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WO2006001806A3 - Methode de thermometrie non invasive dans laquelle sont utilises des conjugues polypeptidiques semblables a l'elastine - Google Patents

Methode de thermometrie non invasive dans laquelle sont utilises des conjugues polypeptidiques semblables a l'elastine Download PDF

Info

Publication number
WO2006001806A3
WO2006001806A3 PCT/US2004/019132 US2004019132W WO2006001806A3 WO 2006001806 A3 WO2006001806 A3 WO 2006001806A3 US 2004019132 W US2004019132 W US 2004019132W WO 2006001806 A3 WO2006001806 A3 WO 2006001806A3
Authority
WO
WIPO (PCT)
Prior art keywords
elastin
polypeptide conjugates
elp
invasive thermometry
epr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/019132
Other languages
English (en)
Other versions
WO2006001806A2 (fr
Inventor
Mark Dewhirst
Matthew Dreher
Ashutosh Chilkoti
Howard Halpern
Gerald Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duke University
Original Assignee
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duke University filed Critical Duke University
Priority to PCT/US2004/019132 priority Critical patent/WO2006001806A2/fr
Publication of WO2006001806A2 publication Critical patent/WO2006001806A2/fr
Publication of WO2006001806A3 publication Critical patent/WO2006001806A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
    • G01K7/00—Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat ; Power supply therefor, e.g. using thermoelectric elements
    • G01K7/32—Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat ; Power supply therefor, e.g. using thermoelectric elements using change of resonant frequency of a crystal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
    • G01K7/00—Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat ; Power supply therefor, e.g. using thermoelectric elements
    • G01K7/36—Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat ; Power supply therefor, e.g. using thermoelectric elements using magnetic elements, e.g. magnets, coils
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/4804—Spatially selective measurement of temperature or pH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/60—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using electron paramagnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
    • G01K2213/00—Temperature mapping

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des compositions comprenant des polypeptides semblables à l'élastine (ELP) thermosensibles combinés avec un marqueur de spin de résonance paramagnétique électronique (EPR). L'invention concerne également des méthodes de synthèse et d'utilisation des conjugués polypeptidiques semblables à l'élastine (ELP) pour l'imagerie et/ou la spectroscopie EPR.
PCT/US2004/019132 2004-06-15 2004-06-15 Methode de thermometrie non invasive dans laquelle sont utilises des conjugues polypeptidiques semblables a l'elastine Ceased WO2006001806A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/US2004/019132 WO2006001806A2 (fr) 2004-06-15 2004-06-15 Methode de thermometrie non invasive dans laquelle sont utilises des conjugues polypeptidiques semblables a l'elastine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2004/019132 WO2006001806A2 (fr) 2004-06-15 2004-06-15 Methode de thermometrie non invasive dans laquelle sont utilises des conjugues polypeptidiques semblables a l'elastine

Publications (2)

Publication Number Publication Date
WO2006001806A2 WO2006001806A2 (fr) 2006-01-05
WO2006001806A3 true WO2006001806A3 (fr) 2006-06-22

Family

ID=35782198

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/019132 Ceased WO2006001806A2 (fr) 2004-06-15 2004-06-15 Methode de thermometrie non invasive dans laquelle sont utilises des conjugues polypeptidiques semblables a l'elastine

Country Status (1)

Country Link
WO (1) WO2006001806A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8841255B2 (en) 2005-12-20 2014-09-23 Duke University Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
US20130172274A1 (en) 2005-12-20 2013-07-04 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
US7709227B2 (en) 2006-01-04 2010-05-04 Phasebio Pharmaceuticals, Inc. Multimeric ELP fusion constructs
JP2009528984A (ja) * 2006-01-27 2009-08-13 ザ・ユニバーシティ・オブ・ミシシッピ・メディカル・センター ドキソルビシンを含む医薬の熱標的化送達
US8841414B1 (en) 2006-01-27 2014-09-23 University Of Mississippi Medical Center Targeted delivery of therapeutic peptides by thermally responsive biopolymers
US9682118B1 (en) 2006-01-27 2017-06-20 University Of Mississippi Medical Center Inhibition of metastasis by cell penetrating peptides
US20100119529A1 (en) * 2006-05-12 2010-05-13 Furgeson Darin Y Elastin-like polymer delivery vehicles
US8367626B2 (en) 2006-05-12 2013-02-05 Wisconsin Alumni Research Foundation Elastin-like polymer delivery vehicles
EP2043689A4 (fr) * 2006-07-24 2013-08-07 Univ Duke Administration de médicament avec biopolymères sensibles aux stimuli
CN101553262A (zh) 2006-11-13 2009-10-07 悉尼大学 原弹性蛋白用于组织修复或恢复的用途
EP2307038A4 (fr) 2008-06-27 2013-03-27 Univ Duke Agents thérapeutiques comprenant des peptides de type élastine
EP2387963A1 (fr) 2010-05-17 2011-11-23 Koninklijke Philips Electronics N.V. Appareil de détermination de la répartition de la température
EP2702400A4 (fr) * 2011-04-29 2015-06-17 Childrens Hosp & Res Ct Oak Compositions et procédés pour évaluer la capacité de lipoprotéine de haute densité (hdl) à supporter le transport inverse du cholestérol
EP3628333A1 (fr) 2018-09-25 2020-04-01 Institut Polytechnique De Bordeaux Bioconjugués de polysaccharides et de polypeptides de type élastine et leurs utilisations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DREHER M.R. ET AL: "Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry", MED. PHYS., vol. 31, no. 10, 31 October 2004 (2004-10-31), pages 2755 - 2762 *

Also Published As

Publication number Publication date
WO2006001806A2 (fr) 2006-01-05

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