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WO2006000911A1 - Blood and tissue component analysis apparatus - Google Patents

Blood and tissue component analysis apparatus Download PDF

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Publication number
WO2006000911A1
WO2006000911A1 PCT/IB2005/002051 IB2005002051W WO2006000911A1 WO 2006000911 A1 WO2006000911 A1 WO 2006000911A1 IB 2005002051 W IB2005002051 W IB 2005002051W WO 2006000911 A1 WO2006000911 A1 WO 2006000911A1
Authority
WO
WIPO (PCT)
Prior art keywords
blood
zones
molecules
palpabral
intravascular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2005/002051
Other languages
French (fr)
Inventor
Alec Blanchard
Steven Taub
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2006000911A1 publication Critical patent/WO2006000911A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes

Definitions

  • Blood and tissue component analysis apparatus Optoelectronic device for measuring molecules present in blood and tissue
  • Non-invasive, non-destructive process for qualitative and quantitative analysis of blood and tissue
  • Blood formula and composition analysis is routinely performed on patients.
  • Today, blood formula composition analysis is invasive and destructive. It is not performed in real time and generally requires the use of costly reagents, high technology equipment and trained laboratory personnel. The sampling of blood and its handling also comports a certain number of risks for both the patient and medical personnel.
  • Blood formula analysis yields information pertinent to metabolism as well as the general health and well being of any human or animal.
  • the presence or absence of specific molecules in the blood or tissue composition may be an indicator of certain pathology, infection or even a cardiac event such as an infarct us.
  • certain molecules need to be monitored for the proper dosing of medication, as in the case of diabetes, where sugar levels need to be measured to optimize administration of insulin.
  • Oxygen blood gas levels are commonly measured through oximeters operating on a optoelectronic based apparatus through a process of photon absorption measurement, however non gas components such as sugar, hemoglobin, bilirubin etc., or performance enhancing substances (amphetamines, cocaine, etc.) are still measured through invasive sampling and destructive analysis.
  • Current state of the art for the measurement of blood formula therefore implies a time consuming, complex, costly, risky procedure that sometimes, such in the case of a thrombosis, may be delaying treatment for life threatening events.
  • the objective of the present invention is overcome the disadvantages of the prior art and offer a new blood formula analysis apparatus, based on a photometric process which is non invasive, non destructive uses no consumable reagents and implies no risk to the patient or the operator and may present immediate results for real time analysis.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Emergency Medicine (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Method and non-invasive apparatus for quantitative and qualitative measurement human/animal components and molecules present in blood and tissue.

Description

Blood and tissue component analysis apparatus Optoelectronic device for measuring molecules present in blood and tissue Non-invasive, non-destructive process for qualitative and quantitative analysis of blood and tissue
Blood formula and composition analysis is routinely performed on patients. Today, blood formula composition analysis is invasive and destructive. It is not performed in real time and generally requires the use of costly reagents, high technology equipment and trained laboratory personnel. The sampling of blood and its handling also comports a certain number of risks for both the patient and medical personnel.
Blood formula analysis yields information pertinent to metabolism as well as the general health and well being of any human or animal. The presence or absence of specific molecules in the blood or tissue composition may be an indicator of certain pathology, infection or even a cardiac event such as an infarct us. In addition, certain molecules need to be monitored for the proper dosing of medication, as in the case of diabetes, where sugar levels need to be measured to optimize administration of insulin.
Oxygen blood gas levels are commonly measured through oximeters operating on a optoelectronic based apparatus through a process of photon absorption measurement, however non gas components such as sugar, hemoglobin, bilirubin etc., or performance enhancing substances (amphetamines, cocaine, etc.) are still measured through invasive sampling and destructive analysis. Current state of the art for the measurement of blood formula therefore implies a time consuming, complex, costly, risky procedure that sometimes, such in the case of a thrombosis, may be delaying treatment for life threatening events.
The objective of the present invention is overcome the disadvantages of the prior art and offer a new blood formula analysis apparatus, based on a photometric process which is non invasive, non destructive uses no consumable reagents and implies no risk to the patient or the operator and may present immediate results for real time analysis.

Claims

Claims
1) A process based on an optoelectronic device which measures molecules present in blood and tissue though a non-destructive non-invasive photometric analysis of the palpabral conjunctiva in vivo. 2) A process based on an optoelectronic device, which detects and measures molecules present in blood though a non-destructive, non-invasive, photometric analysis ex vivo performed through a transparent conduit of the extra corporal circulating blood. 3) A process according to claim 1 above for detecting and measuring strictly intravascular molecules (for example hemoglobin). This, in order to differentiate between extravascular and intravascular zones present in the palpabral conjunctiva allowing for the selection of the zones of measure. 4) A process according to claim 1 above for detecting and measuring strictly extravascular molecules. This, in order to differentiate between extravascular and intravascular zones present in the palpabral conjunctiva allowing for the selection of the zones of measure. 5) An optoelectronic apparatus according to claims 1- 4 above capable of the emission and the detection of photons in the UV, visible, near infrared and far infrared regions. 6) An optoelectronic apparatus according to claim 5 above capable of analysis of the detected photons in comparison with the emitted photon and the subsequent processing of this information in order to yield data on the molecular composition of blood and tissue regions illuminated by the emitted photons.
PCT/IB2005/002051 2004-06-23 2005-06-20 Blood and tissue component analysis apparatus Ceased WO2006000911A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58177004P 2004-06-23 2004-06-23
US60/581,770 2004-06-23

Publications (1)

Publication Number Publication Date
WO2006000911A1 true WO2006000911A1 (en) 2006-01-05

Family

ID=35106988

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/002051 Ceased WO2006000911A1 (en) 2004-06-23 2005-06-20 Blood and tissue component analysis apparatus

Country Status (1)

Country Link
WO (1) WO2006000911A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0722692A1 (en) * 1995-01-20 1996-07-24 Hughes Aircraft Company Noninvasive method and apparatus for determining body chemistry
EP0776628A2 (en) * 1995-10-31 1997-06-04 Akitoshi Yoshida Intraocular substance measuring apparatus
WO2001016577A1 (en) * 1999-08-31 2001-03-08 Cme Telemetrix Inc. Method for determination of analytes using nir, adjacent visible spectrum and discrete nir wavelengths

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0722692A1 (en) * 1995-01-20 1996-07-24 Hughes Aircraft Company Noninvasive method and apparatus for determining body chemistry
EP0776628A2 (en) * 1995-10-31 1997-06-04 Akitoshi Yoshida Intraocular substance measuring apparatus
WO2001016577A1 (en) * 1999-08-31 2001-03-08 Cme Telemetrix Inc. Method for determination of analytes using nir, adjacent visible spectrum and discrete nir wavelengths

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