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WO2006050451A3 - Methods and compositions to treat motor neuron disease - Google Patents

Methods and compositions to treat motor neuron disease Download PDF

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Publication number
WO2006050451A3
WO2006050451A3 PCT/US2005/039710 US2005039710W WO2006050451A3 WO 2006050451 A3 WO2006050451 A3 WO 2006050451A3 US 2005039710 W US2005039710 W US 2005039710W WO 2006050451 A3 WO2006050451 A3 WO 2006050451A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
motor neuron
neuron disease
treat motor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/039710
Other languages
French (fr)
Other versions
WO2006050451A2 (en
Inventor
Brent R Stockwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Columbia University in the City of New York
Whitehead Institute for Biomedical Research
Original Assignee
Columbia University in the City of New York
Whitehead Institute for Biomedical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Columbia University in the City of New York, Whitehead Institute for Biomedical Research filed Critical Columbia University in the City of New York
Publication of WO2006050451A2 publication Critical patent/WO2006050451A2/en
Publication of WO2006050451A3 publication Critical patent/WO2006050451A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention features compositions and methods for treating motor neuron diseases, such as spinal muscular atrophy and amyotrophic lateral sclerosis. The compositions and methods include derivatives of indoprofen.
PCT/US2005/039710 2004-11-02 2005-11-02 Methods and compositions to treat motor neuron disease Ceased WO2006050451A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62422604P 2004-11-02 2004-11-02
US60/624,226 2004-11-02

Publications (2)

Publication Number Publication Date
WO2006050451A2 WO2006050451A2 (en) 2006-05-11
WO2006050451A3 true WO2006050451A3 (en) 2006-09-28

Family

ID=36319807

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/039710 Ceased WO2006050451A2 (en) 2004-11-02 2005-11-02 Methods and compositions to treat motor neuron disease

Country Status (1)

Country Link
WO (1) WO2006050451A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8110681B2 (en) 2006-03-17 2012-02-07 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Compounds for the treatment of spinal muscular atrophy and other uses
CA2700841A1 (en) * 2007-09-27 2009-04-02 The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
EP2872493B1 (en) * 2012-07-13 2018-11-14 Indiana University Research and Technology Corporation 5,6,7-trimethoxy 4-phenyl quinolin-2-one derivatives for treatment of spinal muscular atrophy
KR102560706B1 (en) 2015-10-01 2023-07-27 삼성전자주식회사 Composition comprising indoprofen and use thereof
EP3467497B1 (en) * 2016-05-24 2021-09-29 Tokyo Women's Medical University Method for analyzing expression of smn protein nuclear body
AU2019272881A1 (en) * 2018-05-25 2020-12-10 Revalesio Corporation Inhibition of neurological disease
KR20210053954A (en) 2018-08-31 2021-05-12 레발레시오 코퍼레이션 Methods and compositions for treatment of stroke

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3997669A (en) * 1972-12-26 1976-12-14 Ciba-Geigy Corporation Tertiary aminoacids
US4126691A (en) * 1968-03-27 1978-11-21 Ciba-Geigy Corporation Tertiary aminoacids

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4126691A (en) * 1968-03-27 1978-11-21 Ciba-Geigy Corporation Tertiary aminoacids
US3997669A (en) * 1972-12-26 1976-12-14 Ciba-Geigy Corporation Tertiary aminoacids

Also Published As

Publication number Publication date
WO2006050451A2 (en) 2006-05-11

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