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WO2006087037A1 - Pompe a dosage haute pression et debit haute pression - Google Patents

Pompe a dosage haute pression et debit haute pression Download PDF

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Publication number
WO2006087037A1
WO2006087037A1 PCT/EP2005/050689 EP2005050689W WO2006087037A1 WO 2006087037 A1 WO2006087037 A1 WO 2006087037A1 EP 2005050689 W EP2005050689 W EP 2005050689W WO 2006087037 A1 WO2006087037 A1 WO 2006087037A1
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WO
WIPO (PCT)
Prior art keywords
pumping apparatus
fluid
metering
pressure
metering devices
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2005/050689
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English (en)
Inventor
Klaus Witt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agilent Technologies Inc
Original Assignee
Agilent Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agilent Technologies Inc filed Critical Agilent Technologies Inc
Priority to PCT/EP2005/050689 priority Critical patent/WO2006087037A1/fr
Publication of WO2006087037A1 publication Critical patent/WO2006087037A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B13/00—Pumps specially modified to deliver fixed or variable measured quantities
    • F04B13/02—Pumps specially modified to deliver fixed or variable measured quantities of two or more fluids at the same time
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B11/00—Equalisation of pulses, e.g. by use of air vessels; Counteracting cavitation
    • F04B11/005—Equalisation of pulses, e.g. by use of air vessels; Counteracting cavitation using two or more pumping pistons
    • F04B11/0075—Equalisation of pulses, e.g. by use of air vessels; Counteracting cavitation using two or more pumping pistons connected in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B7/00—Mixing; Kneading
    • B29B7/30—Mixing; Kneading continuous, with mechanical mixing or kneading devices
    • B29B7/58—Component parts, details or accessories; Auxiliary operations
    • B29B7/60—Component parts, details or accessories; Auxiliary operations for feeding, e.g. end guides for the incoming material
    • B29B7/603—Component parts, details or accessories; Auxiliary operations for feeding, e.g. end guides for the incoming material in measured doses, e.g. proportioning of several materials

Definitions

  • the present invention relates to high-pressure fluid pumps.
  • Delivering under high pressure is useful, for example, in liquid chromatography to pump the mobile phase (e.g. a mixture of solvents) through the chromatographic system including the separation column.
  • the pumping apparatus may form a part of a solvent delivery system which then comprises additional units for drawing in and mixing solvents.
  • EP 0 309 59& B1 shows a pumping* apparatus comprising two pistons and two according pump chambers and control means coupled to drive means for adjusting the stroke length of the pistons.
  • a combination of a pump producing a pulsating stream of liquid such as a diaphragm pump and a pulse damper is disclosed the EP 0 115672 B1 (by the same applicant).
  • US 4,003,679 discloses a pumping system provided in which a low pressure metering pump injects fluid charges into a high pressure pump which in turn operates into a high pressure load.
  • US 4,599,049 discloses a high pressure meter pump system with improved accuracy by subdividing a large meter pump capacity into metered subvolume charges which are incrementally delivered to a high pressure slave pump.
  • a pumping apparatus adapted for delivering fluid against pressure.
  • the pumping apparatus can be adapted for blending at least two different fluids, for example liquids.
  • the pumping apparatus can be adapted for delivering the blended fluid at high pressure at which compressibility of the fluid becomes noticeable.
  • the pumping apparatus comprises a plurality of metering devices with at least a first metering device and a second metering device.
  • the metering devices each comprise an inlet and an outlet.
  • the outlets of the metering devices are coupled to an inlet ⁇ f a damping device.
  • the metering devices caft'be connected in parallel or side-by-side. Consequently, different flows, for example flows of different fluids, can flow through the metering devices in parallel, wherein all flows of said different fluids lead into one common flow leading into the damping device.
  • the metering devices can deliver different fluids to the damping device at high pressure.
  • the metering devices can be adapted for increasing the pressure of the metered fluids to said high pressure.
  • the damping device can de designed and operated to compensate any occurring flow and thus pressure fluctuation. This makes it possible to deliver a stream of fluid at higher pressures, relatively low flow rates, and fewer pulsations.
  • miniaturized chromatographic systems which generally need lower flow rates, higher pressures, and refined mixing ratios, can be supplied with fluid, for example liquid, by the pumping apparatus.
  • the pumping apparatus comprises an improve performance and can therefore enhance the performance of such coupled chromatographic systems. This is why the mobile phase can be pumped through said chromatographic systems with an increased accuracy of system parameters like flow rate and pressure.
  • such coupled systems allow an increased total number of peaks per time interval. Due to the improved pumping apparatus, such coupled systems can comprise one or more of the following features for enhancing the performance: Smaller size of packing material, smaller id columns, faster linear speed of solutions during separation, faster compositional gradients, and longer separations beds. Summarizing, the total amount of liquid in use can be reduced without seriously endangering the quality of the separation process.
  • a flow rate of fluid can be delivered to the column by the pumping apparatus being adjustable across a wide range of flow rates.
  • the pumping apparatus permits the generation of mixtures of solvents and changing the mixing ratio of the various solvents of the mixture in the course of time (gradient operation).
  • the pumping apparatus can deliver a tunable blend of different fluids allowing an exact mixing ratio.
  • Such versatility of the pumping apparatus allows optimizing the analysis conditions for the specific sample to be chromatographically separated.
  • the flow rate can be adjustable or selectable and can be - once selected — kept substantially constant by the damping device. This can avoid any fluctuation of the flow rate through the separation column leading to variations in the retention time and peak width of the examined sample compounds so that the areas of the chromatographic peaks produced by a detector connected to the outlet of the column, for example, an absorption detector, a fluorescence detector, or a refractive index detector, may vary.
  • a detector connected to the outlet of the column for example, an absorption detector, a fluorescence detector, or a refractive index detector
  • an embodiment of the pumping apparatus only needs three devices, namely the two metering devices and the damping device, and can produce a ripple free stream of tunably blended fluid against high pressure.
  • this can allow a mechanically simple and cost saving design.
  • Embodiments may comprise one or more of the following.
  • the metering devices can deliver fluid synchronously to the damping device.
  • the damping device is realized as an active damping device or in other words as an active pulse damper.
  • An active pulse damper can comprise at least one correcting element for influencing at least one parameter, for example the outflow from the damper.
  • the damping device can actively stabilize the output flow and thus pressure of the pumping apparatus by being controlled in reaction to a sensing device.
  • the metering devices can concurrently produce a plurality of exactly metered streams of fluid into the inlet of the damping device.
  • the streams can be blended homogenously just by transporting them into a common connection conduit to the inlet of the damping device. While sucking fresh fluid, the metering devices do not have to produce a stream of fluid because the damping device can fill this time gap by dispensing volume. This can result in a substantially ripple-free streaming out of defined amount of specific fluid composition delivered by the complete pumping apparatus.
  • Embodiments may comprise one or more of the following.
  • the outputs of the metering devices can be coupled to the inlet of the damping device via a mixing device.
  • the mixing device can comprise a certain volume for filtering the streams of the metering devices.
  • the mixing device comprises one inlet for each of the metering devices and one common outlet coupled to the inlet of the damping device.
  • the apparatus can comprise according connection conduits adapted for coupling the separate outlets of the metering devices each to separate inlets of the mixing device.
  • the mixing device comprises a certain volume for filtering or mixing the streams produced by the metering devices.
  • the metering devices are adapted for delivering fluid concurrently to the inlets of the mixing device.
  • the mixing device can be realized by a simple branch tee - or by a multi-branch connector having a plurality of inlets and one common outlet when more than two metering devices are employed — for avoiding any dead volume.
  • the different fluids can be mixed exactly and simply just by delivering or metering them concurrently into the connection conduit between the outlet of the branch tee and the damping device.
  • the length of said connection conduits can be reduced to a minimum.
  • the branch tee can be integrated in the damping device.
  • the volume of the damping device is structured such being useful for filtering fluctuations of composition of the inflowing blend of different fluids.
  • the damping device additionally realizes a mixing device resulting in a highly homogenous blend of the different fluids deliverable by the pumping apparatus.
  • Embodiments may comprise one or more of the following.
  • the pumping apparatus is operated substantially at two different pressures: A sucking pressure and an output pressure.
  • the metering devices each are adapted for letting in fluid at the sucking pressure and for delivering fluid, in particular to the mixing device, at the output pressure. Consequently, the metering devices are adapted for increasing the system pressure from the low sucking pressure up to the high output pressure.
  • the mixing device and the damping device both can be operated always at output pressure. More precisely, the metering devices can be operated between the low sucking pressure and the high output pressure.
  • the sucking pressure can be as low as 20 mbar and the output pressure can be as high as 2000 bar.
  • Embodiments may comprise one or more of the following.
  • the metering devices and the damping device each can comprise a piston for reciprocation in an according pump or damper chamber.
  • the pumping apparatus comprises a valve arrangement with a plurality of valves adapted for allowing the flow of fluid into the inlets of the metering devices and the damping device or rather the according pump chambers, and for inhibiting the flow in the opposite direction.
  • the valve arrangement can comprise one or more flow check valves, on-off valves, and/or flow control valves or any other valves suitable for this purpose.
  • the pump chambers or rather the inlets of the metering devices each are coupled to inlet valves adapted for allowing the flow of fluid into the pump chambers of the metering devices and for inhibiting the flow in the opposite direction.
  • the pump chambers each are located downstream of the inlet valves.
  • the inlets of the mixing device are coupled to mixing inlet valves adapted for allowing the flow of fluid into the mixing device and for inhibiting the flow in the opposite direction.
  • the inlets of the mixing device are located downstream of the mixing inlet valves.
  • the outlet of the mixing device is directly coupled to the inlet of the damping device.
  • the connection conduit between the mixing device and the damping device can comprise an according valve.
  • the pumping apparatus comprises a control unit.
  • the control unit controls at least one controllable feature such as the metering devices, the damper device, and the valves of the valve arrangement.
  • the control unit can communicate with the different elements in an open or closed loop mode.
  • the embodiments of the pumping apparatus can comprise one or more different sensors, such as a pressure sensor for measuring the pressure within any of the conduits of the pumping apparatus, a flow sensor for measuring the flow rate within any of the conduits of the pumping apparatus, a position sensor for measuring the position of any of the pistons of the metering devices, or any other suitable sensor using any suited method of measuring the needed system variables.
  • sensors such as a pressure sensor for measuring the pressure within any of the conduits of the pumping apparatus, a flow sensor for measuring the flow rate within any of the conduits of the pumping apparatus, a position sensor for measuring the position of any of the pistons of the metering devices, or any other suitable sensor using any suited method of measuring the needed system variables.
  • control unit can realize, for example, a pressure controller, a position controller, and/or a flow controller for controlling the inlet pressure, for controlling the output pressure, the switching status of any one of the valves, the position of any one of the pistons of the metering devices, the position of the pistons of the pumping devices and/or the damping device, and/or the flow within any one of the connection conduits or at the outlet of the pumping apparatus.
  • the control unit can control the damping device, in particular the movement of the piston of the damping device within the pumping or damper chamber of the damping device for realizing an active pulse damping unit in a manner that the output flow and thus pressure is substantially stabilized.
  • the pressure and/or the flow can be substantially stabilized.
  • the damping device comprises a flow and/or pressure sensor.
  • this enables a smoother changeover of composed fluid from the metering devices into the damping device. In a period of constant pressure mode, the volume contraction can be measured during the time when both metering devices dispense their respective volume.
  • the mixing volume can be adapted to achieve best performance at a given flow rate by running the pistons at variable stroke and frequency, whether the volume of the pump chamber of the damping device is used for filtering or mixing the inflowing fluid.
  • a method of running pistons at variable stroke and frequency is disclosed in the EP 0309596 B1 , which is incorporated herein by reference.
  • the inlet and the outlet of the damping device are positioned at the pump chamber of the damping device in a manner, that a FIFO concept is realized. Consequently, any fluid streaming into the pump chamber of the damping device through the inlet is flowing out first as well. This makes it possible to deposit a gradient in the pump chamber of the damping device, which is then dispensed to the system as a homogenous blend.
  • Embodiments may comprise one or more of the following.
  • the pistons of the metering devices can be acting in synchronous fashion when individual flow rates are at comparable levels, but when flow rates differ, say e.g. 10/1, the slower moving piston may just start/stop dispensing until its volume is at a minimum limit. In other words, the slower moving piston stops for each half cycle of the faster moving piston sucking fresh fluid.
  • the proportion of the amplitudes of the synchronous strokes of the pistons of the metering devices is substantially equal to the mixing ratio. Considering side effects caused by the compressibility of the fluids may modulate this proportion appropriately.
  • Embodiments may comprise one or more of the following.
  • the control unit can comprise data of the fluids to be mixed, in particular the compressibility, used for calculating and controlling the optimal movement of the pistons of the pumping apparatus for realizing the substantial stabilized output flow and thus pressure.
  • the data can comprise, for example, one or more of the following parameters: The compressibility of each fluid as a function of the pressure and the temperature, the compressibility of the blend as a function of the pressure and the temperature, the viscosity of the fluids and of the blend as a function of the pressure and the temperature, and the mixing volume as a function of the mixing ratio, the mixed fluids, the temperature, and the pressure.
  • the specific volume of the fluids after blending them shall be understood herein, for example, as the mixing volume.
  • Of special interest can be the loss or gain of volume during blending.
  • the control unit can calculate the optimal movement and timing of the pistons of the metering devices and the damping device.
  • the control unit has to be fed with the corresponding parameters.
  • the control unit can realize an adaptive system, wherein the control unit measures the parameters needed during an initial phase before operating the pumping apparatus.
  • the control unit can realize a mixture of the closed and open loop modes.
  • control unit can realize a drive control for all metering devices and the damping device of the pumping apparatus in a manner that the output flow and thus pressure is substantially stabilized and a stream of a homogenous blend with an exactly determined mixing ratio is generated.
  • a fluid separation system comprising a fluid, for example liquid, delivery system comprising a pumping apparatus as described above and a separation device for separating components of the fluid, for example liquid, delivered by the fluid delivery system
  • the pumping apparatus can produce an exact ripple-free flow of fluid, for example liquid, for optimizing the performance of the fluid separation system.
  • Further embodiments of the present invention relate to a method of delivering fluid, for example at high pressure at which compressibility of the fluid becomes noticeable.
  • a plurality of different fluids is metered by a plurality of metering devices.
  • the fluids are received from the plurality of metering devices upstream by a damping device.
  • pressure fluctuations of the fluids metered by the plurality of metering devices are substantially compensated by the damping device.
  • a pumping apparatus as described above is employed for executing the method.
  • the fluids can be concurrently metered by the metering devices and the pressure can be increased up to said high pressure.
  • the different fluids can be mixed before the damping device receives them. Any side effects, for example occurring while blending them within the mixing device can be substantially compensated by the downstream damping device.
  • the damping device does not have to increase the pressure and can be employed therefore for stabilizing the output pressure.
  • Embodiments of the invention can be partly or entirely embodied or supported by one or more suitable software programs, which can be stored on or otherwise provided by any kind of data carrier, and which might be executed in or by any suitable data processing unit.
  • Software programs or routines are preferably applied for controlling the steps of the method as described above. For example, for controlling set points of the pumping apparatus or said steps by using a control unit comprising the software programs or routines, for example as firmware.
  • Fig. 1 shows a pumping apparatus with two metering devices and a damping device controlled by a control unit and
  • FIG.2 shows a schematic view of a fluid separation system with a fluid delivery system comprising a pumping apparatus.
  • Fig. 1 shows a pumping apparatus 1 with a first metering device 3, a second metering device 5, and a damping device 7 controlled by a control unit 9.
  • the first metering device of the pumping apparatus 1 comprises a first piston 11 for reciprocation in a first pump chamber 13
  • the second metering device 5 of the pumping apparatus 1 comprises a second piston 15 for reciprocation in a second pump chamber 17
  • the damping device 7 of the pumping apparatus 1 comprises a third piston 19 for reciprocation in a damper chamber 21.
  • the pistons 11, 15, and 19 each are coupled to a screw link actuator 23 driven by a motor 25.
  • the screw link actuators 23 may be coupled via a ball 27 to the metering devices 3, 5, the damping device 7 and to according return springs 29 of the devices 3, 5, and 7.
  • These components realize three drives 31 for the metering devices 3, 5, and for the damping device 7.
  • Drives as the drives 31 for actuating pistons for reciprocating in pump chambers are known in the art and therefore not described in detail in this application.
  • Other embodiments may use crank drives, excenter drives or direct or indirect coupled linear motors.
  • the outer diameter of the pistons 11, 15, and 19 are smaller than the inner diameter of bore 33 of the respective pump chambers 13, 17, and the damper chamber 21 so that fluid can flow in the gap between the pistons 11, 15, and 19 and the inner surface of the bores 33.
  • Each of the devices 3, 5, and 7 comprises an inlet 35 and an outlet 37.
  • the inlets 35 of the devices 3, 5, and 7 are coupled to an end off the bores 33 located upstream of the upstream inflection point of the pistons 11 , 15, and 19, wherein the outlets 37 of the devices 3, 5, and 7 are coupled to the opposite end of the bores 33 located downstream of the downstream inflection point of the pistons 11 , 15, and 19.
  • the first pump chamber 13 of the first metering device 3 is coupled to a mixing device 39 via the outlet 37, a first connection conduit 41 comprising a first mixing inlet valve 43.
  • the first pump chamber 13 of the first metering device 3 is located upstream of the mixing device 39.
  • the second pump chamber 17 of the second metering device 5 is coupled to the mixing device 39 via the outlet 37 and a second connection conduit 45 comprising a second mixing inlet valve 47.
  • the second pump chamber 17 of the second metering device 5 is located upstream of the mixing device 39.
  • the position of the mixing inlet valves 43 and 47 within the conduit 41 and 45 may vary. In other embodiments, the mixing inlet valves 43 and 47 are positioned as close as possible to the mixing device 39.
  • the mixing inlet valves 43 and 47 can be integrated in the mixing device 39 or in the metering devices 3 and 5.
  • the mixing inlet valves 43 and 47 are adapted for allowing the flow of fluid into the mixing device and for inhibiting the flow in the opposite direction.
  • the mixing device 39 comprises two or more inlets 49.
  • the number of inlets 49 of the mixing device 39 is preferably equal to the number of metering devices.
  • the pumping apparatus 1 can comprise an arbitrary higher amount of metering devices and according inlets 49 of the mixing device 39.
  • the mixing device 39 is coupled to the damper chamber 21 via an outlet 51, a third connection conduit 53 and the inlet 35 of the damper device 7.
  • the mixing device 39 is located upstream of the damper chamber 21.
  • the damper chamber 21 is coupled to the outlet 37 of the damping device 7.
  • the damper chamber 21 is located upstream of the outlet 37.
  • the stream of fluid provided by the pumping apparatus 1 is provided at the outlet 37 of the damping device 7.
  • the damping device 7 can be coupled to a pressure sensor 55 for measuring the output pressure of the pumping apparatus.
  • the conduits 41 , 45, and 53 are operated at the output pressure.
  • the first pump chamber 13 of the first metering device 3 is coupled downstream to a first inlet valve 57 via the inlet 35 of the first metering device 3 and a first inlet connection conduit 59.
  • the first pump chamber 13 is located downstream of the first inlet valve 57.
  • the second pump chamber 17 of the second metering device 5 is coupled to a second inlet valve 61 via the inlet 35 of the second metering device 5 and a second inlet connection conduit 63.
  • the second pump chamber 17 is located downstream of the second inlet valve 61.
  • the inlet valves 57 and 61 can be realized as integrated valves within the metering devices 3 and 5. Consequently, in such embodiments, the pumping apparatus needs no connection conduits 59 and 63 between the valves 57 and 61 and the devices 3 and 5.
  • the inlet valves 57 and 61 can be realized as controlled valves, for example as an on-off or a flow control valve.
  • the valves 57 and 61 can comprise valve controllers 65, for example controlled by the control unit 9.
  • the valves 57 and 61 are realized as simple flow check valves.
  • the valves 43 and 47 can be realized as on-off or flow control valves also.
  • all valves 43, 47, 57, and 61 are realized as simple flow check valves, as known in the art.
  • the pumping apparatus 5 -! can be coupled with the control unit 9 via control connections 1 67.
  • the control unit 9 can realize, for example, a pressure controller 69 for the output pressure of the pumping apparatus 1 , a position controller 71 for the drives 31 for the devices 3, 5, and 7, or a flow controller 73 for the flow rates within the connection conduits 41 , 45, or at the outlet 37 of the pumping apparatus 1.
  • the pumping apparatus 1 can comprise additionally not shown suitable pressures sensors, flow sensors, and/or position sensors.
  • control unit 9 may communicate with encoders 75 coupled to the motors 25 of the drives 31.
  • Each of the drives 31 comprises one drive controller 66 connected via at least one of the control connections 67 to the control unit 9.
  • the control unit 9 interprets all data delivered by the pumping apparatus for realizing a high sophisticated drive control for the pistons 11, 15, and 19.
  • the drive control unit 9 can store and/or measure relevant parameters within the connection conduits within the pumping apparatus 1 , for example the compressibility or viscosity.
  • the control unit can communicate with said sensors in order to compensate any side effect caused by eventually leaking piston seals.
  • the pistons 11 and 15 of the metering devices 3 and 5 are moved in phase while delivering.
  • compressibility of the solvents becomes noticeable resulting in an additional source of pulsation when not corrected.
  • the pistons 11 and 15 have to move a certain path to compress the fluid to its final output pressure before actual delivery of fluid s tarts.
  • the damping device 7 can compensate this effect. Side effects caused by the change of the mixing volume and/or the viscosity of the fluids can be compensated also.
  • control unit 9 can compensate additionally any differences in the compressibility of the different fluids sucked by the metering devices 3 and 5 in a manner that the metering devices 3 and 5 deliver just concurrently fluid through the connection conduits 41 and 45 into the mixing device 39. By this, it is possible to produce a homogenous blend of the different fluids delivered by the metering devices
  • the mixing device 39 can comprise a volume for mixing or better filtering fluctuations of composition of the different fluids.
  • Fig. 2 shows a schematic view of a fluid separation system 95 with a fluid delivery system 97 comprising the pumping apparatus 1 and a separation device 99 for separating components of the fluid delivered by the fluid delivery system 97.
  • the fluid separation system 95 can comprise a detecting device 101 or a coupling 103 to the detection device 101.
  • the detection device 101 can be employed for detecting components of the fluid separated by the separation device 99.
  • the fluid separation system 95 can be connected to a not shown apparatus, for example a mass spectrograph, for analyzing the fluid, for example liquid, via a connection conduit 105.
  • the separation device 99 can be realized, for example, as a high performance liquid chromatography chip.
  • the pumping apparatus 1 for example coupled to the control unit 9, can deliver a ripple-free stream of a blend of different fluids, for example a gradient of two solvents, to the separation device 99, for example the high performance liquid chromatography chip.
  • a second phase the pistons 11 and 15 of the metering devices 3 and 5 are moved — in direction of the Fig. — upwards for increasing the pressure within the pump chambers 13 and 17 from the sucking pressure up to the output pressure.
  • all valves 43, 47, 57, and 61 are closed. Consequently, the pressure in the conduits between the valves 57, 61 and 43, 47 varies between the sucking pressure and the output pressure in this second phase.
  • the complete system upstream to the valves 57 and 61 is operated substantially at the output pressure. Consequently, the valves 57 and 61 are closed and the valves 43 and 47 are open.
  • the control unit 9 controls the movement of all pistons 11, 15, and 19 for guaranteeing an optimal hand shake of the metering devices 3 and 5 with the damping device for guaranteeing a ripple free and constant stream of fluid delivered by the pumping apparatus 1.
  • the damping device 7 acts as an active damping device
  • a fourth phase the pistons 11 and 15 of the metering devices 3 and 5 are moved - in direction of the Fig. - downwards for decreasing the pressure within the pump chambers 13 and 17 from the output pressure down to the sucking pressure.
  • all valves 43, 47, 57, and 61 are closed. Consequently, the pressure in the conduits between the valves 57, 61 and 43, 47 varies between the output pressure and the sucking pressure in this fourth phase.
  • the control unit 9 has to calculate the exact point of time when the valves 43 and 47 open or can be opened, for example by the control unit 9. At this point of time, the direction of movement of the third piston 19 within the damper chamber 21 of the damping device 7 has to be changed, in particular inversed. Possibly, shortly before the hand shake, the speed of the pistons 11 and 15 can be reduced for allowing a smoother hand shake. The movement of the third piston 19 of the damping device has to be modified accordingly during and after the hand shake.
  • the phases are repeated in the following order; first phase for sucking, second phase for increasing the pressure downstream of the valves 43 and 47, third phase for delivering fluid by the metering devices 3 and 5 under high pressure or output pressure to the damping device 7, and fourth phase for decreasing the pressure downstream of the valves 43 and 47.
  • the control unit 9 has to handle the handshake and consequently to change the movement of the third piston 19 of the damping device 7 for allowing the ripple-free output stream from the pumping apparatus 1.
  • control unit 9 controls the movement of all pistons 11, 15 and 19 for guaranteeing an optimal handshake or better a smooth changeover of the metering devices 3 and 5 with the damping devices 7 for ensuring a ripple-free and constant stream of fluid delivered by the pumping apparatus 1.
  • damping device 7 can act as an active damping device.
  • a plurality of different fluids is metered with a plurality of metering devices 3, 5.
  • the fluids are received from the plurality of metering devices 3, 5, for example by the damping device 7 via the mixing device 39.
  • the fluids can be transported from the plurality of metering devices 3, 5 into the mixing device 39, and from there into the damping device 7.
  • fluctuations, for example flow and/or pressure fluctuations, of the fluids metered by the plurality of metering devices 3, 5 are substantially compensated by the damping device 7.
  • the different fluids can be mixed, for example within the mixing device and/or within the damper chamber 21 of the damper device 7.
  • the pressure of the different fluids can be increased in the metering devices before mixing them, for example up to said high pressure.
  • the fluids can be transported subsequently under said high pressure, for example after passing the mixing device 39, to the damping device 7.
  • a control unit 9 for example comprising suited software programs or routines, can control the steps as described above.
  • the pumping apparatus can be coupled to a fluid separation system for analyzing and or separating fluid, more specifically, for executing at least one separation process, for example a liquid chromatographic process, for example a high performance liquid chromatographic process (HPLC).
  • a liquid chromatographic process for example a high performance liquid chromatographic process (HPLC).
  • HPLC high performance liquid chromatographic process
  • the coupled system can comprise a detection area, such as an optical detection area and/or an electrical detection area being arranged close to a flow path within the system.
  • the fluid separation system can be coupled to a detection area or a detecting apparatus such as a mass spectrograph.
  • the fluid separation system can be realized as a chromatographic system (LC), a high performance fluid chromatographic (HPLC) system, an HPLC arrangement comprising a chip and an mass spectrograph (MS), a high throughput LC/MS system, a purification system, micro fraction collection/spotting system, a system adapted for identifying proteins, a system comprising' a GPC/SEC column, a nanoflow LC system, and/qn a multidimensional LC system adapted for separation of protein digests, or alike.
  • the pumping apparatus can be a component part of a laboratory arrangement.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Accessories For Mixers (AREA)

Abstract

L'invention concerne un dispositif de pompage conçu pour mélanger au moins deux fluides différents et pour débiter ce mélange de fluides sous pression. Le dispositif de pompage possède une pluralité de dispositifs doseurs conçus pour doser une pluralité de fluides différents, et un dispositif amortisseur prévu pour rattraper les variations de pressions des fluides dosés par les dispositifs doseurs. Chaque dispositif présente une entrée et une sortie. Les sorties des dispositifs doseurs sont raccordés sur l'entrée du dispositif amortisseur.
PCT/EP2005/050689 2005-02-16 2005-02-16 Pompe a dosage haute pression et debit haute pression Ceased WO2006087037A1 (fr)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010015279A1 (fr) * 2008-08-07 2010-02-11 Agilent Technologies, Inc. Synchronisation de trajets d'écoulement d'alimentation
WO2010124741A1 (fr) * 2009-04-30 2010-11-04 Agilent Technologies, Inc. Détermination de la compressibilité d'un fluide pendant sa distribution

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2217020A1 (de) * 1972-04-08 1973-10-25 Bran & Luebbe Verfahren und vorrichtung zur pulsationsarmen dosierung mehrerer fluessigkeitskomponenten einer mischung
US5450743A (en) * 1994-01-10 1995-09-19 Zymark Corporation Method for providing constant flow in liquid chromatography system
DE4412703A1 (de) * 1994-04-13 1995-10-26 Guenes Dipl Chem Dr Barka Verfahren und Vorrichtung zur Herstellung von Lösungsmittelgemischen bei der Hochdruck-Flüssigkeits-Chromatographie
US5755561A (en) * 1994-10-26 1998-05-26 Francois Couillard Piston pumping system delivering fluids with a substantially constant flow rate

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2217020A1 (de) * 1972-04-08 1973-10-25 Bran & Luebbe Verfahren und vorrichtung zur pulsationsarmen dosierung mehrerer fluessigkeitskomponenten einer mischung
US5450743A (en) * 1994-01-10 1995-09-19 Zymark Corporation Method for providing constant flow in liquid chromatography system
DE4412703A1 (de) * 1994-04-13 1995-10-26 Guenes Dipl Chem Dr Barka Verfahren und Vorrichtung zur Herstellung von Lösungsmittelgemischen bei der Hochdruck-Flüssigkeits-Chromatographie
US5755561A (en) * 1994-10-26 1998-05-26 Francois Couillard Piston pumping system delivering fluids with a substantially constant flow rate

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010015279A1 (fr) * 2008-08-07 2010-02-11 Agilent Technologies, Inc. Synchronisation de trajets d'écoulement d'alimentation
GB2474388A (en) * 2008-08-07 2011-04-13 Agilent Technologies Inc Synchronization of supply flow paths
US20110132463A1 (en) * 2008-08-07 2011-06-09 Aglient Technologies, Inc. Synchronization of supply flow paths
CN102112741A (zh) * 2008-08-07 2011-06-29 安捷伦科技有限公司 供应流路的同步
GB2474388B (en) * 2008-08-07 2012-11-21 Agilent Technologies Inc Synchronization of supply flow paths
CN102112741B (zh) * 2008-08-07 2016-01-13 安捷伦科技有限公司 供应流路的同步
US10107273B2 (en) 2008-08-07 2018-10-23 Agilent Technologies, Inc. Synchronization of supply flow paths
US11035350B2 (en) 2008-08-07 2021-06-15 Agilent Technologies, Inc. Synchronization of supply flow paths
US11635065B2 (en) 2008-08-07 2023-04-25 Agilent Technologies, Inc. Synchronization of supply flow paths
WO2010124741A1 (fr) * 2009-04-30 2010-11-04 Agilent Technologies, Inc. Détermination de la compressibilité d'un fluide pendant sa distribution
CN102439309B (zh) * 2009-04-30 2016-03-16 安捷伦科技有限公司 在传输流体时确定流体可压缩性

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