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WO2006099877A1 - Suppositoires rectaux et vaginaux contenant de la bromocriptine et un poloxamere bioadhesifs - Google Patents

Suppositoires rectaux et vaginaux contenant de la bromocriptine et un poloxamere bioadhesifs Download PDF

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Publication number
WO2006099877A1
WO2006099877A1 PCT/EG2005/000032 EG2005000032W WO2006099877A1 WO 2006099877 A1 WO2006099877 A1 WO 2006099877A1 EG 2005000032 W EG2005000032 W EG 2005000032W WO 2006099877 A1 WO2006099877 A1 WO 2006099877A1
Authority
WO
WIPO (PCT)
Prior art keywords
rectal
bromocriptine
poloxamer
vaginal suppositories
suppositories containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EG2005/000032
Other languages
English (en)
Inventor
Atef Mohammed Mostafa Darwish
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2006099877A1 publication Critical patent/WO2006099877A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules

Definitions

  • Bromocriptine methylate is a water insoluble drug. It is associated with a lot of side effects that lead to 10% discontinuation rate. Its solubility and subsequently absorption could be increased by adding pluronics as demonstrated in a previous study ( Darwish et al. Fertility and sterility- April, 2005 (755)
  • the previous formula is mixed with bioadhesive polymers including caobopol 974P, chitosan and is created in a suppository form suitable for both male ( rectal ) and female ( vaginal ) usage to extend the scope of this treatment modality.
  • bioadhesive polymers including caobopol 974P, chitosan

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention a trait à des suppositoires qui peuvent être introduits rectalement ou vaginalement, contenant du mésylate de bromocriptine et un poloxamère. Pour la réalisation de bioadhésivité, la formulation contient un carbopol ou chitosane.
PCT/EG2005/000032 2005-03-24 2005-10-01 Suppositoires rectaux et vaginaux contenant de la bromocriptine et un poloxamere bioadhesifs Ceased WO2006099877A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EG2005030150 2005-03-24
EG2005030150 2005-03-24

Publications (1)

Publication Number Publication Date
WO2006099877A1 true WO2006099877A1 (fr) 2006-09-28

Family

ID=37023380

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EG2005/000032 Ceased WO2006099877A1 (fr) 2005-03-24 2005-10-01 Suppositoires rectaux et vaginaux contenant de la bromocriptine et un poloxamere bioadhesifs

Country Status (1)

Country Link
WO (1) WO2006099877A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3752814A (en) * 1968-05-31 1973-08-14 Sandoz Ltd 2-bromo-alpha-ergocryptine
US6267985B1 (en) * 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3752814A (en) * 1968-05-31 1973-08-14 Sandoz Ltd 2-bromo-alpha-ergocryptine
US6267985B1 (en) * 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions

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