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WO2006066224A3 - Virulence targeted antibiotics - Google Patents

Virulence targeted antibiotics Download PDF

Info

Publication number
WO2006066224A3
WO2006066224A3 PCT/US2005/045981 US2005045981W WO2006066224A3 WO 2006066224 A3 WO2006066224 A3 WO 2006066224A3 US 2005045981 W US2005045981 W US 2005045981W WO 2006066224 A3 WO2006066224 A3 WO 2006066224A3
Authority
WO
WIPO (PCT)
Prior art keywords
virulence
targeted
targeted antibiotics
bacteriocins
bacteriophage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/045981
Other languages
French (fr)
Other versions
WO2006066224A2 (en
Inventor
Paul E Turner
John Wertz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Original Assignee
Yale University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yale University filed Critical Yale University
Publication of WO2006066224A2 publication Critical patent/WO2006066224A2/en
Publication of WO2006066224A3 publication Critical patent/WO2006066224A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The disclosure provides, in part, antimicrobial agents in the form of bacteriophage or bacteriocins that are designed so as to target one or more virulence factors of a pathogenic bacterium ('Virulence factor Targeted Bacteriophage' ['VTB'] or 'Virulence factor Targeted Bacteriocins' ['VTBC'], respectively).
PCT/US2005/045981 2004-12-14 2005-12-14 Virulence targeted antibiotics Ceased WO2006066224A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63623804P 2004-12-14 2004-12-14
US60/636,238 2004-12-14

Publications (2)

Publication Number Publication Date
WO2006066224A2 WO2006066224A2 (en) 2006-06-22
WO2006066224A3 true WO2006066224A3 (en) 2007-03-29

Family

ID=36282776

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/045981 Ceased WO2006066224A2 (en) 2004-12-14 2005-12-14 Virulence targeted antibiotics

Country Status (1)

Country Link
WO (1) WO2006066224A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2910492B1 (en) * 2006-12-20 2013-02-15 Bio Modeling Systems Ou Bmsystems PROCESS FOR THE PREPARATION OF MODIFIED BACTERIOPHAGES BY INSERTION OF RANDOM SEQUENCES IN THE TARGETING PROTEINS OF SAID BACTERIOPHAGES
FR2910493B1 (en) * 2006-12-20 2012-12-14 Bio Modeling Systems Ou Bmsystems METHOD FOR THE RANDOM DIVERSIFICATION OF A GENETIC SEQUENCE FOR PRESERVING THE IDENTITY OF CERTAIN INTERNAL SEGMENTS OF THE GENETIC SEQUENCE

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024617A1 (en) * 1997-11-06 1999-05-20 Ventana Genetics, Inc. Methods and compositions for peptide libraries displayed on light-emitting scaffolds
WO2001079559A1 (en) * 2000-04-18 2001-10-25 Wayne State University System to detect protein-protein interactions
WO2002007742A2 (en) * 2000-07-25 2002-01-31 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bacteriophage having multiple host range
WO2004013317A1 (en) * 2002-08-05 2004-02-12 Instytut Immunologii I Terapii Doswiadczalnej Pan A method of obtaining a bacteriophage strain of increased affinity to eukaryotic cells, preparations containing it, and applications of bacteriophages
WO2005058006A2 (en) * 2003-12-17 2005-06-30 Venigalla Basaveswara Rao Methods and compositions comprising bacteriophage nanoparticles

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024617A1 (en) * 1997-11-06 1999-05-20 Ventana Genetics, Inc. Methods and compositions for peptide libraries displayed on light-emitting scaffolds
WO2001079559A1 (en) * 2000-04-18 2001-10-25 Wayne State University System to detect protein-protein interactions
WO2002007742A2 (en) * 2000-07-25 2002-01-31 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bacteriophage having multiple host range
WO2004013317A1 (en) * 2002-08-05 2004-02-12 Instytut Immunologii I Terapii Doswiadczalnej Pan A method of obtaining a bacteriophage strain of increased affinity to eukaryotic cells, preparations containing it, and applications of bacteriophages
WO2005058006A2 (en) * 2003-12-17 2005-06-30 Venigalla Basaveswara Rao Methods and compositions comprising bacteriophage nanoparticles

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MILLER ERIC S ET AL: "Bacteriophage T4 genome.", MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS : MMBR. MAR 2003, vol. 67, no. 1, March 2003 (2003-03-01), pages 86 - 156 , tab, XP002393665, ISSN: 1092-2172 *
MONTAG D ET AL: "A component of the side tail fiber of Escherichia coli bacteriophage lambda can functionally replace the receptor-recognizing part of a long tail fiber protein of the unrelated bacteriophage T4.", JOURNAL OF BACTERIOLOGY. AUG 1989, vol. 171, no. 8, August 1989 (1989-08-01), pages 4378 - 4384, XP002393666, ISSN: 0021-9193 *
REN Z-J ET AL: "Phage T4 SOC and HOC display of biologically active, full-length proteins on the viral capsid", GENE, ELSEVIER, AMSTERDAM, NL, vol. 215, no. 2, July 1998 (1998-07-01), pages 439 - 444, XP004149268, ISSN: 0378-1119 *
SWITALA-JELEN K ET AL: "Mutations in bacteriophage T4 genome", ACTA VIROLOGICA, ACADEMIA PRAGUE, PRAGUE, CS, vol. 46, no. 2, 2002, pages 57 - 62, XP008025059, ISSN: 0001-723X *

Also Published As

Publication number Publication date
WO2006066224A2 (en) 2006-06-22

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