[go: up one dir, main page]

WO2006072348A3 - Alkinyl-substituierte thiophene - Google Patents

Alkinyl-substituierte thiophene Download PDF

Info

Publication number
WO2006072348A3
WO2006072348A3 PCT/EP2005/013218 EP2005013218W WO2006072348A3 WO 2006072348 A3 WO2006072348 A3 WO 2006072348A3 EP 2005013218 W EP2005013218 W EP 2005013218W WO 2006072348 A3 WO2006072348 A3 WO 2006072348A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkinyl
substituted thiophenes
illnesses
prophylaxis
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2005/013218
Other languages
English (en)
French (fr)
Other versions
WO2006072348A2 (de
Inventor
Tobias Wunberg
Judith Baumeister
Dirk Gottschling
Kerstin Henninger
Diana Koletzki
Josef Pernerstorfer
Andreas Urban
Alexander Birkmann
Axel Harrenga
Mario Lobell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aicuris GmbH and Co KG
Original Assignee
Aicuris GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris GmbH and Co KG filed Critical Aicuris GmbH and Co KG
Publication of WO2006072348A2 publication Critical patent/WO2006072348A2/de
Publication of WO2006072348A3 publication Critical patent/WO2006072348A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Die Erfindung betrifft Alkinyl-substituierte Thiophene und Verfahren zu ihrer Herstellung, ihre Verwendung zur Behandlung und/oder Prophylaxe von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von Krankheiten, insbesondere zur Verwendung als antivirale Mittel, insbesondere gegen Hepatitis C Viren.
PCT/EP2005/013218 2004-12-22 2005-12-09 Alkinyl-substituierte thiophene Ceased WO2006072348A2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102004061745.7 2004-12-22
DE102004061745 2004-12-22
DE102005028077A DE102005028077A1 (de) 2004-12-22 2005-06-17 Alkinyl-substituierte Thiophene
DE102005028077.3 2005-06-17

Publications (2)

Publication Number Publication Date
WO2006072348A2 WO2006072348A2 (de) 2006-07-13
WO2006072348A3 true WO2006072348A3 (de) 2006-09-21

Family

ID=36599492

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/013218 Ceased WO2006072348A2 (de) 2004-12-22 2005-12-09 Alkinyl-substituierte thiophene

Country Status (2)

Country Link
DE (1) DE102005028077A1 (de)
WO (1) WO2006072348A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL395097A1 (pl) 2001-06-11 2011-10-10 Vertex Pharmaceuticals (Canada) Incorporated Sposób wytwarzania związku o wzorze A stanowiącego pochodną tiofenu
ES2345438T3 (es) 2002-12-10 2010-09-23 Virochem Pharma Inc. Compuestos y metodos para el tratamiento o prevencion de infecciones por flavivirus.
EP2546246A3 (de) 2005-05-13 2013-04-24 Virochem Pharma Inc. Verbindungen und Verfahren zur Behandlung oder Vorbeugung von Flavivirus-Infektionen
DE102006013957A1 (de) * 2006-03-27 2007-10-04 Bayer Healthcare Aktiengesellschaft Substituierte N-Benzyl-N-phenylbenzolsulfonamide
EA201101492A1 (ru) 2006-11-15 2012-09-28 Вирокем Фарма Инк. Аналоги тиофена для лечения или предупреждения флавивирусных инфекций
NZ597528A (en) 2009-07-21 2014-08-29 Gilead Sciences Inc Inhibitors of flaviviridae viruses
BR112012005438A2 (pt) 2009-09-09 2018-03-20 Gilead Sciences Inc inibidores de vírus flaviviridae
MX2012006026A (es) * 2009-11-25 2012-08-15 Vertex Pharma Derivados de acido 5-alquinil-tiofen-2-carboxilico y usos para tratamiento o prevencion de infecciones por flavivirus.
UA108221C2 (uk) * 2010-01-15 2015-04-10 Похідні тіофен-2-карбонової кислоти як інгібітори вірусів flaviviridae
US8513298B2 (en) 2010-01-15 2013-08-20 Gilead Sciences, Inc. Inhibitors of flaviviridae viruses
ES2561888T3 (es) 2011-07-13 2016-03-01 Gilead Sciences, Inc. Derivados de ácido tiofeno-2-carboxílico útiles como inhibidores de virus Flaviviridae
US8841340B2 (en) 2012-08-17 2014-09-23 Gilead Sciences, Inc. Solid forms of an antiviral compound
US8759544B2 (en) 2012-08-17 2014-06-24 Gilead Sciences, Inc. Synthesis of an antiviral compound
US8927741B2 (en) 2012-08-17 2015-01-06 Gilead Sciences, Inc. Synthesis of an antiviral compound

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002100851A2 (en) * 2001-06-11 2002-12-19 Shire Biochem Inc. Thiophene derivatives as antiviral agents for flavivirus infection
EP1321463A1 (de) * 2001-12-21 2003-06-25 Shire Biochem Inc. Thiazolderivate und ihre Verwendung zur Behandlung oder Vorbeugung von Infektionen durch Flaviviren
WO2005063734A2 (de) * 2003-12-19 2005-07-14 Aicuris Gmbh & Co. Kg Substituierte thiophene

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002100851A2 (en) * 2001-06-11 2002-12-19 Shire Biochem Inc. Thiophene derivatives as antiviral agents for flavivirus infection
EP1321463A1 (de) * 2001-12-21 2003-06-25 Shire Biochem Inc. Thiazolderivate und ihre Verwendung zur Behandlung oder Vorbeugung von Infektionen durch Flaviviren
WO2005063734A2 (de) * 2003-12-19 2005-07-14 Aicuris Gmbh & Co. Kg Substituierte thiophene

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHAN L ET AL: "Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 14, no. 3, 9 February 2004 (2004-02-09), pages 793 - 796, XP002328928, ISSN: 0960-894X *

Also Published As

Publication number Publication date
DE102005028077A1 (de) 2006-07-13
WO2006072348A2 (de) 2006-07-13

Similar Documents

Publication Publication Date Title
WO2006072347A3 (de) Alkinyl-substituierte thiophene
WO2005063734A3 (de) Substituierte thiophene
NL300933I2 (nl) Letermovir
WO2007081974A3 (en) Viral hepatitis treatment
WO2008104306A3 (de) Substituierte 4-aryl-1,4-dihydro-1,6-naphthyridinamide und ihre verwendung
IL173204A0 (en) Novel cyanopyrrolidides, methods for the production thereof, and use of the same as medicaments
CA111635S (en) Bottle
WO2008046581A3 (de) Substituierte tetrahydropyrrolopyrazin-verbindungen als inhibitoren der monoaminwiederaufnahme und deren verwendung in arzeimitteln
WO2006032342A3 (de) Arzneimittel enthaltend carbonylverbindungen sowie deren verwendung
WO2003084539A3 (en) New pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors
WO2004112687A3 (en) Antiviral acylguanidine compounds and methods
IL181012A0 (en) Substituted 8-aminoalkoxi-xanthines, method for the production thereof and use thereof as medicaments
WO2007015017A3 (fr) Nouveaux derives de polyquinoleines et leur utilisation therapeutique
WO2004071382A3 (en) Substituted heterocycles
WO2006072348A3 (de) Alkinyl-substituierte thiophene
IL179758A (en) Substituted tetrahydro-2h-isoquinolin-1-one derivatives, method for the production thereof and use of the same as medicaments
WO2006124861A3 (en) Benzofuran compounds
MX2007002470A (es) Fenilaminotiazoles sustituidos y su uso.
WO2010052559A8 (en) Cycloundecadepsipeptide compounds and use of said compounds as a medicament
TW200633992A (en) Biaryloxymethylarenecarboxylic acids
IL179170A0 (en) Novel substituted thiophenecarboxamides, their production and their use as medicaments
TW200621799A (en) Acylated nonadepsipeptides II
IL194353A0 (en) Lysobactin amides
UA94080C2 (ru) Ациклически-замещенные производные фуропиримидина и их применение для лечения сердечно-сосудистых заболеваний
WO2006089664A3 (de) Heterocyclylamid-substituierte imidazole

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 05814606

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 05814606

Country of ref document: EP

Kind code of ref document: A2

WWW Wipo information: withdrawn in national office

Ref document number: 5814606

Country of ref document: EP