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WO2006067255A1 - Lentille intraoculaire permettant d'achromatiser l'oeil et de reduire ses aberrations - Google Patents

Lentille intraoculaire permettant d'achromatiser l'oeil et de reduire ses aberrations Download PDF

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Publication number
WO2006067255A1
WO2006067255A1 PCT/ES2005/070163 ES2005070163W WO2006067255A1 WO 2006067255 A1 WO2006067255 A1 WO 2006067255A1 ES 2005070163 W ES2005070163 W ES 2005070163W WO 2006067255 A1 WO2006067255 A1 WO 2006067255A1
Authority
WO
WIPO (PCT)
Prior art keywords
iol
refractive
diffractive
spherical
aspherical
Prior art date
Application number
PCT/ES2005/070163
Other languages
English (en)
Spanish (es)
Inventor
Jorge Luciano ALIÓ SANZ
Norberto Lopez Gil
Robert Montes Mico
Original Assignee
Instituto Oftalmológico De Alicante, S.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instituto Oftalmológico De Alicante, S.L. filed Critical Instituto Oftalmológico De Alicante, S.L.
Publication of WO2006067255A1 publication Critical patent/WO2006067255A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1648—Multipart lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses

Definitions

  • the invention is encompassed within ophthalmology, optometry and optics. Specifically, the invention relates to an intraocular lens to acromatize the eye and reduce its aberrations.
  • the eye like other refractive systems, has aberrations that affect the resolution and quality of the image that forms in the retina.
  • the eye suffers from monochromatic aberrations (blur, astigmatism, spherical aberration, and others) and chromatic (longitudinal and transverse).
  • monochromatic aberrations blue, astigmatism, spherical aberration, and others
  • chromatic longitudinal and transverse
  • Monochromatic aberrations such as blurring and astigmatism can be corrected by ophthalmic lenses, contact lenses, refractive surgery or by implantation of intraocular lenses (IOLs) into the eye.
  • IOLs intraocular lenses
  • Monochromatic aberrations such as spherical aberration can also be corrected by ophthalmic and contact lenses and IOL systems are currently beginning to be developed for correction.
  • U.S. Patent 6,609,793 states a methodology for obtaining aphakic IOLs providing the eye with a reduction in monochromatic aberrations: spherical aberration of high order, blurring and astigmatism.
  • These researchers and others who develop a similar methodology base their calculations on measurements or simulations performed in monochromatic or quasi-monochromatic light, and suggest eliminating aberration from calculations performed in which intraocular refractive indices remain constant. Said calculation therefore does not take into account the variation of the refractive indices of the media for different wavelengths, that is, the chromatic dispersion of the ocular media.
  • Chromatic aberration presents an important complication in its correction due to the scattering of light by its very nature and to acromatize the eye, it is usually necessary to couple two or more optical systems (doublets or triplets) for correction.
  • IOLs have been devised to achromaticize the eye for the purpose to improve its optical quality.
  • US Patent 5,895,422 and international application WO 94/13225 state an aphakic IOL for the correction of chromatic aberration.
  • cataracts In the eye, other problems also occur, such as cataracts. Cataract is the loss of transparency of the lens.
  • the lens is a transparent lens that we have behind the pupil and that helps us sharply focus on the objects. Over the years, due to trauma, disease, the lens may lose its natural transparency.
  • the treatment of cataracts is fundamentally surgical.
  • the cataract operation consists of the extraction of the lens that is opacified and its replacement by an artificial lens: IOL, which is placed in the same place as the original lens, restoring the vision that had been lost as a result of the cataracts (Agarwal S et al. in Phacoemulsification, Third Edition. SLACK Inc. 2004).
  • the lens can also be removed even if it is not opacified and replaced by an IOL.
  • the extraction seeks a refractive end: the elimination of a refractive error (myopia, farsightedness and / or astigmatism).
  • a refractive error myopia, farsightedness and / or astigmatism
  • the lens can also be maintained, an IOL inserted into the anterior / posterior chamber of the eye and thus eliminate the refractive error (phakic IOL, Alió JL and Pérez-Santonja JJ in Refractive Surgery with Phakic IOLs, SLACK Inc. 2004) .
  • the objective of the invention is to develop a new IOL to be implanted in the human eye.
  • the presence in the eye of monochromatic spherical aberration and chromatic aberration has been considered.
  • the implementation of the proposed IOL is intended to reduce these aberrations and provide better optical quality and consequently greater visual performance of the human eye.
  • the design of the new IOL is based on a hybrid lens with two surfaces, being a refractive surface and the other diffractive, that is, with different optical properties.
  • the combination of both surfaces in the same lens compensates for the chromatic dispersion of the human eye.
  • at least one of the surfaces is aspheric, which makes it possible to reduce the spherical aberration of the entire eye once the IOL is inserted.
  • the compensation of both aberrations also decreases the spherochromatic aberration and can increase the depth of focus of the eye allowing better vision at different distances.
  • a first aspect of the invention relates to an IOL (intraocular lens) configured to be implanted in a human eye comprising a first surface and a second surface with different optical properties, where
  • one of said surfaces is diffractive
  • one of said surfaces is refractive
  • At least one of said surfaces is aspheric
  • said first surface and said second surface defining a structure that has a plurality of optical properties that take into account: [19] chromatic dispersions of the ocular media,
  • spherochromatic aberrations due to the change of spherical monochromatic aberrations with light scattering [22] to reduce spherical monochromatic aberrations, chromatic aberrations and spherochromatic aberrations.
  • different variants of the invention are defined: [24] - IOL where the first surface is spherical refractive and the second surface is aspherical diffractive. [25] - IOL where the first surface is aspherical diffractive and the second surface is spherical refractive. [26] - IOL where the first surface is aspherical refractive and the second surface is spherical diffractive.
  • the IOL of the invention is configured to be placed in a position in the human eye selected from: a posterior chamber, an anterior chamber, a capsule, a cornea and a vitreous. [35] Also, the IOL is configured to be placed in a human eye with or without a lens. [36] On the other hand, the IOL is composed of a soft or hard material that presents biocompatibility with the human eye.
  • the IOL material may be selected from: acrylic, silicone, hydrogel, methyl methacrylate and combinations thereof.
  • the IOL also includes haptics to be implanted in the human eye, said haptics being configured to place the IOL in a position in the human eye selected from: a posterior chamber, an anterior chamber, a capsule, a coma and a vitreous.
  • the IOL may also comprise a material with selective transmittance at certain wavelengths.
  • the IOL is configured to allow movement and pseudo-accommodation of said lens.
  • the first and / or second surfaces of the IOL have radial variations in curvature so that the lens has different foci to obtain a
  • FIG. 1 shows the polychromatic Modulation transfer (MTF) function for the example eye model, with the IOL proposed in the example
  • Figure 3 shows the focus offset (D, diopters) for different wavelengths for the example eye model, with the IOL proposed in the example (solid line), and the reference IOL (dotted line ) proposal in example.
  • Figure 4 shows the optical path difference (Optical Path Difference, OPD) in axis at the entrance pupil for the five wavelengths used (see figure) in the example eye model, with the proposed IOL ( a), and the reference IOL (b).
  • OPD optical Path Difference
  • the proposed lens is a combination of a refractive and a diffractive surface presented below:
  • the new IOL can be designed with a material that includes a chromophore capable of selectively reducing the transmittance of certain wavelengths.
  • the main application of the proposed IOL is the improvement of optical and visual quality [Visual Acuity, Monochromatic and Polychromatic Modulation Transfer Function (MTF, hereinafter), Contrast Sensitivity Function, ...] person who has been implanted.
  • MTF Monochromatic and Polychromatic Modulation Transfer Function
  • the proposed eye model is composed of four surfaces (two for the cornea and two for the IOL), a flat iris and a spherical retina.
  • the specific data are indicated in table 1.
  • Table 1 [72] The ⁇ , and ⁇ parameters have been optimized to minimize the mean square value (Root Mean Square or RMS) measured in the pupil plane, but can also be optimized to minimize another type of quality parameter of image both in the pupil plane and in the retina plane.
  • RMS Root Mean Square
  • n n + A / ⁇ + B / ⁇ 3.5 [79] where the specific values of n, A and B used in the model come from table 2.
  • the material of the IOL is PMMA (PolyMetilMetAcrylate), but it could be another for example: a soft or hard material that has biocompatibility with the human eye selected from: acrylic, silicone, hydrogel, methyl methacrylate.
  • Figure 2 shows the values of polychromatic MTF on the horizontal axis of the eye model with the proposed IOL (solid line); the reference IOL (dotted line) and the one corresponding to the diffraction limited system (gray line).
  • Figure 3 shows the focus offset (D) for different wavelengths (longitudinal chromatic aberration) with the proposed IOL (solid line), and the reference IOL (dotted line).
  • OPD optical path difference
  • Figures 2, 3 and 4 show the significant reduction of both monochromatic and chromatic aberrations of the proposed eye model when the proposed IOL is implanted in comparison to a conventional spherical surface IOL.
  • the eye model values presented are approximate values that may change depending on the specific eye model used. The change of these values would vary the values of ⁇ and ⁇ (and that of ⁇ in case a diffractive and aspherical surface type S4 is used) obtained and presented in table 1. More wavelengths and other wavelengths can also be taken pupillary radius that also They would dictate these values.

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne une lentille intraoculaire (LIO) conçue pour être implantée dans un oeil humain. Cette lentille comprend une première surface (1) et une seconde surface (2) présentant différentes propriétés optiques, une de ces surfaces étant diffractive tandis que l'autre est réfractive. La première surface (1) et la seconde surface (2) définissent une structure qui présente une pluralité de propriétés optiques afin de réduire les aberrations sphériques monochromatiques, les aberrations chromatiques et les aberrations sphérochromatiques. Les surfaces qui peuvent être combinées sont : diffractive asphérique, diffractive sphérique, réfractive sphérique, réfractive asphérique. Les surfaces sphériques peuvent être remplacées par des surfaces planes.
PCT/ES2005/070163 2004-12-22 2005-11-29 Lentille intraoculaire permettant d'achromatiser l'oeil et de reduire ses aberrations WO2006067255A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200403061 2004-12-22
ES200403061A ES2272143B1 (es) 2004-12-22 2004-12-22 Lente intraocular para acromatizar el ojo y reducir sus aberraciones.

Publications (1)

Publication Number Publication Date
WO2006067255A1 true WO2006067255A1 (fr) 2006-06-29

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Family Applications (1)

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PCT/ES2005/070163 WO2006067255A1 (fr) 2004-12-22 2005-11-29 Lentille intraoculaire permettant d'achromatiser l'oeil et de reduire ses aberrations

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ES (1) ES2272143B1 (fr)
WO (1) WO2006067255A1 (fr)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110020627A1 (en) * 2007-11-02 2011-01-27 Benjamin Falk Textiles treated with copolymers of epoxy compounds and amino silanes having enhanced wet-strength
US9335563B2 (en) 2012-08-31 2016-05-10 Amo Groningen B.V. Multi-ring lens, systems and methods for extended depth of focus
US20170258578A1 (en) * 2016-03-11 2017-09-14 Amo Groningen B.V. Intraocular lenses that improve peripheral vision
US10327888B2 (en) 2014-03-10 2019-06-25 Amo Groningen B.V. Enhanced toric lens that improves overall vision where there is a local loss of retinal function
US10588739B2 (en) 2014-04-21 2020-03-17 Amo Groningen B.V. Ophthalmic devices, system and methods that improve peripheral vision
US10624735B2 (en) 2016-02-09 2020-04-21 Amo Groningen B.V. Progressive power intraocular lens, and methods of use and manufacture
US10758340B2 (en) 2013-03-11 2020-09-01 Johnson & Johnson Surgical Vision, Inc. Intraocular lens that matches an image surface to a retinal shape, and method of designing same
US11096778B2 (en) 2016-04-19 2021-08-24 Amo Groningen B.V. Ophthalmic devices, system and methods that improve peripheral vision
US11156853B2 (en) 2017-06-28 2021-10-26 Amo Groningen B.V. Extended range and related intraocular lenses for presbyopia treatment
US11262598B2 (en) 2017-06-28 2022-03-01 Amo Groningen, B.V. Diffractive lenses and related intraocular lenses for presbyopia treatment
US11327210B2 (en) 2017-06-30 2022-05-10 Amo Groningen B.V. Non-repeating echelettes and related intraocular lenses for presbyopia treatment
US11497599B2 (en) 2017-03-17 2022-11-15 Amo Groningen B.V. Diffractive intraocular lenses for extended range of vision
US11523897B2 (en) 2017-06-23 2022-12-13 Amo Groningen B.V. Intraocular lenses for presbyopia treatment
US11583392B2 (en) 2019-12-30 2023-02-21 Amo Groningen B.V. Achromatic lenses for vision treatment
US11844688B2 (en) 2019-12-30 2023-12-19 Amo Groningen B.V. Achromatic lenses with zone order mixing for vision treatment
US11844689B2 (en) 2019-12-30 2023-12-19 Amo Groningen B.V. Achromatic lenses and lenses having diffractive profiles with irregular width for vision treatment
US12204178B2 (en) 2018-12-06 2025-01-21 Amo Groningen B.V. Diffractive lenses for presbyopia treatment

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5895422A (en) * 1993-06-17 1999-04-20 Hauber; Frederick A. Mixed optics intraocular achromatic lens
WO2001089424A1 (fr) * 2000-05-23 2001-11-29 Pharmacia Groningen Bv Procedes de production de lentilles ophtalmiques capables de reduire des aberrations de l'oeil
US6338559B1 (en) * 2000-04-28 2002-01-15 University Of Rochester Apparatus and method for improving vision and retinal imaging
WO2002084381A2 (fr) * 2001-04-11 2002-10-24 Pharmacia Groningen Bv Lentille ophtalmique
WO2005098518A1 (fr) * 2004-04-05 2005-10-20 Advanced Medical Optics, Inc. Verres ophtalmiques pouvant reduire l'aberration chromatique

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5895422A (en) * 1993-06-17 1999-04-20 Hauber; Frederick A. Mixed optics intraocular achromatic lens
US6338559B1 (en) * 2000-04-28 2002-01-15 University Of Rochester Apparatus and method for improving vision and retinal imaging
WO2001089424A1 (fr) * 2000-05-23 2001-11-29 Pharmacia Groningen Bv Procedes de production de lentilles ophtalmiques capables de reduire des aberrations de l'oeil
WO2002084381A2 (fr) * 2001-04-11 2002-10-24 Pharmacia Groningen Bv Lentille ophtalmique
WO2005098518A1 (fr) * 2004-04-05 2005-10-20 Advanced Medical Optics, Inc. Verres ophtalmiques pouvant reduire l'aberration chromatique

Cited By (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110020627A1 (en) * 2007-11-02 2011-01-27 Benjamin Falk Textiles treated with copolymers of epoxy compounds and amino silanes having enhanced wet-strength
US10197815B2 (en) 2008-05-13 2019-02-05 Amo Groningen B.V. Multi-ring lens, systems and methods for extended depth of focus
US9335563B2 (en) 2012-08-31 2016-05-10 Amo Groningen B.V. Multi-ring lens, systems and methods for extended depth of focus
US12158638B2 (en) 2012-08-31 2024-12-03 Amo Groningen B.V. Multi-ring lens, systems and methods for extended depth of focus
US11022815B2 (en) 2012-08-31 2021-06-01 Amo Groningen B.V. Multi-ring lens, systems and methods for extended depth of focus
US10758340B2 (en) 2013-03-11 2020-09-01 Johnson & Johnson Surgical Vision, Inc. Intraocular lens that matches an image surface to a retinal shape, and method of designing same
US10456242B2 (en) 2014-03-10 2019-10-29 Amo Groningen B.V. Intraocular lens that improves overall vision where there is a local loss of retinal function
US11331181B2 (en) 2014-03-10 2022-05-17 Amo Groningen B.V. Fresnel piggyback intraocular lens that improves overall vision where there is a local loss of retinal function
US10327888B2 (en) 2014-03-10 2019-06-25 Amo Groningen B.V. Enhanced toric lens that improves overall vision where there is a local loss of retinal function
US11534291B2 (en) 2014-03-10 2022-12-27 Amo Groningen B.V. Intraocular lens that improves overall vision where there is a local loss of retinal function
US11517423B2 (en) 2014-03-10 2022-12-06 Amo Groningen B.V. Piggyback intraocular lens that improves overall vision where there is a local loss of retinal function
US10588739B2 (en) 2014-04-21 2020-03-17 Amo Groningen B.V. Ophthalmic devices, system and methods that improve peripheral vision
US11660183B2 (en) 2014-04-21 2023-05-30 Amo Groningen B.V. Ophthalmic devices, system and methods that improve peripheral vision
US10624735B2 (en) 2016-02-09 2020-04-21 Amo Groningen B.V. Progressive power intraocular lens, and methods of use and manufacture
US11116624B2 (en) 2016-02-09 2021-09-14 Amo Groningen B.V. Progressive power intraocular lens, and methods of use and manufacture
US12257144B2 (en) 2016-02-09 2025-03-25 Amo Groningen B.V. Progressive power intraocular lens, and methods of use and manufacture
US10588738B2 (en) * 2016-03-11 2020-03-17 Amo Groningen B.V. Intraocular lenses that improve peripheral vision
US11160651B2 (en) 2016-03-11 2021-11-02 Amo Groningen B.V. Intraocular lenses that improve peripheral vision
US20170258578A1 (en) * 2016-03-11 2017-09-14 Amo Groningen B.V. Intraocular lenses that improve peripheral vision
US11793626B2 (en) 2016-03-11 2023-10-24 Amo Groningen B.V. Intraocular lenses that improve peripheral vision
US11096778B2 (en) 2016-04-19 2021-08-24 Amo Groningen B.V. Ophthalmic devices, system and methods that improve peripheral vision
US11877924B2 (en) 2016-04-19 2024-01-23 Amo Groningen B.V. Ophthalmic devices, system and methods that improve peripheral vision
US11497599B2 (en) 2017-03-17 2022-11-15 Amo Groningen B.V. Diffractive intraocular lenses for extended range of vision
US11523897B2 (en) 2017-06-23 2022-12-13 Amo Groningen B.V. Intraocular lenses for presbyopia treatment
US11573433B2 (en) 2017-06-28 2023-02-07 Amo Groningen B.V. Extended range and related intraocular lenses for presbyopia treatment
US11262598B2 (en) 2017-06-28 2022-03-01 Amo Groningen, B.V. Diffractive lenses and related intraocular lenses for presbyopia treatment
US11156853B2 (en) 2017-06-28 2021-10-26 Amo Groningen B.V. Extended range and related intraocular lenses for presbyopia treatment
US11914229B2 (en) 2017-06-28 2024-02-27 Amo Groningen B.V. Diffractive lenses and related intraocular lenses for presbyopia treatment
US11327210B2 (en) 2017-06-30 2022-05-10 Amo Groningen B.V. Non-repeating echelettes and related intraocular lenses for presbyopia treatment
US12204178B2 (en) 2018-12-06 2025-01-21 Amo Groningen B.V. Diffractive lenses for presbyopia treatment
US11844689B2 (en) 2019-12-30 2023-12-19 Amo Groningen B.V. Achromatic lenses and lenses having diffractive profiles with irregular width for vision treatment
US12115061B2 (en) 2019-12-30 2024-10-15 Amo Groningen B.V. Achromatic lenses for vision treatment
US11844688B2 (en) 2019-12-30 2023-12-19 Amo Groningen B.V. Achromatic lenses with zone order mixing for vision treatment
US12245931B2 (en) 2019-12-30 2025-03-11 Amo Groningen B.V. Achromatic lenses with zone order mixing for vision treatment
US11583392B2 (en) 2019-12-30 2023-02-21 Amo Groningen B.V. Achromatic lenses for vision treatment

Also Published As

Publication number Publication date
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ES2272143B1 (es) 2008-03-01

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