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WO2006081152A3 - Estrogen receptor modulators - Google Patents

Estrogen receptor modulators Download PDF

Info

Publication number
WO2006081152A3
WO2006081152A3 PCT/US2006/002148 US2006002148W WO2006081152A3 WO 2006081152 A3 WO2006081152 A3 WO 2006081152A3 US 2006002148 W US2006002148 W US 2006002148W WO 2006081152 A3 WO2006081152 A3 WO 2006081152A3
Authority
WO
WIPO (PCT)
Prior art keywords
disease
estrogen
compounds
receptor modulators
bone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/002148
Other languages
French (fr)
Other versions
WO2006081152A2 (en
Inventor
Timothy A Blizzard
Candido Gude
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of WO2006081152A2 publication Critical patent/WO2006081152A2/en
Publication of WO2006081152A3 publication Critical patent/WO2006081152A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Paget’s disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, inflammation, inflammatory bowel disease and cancer, in particular of the breast, uterus and prostate.
PCT/US2006/002148 2005-01-24 2006-01-20 Estrogen receptor modulators Ceased WO2006081152A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64675405P 2005-01-24 2005-01-24
US60/646,754 2005-01-24

Publications (2)

Publication Number Publication Date
WO2006081152A2 WO2006081152A2 (en) 2006-08-03
WO2006081152A3 true WO2006081152A3 (en) 2007-02-08

Family

ID=36740963

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/002148 Ceased WO2006081152A2 (en) 2005-01-24 2006-01-20 Estrogen receptor modulators

Country Status (1)

Country Link
WO (1) WO2006081152A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12403115B2 (en) 2017-08-28 2025-09-02 Zhejiang Jiachi Development Pharmaceuticals Ltd Asymmetric synthesis and uses of compounds in disease treatments

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
US9623021B2 (en) 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
BRPI0806371A2 (en) 2007-01-22 2011-09-13 Gtx Inc nuclear receptor binding agents
CN102558267A (en) * 2012-01-13 2012-07-11 宜城市共同药业有限公司 Preparation method of testosterone enanthate
WO2018023017A1 (en) 2016-07-29 2018-02-01 Janssen Pharmaceutica Nv Methods of treating prostate cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3218316A (en) * 1963-08-26 1965-11-16 Syntex Corp 10beta-ethynyl-19-norandrostane derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3218316A (en) * 1963-08-26 1965-11-16 Syntex Corp 10beta-ethynyl-19-norandrostane derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12403115B2 (en) 2017-08-28 2025-09-02 Zhejiang Jiachi Development Pharmaceuticals Ltd Asymmetric synthesis and uses of compounds in disease treatments

Also Published As

Publication number Publication date
WO2006081152A2 (en) 2006-08-03

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Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase

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