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WO2006087209A1 - Dispositif et procede pour identifier un tissu de corps humain et animal - Google Patents

Dispositif et procede pour identifier un tissu de corps humain et animal Download PDF

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Publication number
WO2006087209A1
WO2006087209A1 PCT/EP2006/001456 EP2006001456W WO2006087209A1 WO 2006087209 A1 WO2006087209 A1 WO 2006087209A1 EP 2006001456 W EP2006001456 W EP 2006001456W WO 2006087209 A1 WO2006087209 A1 WO 2006087209A1
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
data
comparison
veins
comparison data
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2006/001456
Other languages
German (de)
English (en)
Inventor
Thomas Ley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitaet Duisburg Essen
Original Assignee
Universitaet Duisburg Essen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitaet Duisburg Essen filed Critical Universitaet Duisburg Essen
Publication of WO2006087209A1 publication Critical patent/WO2006087209A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A61B5/0261—Measuring blood flow using optical means, e.g. infrared light

Definitions

  • the present invention relates to a device and a method for the determination of tissue of the human or animal body and / or a state of the tissue as well as their use for the recognition of the effect of a drug or medicament.
  • tissue identification of a tissue
  • condition of a tissue ie, for example, malignant, benign, underserved or the like. So far, usually done by a biopsy and a subsequent laboratory examination. During an operation, a so-called quick cut is performed, in which case the surgical team often has to wait until the result is available.
  • the present invention has for its object to provide a device and a method for the determination of tissue of the human or animal body and / or the condition of the tissue and their use for detecting the effect of a drug or drug, the determination or detection in particular non-invasive, easy and fast, especially without laboratory tests, can be done.
  • Tissue region optically detected and compared with comparative data of known tissues or states.
  • the result namely the tissue or the type of tissue and / or its condition or the tissue and / or conditions in question.
  • the respective state of the examined tissue or the states in question for example whether the tissue is well or poorly perfused, to be good or malignant or the like, with minimal effort and, above all, very quickly detect.
  • Another aspect of the present invention is that both the sizes and / or number of leads and the rate of blood flow in the leads are detected as tissue data.
  • tissue data is detected as tissue data.
  • Another aspect of the present invention is that preferably the size distribution of veins and / or the velocity distribution of the blood flow in the veins, in particular depending on the diameter of the veins, are detected in a tissue area with multiple veins as tissue data. This allows a particularly good characterization and thus identification of tissue.
  • the proposed device and the proposed method can for example be used directly during an operation.
  • the tissue data of a tissue area with multiple veins of a tissue to be examined are optically detected and preferably compared directly with stored comparison data so that the result can be determined and displayed to the surgeon or surgical team - virtually without delay.
  • it is then in particular indicated which tissue is concerned or which tissue is suitable.
  • it is indicated in which state the examined tissue is or which states are in question.
  • the respective probability or correlation with comparison data is given in the determination or display of candidate tissues and / or states. This allows a very good assessment, in particular the reliability, of the result.
  • Another advantage of the proposed device and the proposed method is in addition to the rapid availability of the result is that the effort compared to the usual use of tissue in the laboratory, especially by making cuts, staining and assessment in the microscope, omitted. Accordingly, even in non-urgent matters with the proposed device and the proposed method of laboratory work can be significantly reduced.
  • Another advantage is that with the proposed device and the proposed method no biopsy, so no tissue removal is required. In this way possible risks from tissue removal can be avoided.
  • the proposed device and the proposed method can also be used, for example, to detect the effect of an active ingredient or medicament or, if appropriate, to continuously monitor tissue. Faster detection or even continuous monitoring can achieve much greater safety and / or more accurate dosing.
  • FIG. 1 shows a schematic representation of a proposed device
  • Fig. 2 is a size distribution of lung tissue
  • Fig. 3 shows a velocity distribution of lung tissue
  • Fig. 5 is a velocity distribution of tongue tissue.
  • FIG. 1 shows a schematic representation of a proposed device 1 for determining tissue 2 of the human or animal body and / or the condition of the tissue 2.
  • the term "determination of tissue” in the present invention is to be understood as meaning that the tissue thus the respective tissue type is identified.
  • the device 1 has a detection device 3 for detecting tissue data of the tissue 2 to be examined.
  • the detection takes place in particular optically.
  • the detection device 3 preferably comprises a suitable optical device 4, as shown schematically in FIG. 1, or the like.
  • WO 97/15229 A1 which is introduced in this regard as a supplementary disclosure and discloses ways of device and procedural implementation.
  • the tissue 2 to be examined is preferably illuminated in order, for example, to be able to record optical signals by means of a camera.
  • the lighting can basically be done by ambient light.
  • a targeted illumination preferably takes place, for example, by means of a lighting device, not shown, separate from the device 1 or a lighting device integrated into the device 1.
  • white light, colored light or laser light can be used as required.
  • tissue region 5 with veins, in particular capillaries K, of the tissue 2 is examined optically.
  • the tissue data is then determined or detected from the optical signals.
  • the sizes and / or number of the veins and the speeds of blood flow in the veins are detected as tissue data.
  • the diameter of the wires or a related value such as the cross-sectional area or the like.
  • the diameter is detected, most preferably the average diameter.
  • the number of wires represents a measure of how many wires are present in a certain volume range or in the entire optically detected or evaluated fabric area 5.
  • an additional evaluation takes place with regard to the size, in particular with regard to the diameter. This results in a size distribution, as shown by way of example in FIG. 2.
  • the x-axis indicates the preferably average diameter of the detected wires in ⁇ m.
  • the y-axis indicates the number of respective cores having a corresponding diameter, not in absolute values, but in% in the present illustration. This is a normalized size distribution.
  • the black bars and the solid line show by way of example the size distribution of healthy lung tissue with normally opened alveolar capillaries.
  • the white bars and the associated dashed line show the size distribution when the capillaries are more closed. This may be the case, for example, with smokers or after using a drug that blocks capillaries.
  • Such capillaries can also characterize abnormal lung tissue.
  • FIG. 3 shows, by way of example, the velocity distribution in the lung tissue whose size distribution is shown in FIG.
  • the y-axis in Fig. 3 indicates the speed, in particular the mean flow velocity in the individual wires in ⁇ m / s as a function of the already mentioned diameter of the wires (plotted on the x-axis).
  • Fig. 3 the black bars and solid line again show the exemplary distribution of healthy lung tissue.
  • the white bars and the dashed line indicate the distribution that results for the lung tissue with less open alveolar capillaries.
  • Figs. 4 and 5 show similar to Figs. 2 and 3 distributions, which were detected in tongue tissue.
  • 4 shows a corresponding size distribution of the wires in the examined tissue area 5
  • FIG. 5 shows the corresponding velocity distribution of the blood flow in the wires.
  • the black bars and solid lines show the values of treated tongue tissue.
  • the white bars and dashed lines show the values of healthy tongue tissue.
  • FIGS. 2 to 5 show the respectively resulting curves in an approximation of the values determined by polynomials.
  • the resulting curves show some tendency of the respective changes.
  • experiments have shown that an approximation by polynomials and their comparison, ie a comparison of the coefficients of the polynomials, is often insufficient.
  • both the size distribution and the velocity distribution-or corresponding distributions or values-with respect to the tissue 2 to be examined or its tissue region 5 are determined by the detection device 3 and provided as tissue data.
  • the device 1 has an evaluation device 6 for comparing the tissue data with comparison data of known tissues 2 and / or known states.
  • the comparison data are stored for example in an associated memory 7 or accessible in some other way.
  • the comparison data can also be accessed via a data connection or the Internet, at least relevant comparison data.
  • the required comparison data requested via the data connection or the Internet then transmitted to the evaluation device 6 and compared there with the tissue data.
  • the result is determined and preferably displayed by means of an associated display device 8. Additionally or alternatively, however, the result can also be stored, printed out, output via an interface and / or further processed in any other way.
  • the device 1 or its components can be integrated in a device and / or realized by means of a computer or software.
  • preferably digital filters, correlation function, Fourier transforms and the like can be used for comparison of the tissue data and the comparison data.
  • Cross-correlations between the respective size distributions of the tissue data and the comparison data on the one hand and the velocity distributions of the tissue data and the comparison data on the other hand are particularly preferably determined. If necessary, these cross-correlations can also or exclusively be determined only for the products, in particular cross products, from the respective size and velocity distribution.
  • a restriction is made with regard to the cores considered.
  • veins up to a predetermined maximum size, for example, a maximum diameter of 20 or 30 microns, are considered.
  • corresponding or comparable limit values can also be used with regard to the flow velocities in the wires.
  • only wires can be considered, in which the speed exceeds a certain minimum value and / or does not exceed a predetermined maximum value.
  • the determined data ie both the tissue data and the comparison data, can be made more comparable and / or unwanted variants of the data can be reduced.
  • the comparison data are preferably detected with a corresponding device 1 or a corresponding detection device 3 with corresponding optical device 4 or the like in known tissues with known states and stored in a suitable manner, in particular in a database, or made available, for example via a via the Internet accessible database server or the like, as already explained above.
  • the tissue 2 to be examined is preferably determined, that is to say the type of tissue identified, and / or the state of the tissue 2 determined. In each case, it can be specified in each case with what probability the determination has taken place.
  • the tissue 2 and / or states in question can also be determined and, in particular, displayed, with the respective probabilities preferably being specified.
  • the proposed device 1 and the proposed method allow a very fast, simple and therefore cost-effective determination of tissue of the human or animal body and / or the state of the tissue, in particular the determination of a result in the above sense.
  • This can be used very advantageously in operations, for example by means of the optical device 4 directly on the open patient and / or by means of a catheter, the tissue data of the to be examined tissue 2 optically detected and then evaluated accordingly.
  • the proposed device 1 and the proposed method for detecting or monitoring the effect of a drug or drug can be used.
  • the proposed device and the proposed method can be used not only for operations, but also independently for determining a tissue or a state of a tissue.
  • the tissue condition and, moreover, other conditions or influences relating to blood circulation, blood or other body values can be detected and / or monitored.
  • This detection or monitoring is particularly preferably in tongue tissue, that is, for example, under the tongue, and / or in the nose of a patient.
  • the proposed device 1 and the proposed method for monitoring the effect of a drug or drug can be used.
  • the device 1 can be designed to be mobile and attached to the patient in such a way that the patient can pursue other activities with the device 1 virtually undisturbed.
  • the device 1 then preferably stores continuously the desired data or results.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physiology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

La présente invention concerne un dispositif et un procédé pour identifier un tissu de corps humain ou animal et/ou l'état de ce tissu. Le procédé d'identification est très simple et rapide et consiste à détecter la répartition par taille de vaisseaux sanguins dans une zone de tissu et la répartition de vitesse de la circulation sanguine dans les vaisseaux sanguins, puis à les comparer à des données de comparaison de tissus et/ou d'états connus.
PCT/EP2006/001456 2005-02-21 2006-02-17 Dispositif et procede pour identifier un tissu de corps humain et animal Ceased WO2006087209A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102005008122.3 2005-02-21
DE102005008122 2005-02-21
DE102005022360.5 2005-05-10
DE102005022360A DE102005022360A1 (de) 2005-02-21 2005-05-10 Vorrichtung und Verfahren zur Bestimmung von Gewebe des menschlichen oder tierischen Körpers

Publications (1)

Publication Number Publication Date
WO2006087209A1 true WO2006087209A1 (fr) 2006-08-24

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PCT/EP2006/001456 Ceased WO2006087209A1 (fr) 2005-02-21 2006-02-17 Dispositif et procede pour identifier un tissu de corps humain et animal

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DE (1) DE102005022360A1 (fr)
WO (1) WO2006087209A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006105941A3 (fr) * 2005-04-07 2007-02-15 Univ Duisburg Essen Dispositif et procede pour l'examen optique du corps humain ou animal

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5383463A (en) * 1993-08-02 1995-01-24 Friedman; Zvi Mapping of flow parameters
US20030050553A1 (en) * 2001-09-07 2003-03-13 Michael Samoszuk Methods for measuring microvascular density in tumors
US20030236458A1 (en) * 1999-08-03 2003-12-25 Biophysica Llc Spectroscopic systems and methods for detecting tissue properties

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US4109237A (en) * 1977-01-17 1978-08-22 Hill Robert B Apparatus and method for identifying individuals through their retinal vasculature patterns
AU608807B2 (en) * 1987-03-03 1991-04-18 Hitoshi Fujii Apparatus for monitoring bloodstream
AP931A (en) * 1995-10-23 2001-02-02 Cytometrics Inc Method and apparatus for reflected imaging analysis.
DE19630381C2 (de) * 1995-11-03 1998-12-03 Lutz Ott Verfahren, Vorrichtung und Verwendung einer Vorrichtung zur Detektion des Blutflusses und/oder des Flusses intrakorporal fließender Flüssigkeiten in menschlichem oder tierischem Gewebe
DE19838606A1 (de) * 1998-08-25 2000-03-23 Siemens Ag Verfahren und Vorrichtung zur Messung der lokalen Gehirndurchblutung
AU1531302A (en) * 2000-09-29 2002-04-08 New Health Sciences Inc Decision support systems and methods for assessing vascular health
US20050085725A1 (en) * 2001-08-09 2005-04-21 Ron Nagar Photoacoustic assay and imaging system
DE10257743B4 (de) * 2002-12-10 2006-11-23 Irmgard Zerrle Vorrichtung zur Bestimmung der Perfusion in einem Gewebebereich und des Blutflusses durch einzelne Blutgefäße

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5383463A (en) * 1993-08-02 1995-01-24 Friedman; Zvi Mapping of flow parameters
US20030236458A1 (en) * 1999-08-03 2003-12-25 Biophysica Llc Spectroscopic systems and methods for detecting tissue properties
US20030050553A1 (en) * 2001-09-07 2003-03-13 Michael Samoszuk Methods for measuring microvascular density in tumors

Non-Patent Citations (1)

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Title
VAZ J. ET AL.: "Nailfold videocapillaroscopy in primary antiphospholipid syndrome (PAPS)", RHEUMATOLOGY, vol. 43, August 2004 (2004-08-01), oxford, pages 1025 - 1027, XP009067441 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006105941A3 (fr) * 2005-04-07 2007-02-15 Univ Duisburg Essen Dispositif et procede pour l'examen optique du corps humain ou animal

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DE102005022360A1 (de) 2006-08-31

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