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WO2006051313A3 - Peptides designed to switch folded state upon binding metals - Google Patents

Peptides designed to switch folded state upon binding metals Download PDF

Info

Publication number
WO2006051313A3
WO2006051313A3 PCT/GB2005/004360 GB2005004360W WO2006051313A3 WO 2006051313 A3 WO2006051313 A3 WO 2006051313A3 GB 2005004360 W GB2005004360 W GB 2005004360W WO 2006051313 A3 WO2006051313 A3 WO 2006051313A3
Authority
WO
WIPO (PCT)
Prior art keywords
folded state
peptides designed
binding metals
switch
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2005/004360
Other languages
French (fr)
Other versions
WO2006051313A2 (en
Inventor
Derek Woolfson
Eleonora Cerasoli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Sussex
Original Assignee
University of Sussex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Sussex filed Critical University of Sussex
Publication of WO2006051313A2 publication Critical patent/WO2006051313A2/en
Publication of WO2006051313A3 publication Critical patent/WO2006051313A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A peptide having sequence and structural duality that can reversibly switch between a first structural form and a second structural form in response to an agent, wherein the peptide comprises interactive motifs that interact to form a bond in response to the agent and thereby cause the peptide to assume the second structural form, wherein the second structural form includes an agent binding site.
PCT/GB2005/004360 2004-11-12 2005-11-14 Peptides designed to switch folded state upon binding metals Ceased WO2006051313A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0425033A GB0425033D0 (en) 2004-11-12 2004-11-12 Peptides
GB0425033.8 2004-11-12

Publications (2)

Publication Number Publication Date
WO2006051313A2 WO2006051313A2 (en) 2006-05-18
WO2006051313A3 true WO2006051313A3 (en) 2006-07-27

Family

ID=33523647

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2005/004360 Ceased WO2006051313A2 (en) 2004-11-12 2005-11-14 Peptides designed to switch folded state upon binding metals

Country Status (2)

Country Link
GB (1) GB0425033D0 (en)
WO (1) WO2006051313A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001021646A1 (en) * 1999-09-17 2001-03-29 University Of Sussex Protein structures and protein fibres
WO2004020464A2 (en) * 2002-08-28 2004-03-11 University Of Sussex Peptides able to switch between two structural states and their use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001021646A1 (en) * 1999-09-17 2001-03-29 University Of Sussex Protein structures and protein fibres
WO2004020464A2 (en) * 2002-08-28 2004-03-11 University Of Sussex Peptides able to switch between two structural states and their use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
E CERASOLI ET AL.: "ZiCo. a peptide designed to switch folded state upon binding zinc", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 127, no. 43, 2005, US AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., pages 15008 - 15009, XP002380794 *
M J PANDYA ET AL.: "Sequence and structural duality: designing peptides to adopt two stable conformations", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 126, no. 51, 2 December 2004 (2004-12-02), US AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., pages 17016 - 17024, XP002380793 *

Also Published As

Publication number Publication date
GB0425033D0 (en) 2004-12-15
WO2006051313A2 (en) 2006-05-18

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