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WO2006050091A3 - Pansement pour blessures bioactif, dispositifs implantables et procedes d'utilisation - Google Patents

Pansement pour blessures bioactif, dispositifs implantables et procedes d'utilisation Download PDF

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Publication number
WO2006050091A3
WO2006050091A3 PCT/US2005/038925 US2005038925W WO2006050091A3 WO 2006050091 A3 WO2006050091 A3 WO 2006050091A3 US 2005038925 W US2005038925 W US 2005038925W WO 2006050091 A3 WO2006050091 A3 WO 2006050091A3
Authority
WO
WIPO (PCT)
Prior art keywords
wound dressings
dispersed
methods
precursor cells
conditioned medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/038925
Other languages
English (en)
Other versions
WO2006050091A2 (fr
Inventor
Kenneth W Carpenter
William G Turnell
Kristin M Defife
Kathryn A Grako
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medivas LLC
Original Assignee
Medivas LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivas LLC filed Critical Medivas LLC
Priority to JP2007539165A priority Critical patent/JP2008518666A/ja
Priority to AU2005302469A priority patent/AU2005302469A1/en
Priority to EP05825008A priority patent/EP1809310A4/fr
Priority to CA002585740A priority patent/CA2585740A1/fr
Publication of WO2006050091A2 publication Critical patent/WO2006050091A2/fr
Priority to US11/796,267 priority patent/US7794706B2/en
Anticipated expiration legal-status Critical
Publication of WO2006050091A3 publication Critical patent/WO2006050091A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Materials Engineering (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne des pansements pour blessures, éventuellement implantables par voie chirurgicale, qui contiennent des composants biodégradables, des polymères et des hydrogels possédant des cellules de précurseurs allogènes ou autologues telles que les cellules souches ou les cellules progénitrices dispersées. En variante, les pansements pour blessures peuvent contenir un milieu conditionné obtenu à partir de cellules de précurseurs allogènes dispersés. Les pansements pour blessures favorisent les processus de restauration de tissus sur un site d'application ou d'implantation. Des agents bioactifs supplémentaires peuvent aussi être dispersés à l'intérieur de la matrice polymère / hydrogel, qui peut être formulée pour se biodégrader à une vitesse contrôlée par l'ajustement de la composition. L'invention concerne aussi des procédés pour utiliser ces pansements pour blessures biodégradables en tant que dispositif d'administration ou en tant qu'excipient pour les cellules de précurseurs, un milieu conditionné ou des agents bioactifs, ou en tant que revêtements sur des dispositifs médicaux implantables visant à favoriser la restauration d'un tissu sur le site d'une lésion.
PCT/US2005/038925 2003-10-14 2005-10-27 Pansement pour blessures bioactif, dispositifs implantables et procedes d'utilisation Ceased WO2006050091A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2007539165A JP2008518666A (ja) 2004-10-28 2005-10-27 生物活性創傷包帯および移植可能な装置ならびに使用法
AU2005302469A AU2005302469A1 (en) 2004-10-28 2005-10-27 Bioactive wound dressings and implantable devices and methods of use
EP05825008A EP1809310A4 (fr) 2004-10-28 2005-10-27 Pansement pour blessures bioactif, dispositifs implantables et procedes d'utilisation
CA002585740A CA2585740A1 (fr) 2004-10-28 2005-10-27 Pansement pour blessures bioactif, dispositifs implantables et procedes d'utilisation
US11/796,267 US7794706B2 (en) 2003-10-14 2007-04-26 Bioactive wound dressings and implantable devices and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62344604P 2004-10-28 2004-10-28
US60/623,446 2004-10-28

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/362,848 Continuation-In-Part US7304122B2 (en) 2000-08-30 2001-08-30 Elastomeric functional biodegradable copolyester amides and copolyester urethanes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/796,267 Continuation-In-Part US7794706B2 (en) 2003-10-14 2007-04-26 Bioactive wound dressings and implantable devices and methods of use

Publications (2)

Publication Number Publication Date
WO2006050091A2 WO2006050091A2 (fr) 2006-05-11
WO2006050091A3 true WO2006050091A3 (fr) 2009-04-09

Family

ID=36319671

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/038925 Ceased WO2006050091A2 (fr) 2003-10-14 2005-10-27 Pansement pour blessures bioactif, dispositifs implantables et procedes d'utilisation

Country Status (6)

Country Link
EP (1) EP1809310A4 (fr)
JP (1) JP2008518666A (fr)
CN (1) CN101437528A (fr)
AU (1) AU2005302469A1 (fr)
CA (1) CA2585740A1 (fr)
WO (1) WO2006050091A2 (fr)

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US20060177416A1 (en) * 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
WO2007038246A2 (fr) 2005-09-22 2007-04-05 Medivas, Llc Compositions polymeres solides pour administration et methodes d'utilisation de celles-ci
CA2623198C (fr) 2005-09-22 2014-08-05 Medivas, Llc Formules de poly(ester amide) et de poly(ester urethane) contenant des diesters de bis-(a-amino)-diol et methodes d'emploi
US7771739B2 (en) * 2006-06-30 2010-08-10 Abbott Cardiovascular Systems Inc. Implantable medical devices comprising semi-crystalline poly(ester-amide)
JP2010502822A (ja) * 2006-09-05 2010-01-28 メディバス エルエルシー ポリマー安定化リポソーム組成物および使用方法
ES2583371T3 (es) 2006-10-11 2016-09-20 The General Hospital Corporation Composiciones, métodos, y dispositivos para tratar enfermedades hepáticas
JP2010529987A (ja) * 2007-06-15 2010-09-02 ガーネット バイオセラピューティクス インコーポレイテッド ｉｎｖｉｔｒｏで培養および増殖させた自己複製性コロニー形成細胞を用いる疾患および障害の治療
US20110020291A1 (en) * 2007-11-17 2011-01-27 Debrabrata Banerjee Use of stem cells for wound healing
RU2394593C2 (ru) * 2008-09-25 2010-07-20 Андрей Степанович БРЮХОВЕЦКИЙ Имплантируемая нейроэндопротезная система, способ ее получения и способ проведения реконструктивной нейрохирургической операции
AU2010347212B2 (en) * 2010-09-14 2016-07-14 Cell Ideas Pty Ltd Cell free preparation and uses thereof
JP6135870B2 (ja) * 2011-05-02 2017-05-31 ディーエスエム アイピー アセッツ ビー．ブイ． 生分解性ポリマーを含む繊維
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
ES2558357T3 (es) 2011-06-23 2016-02-03 Dsm Ip Assets B.V. Micro- o nanopartículas que comprenden un copolímero de poliesteramida biodegradable para uso en el suministro de agentes bioactivos
EP4321151A3 (fr) * 2012-10-24 2024-05-22 DSM IP Assets B.V. Fibres comprenant des copolymères de polyesteramide pour l'administration de médicaments
JP6460540B2 (ja) * 2014-04-08 2019-01-30 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． 関節障害の処置のために使用される生分解性ポリエステルアミド
JP6338468B2 (ja) * 2014-06-19 2018-06-06 テルモ株式会社 細胞を分散したゲルの製造方法およびその製造方法により製造された細胞分散ゲル
CA2969171C (fr) 2014-12-18 2023-12-12 Dsm Ip Assets B.V. Systeme d'administration de medicament pour administration de medicaments sensibles aux acides
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
CN105079859B (zh) * 2015-08-20 2018-01-26 广州赛莱拉干细胞科技股份有限公司 一种敷料及其制备方法
US10322034B1 (en) 2015-09-04 2019-06-18 University Of South Florida Hydrocolloid dressing for precise nipple positioning after nipple- or skin-sparing mastectomy
WO2017124040A1 (fr) * 2016-01-17 2017-07-20 Guoming Sun Hydrogels de polysaccharide biocompatible et procédés d'utilisation
CN105709270B (zh) * 2016-03-18 2019-01-01 中国科学院长春应用化学研究所 一种用于干细胞治疗的水凝胶敷料
CN106581763A (zh) * 2016-12-28 2017-04-26 溯源生命科技股份有限公司 一种干细胞人微型器官的制备方法
WO2018183998A1 (fr) * 2017-03-31 2018-10-04 Cellum Biomedical, Inc. Compositions de milieu cellulaire conditionné biocompatible et leurs utilisations
CN107261213A (zh) * 2017-06-13 2017-10-20 北京恒峰铭成生物科技有限公司 一种活性水凝胶及其制备方法和在手术创伤修复中的应用
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WO2002018477A2 (fr) * 2000-08-30 2002-03-07 Cornell Research Foundation, Inc. Copolyester amides et copolyester urethannes fonctionnels biodegradables et elastomeres

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WO2002018477A2 (fr) * 2000-08-30 2002-03-07 Cornell Research Foundation, Inc. Copolyester amides et copolyester urethannes fonctionnels biodegradables et elastomeres

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Title
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YAMAGUCHI ET AL.: "Bone marrow cells differenitate into wound myofibroblasts and accelerate the healing of wounds with exposed bones when combined with an occlusive dressing.", BRITISH JOURNAL OF DERMATOLOGY., vol. 152, 2005, pages 616 - 622, XP008119299 *

Also Published As

Publication number Publication date
WO2006050091A2 (fr) 2006-05-11
JP2008518666A (ja) 2008-06-05
CA2585740A1 (fr) 2006-05-11
CN101437528A (zh) 2009-05-20
EP1809310A4 (fr) 2011-10-26
AU2005302469A1 (en) 2006-05-11
EP1809310A2 (fr) 2007-07-25

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