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WO2006082063A3 - Gpc-odn (oligodesoxynucleotides) comportant des sequences tige-boucle et des sequences flanquantes, sans motif cpg, destines au traitement de maladies cutanees - Google Patents

Gpc-odn (oligodesoxynucleotides) comportant des sequences tige-boucle et des sequences flanquantes, sans motif cpg, destines au traitement de maladies cutanees Download PDF

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Publication number
WO2006082063A3
WO2006082063A3 PCT/EP2006/000943 EP2006000943W WO2006082063A3 WO 2006082063 A3 WO2006082063 A3 WO 2006082063A3 EP 2006000943 W EP2006000943 W EP 2006000943W WO 2006082063 A3 WO2006082063 A3 WO 2006082063A3
Authority
WO
WIPO (PCT)
Prior art keywords
cpg
loop
stem
odn
oligodeoxynucleotides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2006/000943
Other languages
German (de)
English (en)
Other versions
WO2006082063A2 (fr
Inventor
Andreas Bock
Stefan Kippenberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phenion GmbH and Co KG
Original Assignee
Phenion GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phenion GmbH and Co KG filed Critical Phenion GmbH and Co KG
Priority to EP06706612A priority Critical patent/EP1844146A2/fr
Publication of WO2006082063A2 publication Critical patent/WO2006082063A2/fr
Publication of WO2006082063A3 publication Critical patent/WO2006082063A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne des préparations cosmétiques ou pharmaceutiques pour la prophylaxie et/ou le traitement d'un tissu de couverture épithélial, ces préparations contenant des acides nucléiques dotés de séquences aptes à former des structures secondaires tige-boucle. La présente invention concerne également l'utilisation d'acides nucléiques de ce type pour la prophylaxie et/ou le traitement d'un tissu de couverture épithélial, ainsi que des adoucissants textiles, des savons pour les mains, des produits de soins corporels et capillaires, des colorants capillaires et des liquides vaisselle contenant de tels acides nucléiques dotés de séquences aptes à former des structures secondaires tige-boucle.
PCT/EP2006/000943 2005-02-06 2006-02-03 Gpc-odn (oligodesoxynucleotides) comportant des sequences tige-boucle et des sequences flanquantes, sans motif cpg, destines au traitement de maladies cutanees Ceased WO2006082063A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06706612A EP1844146A2 (fr) 2005-02-06 2006-02-03 Preparations cosmetiques ou pharmaceutiques contenant des acides nucleiques dotes de sequences aptes a former des structures secondaires tiges-boucles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005005642A DE102005005642A1 (de) 2005-02-06 2005-02-06 Kosmetische oder pharmazeutische Zubereitungen enthaltend Nukleinsäuren, die zur Ausbildung von stem-loop-Sekundärstrukturen geeignete Sequenzen umfassen
DE102005005642.3 2005-02-06

Publications (2)

Publication Number Publication Date
WO2006082063A2 WO2006082063A2 (fr) 2006-08-10
WO2006082063A3 true WO2006082063A3 (fr) 2007-06-14

Family

ID=36709756

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/000943 Ceased WO2006082063A2 (fr) 2005-02-06 2006-02-03 Gpc-odn (oligodesoxynucleotides) comportant des sequences tige-boucle et des sequences flanquantes, sans motif cpg, destines au traitement de maladies cutanees

Country Status (4)

Country Link
EP (1) EP1844146A2 (fr)
CN (1) CN101115835A (fr)
DE (1) DE102005005642A1 (fr)
WO (1) WO2006082063A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007044093A1 (de) * 2007-09-14 2009-03-19 Phenion Gmbh & Co. Kg Nukleinsäurehaltige kosmetische und/oder pharmazeutische Zubereitungen zur Induktion antimikrobieller Peptide in epithelialen Deckgeweben

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19750702A1 (de) * 1997-11-15 1999-05-27 Hoechst Marion Roussel De Gmbh Antisense Oligonucleotide gegen Tenascin zur Behandlung von Vitiligo
WO2001022990A2 (fr) * 1999-09-27 2001-04-05 Coley Pharmaceutical Group, Inc. Methodes concernant l'interferon induit par acides nucleiques immunostimulateur
US20010044416A1 (en) * 2000-01-20 2001-11-22 Mccluskie Michael J. Immunostimulatory nucleic acids for inducing a Th2 immune response
US20030104523A1 (en) * 2000-09-15 2003-06-05 Stefan Bauer Process for high throughput screening of CpG-based immuno-agonist/antagonist
WO2004012688A2 (fr) * 2002-07-25 2004-02-12 Phenion Gmbh & Co. Kg Preparations cosmetiques ou pharmaceutiques contenant des acides nucleiques a base de motifs cpg non methyles
WO2006028742A2 (fr) * 2004-09-01 2006-03-16 Dynavax Technologies Corporation Procedes et compositions permettant d'inhiber des reponses immunitaires innees et auto-immunite correspondante

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19750702A1 (de) * 1997-11-15 1999-05-27 Hoechst Marion Roussel De Gmbh Antisense Oligonucleotide gegen Tenascin zur Behandlung von Vitiligo
WO2001022990A2 (fr) * 1999-09-27 2001-04-05 Coley Pharmaceutical Group, Inc. Methodes concernant l'interferon induit par acides nucleiques immunostimulateur
US20010044416A1 (en) * 2000-01-20 2001-11-22 Mccluskie Michael J. Immunostimulatory nucleic acids for inducing a Th2 immune response
US20030104523A1 (en) * 2000-09-15 2003-06-05 Stefan Bauer Process for high throughput screening of CpG-based immuno-agonist/antagonist
WO2004012688A2 (fr) * 2002-07-25 2004-02-12 Phenion Gmbh & Co. Kg Preparations cosmetiques ou pharmaceutiques contenant des acides nucleiques a base de motifs cpg non methyles
WO2006028742A2 (fr) * 2004-09-01 2006-03-16 Dynavax Technologies Corporation Procedes et compositions permettant d'inhiber des reponses immunitaires innees et auto-immunite correspondante

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
AKHTAR MAHMOOD ET AL: "Bacterial DNA evokes epithelial IL-8 production by a MAPK-dependent, NF-kappaB-independent pathway.", THE FASEB JOURNAL : OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY JUL 2003, vol. 17, no. 10, July 2003 (2003-07-01), pages 1319 - 1321, XP002422729, ISSN: 1530-6860 *
AKHTAR MAHMOOD ET AL: "Human-derived colonic epithelial cells express the toll-like receptor 9 (TLR9) and respond to E. coli DNA by up-regulation of IL-8 and COX-2 messenger RNA", GASTROENTEROLOGY, vol. 122, no. 4 Suppl. 1, April 2002 (2002-04-01), & DIGESTIVE DISEASE WEEK AND THE 103RD ANNUAL MEETING OF THE AMERICAN GASTROENTEROLOGICAL ASSOCIATION; SAN FRANCISCO, CA, USA; MAY 19-22, 2002, pages A - 281, XP009080005, ISSN: 0016-5085 *
ASHMAN ROBERT F ET AL: "Sequence requirements for oligodeoxyribonucleotide inhibitory activity", INTERNATIONAL IMMUNOLOGY, OXFORD UNIVERSITY PRESS, GB, vol. 17, no. 4, 3 March 2005 (2005-03-03), pages 411 - 420, XP002380605, ISSN: 0953-8178 *
BALLAS Z K ET AL: "divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 167, no. 9, 1 November 2001 (2001-11-01), pages 4878 - 4886, XP002267234, ISSN: 0022-1767 *
BARRAT FRANCK J ET AL: "Nucleic acids of mammalian origin can act as endogenous ligands for toll-like receptors and may promote systemic lupus erythematosus", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 202, no. 8, 17 October 2005 (2005-10-17), pages 1131 - 1139, XP002380606, ISSN: 0022-1007 *
GREENE CATHERINE M ET AL: "TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells", JOURNAL OF IMMUNOLOGY, vol. 174, no. 3, 1 February 2005 (2005-02-01), pages 1638 - 1646, XP002422731, ISSN: 0022-1767 *
KLINMAN DENNIS M ET AL: "Regulation of CpG-induced immune activation by suppressive oligodeoxynucleotides", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, NEW YORK, NY, US, vol. 1002, December 2003 (2003-12-01), pages 112 - 123, XP002380607, ISSN: 0077-8923 *
LENERT PETAR ET AL: "Structural characterization of the inhibitory DNA motif for the type A (D)-CpG-induced cytokine secretion and NK-cell lytic activity in mouse spleen cells.", DNA AND CELL BIOLOGY, vol. 22, no. 10, October 2003 (2003-10-01), pages 621 - 631, XP002422640, ISSN: 1044-5498 *
OUMOUNA M ET AL: "Activation of nonspecific cytotoxic cells (NCC) with synthetic oligodeoxynucleotides and bacterial genomic DNA: Binding, specificity and identification of unique immunostimulatory motifs", DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, vol. 26, no. 3, April 2002 (2002-04-01), pages 257 - 269, XP002422642, ISSN: 0145-305X *
PLATZ JULIANE ET AL: "Microbial DNA induces a host defense reaction of human respiratory epithelial cells", JOURNAL OF IMMUNOLOGY, vol. 173, no. 2, 15 July 2004 (2004-07-15), pages 1219 - 1223, 1209, XP002422730, ISSN: 0022-1767 *
REBOWSKI GRZEGORZ ET AL: "Antisense hairpin loop oligonucleotides as inhibitors of expression of multidrug resistance-associated protein 1: Their stability in fetal calf serum and human plasma", ACTA BIOCHIMICA POLONICA, vol. 48, no. 4, 2001, pages 1061 - 1076, XP002422641, ISSN: 0001-527X *

Also Published As

Publication number Publication date
EP1844146A2 (fr) 2007-10-17
CN101115835A (zh) 2008-01-30
WO2006082063A2 (fr) 2006-08-10
DE102005005642A1 (de) 2006-08-10

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