[go: up one dir, main page]

WO2006064340A3 - Elaboration de n-acyl beta-aminoaldehydes - Google Patents

Elaboration de n-acyl beta-aminoaldehydes Download PDF

Info

Publication number
WO2006064340A3
WO2006064340A3 PCT/IB2005/003759 IB2005003759W WO2006064340A3 WO 2006064340 A3 WO2006064340 A3 WO 2006064340A3 IB 2005003759 W IB2005003759 W IB 2005003759W WO 2006064340 A3 WO2006064340 A3 WO 2006064340A3
Authority
WO
WIPO (PCT)
Prior art keywords
aminoaldehydes
preparation
acyl
acyl beta
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2005/003759
Other languages
English (en)
Other versions
WO2006064340A2 (fr
Inventor
Jens Bertil Ahman
Lee Terence Boulton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd Great Britain
Original Assignee
Pfizer Ltd Great Britain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0427293A external-priority patent/GB0427293D0/en
Application filed by Pfizer Ltd Great Britain filed Critical Pfizer Ltd Great Britain
Publication of WO2006064340A2 publication Critical patent/WO2006064340A2/fr
Publication of WO2006064340A3 publication Critical patent/WO2006064340A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne un traitement destiné à l'élaboration de N-acyl ß-aminoaldéhydes énantiomériquement enrichis. L'invention concerne plus particulièrement l'hydrogénation asymétrique de N-acyl énamides.
PCT/IB2005/003759 2004-12-13 2005-12-06 Elaboration de n-acyl beta-aminoaldehydes Ceased WO2006064340A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0427293.6 2004-12-13
GB0427293A GB0427293D0 (en) 2004-12-13 2004-12-13 A process
US64565805P 2005-01-20 2005-01-20
US60/645,658 2005-01-20

Publications (2)

Publication Number Publication Date
WO2006064340A2 WO2006064340A2 (fr) 2006-06-22
WO2006064340A3 true WO2006064340A3 (fr) 2006-09-08

Family

ID=36295107

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/003759 Ceased WO2006064340A2 (fr) 2004-12-13 2005-12-06 Elaboration de n-acyl beta-aminoaldehydes

Country Status (1)

Country Link
WO (1) WO2006064340A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111217809B (zh) * 2018-11-27 2021-06-08 江苏奥赛康药业有限公司 一类手性含氮双烯配体及其制备方法和应用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010025663A1 (de) * 2010-06-30 2012-01-05 Karl-Heinz Glüsenkamp Neue beta-Aminoaldehyd-Derivate, Verfahren zu ihrer Herstellung und ihre chemische Verwendung als reaktive Intermediate
CN105330550B (zh) * 2015-10-13 2018-01-30 凯瑞斯德生化(苏州)有限公司 一种光学活性的1‑环己基乙胺的制备方法
CN108610267A (zh) * 2018-06-15 2018-10-02 中触媒新材料股份有限公司 一种频呐酮肟合成方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4073795A (en) * 1976-06-22 1978-02-14 Hoffmann-La Roche Inc. Synthesis of tryptophans
US6214763B1 (en) * 1997-05-20 2001-04-10 Firmenich Sa Ruthenium catalysts and their use in the asymmetric hydrogenation of weakly coordinating substrates
WO2001090106A2 (fr) * 2000-05-26 2001-11-29 Pfizer Limited Derives du tropane utiles en therapie
EP1199301A1 (fr) * 2000-10-16 2002-04-24 Pfizer Limited Formation d'oléfines pour la préparation de dérivés d'acide itaconique et succinique
WO2003084954A1 (fr) * 2002-04-08 2003-10-16 Pfizer Limited Derives de tropane utilises comme modulateur as de ccr5

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4073795A (en) * 1976-06-22 1978-02-14 Hoffmann-La Roche Inc. Synthesis of tryptophans
US6214763B1 (en) * 1997-05-20 2001-04-10 Firmenich Sa Ruthenium catalysts and their use in the asymmetric hydrogenation of weakly coordinating substrates
WO2001090106A2 (fr) * 2000-05-26 2001-11-29 Pfizer Limited Derives du tropane utiles en therapie
EP1199301A1 (fr) * 2000-10-16 2002-04-24 Pfizer Limited Formation d'oléfines pour la préparation de dérivés d'acide itaconique et succinique
WO2003084954A1 (fr) * 2002-04-08 2003-10-16 Pfizer Limited Derives de tropane utilises comme modulateur as de ccr5

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A.H.COOK AND I.M.HEILBRON: "Thiazolidines derived from cysteine", CHEM.PENICILLIN PRINCETON, 1949, pages 968, XP001247057 *
HELLER D ET AL: "PRESSURE DEPENDENT HIGHLY ENANTIOSELECTIVE HYDROGENATION OF UNSATURATED BETA-AMINO ACID PRECURSORS", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 66, no. 20, 5 October 2001 (2001-10-05), pages 6816 - 6817, XP002198463, ISSN: 0022-3263 *
NW.ALCOCK ET AL: "degradation of cobaloximes to derivatives of imidazo(1,2-a)pyridine", J.CHEM.SOC. PERKIN TRANS., vol. 1, 1975, pages 386 - 394, XP009066725 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111217809B (zh) * 2018-11-27 2021-06-08 江苏奥赛康药业有限公司 一类手性含氮双烯配体及其制备方法和应用

Also Published As

Publication number Publication date
WO2006064340A2 (fr) 2006-06-22

Similar Documents

Publication Publication Date Title
EG24887A (en) Functional sugar replacement
IL208607A0 (en) Improved nanobodiestm for the treatment of aggregation-mediated disorders
SG10201508066VA (en) Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto
ZA200705161B (en) Chocolate composition
IL183379A0 (en) Processes for the preparation of linezolid intermediate
IL196481A0 (en) Process for the preparation of levetiracetam
WO2005075412A3 (fr) Composes cycloaliphatiques a base de norbonane contenant des groupes nitriles
PL2104658T3 (pl) Sposób uwodorniania cukru lub mieszaniny cukrów
GB0500815D0 (en) Method for preparation of 10, 11-dihydro-10-hydroxy-5H-divenz/b,f/azepine-5-carboxamide
PT1737820E (pt) Processo de hidrogenação assimétrica útil para a preparação de derivados de cicloalcanoindole
WO2006064340A3 (fr) Elaboration de n-acyl beta-aminoaldehydes
IL177561A0 (en) Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
ZA200902453B (en) PAI-1 binding modulators for the treatment of ocular disorders
IL183287A0 (en) Process for the production of anilines
IL173577A0 (en) Process for the asymmetric hydrogenation of beta-amino ketones
ZA200701882B (en) Functional sugar replacement
TW200621769A (en) Process for the preparation of n-acyl β-aminoaldehydes
GB2445531B (en) A melt transurethane process for the preparation of polyurethanes
PL1627881T3 (pl) Sposób otrzymywania topiramatu
GB2457386B (en) Process for reducing the restart pressure of streams
GB0509363D0 (en) Process for the manufacture of reduced fat chocolate
IL185076A0 (en) Process for the prepartion of enantiomerically pure 1-substituted-3-aminoalcohols
GB0515909D0 (en) Process for asymmetric catalytic hydrogenation
IL182589A0 (en) Process for the de-enrichment of enantiomerically enriched substrates
IL173709A0 (en) Process for the purification of terbinafine

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 05817973

Country of ref document: EP

Kind code of ref document: A2