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WO2006085607A1 - Preparation d’une emulsion contenant un composant vegetal et procede de production de celle-ci - Google Patents

Preparation d’une emulsion contenant un composant vegetal et procede de production de celle-ci Download PDF

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Publication number
WO2006085607A1
WO2006085607A1 PCT/JP2006/302338 JP2006302338W WO2006085607A1 WO 2006085607 A1 WO2006085607 A1 WO 2006085607A1 JP 2006302338 W JP2006302338 W JP 2006302338W WO 2006085607 A1 WO2006085607 A1 WO 2006085607A1
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Prior art keywords
plant
component
oil phase
water
containing emulsion
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Japanese (ja)
Inventor
Masanori Kanayama
Fumiyoshi Ishii
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Pure Green Co Ltd
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Pure Green Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
    • A23D7/0053—Compositions other than spreads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to an emulsion formulation containing a plant component and a method for producing the same. More specifically, an oZw emulsion formulation in which water-soluble components such as water-soluble catechins that are easily oxidized in the air or water as a plant component are dispersed in the oil phase, and this oil phase is dispersed in the water phase. It relates to the manufacturing method.
  • Plant leaves, stems, fruits, seeds, petals, etc. contain many components that are useful to the human body, and they are unstable that are easily oxidized in the air or water.
  • Many water-soluble ingredients exist. Examples of such water-soluble components lacking acidity stability include, for example, polyphenols such as catechins, which have antioxidant, antibacterial, and deodorizing effects contained in green tea leaves, black tea leaves, coffee, grapes, grapes, For example, anthocyanins that promote the resynthesis of rhodopsin contained in blueberries, blueins, etc., vitamin C that inhibits active oxygen contained in lemons, oranges, etc., and vitamin C that promotes collagen production are not limited.
  • the present invention is an emulsion preparation that stably contains such an unstable water-soluble component that is easily oxidized in air or water, and a method for producing the same.
  • the following is a more specific example of tea leaf components. Explained.
  • Patent Document 1 Japanese Patent Application Laid-Open No. 2002-142677
  • Patent Literature 1 “Science and Biology” vol. 38, No. 2, 2000 (104–114 pages)
  • tea leaves such as green tea, which is a natural product.
  • Water-soluble ingredients in tea leaves include catechins, caffeine, ascorbic acid (vitamin C), ⁇ -aminobutyric acid, theanine, vitamin koji, water-soluble dietary fiber, saponin, minerals, etc.
  • vitamin C ascorbic acid
  • ⁇ -aminobutyric acid theanine
  • vitamin koji water-soluble dietary fiber
  • saponin minerals
  • minerals etc.
  • dietary fiber carotene
  • tocopherol vitamin ⁇
  • protein chlorophyll
  • tea leaves contain a large amount of water-soluble catechins
  • container-packed tea beverages containing high strength catechins are generally commercially available (Patent Document 1).
  • the catechins contained in green tea include epigallocatechin gallate (EGCg), epicatechin, epigallocatechin, epicatechin gallate and the like.
  • EGCg epigallocatechin gallate
  • EGCg accounts for 50-60% of catechins in green tea, has many phenolic hydroxyl groups in the molecule, and has the strongest anti-oxidative activity among catechins. It is known that a wide range of physiological activities are expected.
  • the present invention has been found in various studies on tea leaves as described above, and is a plant that stably contains water-soluble components derived from plants that are easily oxidized in air or water.
  • the purpose is to provide an ingredient-containing emulsion preparation and a method for producing the same.
  • the plant component is a tea leaf component, and various active ingredients in tea leaves typified by power tekins are comprehensively used. It is an object of the present invention to provide a tea leaf component-containing emulsion preparation that stably contains tea leaf components in an oil phase, and a method for producing the same, which can broaden the use of tea leaves.
  • the present invention is characterized in that a plant-derived water-soluble component that is easily oxidized in air or water is dispersed in an oil phase, and the oil phase is dispersed in the water phase. It is an emulsion formulation containing plant ingredients.
  • a plant-derived water-soluble component is a catechin as a tea leaf component, the catechin is dispersed in the oil phase, and the oil phase is dispersed in the water phase. It is an emulsion formulation.
  • the present invention pulverizes a plant material containing a water-soluble component that is easily oxidized in air or water, and performs a fine powder treatment while mixing the pre-ground plant material and an oily base material.
  • the plant fine powder is removed to separate the oily solution, and the obtained oily solution, surfactant, and water are stirred to emulsify or dissolve the oily phase in the aqueous phase.
  • It is a method for producing a plant component-containing emulsion preparation.
  • it is a method for producing a green tea ingredient-containing emulsion preparation, wherein the plant material is tea leaves and contains tea leaf ingredients as plant ingredients.
  • a plant-derived water-soluble component that is easily oxidized in air or water (hereinafter referred to as “plant-derived easily oxidizable water-soluble component”) is an oil phase.
  • An oily phase that is dispersed therein and contains an easily acidic water-soluble component derived from this plant is dispersed in the aqueous phase.
  • the dispersion means dispersion (emulsification) in a turbid or translucent state or dispersion (solubilization) in a transparent state.
  • “solubilization” is transparent to the naked eye, but microscopically, there are an oil phase and an aqueous phase, and the oil phase is dispersed in the aqueous phase.
  • the emulsion formulation refers to an emulsion prepared so that it can be used directly or indirectly in the fields of food, cosmetics, pharmaceuticals and the like.
  • an easily oxidizable water-soluble component derived from a plant is dispersed in an oil phase to make it oily in a dosage form, so that when a plant component-containing emulsion preparation is orally administered, skin, When applied to mucous membranes, it can be expected to improve the biomembrane permeability, that is, the absorbability in the body, of plant-derived easily acidic water-soluble components.
  • biomembrane permeability that is, the absorbability in the body
  • water-soluble substances such as ions do not easily pass through biological membranes, but lipid-soluble substances of molecular type pass through biological membranes relatively easily. Therefore, it is considered that the absorption in the body can be increased by wrapping an easily acidic water-soluble component derived from a plant with an oily base material to make it fat-soluble.
  • tea leaves are leaves of the plant name Theasinensis or its cultivated varieties. Tea leaves include non-fermented teas such as green tea, fermented teas such as black tea, and other semi-fermented teas and incompletely fermented teas, all of which are used as raw materials for producing the plant component-containing emulsion preparation of the present invention. Can be used.
  • the tea leaf as used in the present invention includes such a tea husk.
  • the plant-derived water-soluble component is dispersed in the oil phase, and this oil phase is dispersed in the water phase, an oZw type emulsion is formed. Even if it is an easily acidic water-soluble component such as catechins derived from tea leaves that are easily oxidized in air or water, direct contact with air and water is avoided and it is difficult to oxidize Thus, it is possible to stably maintain this easily oxidizable water-soluble active ingredient over a long period of time.
  • an easily acidic water-soluble component such as catechins derived from tea leaves that are easily oxidized in air or water
  • the plant component-containing emulsion preparation of the present invention is a water-soluble emulsion preparation in which the oil phase is soluble or emulsified in an aqueous phase, so that it can be applied to an easily drinkable skin or mucous membrane as an oral beverage. Is very easy to handle.
  • the plant-containing emulsion preparation of the present invention is usually water-soluble or fat-based compared to the fact that the easily-acid-soluble water-soluble components derived from plants such as extracted green tea catechins are poorly absorbed by the body. Since soluble plant components are stably dispersed in the oil phase, absorption into the body is remarkably superior, and its usefulness is expected to increase dramatically.
  • the plant component-containing emulsion preparation of the present invention can contain a plant component containing a plant-derived easily oxidizable water-soluble component such as catechins in a high concentration in the oil phase. Because it is an emulsion formulation that is particularly excellent in absorbability, it can effectively exert the functions of plant components such as catechins, making it suitable for the food, cosmetics, and pharmaceutical fields. Can be used.
  • the oil phase contains 0.01 to 70 g of plant components per lOOg of oil phase. 0.1 to 30 g of plant components per lOOg of oil phase It is particularly preferred to contain from 0.1 to 10 g of plant components per lOOg of oil phase.
  • the oil phase may contain 10 to 7000 mg of force techins per lOOg oil phase. Preference is given to containing 50 to 500 mg of force techins per lOOg oil phase. It is particularly preferred to contain 80 to 300 mg of force techins per 10 Og oil phase.
  • the tea leaf component-containing emulsion preparation is:
  • the plant-derived plant component is a tea leaf component derived from tea leaves
  • the tea leaf component can be suitably ingested in a balanced manner. Further, in the oil phase containing these fat-soluble tea leaf components at the same time, it is possible to uniformly disperse water-soluble power techins.
  • both water-soluble vitamin C and fat-soluble vitamin E in the tea leaf component have anti-oxidative activity. Therefore, it can be used synergistically by working simultaneously with the anti-acidic action of catechins.
  • water-soluble vitamin C can be added to the water phase
  • fat-soluble vitamin E can be further added to the oil phase. It is possible.
  • the average particle size of the oil droplets is designed to be smaller in order to facilitate ingestion and improve handling of the emulsion preparation.
  • the average particle diameter of the oil droplets in the oil phase is preferably 1000 m or less, more preferably 5 m or less, and even more preferably 1 m or less.
  • the average particle size of the oil droplets is 50 nm to 1000 ⁇ m by appropriately adjusting the ratio of the aqueous phase to the oil phase, the type and addition ratio of the surfactant, the dispersion method, and the like.
  • An emulsified plant component-containing emulsion preparation can also be prepared, and a solubilized plant component-containing emulsion preparation having an average oil droplet size of 200 nm or less can also be prepared.
  • the oil phase per 100 g of the plant component-containing emulsion formulation is more preferably in the range of 0.02 to 20 g, particularly preferably in the range of 0.05 to 10 g.
  • the oily base material constituting the oil phase of the plant component-containing emulsion preparation of the present invention is a plant.
  • the oil is not limited as long as it has good compatibility with physical components, but edible oils such as vegetable oils and animal oils are preferable.
  • vegetable oils include sesame oil, rice oil, palm oil, olive oil, peanut oil, coconut oil, rapeseed oil, soybean oil, corn oil, sunflower oil, sunflower oil, cottonseed oil, coconut oil, grape seed oil
  • animal oils include squalene.
  • coconut oil containing a large amount of medium chain fatty acid triglycerides is more preferred as an oily base material used for the plant component-containing emulsion preparation of the present invention. Alternatively, a mixture of these can also be used.
  • the oily base material used for the plant component-containing emulsion preparation of the present invention it is particularly preferable to use a medium-chain fatty acid triglyceride as a main component.
  • the medium chain fatty acid triglyceride refers to a C8 to C12 saturated fatty acid triglyceride. Since medium-chain fatty acid triglycerides are chemically inert (radical-free), the chemical stability of catechins is dramatically improved in the oil phase containing medium-chain fatty acid triglycerides as the main component compared to that in the aqueous phase.
  • water-soluble force techins can be more stably dispersed in the oil phase than when an oily base material containing a large amount of other unsaturated fatty acid triglycerides is used.
  • medium-chain fatty acid triglycerides can be expected to improve the in vivo absorbability of plant-derived easily acidic water-soluble components such as catechins.
  • the oil phase in the vegetable component-containing emulsion preparation of the present invention preferably contains 50 g or more of medium chain fatty acid triglyceride per 10 g of fat and oil component, more preferably 70 g or more, and particularly preferably 80 g or more.
  • the content of the fatty acid triglyceride can be easily measured by high performance liquid chromatography after separating the plant component-containing emulsion preparation into an oil phase and an aqueous phase.
  • purified water, drinking water, ion-exchanged water, and the like can be used as the aqueous base material constituting the aqueous phase.
  • a tea extract obtained by extracting tea leaves with these aqueous base materials can be used, and if necessary, an aqueous base material blended with a fragrance or the like can be used.
  • a surfactant as an emulsifier or solubilizer in order to disperse the oil phase more stably in the aqueous phase. It is preferable to use 0.01 to 40 g of a surfactant. 0.2 to 20 g of a surfactant is more preferable. It is particularly preferable to use 0.5 to 10 g of a surfactant. preferable.
  • the oZw type plant component-containing emulsion preparation of the present invention is capable of using a surfactant having an HLB value of 7 to 40. The emulsion is basically more stable as a surfactant having a higher HLB value is used.
  • the optimum value for the HLB value of the surfactant used is a force that depends on the compatibility of the water phase, oil phase, and surfactant.
  • the HLB value is more preferably 7-20. 20 is particularly preferred.
  • a surfactant having a relatively high HLB value and a surfactant having a relatively low HLB value can also be used in combination.
  • a surfactant for food addition, cosmetic addition, or pharmaceutical addition can be widely used.
  • Nikko Chemical's polyoxyethylene hydrogenated castor oil 60 (HC060: HLB value 14.0) Daiichi Kogyo Seiyaku Sugar Ester SS (S—SS: HLB value 19.0), Daiichi Kogyo Seiyaku Sugar Ester F110 (S—F110HLB 11.0), Daiichi Kogyo Seiyaku Sugar Ester F160 (S—F160HLB) The value 15.0) etc.
  • TWEEN80 T80: HLB value 15.0
  • Sigma's TW EEN80 sT80: HLB value 15.0
  • Nikko Chemical's polyoxyethylene hydrogenated castor oil 60 HC060: HLB value 14.0
  • Various methods can be considered as a method for producing the plant component-containing emulsion preparation of the present invention, but roughly divided, a method of emulsifying or solubilizing an oily solution containing plant components and water by stirring. And a method of emulsifying or solubilizing an oily paste containing plant components and water by stirring.
  • a method for producing an oily solution containing a plant component a method for producing an oily solution by dissolving components obtained by extracting plant materials such as tea leaves into an oily base material can be mentioned,
  • a method of leaching plant components by immersing the finely pulverized plant material itself in an oily base material can be mentioned.
  • Extraction of plant components can be performed by a conventional method, and the dried plant material such as tea leaves is powdered or shredded, and then heated to water, steam distilled, or alcohol or a mixture of alcohol and water. It is performed by dipping.
  • components rich in catechins can be obtained in the form of a solution by extraction with water at room temperature for 1 to: LO days and then treatment with alcohol.
  • the extract obtained by force is filtered if necessary, the filtrate is concentrated, and if necessary, it is subjected to a drying process. Concentration is generally by distillation under reduced pressure. Drying includes spray drying, vacuum drying, freeze drying, and the like, which can be appropriately selected and employed.
  • the plant component obtained by force is mixed and dissolved in an oily base material to obtain an oily solution, and this oily solution is added to water and stirred to emulsify or dissolve, thereby containing the plant component of the present invention.
  • An emulsion formulation can be obtained.
  • the mixing ratio can be appropriately selected.
  • the amount of the plant component per liter of the oily base material is usually 10 to: LOOg, preferably 20 to 50 g.
  • ultrasonic treatment or physical means using high-speed stirring is employed. If necessary, other components such as fragrances can be blended with the plant component-containing oily base material obtained by caulking.
  • Examples of the method for producing an oily solution containing a plant component include a method in which plant materials such as tea leaves are directly added to an oily substrate and the plant component is transferred to the oily substrate.
  • plant materials such as tea leaves are directly added to an oily substrate and the plant component is transferred to the oily substrate.
  • the plant material dried and pulverized in advance and the oily base material are mixed to transfer the plant components to the oily base material.
  • the amount of plant material varies depending on the type, degree of drying, etc.Under normal temperature, oil'14 base material 30 ⁇ 800g, preferably 100 ⁇ 500g, more preferably 250 ⁇ 400g It is.
  • the extraction time is 3 to 48 hours, preferably 6 to 24 hours, more preferably 10 to 18 hours. After extraction, the residue is removed by filtration to obtain an oily solution containing plant components.
  • a plant component-containing emulsion preparation can be obtained by stirring and emulsifying or dissolving the obtained oily solution and water. If necessary, other components such as a fragrance can be added to the oily solution containing plant components and Z or the plant component-containing emulsion preparation.
  • the fine powdering treatment is performed until the plant material strength is preferably 0.01 to 40 ⁇ m, more preferably 1 to 10 ⁇ m.
  • the fine pulverization treatment step is preferably performed for 5 to 20 minutes, more preferably for 10 to 15 minutes. If the oily paste containing fine powder of insoluble plant material is removed by filtration or centrifugation after completion of the fine powdering treatment step, an oily solution containing plant components at a high concentration can be separated. .
  • the extraction effect is promoted.
  • the process of extracting plant components is simple, and the strength is Catechins and the like can be dissolved in an oily substrate at a high concentration.
  • a plant component-containing emulsion preparation can be obtained by stirring and emulsifying or solubilizing the obtained oily solution and water.
  • the oil phase can contain 10 ⁇ : LOOOmg of catechins per lOOg of oil phase.
  • a fragrance or the like may be blended with the oily solution containing plant components and Z or the plant component-containing emulsion preparation as necessary.
  • the plant component-containing emulsion preparation of the present invention can also be obtained by stirring and emulsifying or solubilizing the oily paste containing water and the fine powder of the plant material, which is separated as described above, and water.
  • the oil phase may contain 20 to 7000 mg of force techins per lOOg of oil phase.
  • a fragrance or the like may be added to the oil-based paste containing plant components and Z or the plant component-containing emulsion preparation as necessary.
  • a surfactant is further added as an emulsifier or solubilizer so that the emulsified state or the soluble state is obtained. It is possible to obtain an emulsion that lasts more stably.
  • ultrasonic treatment or high-pressure homogenizer treatment can be employed as the dispersion (emulsification or solubilization) treatment.
  • an emulsion (emulsified formulation) with an average particle size of oil droplets of 180 nm can be prepared by appropriate ultrasonic treatment, and when processed with a high-pressure homogenizer, the average particle size of oil droplets decreases with increasing diameter.
  • a formulation having 130 nm could be prepared after 20 treatments. Judging by the observation ability of the emulsion preparation after 1 week, stable emulsion could be prepared even by emulsification by ultrasonic treatment.
  • a high-pressure homogenizer treatment is preferable in order to increase stability in consideration of the particle size of the oil droplets.
  • Vitamin A (Retino 1) 1 800 gZlOOg
  • the fatty acid composition is shown below.
  • an emulsion preparation containing tea leaf components was prepared by the following method.
  • TWEEN80 manufactured by Nikko Chemical Co.
  • polyoxyethylene hydrogenated castor oil 60 HC060
  • HC060 polyoxyethylene hydrogenated castor oil 60
  • Five types were selected: Sugar Ester SS (S-SS), Daiichi Kogyo Seiyaku Sugar Ester F1 10 (S-F110), Daiichi Kogyo Seiyaku Sugar Ester F160 (S-F160).
  • the concentration of the oil phase in the final obtained tea leaf component-containing emulsion formulation is 1, 5, or 10% by mass, and the surfactant concentration is 6 types or 7 types for each oil phase concentration, respectively. I changed it step by step.
  • a predetermined amount of surfactant was placed in a 50 ml wide-mouth glass bottle, a predetermined amount of oily solution was added, and finally a predetermined amount of purified water was added to make a total amount of 20 g. That is, when the oil phase concentration is 1%, weigh the surfactant concentration in a 5 Oml wide-mouth glass bottle (based on the total amount of 20 g) to 0.1, 0.5, 1, 2, 5 or 10% by mass. Then, an oily solution and purified water were added to make a total amount of 20 g.
  • the oil phase concentration When the oil phase concentration is 5%, weigh the surfactant concentration to 1, 2, 5, 10, 15 or 20% by mass (relative to the total amount of 20g), add the oily solution and purified water, and add the total amount. 20g. In the case of T80 and HC060, 25% by mass was also added. When the oil phase concentration is 10%, weigh the surfactant concentration to 5, 10, 20, 30, 40 or 50% (based on the total amount of 20 g), add the oily solution and purified water, and add the total amount. 20g.
  • the prepared tea leaf component-containing emulsion preparation was subjected to a digital optical microscope (manufactured by Shimadzu Corporation). GLBB1500MBlTa, X100), and the ease of dispersion was evaluated based on the uniformity of the particle size of the oil droplets in the emulsion and the presence or absence of separation of the dusting layer. Furthermore, the sample was transferred to a 20 ml sample bottle, stored at 20 ° C for 1 month, and then observed under a microscope. The dispersion stability was evaluated based on the results of oil droplet generation and the tarming phenomenon. The evaluation results are shown in Table 1, Table 2 and Table 3.
  • the emulsion preparation containing No. 58 tea leaf component was separated into an oil phase and an aqueous phase using a membrane filter having a molecular weight cut off of 300,000 (trade name: Molecat, Millipore (under pressure)).
  • the oil phase was green and the aqueous phase was almost colorless and transparent.
  • the No. 58 tea leaf ingredient-containing emulsion preparation and the No. 58 tea leaf ingredient-containing emulsion preparation were separated from the separated aqueous phase by high performance liquid chromatography, respectively, with vitamin A (retinol equivalent) and vitamin ⁇ . ( ⁇ -tocopherol equivalent), phylloquinone Quantitative analysis of Tamine Kl) and Epigalocatechin Garade, and quantitative analysis of total chlorophyll by absorptiometry (visible), and each of the above ingredients in the No. 58 tea leaf ingredient-containing emulsion formulation is in the oil phase. Whether it exists in the water phase or in the aqueous phase. The results are shown in Table 4.
  • ⁇ -tocopher D-l lOOmg was defined as a-tocophere D-l equivalent Img, respectively.
  • the average particle size of oil droplets in the oil phase is about 180 nm without high-pressure homogenizer treatment, and about 130 nm with 20 high-pressure homogenizer treatments in the optimally emulsified No. 58 tea leaf component-containing emulsion preparation.
  • the average particle size was measured again one week after preparation, but there was no change in the size of the oil droplets.
  • the average particle size of the oil droplets was about 190 nm without high-pressure homogenizer treatment, and about 80 nm with 20 high-pressure homogenizer treatments. It gradually decreased as the number of treatments increased.
  • the average particle size of the oil droplets in the oil phase is about 180 nm without high-pressure homogenizer treatment, about 80 nm with 20 high-pressure homogenizer treatments, and the number of high-pressure homogenizer treatments with the No. 58 tea leaf component-containing emulsion formulation. It gradually became smaller as it increased. In each case, the average particle size was re-measured one week after preparation, but there was no change in the size of the oil droplets. In addition, even the optimally soluble No. 18 emulsion formulation containing tea leaf components, the average particle size of the oil droplets was about 190 nm without high-pressure homogenizer treatment, and about 70 nm with 20 high-pressure homogenizer treatments. It gradually decreased as the number of treatments increased.
  • a plant-derived water-soluble component is dispersed in an oil phase, and this oil phase is dispersed in an aqueous phase to form an oZw type emulsion.
  • Even easily oxidizable water-soluble components that are easily oxidized are not easily oxidized by avoiding direct contact with air or water.
  • Long-term use of easily oxidizable water-soluble active components such as catechins Plant component-containing emulsion preparations that can be stably maintained over a long period of time.
  • various oxidizable water-soluble ingredients derived from plants are used as active ingredients. Is available for any product.
  • Fig. 1 is a graph showing the relationship between the number of treatments with a high-pressure homogenizer (pressure: 500 kgZcm 2 ) and the average particle size of oil droplets for the No. 58 tea leaf component-containing emulsion formulation.

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Abstract

L’invention prévoit de fournir une préparation d'une émulsion contenant un composant végétal qui contient de manière stable un composant hydrosoluble dérivé d'un végétal qui est facilement oxydé dans l'air ou dans l'eau et un procédé de production de celle-ci. En particulier, l’invention prévoit de fournir une préparation d'une émulsion contenant un composant de feuille de thé qui contient de manière stable un composant végétal dans une phase huileuse, où diverses substances actives dans les feuilles de thé caractérisées par la catéchine peuvent être utilisées d'une manière générale et l'application des feuilles de thé peut être largement augmentée. La préparation d'une émulsion contenant un composant végétal est caractérisée en ce que le composant hydrosoluble dérivé d'un végétal qui est facilement oxydé dans l'air ou dans l'eau est dispersé dans une phase huileuse et la phase huileuse est dispersée dans une phase aqueuse. En particulier, le composant hydrosoluble dérivé d'un végétal est une catéchine sous la forme d’un composant de feuille de thé et la catéchine est dispersée dans la phase huileuse et la phase huileuse est dispersée dans la phase aqueuse.
PCT/JP2006/302338 2005-02-10 2006-02-10 Preparation d’une emulsion contenant un composant vegetal et procede de production de celle-ci Ceased WO2006085607A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005-034237 2005-02-10
JP2005034237 2005-02-10

Publications (1)

Publication Number Publication Date
WO2006085607A1 true WO2006085607A1 (fr) 2006-08-17

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PCT/JP2006/302338 Ceased WO2006085607A1 (fr) 2005-02-10 2006-02-10 Preparation d’une emulsion contenant un composant vegetal et procede de production de celle-ci

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WO (1) WO2006085607A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117223854A (zh) * 2023-11-03 2023-12-15 海南省农业科学院三亚研究院(海南省实验动物研究中心) 大叶茶多酚-山柚油-胡椒碱Pickering乳液制备方法及应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001316259A (ja) * 2000-05-01 2001-11-13 Taiyo Kagaku Co Ltd ポリフェノール類製剤
WO2001095865A1 (fr) * 2000-06-14 2001-12-20 Pure Green Co., Ltd. Cosmetiques huileux
JP2003092988A (ja) * 2001-09-21 2003-04-02 Pure Green Kk 茶葉成分を含有する食用油の製法
JP2004089146A (ja) * 2002-09-04 2004-03-25 Asahi Soft Drinks Co Ltd 茶の油溶性成分を含有する茶飲料
JP2004141156A (ja) * 2002-09-30 2004-05-20 Kao Corp 起泡性水中油型乳化物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001316259A (ja) * 2000-05-01 2001-11-13 Taiyo Kagaku Co Ltd ポリフェノール類製剤
WO2001095865A1 (fr) * 2000-06-14 2001-12-20 Pure Green Co., Ltd. Cosmetiques huileux
JP2003092988A (ja) * 2001-09-21 2003-04-02 Pure Green Kk 茶葉成分を含有する食用油の製法
JP2004089146A (ja) * 2002-09-04 2004-03-25 Asahi Soft Drinks Co Ltd 茶の油溶性成分を含有する茶飲料
JP2004141156A (ja) * 2002-09-30 2004-05-20 Kao Corp 起泡性水中油型乳化物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117223854A (zh) * 2023-11-03 2023-12-15 海南省农业科学院三亚研究院(海南省实验动物研究中心) 大叶茶多酚-山柚油-胡椒碱Pickering乳液制备方法及应用

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