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WO2006087233A3 - Release of extracellular membrane particles carrying the stem cell marker prominin-1 (cd133) from neural progenitors and other epithelial cells - Google Patents

Release of extracellular membrane particles carrying the stem cell marker prominin-1 (cd133) from neural progenitors and other epithelial cells Download PDF

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Publication number
WO2006087233A3
WO2006087233A3 PCT/EP2006/001552 EP2006001552W WO2006087233A3 WO 2006087233 A3 WO2006087233 A3 WO 2006087233A3 EP 2006001552 W EP2006001552 W EP 2006001552W WO 2006087233 A3 WO2006087233 A3 WO 2006087233A3
Authority
WO
WIPO (PCT)
Prior art keywords
particles
mammal
prominin
present
extracellular membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2006/001552
Other languages
French (fr)
Other versions
WO2006087233A2 (en
Inventor
Denis Corbeil
Wieland B Huttner
Anne-Marie Marzesco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften
Publication of WO2006087233A2 publication Critical patent/WO2006087233A2/en
Publication of WO2006087233A3 publication Critical patent/WO2006087233A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/16—Ophthalmology
    • G01N2800/164—Retinal disorders, e.g. retinopathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to an extracellular membrane particle carrying integrated into the membrane prominin-1 molecules. In accordance with the present invention, theses particles also referred to as prominin-1 -containing membrane particles. The membrane particles according to the present invention are distinct from exosomes. The invention in a further aspect relates to a method of diagnosing an epithelial cancer or a hematopoietic disease in a mammal comprising assessing in a body fluid of said mammal for the presence of the extracellular membrane particle of the invention wherein a decreased level of said extracellular membrane particles as compared to a control value is indicative of the presence of an epithelial cancer or a hematopoietic disease. Alternatively, an increased level of said particles is indicative of the presence of such a disease in a mammal. Additionally, the present invention relates to a method of prognosing a solid tumor in a mammal, comprising determining the change in the number of the particles of the invention in a body fluid of said mammal over time. Finally, the present invention relates to a method of diagnosing a degeneration of the retina in a mammal or a predisposition thereto comprising assessing for the presence of prominin-1 on the surface of the particles of the invention in a body fluid from said mammal wherein the absence of said particles or a reduced amount of prominin-1 on the surface of said particles in comparison to a control is indicative of degeneration of the retina or a predisposition thereto.
PCT/EP2006/001552 2005-02-21 2006-02-21 Release of extracellular membrane particles carrying the stem cell marker prominin-1 (cd133) from neural progenitors and other epithelial cells Ceased WO2006087233A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05003687.0 2005-02-21
EP05003687 2005-02-21

Publications (2)

Publication Number Publication Date
WO2006087233A2 WO2006087233A2 (en) 2006-08-24
WO2006087233A3 true WO2006087233A3 (en) 2006-11-02

Family

ID=36676697

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/001552 Ceased WO2006087233A2 (en) 2005-02-21 2006-02-21 Release of extracellular membrane particles carrying the stem cell marker prominin-1 (cd133) from neural progenitors and other epithelial cells

Country Status (1)

Country Link
WO (1) WO2006087233A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7897356B2 (en) 2008-11-12 2011-03-01 Caris Life Sciences Methods and systems of using exosomes for determining phenotypes
US8700335B2 (en) 2006-05-18 2014-04-15 Caris Mpi, Inc. System and method for determining individualized medical intervention for a disease state
US8768629B2 (en) 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100255514A1 (en) 2007-08-16 2010-10-07 The Royal Institution For The Advancement Of Learning/Mcgill University Tumor cell-derived microvesicles
EP2176665B1 (en) 2007-08-16 2016-03-02 The Royal Institution for the Advancement of Learning / McGill University Tumor cell-derived microvesicles
CA2732108A1 (en) 2008-07-28 2010-02-04 Children's Medical Center Corporation Prominin-1 peptide fragments and uses thereof
CA2788021A1 (en) 2010-01-27 2011-08-04 Children's Medical Center Corporation Pro-angiogenic fragments of prominin-1 and uses thereof
CN103237901B (en) 2010-03-01 2016-08-03 卡里斯生命科学瑞士控股有限责任公司 For treating the biomarker of diagnosis
CA2795776A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for disease
US20150093447A1 (en) * 2012-03-23 2015-04-02 Neostem, Inc. Stem cell identification and purification method
US20150079046A1 (en) * 2012-04-03 2015-03-19 Reneuron Limited Stem cell microparticles
GB201317887D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product
HK1256911A1 (en) * 2015-11-18 2019-10-04 佐治亚大学研究基金会 Neural cell extracellular vesicles

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CORBEIL D ET AL: "Prominin: a story of cholesterol, plasma membrane protrusions and human pathology.", TRAFFIC (COPENHAGEN, DENMARK) FEB 2001, vol. 2, no. 2, February 2001 (2001-02-01), pages 82 - 91, XP002391918, ISSN: 1398-9219 *
MARZESCO ANNE-MARIE ET AL: "Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells.", JOURNAL OF CELL SCIENCE. 1 JUL 2005, vol. 118, no. Pt 13, 1 July 2005 (2005-07-01), pages 2849 - 2858, XP002391919, ISSN: 0021-9533 *
RICHARDSON GAVIN D ET AL: "CD133, a novel marker for human prostatic epithelial stem cells", JOURNAL OF CELL SCIENCE, CAMBRIDGE UNIVERSITY PRESS, LONDON, GB, vol. 117, no. 16, 15 July 2004 (2004-07-15), pages 3539 - 3545, XP002354680, ISSN: 0021-9533 *
YIN A H ET AL: "AC133, a novel marker for human hematopoietic stem and progenitor cells", BLOOD, W.B. SAUNDERS, PHILADELPHIA, VA, US, vol. 90, no. 12, 15 December 1997 (1997-12-15), pages 5002 - 5012, XP002264586, ISSN: 0006-4971 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8700335B2 (en) 2006-05-18 2014-04-15 Caris Mpi, Inc. System and method for determining individualized medical intervention for a disease state
US7897356B2 (en) 2008-11-12 2011-03-01 Caris Life Sciences Methods and systems of using exosomes for determining phenotypes
US8768629B2 (en) 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors

Also Published As

Publication number Publication date
WO2006087233A2 (en) 2006-08-24

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