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WO2006051374A3 - Arylpiperazines useful as adrenergic receptor antagonists - Google Patents

Arylpiperazines useful as adrenergic receptor antagonists Download PDF

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Publication number
WO2006051374A3
WO2006051374A3 PCT/IB2005/003295 IB2005003295W WO2006051374A3 WO 2006051374 A3 WO2006051374 A3 WO 2006051374A3 IB 2005003295 W IB2005003295 W IB 2005003295W WO 2006051374 A3 WO2006051374 A3 WO 2006051374A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
receptor antagonists
adrenergic receptor
bph
treat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2005/003295
Other languages
French (fr)
Other versions
WO2006051374A2 (en
Inventor
Mohammad Salman
Nitya Anand
Gyan Chand Yadav
Somesh Sharma
Gobind Singh Kapkoti
Anita Chugh
Kamna Nanda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ranbaxy Laboratories Ltd
Original Assignee
Ranbaxy Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Ltd filed Critical Ranbaxy Laboratories Ltd
Publication of WO2006051374A2 publication Critical patent/WO2006051374A2/en
Publication of WO2006051374A3 publication Critical patent/WO2006051374A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/72—4,7-Endo-alkylene-iso-indoles
    • C07D209/76—4,7-Endo-alkylene-iso-indoles with oxygen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to compounds of formula (I), wherein A can be Formula (II), (III) or (IV), as α1a and/or α1d adrenergic receptor antagonists, which can be used to treat a disease or disorder mediated through α1a and/or α1d adrenergic receptors. Compounds and pharmaceutical compositions disclosed herein can be used to treat benign prostatic hyperplasia (BPH) and related symptoms thereof. Further, such compounds can be used to treat lower urinary tract symptoms that may or may not be associated with BPH. The present invention also relates to processes to prepare the disclosed compounds, pharmaceutical compositions thereof, and methods of treating BPH or related symptoms thereof.
PCT/IB2005/003295 2004-11-11 2005-11-04 Arylpiperazines useful as adrenergic receptor antagonists Ceased WO2006051374A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2246DE2004 2004-11-11
IN2246/DEL/2004 2004-11-11

Publications (2)

Publication Number Publication Date
WO2006051374A2 WO2006051374A2 (en) 2006-05-18
WO2006051374A3 true WO2006051374A3 (en) 2006-07-06

Family

ID=35589654

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/003295 Ceased WO2006051374A2 (en) 2004-11-11 2005-11-04 Arylpiperazines useful as adrenergic receptor antagonists

Country Status (1)

Country Link
WO (1) WO2006051374A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006092710A1 (en) * 2005-03-02 2006-09-08 Ranbaxy Laboratories Limited Metabolites of 2-{3-[4-(2-isopropoxyphenyl) piperazin-1-yl]-propyl}-3a,4,7,7a-tetrahydro-1h-isoindole-1,3-(2h)-dione

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005206A1 (en) * 1998-07-21 2000-02-03 Ranbaxy Laboratories Limited Arylpiperazine derivatives useful as uro-selective alpha-1-adrenoceptor blockers
WO2002044151A1 (en) * 2000-11-30 2002-06-06 Ranbaxy Laboratories Limited 1,4-disubstituted piperazine derivatives useful as uro-selective $g(a)1-adrenoceptor blockers
WO2003084928A1 (en) * 2002-04-08 2003-10-16 Ranbaxy Laboratories Limited Alpha, omega-dicarboximide derivatives as useful uro-selective α1α adrenoceptor blockers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005206A1 (en) * 1998-07-21 2000-02-03 Ranbaxy Laboratories Limited Arylpiperazine derivatives useful as uro-selective alpha-1-adrenoceptor blockers
WO2002044151A1 (en) * 2000-11-30 2002-06-06 Ranbaxy Laboratories Limited 1,4-disubstituted piperazine derivatives useful as uro-selective $g(a)1-adrenoceptor blockers
WO2003084928A1 (en) * 2002-04-08 2003-10-16 Ranbaxy Laboratories Limited Alpha, omega-dicarboximide derivatives as useful uro-selective α1α adrenoceptor blockers

Also Published As

Publication number Publication date
WO2006051374A2 (en) 2006-05-18

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