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WO2006074914A3 - Human rna helicase and therapeutic uses thereof - Google Patents

Human rna helicase and therapeutic uses thereof Download PDF

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Publication number
WO2006074914A3
WO2006074914A3 PCT/EP2006/000190 EP2006000190W WO2006074914A3 WO 2006074914 A3 WO2006074914 A3 WO 2006074914A3 EP 2006000190 W EP2006000190 W EP 2006000190W WO 2006074914 A3 WO2006074914 A3 WO 2006074914A3
Authority
WO
WIPO (PCT)
Prior art keywords
rna helicase
human rna
therapeutic uses
rhau
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2006/000190
Other languages
French (fr)
Other versions
WO2006074914A2 (en
Inventor
Yoshikuni Nagamine
Hoanh Tran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCHNOVARTIS FORSCHUNGSSTIFTUNG ZWEIGNIEDERLASSUNG FR
IEDRICH MIESCHER INST FOR BIOM
Original Assignee
IEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCHNOVARTIS FORSCHUNGSSTIFTUNG ZWEIGNIEDERLASSUNG FR
IEDRICH MIESCHER INST FOR BIOM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCHNOVARTIS FORSCHUNGSSTIFTUNG ZWEIGNIEDERLASSUNG FR, IEDRICH MIESCHER INST FOR BIOM filed Critical IEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCHNOVARTIS FORSCHUNGSSTIFTUNG ZWEIGNIEDERLASSUNG FR
Publication of WO2006074914A2 publication Critical patent/WO2006074914A2/en
Publication of WO2006074914A3 publication Critical patent/WO2006074914A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides amino acid sequences of a human RNA helicase, RHAU. The present invention specifically provides isolated peptide and nucleic acid molecules and methods of identifying modulators of RHAU peptides and nucleic acid molecules.
PCT/EP2006/000190 2005-01-13 2006-01-11 Human rna helicase and therapeutic uses thereof Ceased WO2006074914A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64362105P 2005-01-13 2005-01-13
US60/643,621 2005-01-13

Publications (2)

Publication Number Publication Date
WO2006074914A2 WO2006074914A2 (en) 2006-07-20
WO2006074914A3 true WO2006074914A3 (en) 2006-08-31

Family

ID=36586020

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/000190 Ceased WO2006074914A2 (en) 2005-01-13 2006-01-11 Human rna helicase and therapeutic uses thereof

Country Status (1)

Country Link
WO (1) WO2006074914A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110262428A1 (en) * 2008-09-24 2011-10-27 NOVARTIS Forschungsstiftung Zweigniederlassung Fri -edrich Miescher Institute for Biomedical Researc Treating cancer by modulating rna helicases
US20120124682A1 (en) * 2009-05-08 2012-05-17 Janice Lai Dhx36 / rhau knockout mice as experimental models of muscular dystrophy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001057190A2 (en) * 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2002030268A2 (en) * 2000-10-13 2002-04-18 Eos Biotechnology, Inc. Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer
WO2005001031A2 (en) * 2003-05-22 2005-01-06 Isis Pharmaceuticals, Inc. Modulation of the rna interference pathway

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001057190A2 (en) * 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2002030268A2 (en) * 2000-10-13 2002-04-18 Eos Biotechnology, Inc. Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer
WO2005001031A2 (en) * 2003-05-22 2005-01-06 Isis Pharmaceuticals, Inc. Modulation of the rna interference pathway

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TRAN HOANH ET AL: "Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU.", MOLECULAR CELL. 16 JAN 2004, vol. 13, no. 1, 16 January 2004 (2004-01-16), pages 101 - 111, XP002386855, ISSN: 1097-2765 *

Also Published As

Publication number Publication date
WO2006074914A2 (en) 2006-07-20

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