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WO2006095888A2 - Procede de production d'un melange de particules - Google Patents

Procede de production d'un melange de particules Download PDF

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Publication number
WO2006095888A2
WO2006095888A2 PCT/JP2006/304828 JP2006304828W WO2006095888A2 WO 2006095888 A2 WO2006095888 A2 WO 2006095888A2 JP 2006304828 W JP2006304828 W JP 2006304828W WO 2006095888 A2 WO2006095888 A2 WO 2006095888A2
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WO
WIPO (PCT)
Prior art keywords
particles
vessel
type
methyl
examples
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2006/304828
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English (en)
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WO2006095888A3 (fr
Inventor
Nobuhito Ueda
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Sumitomo Chemical Co Ltd
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Sumitomo Chemical Co Ltd
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Publication of WO2006095888A2 publication Critical patent/WO2006095888A2/fr
Publication of WO2006095888A3 publication Critical patent/WO2006095888A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/12—Powders or granules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/60—Mixing solids with solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/10—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic in stationary drums or troughs, provided with kneading or mixing appliances
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/14—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic in rotating dishes or pans

Definitions

  • the present invention relates to a process for producing a mixture of at least two kinds of particles, each being composed of plural components.
  • a vessel rotating-type mixer and a mechanical mixing-type mixer are known.
  • the present invention aims to provide a process of producing a mixture of plural kinds of particles with an improved homogeneity by using a vessel rotating-type mixer or a mechanical mixing-type mixer.
  • the inventor has found that in mixing of at least two kinds of particles each composed of plural components by a vessel rotating-type mixer or a mechanical mixing-type mixer, a homogeneous mixture of particles can be obtained by mixing them in a humidified vessel, and accomplished the present invention.
  • a process for producing a mixture of particles (A) and particles (B) characterized in that the process comprises a step for introducing particles (A) composed of plural components and particles (B) composed of plural components into a vessel, a step for humidifying an inside of the vessel, and a step for either rotating the vessel or rotating a stirring (or agitating) blade (s) located in the vessel;
  • a process for producing a mixture of particles (A) and particles (B) characterized in that the process comprises: a step for introducing particles (A) composed of plural components and particles (B) composed of plural components into a vessel; a step for humidifying an inside of the vessel; and a step for rotating the vessel;
  • [4] The process according to any one of [1] to [3], characterized in that the particles (A) and the particles (B) are particles having a particle diameter in a range of 0.3-10 mm and a volume resistivity not less than IO ⁇ 0 ⁇ -m; [5] The process according to any one of [1] to [4], characterized in that the particles (A) are particles containing a pharmaceutical component, an agrochemical component or a fertilizer component; and [6] The process according to any one of [1] to [5], characterized in that the particles (A) are particles coated with a resin.
  • the process for producing the mixture of particles by a vessel rotating-type mixer comprises a step for introducing the particles to be mixed into the vessel and a step for rotating the vessel.
  • the process for producing the mixture of particles by a mechanical mixing-type mixer comprises a step for introducing the particles to be mixed into the vessel and a step for rotating a stirring blade (s) located in the vessel.
  • the mixture of the particles (A) and the particles (B) obtained by the present invention is a mixture in which each kind of the particles (A) and the particles (B) remains in the form of a particle.
  • a motor mixer used in the process for producing the mixture of particles of the present invention can be the vessel rotating-type mixer or the mechanical mixing-type mixer depending on its manner for imparting momentum to the particles.
  • the vessel rotating-type mixer include a horizontal drum (or cylinder) type mixer, an inclined drum type mixer, a V-type mixer, and a double cone type mixer.
  • the vessel rotating-type mixer is preferably used when the particles to be mixed have little difference in their physical properties and have a good fluidity and when the particles are easily broken or deformed by friction.
  • Examples of the mechanical mixing-type mixer include a ribbon type mixer, a cone type screw mixer, a fast fluidization type mixer, a rotating disk type mixer, and a stirring type mixer.
  • the mechanical mixing-type mixer is preferably used when the particles to be mixed have a large difference in their physical properties.
  • the particles composed of plural components in the present invention mean particles containing in a solid component one or more different components from the solid component.
  • the particles comprise particles of which different component (s) is homogeneously dispersed in the solid component, and particles of which different component (s) is unevenly distributed on or around the solid component .
  • the particles (A) composed of plural components and the particles (B) composed of plural components are different from each other.
  • the particles different from each other means (a) a case where kinds of the components contained in the particles are different from those of the other particles, and (b) a case where a content of a certain component in the particles is different from that of the other particles by two times or more. This, however, does not mean that the particles are different from each other only in the particles shape or the particles diameter.
  • the term "component" contained in the particles means a substance of which content in the particles is not less than 0.1% by weight.
  • the components contained in the particles do not have any chemical bond therebetween, but are retained in the particles by a physical force such as a cohesive force.
  • the process for producing the mixture of particles of the present invention is characterized in that the process comprises (i) a step for introducing the particles (A) composed of plural components and the particles (B) composed of plural components into a vessel, (ii) a step for humidifying an inside of the vessel, and (iii) a step for either rotating the vessel or rotating a stirring (or agitating) blade (s) located in the vessel.
  • the steps (i) and (ii) may be conducted concurrently, and also the steps (ii) and (iii) may be conducted concurrently.
  • the particles (A) and the particles (B) are introduced in the vessel, and additional particles which are different from the particles (A) and the particles (B) may be also introduced therein.
  • the mixing ratio of the particles (A) and the particles (B) is generally 50:50 to 5:95, and preferably 50:50 to 75:25 by weight.
  • the step (ii) is conducted, for example, by supplying the vessel with an air of a high humidity or by supplying the vessel with small water droplets (mist) .
  • the air of a high humidity or the small water droplets can be generated by a humidifier.
  • a humidifier There may be many types of the humidifier, such as a heating type (or steaming type) in which steam is generated by heating water, an ultrasonic type in which small water droplets (mist) are generated by an ultrasonic vibrator, and a mixed type thereof.
  • the step (ii) raises the relative humidity in the vessel by 10% or more and preferably 20% or more with respect to a relative humidity outside the vessel.
  • the relative humidity in the vessel is generally preferable at 50% or more.
  • the relative humidity is a value obtained by dividing a partial pressure of vapor in the air to be measured by a partial pressure of saturated vapor at the temperature to be measured and multiplying it value by 100, and thus the relative humidity is expressed in percentage, % .
  • the step (iii) is a step for mixing the particles (A) and the particles (B) by either rotating the vessel itself in which the particles (A) and the particles (B) are contained, or rotating a stirring blade (s) located in the vessel.
  • the step (iii) is generally conducted at a temperature in the range of -10 to 50 0 C.
  • the particles (A) or the particles (B) contain a pharmaceutical component, an agrochemical component or a fertilizer component, it is preferably conducted in the range of -5 to 40 0 C in view of a stability of such component.
  • a number of particles (or particle counts) in one gram of the particles (A) and the particles (B) is generally 50-5000 particles, and preferably 200-3000 particles.
  • An apparent specific gravity of each kind of the particles is generally 0.3-1.5 g/cc, and preferably 0.7-1.2 g/cc. The apparent specific gravity can be measured according to the Zen-Noh method.
  • a difference in the apparent specific gravity between the particles (A) and the particles (B) is preferably 0.3 g/cc or less, and more preferably 0.2 g/cc or less.
  • a shape of the particle is generally cubic, rectangular, trigonal pyramidal, circular conic, circular cylindrical, spherical, dumbbell-like, ellipsoidal, oval, convex conic, concave conic, plate-like or the like.
  • the particles (A) and the particles (B) used in the present invention generally have an electrostatic property, in other words, they have a volume resistivity, which is obtained by measuring an electric resistance of the particles, not less than 10 10 ⁇ -m.
  • the volume resistivity of the particles can be calculated based on a resistance which is obtained by, for example, filling a vessel of 150 mm (diameter) x 10 mm (thickness) with the particles as a sample, contacting electrodes of 80 mm (diameter) with the opposed ends of the sample of the particles in the direction of its thickness, and measuring the resistance with a Ultra-High Resistance/ Micro Current Meter (more specifically, Model R8340/8340A manufactured by Advantest) .
  • the plural components which compose the particles (A) and the particles (B) include a surfactant as a component of the particles.
  • a surfactant in addition to the surfactant, a pharmaceutical component, an agrochemical component, a fertilizer component, a dye component, and an additive component for polymer, for example, can be listed for the components of the particles.
  • the surfactant include nonionic surfactants, anionic surfactants, cationic surfactants, and zwitterionic (or ampholytic) surfactants.
  • the surfactant When the surfactant is contained in the particles, its amount is 0.1 to 70% by weight, and preferably 0.5 to 30% by weight with respect to the weight of the particles.
  • the nonionic surfactants are exemplified by sugar ester type nonionic surfactants, fatty acid ester type nonionic surfactants, vegetable oil type nonionic surfactants, alcohol type nonionic surfactants, alkylphenol type nonionic surfactants, polyoxyethylene-polyoxypropylene block polymer type nonionic surfactants, bisphenol type nonionic surfactants, polyaromatic type nonionic surfactants, silicone type nonionic surfactants and fluorinated type nonionic surfactants.
  • sugar ester type nonionic surfactant include sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters and sucrose fatty acid esters.
  • Examples of the fatty acid ester type nonionic surfactant include polyoxyethylene fatty acid esters, polyoxyethylene resin acid esters and polyoxyethylene fatty acid diesters.
  • Examples of the vegetable oil type nonionic surfactant include polyoxyethylene castor oil and polyoxyethylene hardened castor oil.
  • Examples of the alcohol type nonionic surfactant include polyoxyethylenealkyl ethers.
  • Examples of the alkylphenol type nonionic surfactant include polyoxyethylenealkyl phenyl ethers, polyoxyethylenedialkyl phenyl ethers and polyoxyethylenealkyl phenyl ether- formalin condensates.
  • polyoxyethylene- polyoxypropylene block polymer type nonionic surfactant examples include polyoxyethylene-polyoxypropylene block polymer, alkylpolyoxyethylene-polyoxypropylene block polymer ethers and alkylphenyl polyoxyethylene-polyoxypropylene block polymer ethers.
  • examples of the bisphenol type nonionic surfactant include polyoxybisphenyl ethers.
  • examples of the polyaromatic type nonionic surfactant include polyoxyalkylenebenzyl phenyl ethers and polyoxyalkylenestyryl phenyl ethers.
  • silicone type nonionic surfactants examples include polyoxyethylene ether type silicone surfactants and polyoxyethylene ester type silicone surfactants.
  • the anionic surfactants are exemplified by sulfate type anionic surfactants, sulfonate type anionic surfactants, phosphate type anionic surfactants and carboxylic acid type anionic surfactants.
  • sulfate type anionic surfactant include alkyl sulfates, polyoxyethylenealkyl ether sulfates, polyoxyethylenealkyl phenyl ether sulfates, polyoxystyryl phenyl ether sulfates and polyoxyethylene-polyoxypropylene block polymer sulfates.
  • sulfonate type anionic surfactant examples include paraffin sulfonates, dialkyl sulfosuccinates, alkylbenzenesulfonates, monoalkylnaphthalenesulfonates, dialkylnaphthalenesulfonates, naphthalenesulfonate-formalin condensates, alkyl diphenyl ether disulfonates and polyoxyethylenealkyl phenyl ether sulfonates.
  • Examples of the phosphate type anionic surfactant include polyoxyethylenealkyl ether phosphate, polyoxyethylenemonoalkyl phenyl ether phosphate, polyoxyethylenedialkyl phenyl ether phosphate, polyoxyethylenestyryl phenyl ether phosphate, polyoxyethylene-polyoxypropylene block polymer phosphate and alkyl phosphate.
  • Examples of the carboxylic acid type anionic surfactant include sodium salts of fatty acid, potassium salts of fatty acid, ammonium salts of fatty acid, N-methylsarcosinate, sodium salts of resin acid and potassium salts of resin acid.
  • the cationic surfactants are exemplified by ammonium type cationic surfactants and benzalkonium type cationic surfactants.
  • ammonium type cationic surfactant include alkyl trimethyl ammonium chloride, methyl polyoxyethylenealkyl ammonium chloride, alkyl N- methylpyridinium bromide, mono or dialkylmethylated ammonium chloride and alkylpentamethylpropylenediamine chloride.
  • Examples of the benzalkonium type cationic surfactant include alkyl dimethyl benzalkonium chloride, benzethonium chloride and octylphenoxyethoxyethyl dimethyl benzylaitu ⁇ oniui ⁇ chloride.
  • the zwitterionic surfactants are exemplified by betaine type zwitterionic surfactants.
  • betaine type zwitterionic surfactant examples include dialkyl diaminoethyl betaine and alkyl dimethyl benzyl betaine.
  • the particles (A) when the particles (A) contain an agrochemical component, these particles are generally contain an agrochemical component, a surfactant, and also a carrier (or support) as a solid component, and may further contain a binder, a solvent, a stabilizing agent, a coloring agent, a coating material and so on, if necessary.
  • Such particles can be made generally by mixing an agrochemical component, a surfactant, a carrier as a solid component, and, if necessary, a binder, a solvent, a stabilizing agent, a coloring agent, a coating material and so on, and granulating and forming the resultant mixture.
  • the agrochemical component may comprise an insecticide, a fungicide, a herbicide, an insect growth regulator, a plant growth regulator and so on, and examples may comprise following compounds: organophosphorus compounds such as O, O-dimethyl-0- (3- methyl-4-nitrophenyl) phosphorothioate, O, O-dimethyl-0- (3- methyl-4- (methylthio) phenyl) phosphorothioate, 0,0-diethyl- 0-2-isopropyl-6-methylpyrimidin-4-yl phosphorothioate, 0,0- diethyl-O-3, 5, 6-trichloro-2-pyridyl phosphorothioate, 0,S- dimethyl acetylphosphoramidothioate, S-2, 3-dihydro-5- methoxy-2-oxo-l, 3, 4-thiadiazol-3-ylr ⁇ ethyl O, 0-dimethyl phosphorodithioate, 0,0-diethyl S-2
  • carbamate compounds such as 2-sec-butylphenyl methylcarbamate, ethyl N- ⁇ 2,3-dihydro-2,2-dimethylbenzofuran-7- yloxycarbonyl (methyl) aminothio ⁇ -N-isopropyl- ⁇ -alaninate, 2- isopropoxyphenyl-N-methylcarbamate, 2, 3-dihydro-2, 2- dimethyl-7-benzo [b] furanyl N- dibutyl amino thio -N- methylcarbamate, 1-naphthyl-N-methylcarbamate, S-methyl-N-
  • the carrier as a solid component can be, for example, a mineral carrier, a vegetable carrier, an animal carrier, a synthetic carrier and so on.
  • the mineral carrier examples include kaolin minerals such as kaolinite, dickite, nacrite and halloysite; serpentinites such as chrysotile, lizardite, antigorite and amesite; montmorillonite minerals such as sodium montmorillonite, calcium montmorillonite and magnesium montmorillonite; smectites such as saponite, hectorite, sauconite and beidellite; micas such as pyrophyllite, talc, agalmatolite, muscovite, phengite, sericite and illite; silicas such as cristobalite and quartz; hydrated magnesium silicates such as attapulgite and sepiolite; calcium carbonates such as dolomite and calcium carbonate fine powder; sulfate minerals such as gypsum and plaster; zeolite; boiling stone; tuff; vermiculite; laponite; pumice; diatomite; acidic clay; activated
  • Examples of the vegetable carrier include cellulose, hull, wheat flour, wood flour, starch, bran, wheat bran, soy bean flour and so on.
  • Examples of the synthetic carrier include wet silica, dry silica, calcinated product of wet silica, surface modified silica, processed starch (for example, Pineflow manufactured by Matsutani Kagaku K. K., Japan) and so on.
  • Such carrier generally makes up 0.5 to 99.9% by weight, and preferably 25 to 99.5% by weight of the particulate material.
  • the particles (A) and/or the particles (B) when the particles (A) and/or the particles (B) contain a fertilizer component, these particles generally contain the fertilizer component and a surfactant, and may further contain a coloring agent, a coating material and so on, if necessary.
  • fertilizer component examples include urea, ammonium sulfate, ammonium chloride, ammonium phosphate, ammonium nitrate, lime nitrogen, sodium nitrate, acetaldehyde condensed urea, calcined phosphate, processed phosphate fertilizer, concentrated superphosphate, phosphate fertilizer mixture, potassium chloride, potassium sulfate magnesia, potassium bicarbonate, potassium silicate, potassium phosphate, potassium nitrite and so on.
  • the particles (A) and/or the particles (B) may be coated with a resin or the like.
  • the resin or the like in this case can be, for example, a water-soluble polymer, a wax, a thermoplastic resin, a thermoset resin and so on.
  • examples of the water-soluble polymer include sugar and alginate.
  • wax examples include synthetic waxes such as carbowax, Hoechst wax, sucrose ester and fatty acid ester; natural waxes such as carnauba wax, beeswax and Japan wax; petroleum waxes such as paraffin wax, petrolactam and so on.
  • thermoplastic resin examples include polyolefins such as polyethylene, polypropylene, polybutene and polystyrene; vinyl polymers such as polyvinyl acetate, polyvinyl chloride, polyvinylidene chloride, polyacrylic acid, polymethacrylic acid, polyacrylic ester and polymethacrylic ester; diene polymers such as butadiene polymer, isoprene polymer, chloroprene polymer, butadiene- styrene copolymer, ethylene-propylene-diene copolymer and styrene-isoprene copolymer; polyolefin copolymers such as ethylene-propylene copolymer, butene-ethylene copolymer, butene-propylene copolymer, ethylene-vinyl acetate copolymer, ethylene-acrylic acid copolymer, ethylene- methacrylic acid copolymer, ethylene-methacryl
  • thermoset resin examples include urethane resin, epoxy resin, alkyd resin, unsaturated polyester resin, phenol resin, urea resin, melamine resin, silicone resin and so on.
  • Urethane resin is usually generated by a reaction of polyisocyanate and polyol in the presence of a curing agent such as an organic metal or amine.
  • a curing agent such as an organic metal or amine.
  • Polyisocyanate and polyol as monomers of the urethane resin are generally used alone as the monomers, or in the form of a solution, a water-based emulsion, an organic solvent-based emulsion or the like.
  • polyisocyanate examples include toluene diisocyanate (TDI), diphenylmethane diisocyanate (MDI), naphthalene diisocyanate, tolidine diisocyanate, hexamethylene diisocyanate, isophorone diisocyanate, xylylene diisocyanate, 4,4- methylenebis (cyclohexylisocyanate) , trimethylhexamethylenediisocyanate, 1, 3- (isocyanatemethyl) cyclohexane, triphenylmethanetriisocyanate, tris (isocyanataphenyl) thiophosphate, and a mixture thereof.
  • TDI toluene diisocyanate
  • MDI diphenylmethane diisocyanate
  • naphthalene diisocyanate tolidine diisocyanate
  • hexamethylene diisocyanate hexamethylene diisocyanate
  • modified one or an oligomer of the above exemplified polyisocyanate can be used.
  • modified polyisocyanate include adducts of diisocyanate, biuret condensation products of three molecules of diisocyanate, isocyanurate condensation products of diisocyanate, isocyanate prepolymers, two molecules condensation products of diisocyanate and so on.
  • the polyol include condensation type polyester polyol, polyether polyol, poly (meta) acrylic acid polyol, lactone type polyether polyol, polycarbonate polyol, natural polyol and modified one thereof.
  • Condensation type polyester polyol is usually generated by a condensation reaction of polyol and dibasic acid
  • polyether polyol is usually generated by a polymerization reaction of cyclic oxide.
  • Poly (meta) acrylic acid polyol is usually generated by a condensation reaction of poly (meta) acrylic acid and polyol, a condensation reaction of (meta) acrylic acid and polyol, or a polymerization reaction of (meta) acrylic ester monomer.
  • Lactone type polyether polyol can be obtained by a ring-opening polymerization of ⁇ -caprolactam with an initiating reagent of polyvalent alcohol.
  • Polycarabonate polyol is usually generated by a reaction of glycol and carbonate.
  • polyol examples include methylene glycol, ethylene glycol, propylene glycol, tetramethylene glycol, hexamethylene diol, trimethylol propane, poly (tetramethylene glycol), glycerin, pentaerythritol, sorbitol, sucrose and oligomers thereof.
  • the dibasic acid may be adipic acid or phthalic acid.
  • acrylic acid acrylic acid, methacrylic acid or the like is generally used.
  • Epoxy resin is usually generated by a reaction of phenol or alcohol with epichlorohydrin in the presence of a curing agent, a reaction of carboxylic acid with epichlorohydrin in the presence of a curing agent, a reaction of amine, cyanuric acid or hydantoin with epichlorohydrin in the presence of a curing agent, a reaction of an aliphatic cyclic epoxy compound in the presence of a curing agent such as peracetic acid, and so on.
  • epoxy resin examples include glycidyl ether type epoxy resins such as bisphenol A type, bisphenol F type, brominated bisphenol A type, hydrogenated bisphenol A type, bisphenol S type, bisphenol AF type, biphenyl type, naphthalene type, fluorene type, phenol novolac type, orthocresol novolac type, DPP novolac type, trishydroxyphenylmethane type, tetraphenylolethane type; glycidyl amine type epoxy resins such as tetraglycidyldiaminodiphenylmethane type, triglycidylisocyanurate type, hydantoin type, aminophenol type, aniline type, toluidine type; alicyclic type epoxy resins, and so on.
  • glycidyl ether type epoxy resins such as bisphenol A type, bisphenol F type, brominated bisphenol A type, hydrogenated bisphenol A type, bisphenol S type, bisphenol
  • Alkyd resin is, for example, generated by a reaction of polybasic acid with polyvalent alcohol in the presence of, if necessary, a modifying agent such as natural vegetable oil or animal fat, a metallic soap, or an antiskinning agent.
  • a modifying agent such as natural vegetable oil or animal fat, a metallic soap, or an antiskinning agent.
  • the polybasic acid include phthalic anhydride, maleic anhydride and so on
  • examples of the polyvalent alcohol include pentaerythritol, glycerin and so on.
  • the modifying agent include, for example, soybean oil, linseed oil, tung oil, safflower oil, coconut oil, palm oil, dehydrated castor oil and so on.
  • Examples of the metallic soap usually include metal salts of naphthenic acid or octylic acid such as manganese, cobalt, zirconium, nickel, iron, and lead salts, for example, zirconium octylate, manganese naphthenate, cobalt octylate, and mixtures thereof.
  • Examples of the antiskinning agent include dipentene, methoxyphenol, cyclohexanone oxime, methyl ethyl ketone oxime, and mixtures thereof.
  • Unsaturated polyester resin is usually obtained by a reaction of unsaturated dibasic acid with divalent alcohol in the presence of vinyl monomer.
  • unsaturated dibasic acid include phthalic anhydride, isophthalic acid, terephthalic acid, succinic acid, adipic acid, azelaic acid, sebacic acid, tetrahydrophthalic anhydride, hexahydrophthalic anhydride, tetrabromophthalic anhydride, tetrachlorophthalic anhydride, HET® acid anhydride (i.e. chlorendic anhydrate) , endomethylenetetrahydrophthalic anhydride, and so on.
  • Examples of the divalent alcohol include ethylene glycol, propylene glycol, 1,3-butylene glycol, 1, ⁇ -hexanediol, diethylene glycol, dipropylene glycol, neopentyl glycol, triethylene glycol, hydrogenated bisphenol A, bisphenol dihydroxypropyl ether, and so on.
  • Examples of the vinyl monomer include styrene, vinyltoluene, chlorostyrene, diallyl phthalate, triallyl cyanurate, methyl methacrylate, and so on.
  • Phenol resin is generated by a reaction of a phenolic compound with aldehyde in the presence of a catalyst such as hydrochloric acid, oxalic acid, hexamethylenetetramine.
  • phenolic compound examples include phenol, o-cresol, m-cresol, p-cresol, xylenol, p-tert-butylphenol, resorcinol, and so on. From this reaction, novolac type phenol resins are obtained under an acidic catalyst condition, and resol type phenol resins are obtained under a basic catalyst condition.
  • Urea resin or melamine resin is usually generated by a reaction of urea or melamine with formaldehyde such as formalin in the presence of a basic catalyst.
  • Particles used for examples • Particles "a” Two parts by weight of polyoxyethylenestyryl phenyl ether, 3 parts by weight of a binder, 13.5 parts by weight of a water-soluble carrier, and 73.5 parts by weight of a mineral carrier were mixed and kneaded with an amount of water. Thus kneaded material was granulated by an extrusion granulator and dried, and the obtained particles were coated with a urethane resin which was prepared from aromatic polyisocyanate and polyether polyol to give cylindrical particles "a” having a particle diameter of 500 to 1190 ⁇ m. -Particles "b"
  • a cylindrical vessel made of SUS304 with a volume of 450 ml (about 7 cm in diameter, about 10 cm in height) was used as a vessel to which particles are introduced.
  • the cylindrical vessel was provided with a detachable lid on the top of the cylinder (or drum) .
  • a motor mixer used was a Turbula Shaker-mixer (manufactured by Willy A. Bachofen (WAB) company, TURBULA Type T2C) which has vessel supports rotatably connected to distinct two axes, and operated at a speed of rotation of 42 rpm.
  • the vessel to which the particles were introduced was attached at 2O 0 C to the Turbula Shaker-mixer (manufactured by Willy A. Bachofen (WAB) company, TURBULA Type T2C) described above. Then, this cylindrical vessel was rotated for 5 minutes at the rotation speed of 42 rpm.
  • Turbula Shaker-mixer manufactured by Willy A. Bachofen (WAB) company, TURBULA Type T2C
  • the cylindrical vessel was detached from the Turbula Shaker-mixer, and left at rest with the lid of the vessel up.
  • the cylindrical vessel to which the particles were introduced was attached at 20 0 C to the Turbula Shaker-mixer (manufactured by Willy A. Bachofen (WAB) company, TURBULA Type T2C) described above. Then, this cylindrical vessel was rotated for 5 minutes at the rotation speed of 42 rpm.
  • Turbula Shaker-mixer manufactured by Willy A. Bachofen (WAB) company, TURBULA Type T2C
  • the cylindrical vessel was detached from the Turbula Shaker-mixer, and left at rest with the lid of the vessel up.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

Selon un procédé d'un mélange de particules (A) et de particules (B), caractérisé en ce que le procédé comprend une étape d'introduction de particules (A) formées de plusieurs composants et de particules (B) formées de plusieurs composants dans un récipient, une étape d'humidification de l'intérieur du récipient et une étape de rotation du récipient ou de rotation d'une aube de brassage se trouvant dans le récipient, il est possible d'obtenir le mélange d'au moins deux types de particules présentant une forte homogénéité.
PCT/JP2006/304828 2005-03-08 2006-03-07 Procede de production d'un melange de particules Ceased WO2006095888A2 (fr)

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JP2005063459 2005-03-08
JP2005-063459 2005-03-08

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WO2006095888A3 WO2006095888A3 (fr) 2007-04-26

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Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3625902A (en) * 1968-10-11 1971-12-07 Stauffer Chemical Co Method of preparing agglomerated detergent composition
US3987138A (en) * 1972-04-06 1976-10-19 Hege Advanced Systems Corporation Inert carrier mixing process
US4562024A (en) * 1982-07-06 1985-12-31 Sterling Drug Inc. Process for preparing granulate containing poorly compressible medicinally active matter
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles

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