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WO2006072818A3 - Procede pour preparer de la benzazepine - Google Patents

Procede pour preparer de la benzazepine Download PDF

Info

Publication number
WO2006072818A3
WO2006072818A3 PCT/IB2005/003804 IB2005003804W WO2006072818A3 WO 2006072818 A3 WO2006072818 A3 WO 2006072818A3 IB 2005003804 W IB2005003804 W IB 2005003804W WO 2006072818 A3 WO2006072818 A3 WO 2006072818A3
Authority
WO
WIPO (PCT)
Prior art keywords
galanthamine
preparation
discusses
chiral
involves
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2005/003804
Other languages
English (en)
Other versions
WO2006072818A2 (fr
Inventor
Milind Moreshwar Gharpure
Baburao Manikrao Bhawal
Umesh Rewaji Zope
Mangala Babu Govankar
Satish Ramanlal Mehta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emcure Pharmaceuticals Ltd
Original Assignee
Emcure Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emcure Pharmaceuticals Ltd filed Critical Emcure Pharmaceuticals Ltd
Publication of WO2006072818A2 publication Critical patent/WO2006072818A2/fr
Publication of WO2006072818A3 publication Critical patent/WO2006072818A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un procédé pour préparer de la galanthamine, qui comprend une étape de réduction stéréosélective permettant d'obtenir l'isomère de galanthamine souhaité. Ce mode de réalisation concerne aussi un procédé pour améliorer la pureté chirale et chimique de galanthamine et de sels de galanthamine.
PCT/IB2005/003804 2005-01-04 2005-12-16 Procede pour preparer de la benzazepine Ceased WO2006072818A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN3/MUM/2005 2005-01-04
IN3MU2005 2005-01-04
IN863MU2005 2005-07-21
IN863/MUM/2005 2005-07-21

Publications (2)

Publication Number Publication Date
WO2006072818A2 WO2006072818A2 (fr) 2006-07-13
WO2006072818A3 true WO2006072818A3 (fr) 2006-08-24

Family

ID=36202462

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/003804 Ceased WO2006072818A2 (fr) 2005-01-04 2005-12-16 Procede pour preparer de la benzazepine

Country Status (1)

Country Link
WO (1) WO2006072818A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1885727B1 (fr) * 2005-05-03 2010-03-03 Medichem, S.A. Syntheses et preparations de narwedine et de nouveaux composes associes
SI2146719T1 (sl) * 2007-04-12 2013-10-30 Scinopharm Taiwan Ltd. Postopek za pripravo galantamina
CN104592243B (zh) * 2014-12-19 2016-08-24 北京大学 加兰他敏和力克拉敏的不对称合成方法
BG67337B1 (bg) * 2018-05-23 2021-06-15 Софарма Ад Метод за получаване на пречистен галантамин хидробромид

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030092700A1 (en) * 1996-04-19 2003-05-15 Laszlo Czollner Benzazepine derivatives, medicaments containing the same and their use to prepare medicaments
US20060009640A1 (en) * 2004-07-08 2006-01-12 Bolugoddu Vijaya B Preparation of (-)-galantamine hydrobromide

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030092700A1 (en) * 1996-04-19 2003-05-15 Laszlo Czollner Benzazepine derivatives, medicaments containing the same and their use to prepare medicaments
US20060009640A1 (en) * 2004-07-08 2006-01-12 Bolugoddu Vijaya B Preparation of (-)-galantamine hydrobromide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VLAHOV R ET AL: "SYNTHESIS OF GALANTHAMINE AND RELATED ALKALOIDS - NEW APPROACHES. I", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 45, no. 11, 1989, pages 3329 - 3345, XP000562833, ISSN: 0040-4020 *

Also Published As

Publication number Publication date
WO2006072818A2 (fr) 2006-07-13

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