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WO2006057011A3 - Use of chitosan for stimulating bone healing and bone formation - Google Patents

Use of chitosan for stimulating bone healing and bone formation Download PDF

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Publication number
WO2006057011A3
WO2006057011A3 PCT/IS2005/000025 IS2005000025W WO2006057011A3 WO 2006057011 A3 WO2006057011 A3 WO 2006057011A3 IS 2005000025 W IS2005000025 W IS 2005000025W WO 2006057011 A3 WO2006057011 A3 WO 2006057011A3
Authority
WO
WIPO (PCT)
Prior art keywords
chitosan
bone
stimulating
healing
bone formation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IS2005/000025
Other languages
French (fr)
Other versions
WO2006057011A2 (en
Inventor
Michael Silbermann
Johannes Gislason
Jon M Einarsson
Martin Peter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genis ehf
Original Assignee
Genis ehf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genis ehf filed Critical Genis ehf
Publication of WO2006057011A2 publication Critical patent/WO2006057011A2/en
Publication of WO2006057011A3 publication Critical patent/WO2006057011A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A use and a composition based on chitosan are provided for stimulating bone healing and bone formation. Chitosan is demonstrated to be a potent osteoinductor and substantially accelerates new bone formation through the endochondrial ossification pathway, by forming cartilage which is subsequently vascularised and mineralized and transformed into a normal healthy bone tissue.
PCT/IS2005/000025 2004-11-29 2005-11-29 Use of chitosan for stimulating bone healing and bone formation Ceased WO2006057011A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IS7572 2004-11-29
IS7572A IS7572A (en) 2004-11-29 2004-11-29 Method and materials for healing

Publications (2)

Publication Number Publication Date
WO2006057011A2 WO2006057011A2 (en) 2006-06-01
WO2006057011A3 true WO2006057011A3 (en) 2006-07-13

Family

ID=36190406

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IS2005/000025 Ceased WO2006057011A2 (en) 2004-11-29 2005-11-29 Use of chitosan for stimulating bone healing and bone formation

Country Status (2)

Country Link
IS (1) IS7572A (en)
WO (1) WO2006057011A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030228288A1 (en) 1999-10-15 2003-12-11 Scarborough Nelson L. Volume maintaining osteoinductive/osteoconductive compositions
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
US7323193B2 (en) 2001-12-14 2008-01-29 Osteotech, Inc. Method of making demineralized bone particles
KR20040047746A (en) 2001-10-12 2004-06-05 오스테오테크, 인코포레이티드 Improved bone graft
KR20060031808A (en) 2003-06-11 2006-04-13 오스테오테크, 인코포레이티드 Osteoimplants and methods for their manufacture
WO2007056671A1 (en) 2005-11-02 2007-05-18 Osteotech, Inc. Hemostatic bone graft
US20080181926A1 (en) * 2006-10-13 2008-07-31 Ndsu Research Foundation Composites and methods of preparation and use thereof
DE102008019748A1 (en) * 2008-04-18 2009-10-22 Gottfried Wilhelm Leibniz Universität Hannover Bioresorbable material
KR20110086045A (en) 2008-10-24 2011-07-27 오스테오테크, 인코포레이티드 Composition for promoting bone formation and method for promoting bone formation
IT1396934B1 (en) * 2009-11-25 2012-12-20 Fin Ceramica Faenza Spa COMPOSITE BIO-MIMETIC MATERIALS, RELATED PREPARATION PROCESS AND THEIR USE FOR THE IMPLEMENTATION OF MONO-, BI- OR MULTI-LAYER STRUCTURES FOR THE REGENERATION OF BONE, CARTILAGE OR OSTEOCARTILAGE
DK2841114T3 (en) * 2012-04-23 2018-09-24 Genis Hf SELF-HARDING BIOACTIVE CEMENT COMPOSITIONS WITH PARTIAL DEACETYLATED CHITIN AS BONE TRANSPLANT REPLACEMENTS
US10751444B2 (en) 2015-08-07 2020-08-25 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
US10660945B2 (en) 2015-08-07 2020-05-26 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
CN107715167A (en) * 2017-09-19 2018-02-23 中国人民武装警察部队后勤学院 Chitosan-based hemostatic paste and preparation method as bone wax substitute
CN115006590B (en) * 2022-06-07 2023-04-14 武汉理工大学 A dual drug-loaded slow-release bone repair scaffold for postoperative reconstruction of osteosarcoma

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63156726A (en) * 1986-12-19 1988-06-29 Lion Corp Bone disease therapeutic agent
WO2001000792A1 (en) * 1999-06-29 2001-01-04 Marchosky J Alexander Compositions and methods for forming and strengthening bone
US20020082220A1 (en) * 2000-06-29 2002-06-27 Hoemann Caroline D. Composition and method for the repair and regeneration of cartilage and other tissues
KR20020076686A (en) * 2001-03-30 2002-10-11 주식회사 리젠 바이오텍 Composition for stimulating bone-forming and bone-consolidation
KR20020093721A (en) * 2002-11-20 2002-12-16 김세권 Phosphorylated chitosan oligosaccharide with low molecular weight as calcium absorption accelerator
EP1308177A1 (en) * 2000-08-10 2003-05-07 Osfarma, S.L. Method for the production of chitosan-based films with enhanced cell adhering capacity, resulting product and applications
WO2003051376A1 (en) * 2001-12-14 2003-06-26 Ism Biopolymer Inc. Chitosan oligosaccharides and uses thereof
US20030134810A1 (en) * 2001-10-09 2003-07-17 Chris Springate Methods and compositions comprising biocompatible materials useful for the administration of therapeutic agents
WO2004028578A1 (en) * 2002-09-30 2004-04-08 Regen Biotech, Inc. Composition for stimulating bone-formation and bone consolidation
WO2004091678A1 (en) * 2003-04-16 2004-10-28 Fti Technologies Gmbh Chitosan film used as a periosteum replacement

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63156726A (en) * 1986-12-19 1988-06-29 Lion Corp Bone disease therapeutic agent
WO2001000792A1 (en) * 1999-06-29 2001-01-04 Marchosky J Alexander Compositions and methods for forming and strengthening bone
US20020082220A1 (en) * 2000-06-29 2002-06-27 Hoemann Caroline D. Composition and method for the repair and regeneration of cartilage and other tissues
EP1308177A1 (en) * 2000-08-10 2003-05-07 Osfarma, S.L. Method for the production of chitosan-based films with enhanced cell adhering capacity, resulting product and applications
KR20020076686A (en) * 2001-03-30 2002-10-11 주식회사 리젠 바이오텍 Composition for stimulating bone-forming and bone-consolidation
US20030134810A1 (en) * 2001-10-09 2003-07-17 Chris Springate Methods and compositions comprising biocompatible materials useful for the administration of therapeutic agents
WO2003051376A1 (en) * 2001-12-14 2003-06-26 Ism Biopolymer Inc. Chitosan oligosaccharides and uses thereof
WO2004028578A1 (en) * 2002-09-30 2004-04-08 Regen Biotech, Inc. Composition for stimulating bone-formation and bone consolidation
KR20020093721A (en) * 2002-11-20 2002-12-16 김세권 Phosphorylated chitosan oligosaccharide with low molecular weight as calcium absorption accelerator
WO2004091678A1 (en) * 2003-04-16 2004-10-28 Fti Technologies Gmbh Chitosan film used as a periosteum replacement

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CHO B C ET AL: "Effect of calcium sulfate-chitosan composite: Pellet on bone formation in bone defect", JOURNAL OF CRANIOFACIAL SURGERY 2005 UNITED STATES, vol. 16, no. 2, 2005, pages 213 - 224, XP008062997, ISSN: 1049-2275 *
CHO B C ET AL: "The role of hyaluronic acid, chitosan, and calcium sulfate and their combined effect on early bony consolidation in distraction osteogenesis of a canine model", JOURNAL OF CRANIOFACIAL SURGERY 2002 UNITED STATES, vol. 13, no. 6, 2002, pages 783 - 793, XP008062996, ISSN: 1049-2275 *
DATABASE WPI Week 19, 29 June 1988 Derwent World Patents Index; Class 883, Page 2, AN 1988-223011, XP002378695, NAMITA KENJI ET AL.: "Remedy for bone disease" *
DATABASE WPI Week 20, 11 October 2002 Derwent World Patents Index; Class 046, Page 6, AN 2003-154643, XP002378697, CHO BYEONG CHAE ET AL.: "Composite for facilitating osteogenesis and osteosclerosis" *
DATABASE WPI Week 20, 16 December 2002 Derwent World Patents Index; Class 032, Page 9, AN 2003-297156, XP002378696, HYUN B.H. ET AL.: "Low molecular weight phosphorylated chitosan oligosaccharide as calcium absorption accelerating agent" *
IWATA H ET AL: "Effects of chitosan oligosaccharides on the femur trabecular structure in ovariectomized rats", ORAL RADIOLOGY 2005 JAPAN, vol. 21, no. 1, 2005, pages 19 - 22, XP008062990, ISSN: 0911-6028 *
KLOKKEVOLD PERRY R ET AL: "Osteogenesis enhanced by chitosan (poly-N-acetyl glucosaminoglycan) in vitro", JOURNAL OF PERIODONTOLOGY, vol. 67, no. 11, 1996, pages 1170 - 1175, XP008062982, ISSN: 0022-3492 *
YAMADA SHIZUKA ET AL: "Mineralization of matrix vesicles isolated from a human osteosarcoma cell line in culture with water-soluble chitosan-containing medium.", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, vol. 66A, no. 3, 1 September 2003 (2003-09-01), pages 500 - 506, XP002378691, ISSN: 0021-9304 *

Also Published As

Publication number Publication date
IS7572A (en) 2006-05-30
WO2006057011A2 (en) 2006-06-01

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