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WO2006086992A3 - Drug delivery systems containing phqspholipase a2 degradable lipid prodrug derivatives and the therapeutic uses thereof as. e.g. wound healing agents and peroxisome proliferator activated receptor ligands - Google Patents

Drug delivery systems containing phqspholipase a2 degradable lipid prodrug derivatives and the therapeutic uses thereof as. e.g. wound healing agents and peroxisome proliferator activated receptor ligands Download PDF

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Publication number
WO2006086992A3
WO2006086992A3 PCT/DK2006/000097 DK2006000097W WO2006086992A3 WO 2006086992 A3 WO2006086992 A3 WO 2006086992A3 DK 2006000097 W DK2006000097 W DK 2006000097W WO 2006086992 A3 WO2006086992 A3 WO 2006086992A3
Authority
WO
WIPO (PCT)
Prior art keywords
wound healing
drug delivery
delivery systems
phqspholipase
therapeutic uses
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DK2006/000097
Other languages
French (fr)
Other versions
WO2006086992A2 (en
Inventor
Kent Joergensen
S Jensen Simon
Thomas L Andresen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Liplasome Pharma ApS
Original Assignee
Liplasome Pharma ApS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liplasome Pharma ApS filed Critical Liplasome Pharma ApS
Publication of WO2006086992A2 publication Critical patent/WO2006086992A2/en
Publication of WO2006086992A3 publication Critical patent/WO2006086992A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention describes a lipid based prodrug and drug delivery system that can be used for treatment or alleviation of disorders that are associated with or resulting from increased levels of secretory phospholipase A2 (PLA2) in the diseased or injured tissue. In particular, the lipid based delivery systems are useful for administration of lipid prodrugs of lysophosphatidic acid (LPA) bioactive analogs, which are known to be potent biological mediators with e.g. growth stimulating and wound healing activities.
PCT/DK2006/000097 2005-02-18 2006-02-17 Drug delivery systems containing phqspholipase a2 degradable lipid prodrug derivatives and the therapeutic uses thereof as. e.g. wound healing agents and peroxisome proliferator activated receptor ligands Ceased WO2006086992A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200500255 2005-02-18
DKPA200500255 2005-02-18

Publications (2)

Publication Number Publication Date
WO2006086992A2 WO2006086992A2 (en) 2006-08-24
WO2006086992A3 true WO2006086992A3 (en) 2007-03-01

Family

ID=36916811

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2006/000097 Ceased WO2006086992A2 (en) 2005-02-18 2006-02-17 Drug delivery systems containing phqspholipase a2 degradable lipid prodrug derivatives and the therapeutic uses thereof as. e.g. wound healing agents and peroxisome proliferator activated receptor ligands

Country Status (1)

Country Link
WO (1) WO2006086992A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2437726T3 (en) * 2009-06-03 2018-12-31 Sequessome Technology Holdings Limited Formulations for the treatment of deep tissue pain
GB2486371A (en) 2009-08-21 2012-06-13 Targeted Delivery Technologies Ltd Vesicular formulations
GB201205642D0 (en) 2012-03-29 2012-05-16 Sequessome Technology Holdings Ltd Vesicular formulations
US20170112861A1 (en) * 2014-04-04 2017-04-27 Osaka University Drug delivery enhancer comprising substance for activating lysophospholipid receptors
US20190167588A1 (en) 2015-06-30 2019-06-06 Sequessome Technology Holdings Limited Blended formulations

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986000309A1 (en) * 1984-06-21 1986-01-16 Health Research Inc. Thiophospholipid conjugates of antitumor agents
WO1999065466A1 (en) * 1998-06-18 1999-12-23 Duke University Temperature-sensitive liposomal formulation
US6165501A (en) * 1995-12-11 2000-12-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Radiation-protective phospholipid and method
WO2001058910A2 (en) * 2000-02-10 2001-08-16 Liplasome Pharma A/S Lipid-based drug delivery systems
US20030170297A1 (en) * 2000-04-12 2003-09-11 Kent Jorgensen Lipid-based drug delivery systems containing phospholipase a2 degradable lipid derivatives for topical application to the skin
WO2004000854A1 (en) * 2002-06-20 2003-12-31 Ic Vec Limited Sulfur-containing phospholipid derivatives

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986000309A1 (en) * 1984-06-21 1986-01-16 Health Research Inc. Thiophospholipid conjugates of antitumor agents
US6165501A (en) * 1995-12-11 2000-12-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Radiation-protective phospholipid and method
WO1999065466A1 (en) * 1998-06-18 1999-12-23 Duke University Temperature-sensitive liposomal formulation
WO2001058910A2 (en) * 2000-02-10 2001-08-16 Liplasome Pharma A/S Lipid-based drug delivery systems
US20030170297A1 (en) * 2000-04-12 2003-09-11 Kent Jorgensen Lipid-based drug delivery systems containing phospholipase a2 degradable lipid derivatives for topical application to the skin
WO2004000854A1 (en) * 2002-06-20 2003-12-31 Ic Vec Limited Sulfur-containing phospholipid derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HRISTOVA ET AL: "Effect of bilayer composition on the phase behavior of liposomal suspensions containing poly(ethylene glycol) lipids", MACROMOLECULES, ACS, WASHINGTON, DC, US, vol. 28, 1995, pages 7693 - 7699, XP002120858, ISSN: 0024-9297 *
JORGENSEN KENT ET AL: "Interaction of a lipid-membrane destabilizing enzyme with PEG-liposomes", INTERNATIONAL JOURNAL OF PHARMACEUTICS (AMSTERDAM), vol. 183, no. 1, 10 June 1999 (1999-06-10), pages 21 - 24, XP002404579, ISSN: 0378-5173 *

Also Published As

Publication number Publication date
WO2006086992A2 (en) 2006-08-24

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