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WO2006061430A3 - Bone metastasis markers as a target regulating bone metastasis and bone development - Google Patents

Bone metastasis markers as a target regulating bone metastasis and bone development Download PDF

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Publication number
WO2006061430A3
WO2006061430A3 PCT/EP2005/056636 EP2005056636W WO2006061430A3 WO 2006061430 A3 WO2006061430 A3 WO 2006061430A3 EP 2005056636 W EP2005056636 W EP 2005056636W WO 2006061430 A3 WO2006061430 A3 WO 2006061430A3
Authority
WO
WIPO (PCT)
Prior art keywords
bone
bone metastasis
metastasis
markers
development
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2005/056636
Other languages
French (fr)
Other versions
WO2006061430A2 (en
Inventor
Philippe Clement-Lacroix
Philippe Clezardin
Amanda Jackson
Philippe Pujuguet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Galapagos SAS
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
ProSkelia SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM, ProSkelia SAS filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Publication of WO2006061430A2 publication Critical patent/WO2006061430A2/en
Publication of WO2006061430A3 publication Critical patent/WO2006061430A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention concerns a method of, and products for, diagnosing bone disorders using bone metastasis specifie gene markers, including ITGBL1.
PCT/EP2005/056636 2004-12-10 2005-12-09 Bone metastasis markers as a target regulating bone metastasis and bone development Ceased WO2006061430A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63459704P 2004-12-10 2004-12-10
US60/634,597 2004-12-10

Publications (2)

Publication Number Publication Date
WO2006061430A2 WO2006061430A2 (en) 2006-06-15
WO2006061430A3 true WO2006061430A3 (en) 2006-08-03

Family

ID=36088317

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/056636 Ceased WO2006061430A2 (en) 2004-12-10 2005-12-09 Bone metastasis markers as a target regulating bone metastasis and bone development

Country Status (1)

Country Link
WO (1) WO2006061430A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL177006A0 (en) * 2005-08-02 2006-12-10 Veridex Llc Predicting bone relapse of breast cancer
EP2370091B1 (en) * 2008-12-05 2017-04-12 Whitehead Institute for Biomedical Research Compositions and methods relating to mir-31

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040009481A1 (en) * 2001-06-11 2004-01-15 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of human prostate cancer
US20040058340A1 (en) * 2001-06-18 2004-03-25 Hongyue Dai Diagnosis and prognosis of breast cancer patients
US20040137489A1 (en) * 2002-12-05 2004-07-15 Shaughnessy John D. Molecular determinants of myeloma bone disease and uses thereof
WO2004063355A2 (en) * 2003-01-10 2004-07-29 Protein Design Labs, Inc. Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of matastatic cancer
WO2004092410A2 (en) * 2003-04-15 2004-10-28 Thiesen Hans-Juergen Method for diagnosing rheumatoid arthritis or osteoarthritis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040009481A1 (en) * 2001-06-11 2004-01-15 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of human prostate cancer
US20040058340A1 (en) * 2001-06-18 2004-03-25 Hongyue Dai Diagnosis and prognosis of breast cancer patients
US20040137489A1 (en) * 2002-12-05 2004-07-15 Shaughnessy John D. Molecular determinants of myeloma bone disease and uses thereof
WO2004063355A2 (en) * 2003-01-10 2004-07-29 Protein Design Labs, Inc. Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of matastatic cancer
WO2004092410A2 (en) * 2003-04-15 2004-10-28 Thiesen Hans-Juergen Method for diagnosing rheumatoid arthritis or osteoarthritis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BERG R W ET AL: "Cloning and Characterization of a Novel beta Integrin-Related cDNA Coding for the Protein TIED (''Ten beta Integrin EGF-like Repeat Domains'') That Maps to Chromosome Band 13q33: A Divergent Stand-Alone Integrin Stalk Structure", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 56, no. 2, 1 March 1999 (1999-03-01), pages 169 - 178, XP004444998, ISSN: 0888-7543 *
ITOH ET AL: "CLONING AND SEQUENCE ANALYSIS OF CDNA ENCODING THE PRECURSOR OF A HUMAN ENDOTHELIUM-DERIVED VASOCONSTRICTOR PEPTIDE, ENDOTHELIN: IDENTITY OF HUMAN AND PORCINE ENDOTHELIN", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 231, no. 2, April 1998 (1998-04-01), pages 440 - 444, XP002936503, ISSN: 0014-5793 *
KANG YIBIN ET AL: "A multigenic program mediating breast cancer metastasis to bone.", CANCER CELL, vol. 3, no. 6, June 2003 (2003-06-01), pages 537 - 549, XP008062522, ISSN: 1535-6108 *
YIN JUAN JUAN ET AL: "A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 100, no. 19, 16 September 2003 (2003-09-16), pages 10954 - 10959, XP008062573, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2006061430A2 (en) 2006-06-15

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