 2004-06-07
US60/577,641 2004-06-07

Publications (2)

Publication Number Publication Date
WO2006007180A2 WO2006007180A2 (en) 2006-01-19
WO2006007180A3 true WO2006007180A3 (en) 2006-11-30

Family

ID=35784291

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/018232 Ceased WO2006007180A2 (en) 2004-06-07 2005-05-24 Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia

Country Status (8)

Country Link
EP (1) EP1761166A4 (en)
JP (2) JP4804464B2 (en)
AU (1) AU2005262701B2 (en)
BR (1) BRPI0511846A (en)
CA (1) CA2566804A1 (en)
IL (5) IL179137A (en)
MX (1) MXPA06014248A (en)
WO (1) WO2006007180A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058125A2 (en) 2002-12-20 2004-07-15 The Charlotte-Mecklenburg Hospital Authority Disposable hand-held device for collection of exhaled breath condensate
US7547285B2 (en) 2003-02-14 2009-06-16 The Charlotte-Mecklenburg Hospital Authority Device and method for collection of exhaled alveolar breath condensate
US7828741B2 (en) 2002-12-20 2010-11-09 The Charlotte-Mecklenburg Hospital Authority Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia
WO2009045163A1 (en) 2007-10-02 2009-04-09 Anna-Carin Olin Collection and measurement of exhaled particles
AU2009256172B2 (en) * 2008-06-04 2015-11-26 Kci Licensing, Inc. Detecting infection in reduced pressure wound treatment
GB201312635D0 (en) 2013-07-15 2013-08-28 Univ Plymouth Water testing
US10413216B2 (en) * 2016-02-03 2019-09-17 Quintron Instrument Company, Inc. Breath testing apparatus
CN106018362B (en) * 2016-05-16 2018-06-08 江苏国恒检测有限公司 A kind of picric analyzer of detection
CN108871908B9 (en) * 2018-09-06 2024-07-26 杭州优思达生物技术股份有限公司 Biological sample processing device
US12429483B2 (en) * 2019-08-13 2025-09-30 Respiration Scan Ltd System and method for determining onset and disease progression
WO2021041571A1 (en) * 2019-08-26 2021-03-04 Zeteo Tech, Inc. Diagnosis of tuberculosis and other diseases using exhaled breath
WO2023038582A2 (en) * 2021-09-10 2023-03-16 National University Of Singapore Exhaled breath condensate collection kit
WO2023041753A1 (en) * 2021-09-20 2023-03-23 Vosbio, Inc. Devices, methods and kits for biological sample capture and processing
WO2024254215A1 (en) * 2023-06-05 2024-12-12 Charles River Laboratories, Inc. Recombinant amebocyte clotting factors and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4349626A (en) * 1980-10-28 1982-09-14 The Monell Chemical Senses Center Method of detecting Pseudomonas aeruginosa infections utilizing selected ketone and/or sulfur metabolites
US5541057A (en) * 1989-09-18 1996-07-30 Biostar, Inc. Methods for detection of an analyte
US20040234971A1 (en) * 2001-02-01 2004-11-25 Joany Jackman Diagnosis of pathogen infections using mass spectral analysis of immune system modulators in post-exposure biological samples

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59383A (en) * 1980-02-14 1983-03-31 Technion Res & Dev Foundation Micromethod for the determination of endotoxins with limulus amebocyte lysate
SE9704329D0 (en) * 1997-11-25 1997-11-25 Siemens Elema Ab Gas meters
WO2000035337A2 (en) * 1998-12-18 2000-06-22 University Of Virginia Patent Foundation Device and method for monitoring asthma
JP2002539429A (en) * 1999-03-09 2002-11-19 オスメテック パブリック リミテッド カンパニー State detection method
AU2001261091A1 (en) * 2000-05-01 2001-11-12 Respiratory Research, Inc. Method and device for collecting and analyzing exhaled breath

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4349626A (en) * 1980-10-28 1982-09-14 The Monell Chemical Senses Center Method of detecting Pseudomonas aeruginosa infections utilizing selected ketone and/or sulfur metabolites
US5541057A (en) * 1989-09-18 1996-07-30 Biostar, Inc. Methods for detection of an analyte
US20040234971A1 (en) * 2001-02-01 2004-11-25 Joany Jackman Diagnosis of pathogen infections using mass spectral analysis of immune system modulators in post-exposure biological samples

Also Published As

Publication number Publication date
EP1761166A4 (en) 2009-11-11
WO2006007180A2 (en) 2006-01-19
EP1761166A2 (en) 2007-03-14
IL218188A0 (en) 2012-04-30
JP4804464B2 (en) 2011-11-02
BRPI0511846A (en) 2008-01-15
JP4852121B2 (en) 2012-01-11
JP2009186487A (en) 2009-08-20
CA2566804A1 (en) 2006-01-19
IL218190A0 (en) 2012-04-30
IL218189A0 (en) 2012-04-30
IL218191A0 (en) 2012-04-30
AU2005262701B2 (en) 2011-12-01
MXPA06014248A (en) 2007-06-25
IL179137A0 (en) 2007-03-08
IL179137A (en) 2012-07-31
JP2008501976A (en) 2008-01-24
AU2005262701A1 (en) 2006-01-19

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