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WO2006087120A3 - Pyrazolopyrimidine - Google Patents

Pyrazolopyrimidine Download PDF

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Publication number
WO2006087120A3
WO2006087120A3 PCT/EP2006/001064 EP2006001064W WO2006087120A3 WO 2006087120 A3 WO2006087120 A3 WO 2006087120A3 EP 2006001064 W EP2006001064 W EP 2006001064W WO 2006087120 A3 WO2006087120 A3 WO 2006087120A3
Authority
WO
WIPO (PCT)
Prior art keywords
pyrazolopyrimidines
relates
substances
producing
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2006/001064
Other languages
English (en)
French (fr)
Other versions
WO2006087120A8 (de
WO2006087120A2 (de
Inventor
Stefan Herrmann
Olaf Gebauer
Herbert Gayer
Stefan Hillebrand
Ulrich Heinemann
Oliver Guth
Kerstin Ilg
Thomas Seitz
Ronald Ebbert
Ulrike Wachendorff-Neumann
Peter Dahmen
Karl-Heinz Kuck
Horst-Peter Antonicek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer CropScience AG
Original Assignee
Bayer CropScience AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP06706711A priority Critical patent/EP1853607A2/de
Priority to CN2006800052137A priority patent/CN101120000B/zh
Priority to BRPI0607765-0A priority patent/BRPI0607765A2/pt
Priority to AU2006215858A priority patent/AU2006215858A1/en
Priority to EA200701707A priority patent/EA200701707A1/ru
Priority to CA002597833A priority patent/CA2597833A1/en
Priority to US11/816,253 priority patent/US7781439B2/en
Priority to JP2007555499A priority patent/JP2008530155A/ja
Application filed by Bayer CropScience AG filed Critical Bayer CropScience AG
Priority to MX2007010045A priority patent/MX2007010045A/es
Publication of WO2006087120A2 publication Critical patent/WO2006087120A2/de
Publication of WO2006087120A3 publication Critical patent/WO2006087120A3/de
Priority to IL185092A priority patent/IL185092A0/en
Anticipated expiration legal-status Critical
Publication of WO2006087120A8 publication Critical patent/WO2006087120A8/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Pyrazolopyrimidine der Formel (I) in welcher R1, R2, R3, R4, R5, und X die in der Beschreibung angegebenen Bedeutungen haben, Verfahren zur Herstellung dieser Stoffe und deren Verwendung zur Bekämpfung von unerwünschten Mikroorganismen.
PCT/EP2006/001064 2005-02-17 2006-02-07 Pyrazolopyrimidine Ceased WO2006087120A2 (de)

Priority Applications (10)

Application Number Priority Date Filing Date Title
US11/816,253 US7781439B2 (en) 2005-02-17 2006-02-07 Pyrazolopyrimidines
BRPI0607765-0A BRPI0607765A2 (pt) 2005-02-17 2006-02-07 pirazolopirimidinas
AU2006215858A AU2006215858A1 (en) 2005-02-17 2006-02-07 Pyrazolopyrimidines
EA200701707A EA200701707A1 (ru) 2005-02-17 2006-02-07 Пиразолопиримидины
CA002597833A CA2597833A1 (en) 2005-02-17 2006-02-07 Pyrazolopyrimidines
JP2007555499A JP2008530155A (ja) 2005-02-17 2006-02-07 ピラゾロピリミジン類
MX2007010045A MX2007010045A (es) 2005-02-17 2006-02-07 Pirazolopirimidinas.
EP06706711A EP1853607A2 (de) 2005-02-17 2006-02-07 Pyrazolopyrimidine
CN2006800052137A CN101120000B (zh) 2005-02-17 2006-02-07 吡唑并嘧啶
IL185092A IL185092A0 (en) 2005-02-17 2007-08-07 Pyrazolopyrimidines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005007534.7 2005-02-17
DE102005007534A DE102005007534A1 (de) 2005-02-17 2005-02-17 Pyrazolopyrimidine

Publications (3)

Publication Number Publication Date
WO2006087120A2 WO2006087120A2 (de) 2006-08-24
WO2006087120A3 true WO2006087120A3 (de) 2006-12-14
WO2006087120A8 WO2006087120A8 (de) 2007-08-30

Family

ID=36793966

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/001064 Ceased WO2006087120A2 (de) 2005-02-17 2006-02-07 Pyrazolopyrimidine

Country Status (16)

Country Link
US (1) US7781439B2 (de)
EP (1) EP1853607A2 (de)
JP (1) JP2008530155A (de)
KR (1) KR20070103473A (de)
CN (1) CN101120000B (de)
AR (1) AR052913A1 (de)
AU (1) AU2006215858A1 (de)
BR (1) BRPI0607765A2 (de)
CA (1) CA2597833A1 (de)
DE (1) DE102005007534A1 (de)
EA (1) EA200701707A1 (de)
IL (1) IL185092A0 (de)
MX (1) MX2007010045A (de)
TW (1) TW200640926A (de)
WO (1) WO2006087120A2 (de)
ZA (1) ZA200706734B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006039255A1 (de) * 2006-08-17 2008-02-21 Bayer Cropscience Ag Insektizide heterocyclische Carbonsäurederivate
EP2014661A1 (de) * 2007-06-13 2009-01-14 Bayer CropScience AG Heterocyclisch substituierte Heterocyclyl-carbonsäurederivate
GB0712653D0 (en) 2007-06-28 2007-08-08 Syngenta Ltd Novel herbicides
GB0717082D0 (en) 2007-09-03 2007-10-10 Syngenta Ltd Novel herbicides
WO2010045615A2 (en) 2008-10-16 2010-04-22 Cenomed Biosciences, Llc Treatment of organophosphate exposure with ocinaplon
SI2649075T1 (sl) 2010-12-08 2018-10-30 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Substituirani pirazolopirimidini kot aktivatorji glukocerebrozidaze
JP2014517079A (ja) 2011-06-22 2014-07-17 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｒキナーゼ阻害剤として有用な化合物
PT4190786T (pt) 2012-12-07 2025-05-29 Vertex Pharma Compostos úteis como inibidores da quinase atr
EP2970286A1 (de) 2013-03-15 2016-01-20 Vertex Pharmaceuticals Inc. Kondensierte pyrazolopyrimidinderivate als inhibitoren der atr-kinase
JP2016512239A (ja) 2013-03-15 2016-04-25 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ａｔｒキナーゼの阻害剤として有用な化合物
JP2016512816A (ja) 2013-03-15 2016-05-09 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ａｔｒキナーゼの阻害剤として有用な化合物
CA2932757C (en) 2013-12-06 2023-10-31 Vertex Pharmaceuticals Incorporated 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof
KR102575125B1 (ko) 2014-06-05 2023-09-07 버텍스 파마슈티칼스 인코포레이티드 Atr 키나제의 저해제로서 유용한 2-아미노-6-플루오로-n-[5-플루오로-피리딘-3-일]-피라졸로[1,5-a]피리미딘-3-카복스아미드 화합물의 방사성표지된 유도체, 상기 화합물의 제조 및 이의 다양한 고체 형태
RU2736219C2 (ru) 2014-06-17 2020-11-12 Вертекс Фармасьютикалз Инкорпорейтед Способ лечения рака с использованием комбинации ингибиторов снк1 и atr
KR102662215B1 (ko) 2014-11-06 2024-05-02 비알 - 알&디 인베스트먼츠, 에스.에이. 치환된 피라졸로(1,5-a)피리미딘 및 의학적 장애의 치료에서의 그의 용도
AU2016331955B2 (en) 2015-09-30 2022-07-21 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors
KR20230104752A9 (ko) 2016-04-06 2024-11-15 비알 - 알&디 인베스트먼츠, 에스.에이. 피라졸로[1,5-a]피리미디닐 카르복스아미드 화합물및 의학적 장애의 치료에서의 그의 용도
US10787454B2 (en) 2016-04-06 2020-09-29 BIAL—BioTech Investments, Inc. Imidazo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
CA3020310A1 (en) 2016-04-06 2017-10-12 Lysosomal Therapeutics Inc. Pyrrolo[1,2-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
JP7164774B2 (ja) 2016-05-05 2022-11-02 ビアル－アール・アンド・ディ・インベストメンツ・ソシエダーデ・アノニマ 置換イミダゾ［１，２－ｂ］ピリダジン、置換イミダゾ［１，５－ｂ］ピリダジン、関連化合物、および医学的障害の治療におけるその使用
EP3658557B1 (de) * 2017-07-28 2024-06-05 Takeda Pharmaceutical Company Limited Tyk2-inhibitoren und verwendungen davon
JP7385658B2 (ja) 2018-10-30 2023-11-22 クロノス バイオ インコーポレイテッド Ｃｄｋ９活性を調節するための化合物、組成物、および方法
CN113287620B (zh) * 2021-06-18 2021-11-19 浙江大学 1H-吡唑并[3,4-d]嘧啶类化合物在制备禾谷镰刀菌杀菌剂中的应用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4838925A (en) * 1986-04-25 1989-06-13 E. I. Du Pont De Nemours And Company Heterocyclic acyl sulfonamides
DE3825043A1 (de) * 1988-07-20 1990-02-15 Schering Ag 3-methylsulfonyl-pyrazolo(1,5-a)pyrimidin-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider, pflanzenwuchsregulierender und fungizider wirkung
WO2004000844A1 (de) * 2002-05-29 2003-12-31 Bayer Cropscience Aktiengesellschaft Pyrazolopyrimidine und ihre verwendung zur bekämpfung von schädlichen organismen
WO2004076458A1 (en) * 2003-02-28 2004-09-10 Teijin Pharma Limited Pyrazolo[1,5-a]pyrimidine derivatives
WO2005000851A1 (de) * 2003-06-27 2005-01-06 Bayer Cropscience Aktiengesellschaft Pyrazolopyrimidine
WO2005056558A1 (de) * 2003-12-10 2005-06-23 Bayer Cropscience Aktiengesellschaft Pyrazolopyrimidine als fungizide wirkstoffe
WO2005056556A1 (de) * 2003-12-10 2005-06-23 Bayer Cropscience Aktiengesellschaft Pyrazolopyrimidine
WO2005082907A2 (de) * 2004-02-20 2005-09-09 Bayer Cropscience Ag Pyrazolopyrimidine zur bekämpfung unerwünschter mikroorganismen

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US2444606A (en) * 1945-12-15 1948-07-06 Gen Aniline & Film Corp Stabilizers for photographic emulsions
US3515715A (en) 1967-01-23 1970-06-02 Eastman Kodak Co Quaternized pyrazolylazo dyes
US3634391A (en) 1969-07-25 1972-01-11 Eastman Kodak Co Pyrazolyl-azo-indole dyestuffs
US6156925A (en) 1998-09-25 2000-12-05 American Cyanamid Company Process for the preparation of halogenated phenylmaloates
IL131912A (en) 1998-09-25 2005-12-18 American Cyanamid Co Process for preparing halogenated phenylmalonates
WO2002048151A1 (en) 2000-12-11 2002-06-20 Basf Aktiengesellschaft 6-phenyl-pyrazolopyrimidines
ES2283626T3 (es) 2001-07-26 2007-11-01 Basf Aktiengesellschaft 7-aminotriazolpirimidinas para controlar hongos nocivos.
NZ518658A (en) * 2002-04-30 2004-10-29 Lionel Evans Method of water treatment
FR2841982B1 (fr) 2002-07-03 2005-03-25 Inst Francais Du Petrole Capteur de pression a fibre optique compense en temperature
BR0312727A (pt) 2002-07-17 2005-04-19 Warner Lambert Co Combinação de um inibidor alostérico da metaloproteinase-13 de matriz com celecoxib ou valdecoxib
AU2004242850A1 (en) 2003-06-03 2004-12-09 Basf Aktiengesellschaft Substituted pyrazolopyrimidines, methods for the production thereof, use of the same for controlling pathogenic fungi, and agents containing said compounds
DE10357565A1 (de) 2003-12-10 2005-07-07 Bayer Cropscience Ag Pyrazolopyrimidine
DE10357569A1 (de) 2003-12-10 2005-07-07 Bayer Cropscience Ag Pyrazolopyrimidine

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4838925A (en) * 1986-04-25 1989-06-13 E. I. Du Pont De Nemours And Company Heterocyclic acyl sulfonamides
DE3825043A1 (de) * 1988-07-20 1990-02-15 Schering Ag 3-methylsulfonyl-pyrazolo(1,5-a)pyrimidin-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider, pflanzenwuchsregulierender und fungizider wirkung
WO2004000844A1 (de) * 2002-05-29 2003-12-31 Bayer Cropscience Aktiengesellschaft Pyrazolopyrimidine und ihre verwendung zur bekämpfung von schädlichen organismen
WO2004076458A1 (en) * 2003-02-28 2004-09-10 Teijin Pharma Limited Pyrazolo[1,5-a]pyrimidine derivatives
WO2005000851A1 (de) * 2003-06-27 2005-01-06 Bayer Cropscience Aktiengesellschaft Pyrazolopyrimidine
WO2005056558A1 (de) * 2003-12-10 2005-06-23 Bayer Cropscience Aktiengesellschaft Pyrazolopyrimidine als fungizide wirkstoffe
WO2005056556A1 (de) * 2003-12-10 2005-06-23 Bayer Cropscience Aktiengesellschaft Pyrazolopyrimidine
WO2005082907A2 (de) * 2004-02-20 2005-09-09 Bayer Cropscience Ag Pyrazolopyrimidine zur bekämpfung unerwünschter mikroorganismen

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HUPPATZ, JOHN L.: "Systemic fungicides. The synthesis of pyrazolo[1,5-a]pyrimidine analogs of carboxin", AUSTRALIAN JOURNAL OF CHEMISTRY , 38(1), 221-30 CODEN: AJCHAS; ISSN: 0004-9425, 1985, XP009072127 *

Also Published As

Publication number Publication date
CN101120000B (zh) 2011-05-18
MX2007010045A (es) 2007-10-02
IL185092A0 (en) 2007-12-03
US7781439B2 (en) 2010-08-24
WO2006087120A8 (de) 2007-08-30
AR052913A1 (es) 2007-04-11
TW200640926A (en) 2006-12-01
WO2006087120A2 (de) 2006-08-24
US20080287463A1 (en) 2008-11-20
CN101120000A (zh) 2008-02-06
EP1853607A2 (de) 2007-11-14
ZA200706734B (en) 2009-01-28
EA200701707A1 (ru) 2008-02-28
BRPI0607765A2 (pt) 2009-10-06
AU2006215858A1 (en) 2006-08-24
CA2597833A1 (en) 2006-08-24
JP2008530155A (ja) 2008-08-07
KR20070103473A (ko) 2007-10-23
DE102005007534A1 (de) 2006-08-31

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