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WO2006045170A2 - Nanoemulsion d'huile dans l'eau, composition et produit cosmetiques la renfermant, procede de preparation de ladite nanoemulsion - Google Patents

Nanoemulsion d'huile dans l'eau, composition et produit cosmetiques la renfermant, procede de preparation de ladite nanoemulsion Download PDF

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Publication number
WO2006045170A2
WO2006045170A2 PCT/BR2005/000222 BR2005000222W WO2006045170A2 WO 2006045170 A2 WO2006045170 A2 WO 2006045170A2 BR 2005000222 W BR2005000222 W BR 2005000222W WO 2006045170 A2 WO2006045170 A2 WO 2006045170A2
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WO
WIPO (PCT)
Prior art keywords
nanoemulsion
composition
cosmetic
oil
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/BR2005/000222
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English (en)
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WO2006045170A3 (fr
Inventor
Jean Luc Gesztesi
Leandra Moraes Santos
Paulo De Tarso Hennies
Leandra Moraes Santos
Karla ARAÚJO MACIAN
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Natura Cosmeticos SA
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Natura Cosmeticos SA
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Filing date
Publication date
Priority to US11/577,931 priority Critical patent/US8956597B2/en
Priority to CA 2585259 priority patent/CA2585259C/fr
Application filed by Natura Cosmeticos SA filed Critical Natura Cosmeticos SA
Priority to EP05800456.5A priority patent/EP1817045B1/fr
Publication of WO2006045170A2 publication Critical patent/WO2006045170A2/fr
Publication of WO2006045170A3 publication Critical patent/WO2006045170A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/21—Emulsions characterized by droplet sizes below 1 micron
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm

Definitions

  • the present invention relates to oil-in-water nanoemulsion used preferably for cosmetic applications for the body and face such as milk, lotions and gels and still in products indicated for hair care.
  • the main function of the skin is to provide a barrier for the transport of water and substances harmful to the body.
  • the capability of a chemical substance to penetrate the skin often depends upon the composition of the carrier.
  • a drug or cosmetic is applied to the skin, some situations limit the rate of cutaneous permeation: first, the release of the active from the carrier and, secondly, the penetration of the latter through the skin barrier.
  • Active ingredients in skin-care treatment pass into the skin through the pores of the pilose follicles, the canal of the tallow glands or through corneous extract.
  • the corneous extract is hygroscopic, in part due to the capability of preserving water of the keratin.
  • the skin needs at least 10% of moisturizing by weight to keep its flexibility and softness.
  • the association of intercellular lipids with the corneocytes of the corneous extract is crucial for keeping the barrier function and the capability of linking with water.
  • Substances favorable to the skin are water-soluble and oil- soluble.
  • the capability of retaining water from the corneous extract may be restored by applying lipids selected for the corneous extract and in a suitable carrier.
  • the size of the particles and their lipophilicity are main factors in the process of penetrating through the corneous extract.
  • the molecules go through the membrane by both passive diffusion and active transport.
  • the transport through the skin takes place primary by passive diffusion, which is governed by Fick's law. It determines that the base rate of diffusion or transport through the membrane is proportional to the difference in concentration of active on the two sides of the membrane.
  • Delivery systems play an important role in the development of effective skin-care products. Anti-aging treatments stimulate the growth of the skin-treatment market. Consumers expect rapid and visible results. In order to achieve these results, many companies are relying on advanced technology.
  • delivery technologies there are systems of lipids, nanoparticles, microcapsules, polymers and films. These technologies are added in a carrier such as creams, liquids, gels and patches.
  • the key aspects of the "delivery systems” are: increasing/improving the penetration and improving the efficacy; controlled delivery; separating incompatible actives; - prolonging the shelf life/decreasing the degradation of active.
  • Nanoparticles may be subdivided into two structure of encapsulated membrane: liposomes and nanoemulsions / nanosomes / nanotopes.
  • Nanoemulsions differ from macroemulsions by their smaller size of oily particles, which are on the order of nanometers.
  • Classic emulsions or macroemulsions have droplets in the size range of 1 to 20 micrometers, which impart to them the white or opaque aspect.
  • Nanoemulsions have been characterized as being transparent or slightly translucent, depending on the particle size and on the difference in refraction index between oil phase and aqueous phase.
  • the nanoemulsion system may be applied in personal hygiene, pharmaceuticals, foods, household sanitary agents, agrochemicals and cosmetics.
  • 6,413,527 describe a process for preparing a nanoemulsion based on phosphoric fatty acid esters. This process comprises mixing an aqueous phase and an oil phase with vigorous stirring at the temperature ranging from 10 to 80 0 C to form a mixture, and homogenizing the mixture under high pressure raging from 600 bar to 1 ,800 bar, further carried out with a shear ranging from 2x10 6 S "1 to 5x10 8 s '1 . Nanoemulsions present an average particle size ranging from 20 nm to 75 nm, for topical application.
  • document US 5,994,414 describes a process for preparing an emulsion, which comprises forming a crude oil-in-water emulsion, which is subjected to homogenization under a pressure of about 900 to about 1 ,100 bar to obtain an average particle size of about 0.1 micron, with a maximal size of about 1 micron.
  • the emulsion may be used in lotions for application onto the skin.
  • Document BR 0100335 describes oil-in-water nanoemulsions comprising particles with less than 150 nm for application in cosmetics, such as lotions and creams to be applied to the face and to the skin.
  • a process for preparing a nanoemulsion is described, which comprises mixing an oil phase and an aqueous phase by means of a homogenizer with a turbine, and then homogenizing with a homogenizer under high pressure, with 4 cycles, while keeping the temperature of the product below about 35 0 C.
  • document BR 9705381 relates to the use of nanoemulsions on keratin fibers, comprising particles having an average size of less than 150 nm. These nanoemulsions are obtained by mixing an aqueous phase and an oil phase, under vigorous stirring, at a room temperature lower than 45 0 C, and then subjected to homogenization under high pressure.
  • document BR 9604724 describes an oil-in-water nanoemulsion comprising an average particle size smaller than 100 nm, intended for use on cosmetic and pharmaceutical products.
  • the nanoemulsion may be prepared under a pressure ranging from 1 ,200 bar to 1 ,800 bar, and may present 7 cycles.
  • the nanoemulsion may assume the form of a lotion or a gel.
  • An objective of the present invention is to provide an oil-in-water nanoemulsion for cosmetic use, composed of an aqueous phase and an oil phase, constituted by oily particles that have an average diameter ranging from 50 to 200 nm, wherein said oily phase comprises an emulsifying system with at least ceteareth-20, ceteareth-12, glyceryl stearate, cetearyl alcohol and cetyl palmitate.
  • Another objective of the present invention is to provide a process for preparing the above-described nanoemulsion, which comprises the following steps: a - adding the components of the oil phase (phase A) in an auxiliary equipment and heating up to 75 0 C; b - adding the components of the aqueous phase (phase B) in a main equipment and heating up to 75 0 C; c - adding the phase A in the main equipment and stirring at 1 ,500 rpm for 30 minutes, while keeping the temperature between 7O 0 C and 75 0 C; d - adding the cooling water (phase C) and stirring for 15 minutes at 1 ,500 rpm; e - transferring the composition obtained in step d to a high- pressure homogenizing equipment provided with at least one piston.
  • This equipment has two chambers, the first one with a pressure of 1200 bar and the second one with a pressure of 120 bar; passing the composition at least once through the equipment (completing one cycle), or for as many cycles as necessary, to obtain the average particle size between 50 and 200 nm.
  • Another objective of the present invention is to provide the nanoemulsion obtainable by the process described above.
  • a further objective of the present invention is to provide cosmetic compositions and cosmetic products that comprise the nanoemulsion characterized above.
  • the present invention describes an oil-in-water type nanoemulsion that presents oily particles of a reduced average diameter ranging from 50 to 200 nm.
  • the nanoemulsion comprises an emulsifying system having components such as ceteareth-20, ceteareth-12, glyceryl stearate, cetearyl alcohol and cetyl palmitate.
  • This composition imparts to the nanoemulsion an opaque coloration, besides providing the skin with inherent properties of the nanoemulsion, such as better absorption of the skin components, providing softness, smoothness and moisturizing.
  • the main examples of products that can be prepared from the nanoemulsion of the present invention are: • body moisturizing milk
  • the nanoemulsion of the present invention has a variety of advantages and characteristics desired in a cosmetic product for the skin, some of them being listed below.
  • the nanoemulsion of the present invention has an opaque coloration, unlike nanoemulsion compositions of the prior art, by virtue of the emulsifying system used therein;
  • the nanoemulsion of the present invention may be added to skin products such as moisturizing lotions, as well as for products intended for hair care;
  • 15 - the coloration of the present nanoemulsion of the present invention has a strong commercial and marketing appeal by virtue of its visual aspect;
  • 16 - the nanoemulsion of the present invention does not comprise a thickening agent in its composition; the amounts of the components of the aqueous phase and of the oil phase and the preparation process are adequate for imparting the emulsification of the oily particles, preventing the separation of the phases and providing prolonged stability. Without a need for a thickening agent, a liquid emulsion becomes feasible in a cosmetic product;
  • the nanoemulsion of the present invention provides the skin with softness, smoothness, moisturizing, non-stickiness, high penetration and good spreadability, besides having an excellent degree of homogeneity and stability;
  • the object of the present invention has bactericidal action, even when it does not comprise a formulation of a bactericidal agent.
  • the nanoparticles of the nanoemulsion of the present invention break the membranes of the bacteria, thus killing them.
  • Nanoparticles comprise oily particles dispersed in an aqueous phase, wherein the average diameter of said particles is on the order of nanometer, preferably between 50 and 200 nanometers.
  • the coloration of the nanoemulsions had been characterized before as being transparent or slightly translucent, depending on the particle size and the difference in the refractive index between oil phase and aqueous phase.
  • the present invention has achieved a novel and unexpected result with regard to its coloration, starting from the knowledge disclosed before.
  • nanoemulsion are characterized as being kinetically stable systems, that is to say, they have physical stability for a longer period of time, coming close to a thermodynamically stable system, and as systems of releasing lipophilic actives, because their small particle size increases the contact area, the spreadability, the homogeneousness of the distribution and the penetration of the active into the substrate (skin/hair).
  • Nanoemulsion of the present invention is characterized as being kinetically stable systems, that is to say, they have physical stability for a longer period of time, coming close to a thermodynamically stable system, and as systems of releasing lipophilic actives, because their small particle size increases the contact area, the spreadability, the homogeneousness of the distribution and the penetration of the active into the substrate (skin/hair).
  • the nanoemulsions of the present invention comprise from 2.0% to 15.0% of oil phase and 85.0% to 98.0% by weight of aqueous phase, based on the total weight of the composition of the nanoemulsion.
  • composition of the nanoemulsion of the present invention is constituted by an oil phase comprising an emulsifying system with at least ceteareth-20, ceteareth-12, glyceryl stearate, cetearyl alcohol and cetyl palmitate and an aqueous phase.
  • an emulsifying system with at least ceteareth-20, ceteareth-12, glyceryl stearate, cetearyl alcohol and cetyl palmitate and an aqueous phase.
  • the range of amount of the above-cited emulsifying system present in the oil phase is from 1.0 to 2.5% by weight, based on the total weight of the composition of the nanoemulsion.
  • Emulgin B2 ceteareth-20
  • Emulgade® SE manufactured by Cognis
  • silicone that may be added to the present invention act as filmogenic agents, emollients, solvents and/or skin conditioners.
  • a few examples of silicone that may be added to the nanoemulsion of the present invention are volatile and non-volatile silicone oils such as, for example, cyclomethicone, alkyldimethicones, dimethicone-copolyols, dimeticonols, phenyl trimethicones, caprylyl trimethicones, aminofunctional silicones, phenyl modified silicones, phenyl trimethicones, alkyl modified silicones, dimethyl and diethyl polysyloxane, C1-C 3 0 mixed alkyl polysiloxane, ⁇ -methyl- ⁇ -methoxypolymethylsiloxane, polyoxydimethylsililene, polydimethyl silicone oil and combinations thereof, or silicone elastomers such as cyclomethicone crosspolymer and dimethicone, vinyl
  • phenyl trimethicone is added in the oil phase in an amount ranging from 1.0% to 5.0% by weight, based on the total weight of the composition of the nanoemulsion.
  • the function of the emollients in cosmetic compositions is to add or replace lipids and natural oils to the skin.
  • emollients to be added to the nanoemulsion of the present invention one may use conventional lipids such as, for example, oils, waxes, lipids and other water-soluble components and polar lipids that are modified lipids so as to increase their solubility in water by esterification of a lipid to a hydrophilic unit such as, for example, hydroxyl, carbonyl groups, among others.
  • Some compounds that may be used as emollients are natural oils such as essential oils and plant derivatives, esters, silicone oils, polyunsaturated fatty acids, lanoline and derivatives thereof.
  • Some natural oils that may be used are derived from damson, passion fruit, Para-nut, carap nut, cupuassu, sesame, soybean, peanut, coconut, olive, cocoa, almond, avocado, carnauba, cotton seed, rice bran, peach stone, mango stone, jojoba, macadamia, coffee, grape seed, pumpkin seed, among others, and mixtures thereof.
  • a number of natural compounds may be used, as for example, microcrystalline wax, carnauba wax, Shea butter, bee-wax, ozokeri wax, among others and mixtures of waxes and/or oils.
  • an oil from the Brazilian biodiversity (cupuassu butter / carap oil/ Para-nut oil/ passion-fruit oil) is used as emollient in the oil phase in an amount ranging from 0.1 % to 10.0% by weight, based on the total weigh of the composition of the nanoemulsion.
  • the moisturizing agent promotes the retention of water in the skin, that is to say, it is capable of supplying water to the skin and also preventing the loss of water from the skin.
  • the wetting agent further helps in increasing the efficacy of the emollient, reduces skin peeling and improves the sensorial properties of the skin (softness, smoothness).
  • wetting agents that may be added to the nanoemusion of the present invention are: glycerin, glycereth-26, PET-4 dilaurate, polyhydroxyl alcohols, alkylene polyols and derivatives thereof, glycerol, ethoxylated glycerol, propoxylated glycerol, sorbitol, hydroxypropyl sorbitol, among others, lactic acid and lactate salts, diols and C 3 -C 6 triols, > A/oe vera extract in any form, as for example, in the form of a gel, sugars, and starches and derivatives thereof, as for example, alkoxylated glucose, hyaluronic acid glycolic acid, lactic acid, glycolic acid and salicylic acid, pantenol and urea.
  • vegetable glycerin or glycereth-26 are used in an amount ranging from 3.0% to 10.0% by weight, and biosaccharide gum 1 in an amount ranging from 1.0% to 5.0% by weight, based on the total weight of the composition of the nanoemulsion. Fragrance
  • compositions of this type perfume or fragrance selected from a variety of possible substances.
  • the amount of fragrance in the oil phase to be added to the nanoemulsion of the present invention preferably ranges, if present, from about 0.2% to about 6.0% by weight, based on the total weight of the composition of the nanoemulsion.
  • Carrier if present, from about 0.2% to about 6.0% by weight, based on the total weight of the composition of the nanoemulsion.
  • the aqueous phase of the nanoemulsion of the present invention comprises preferably demineralized or distilled water at an adequate percentage (q.s.p.) to achieve 100% of the formula, based on the total weight of the composition of the nanoemulsion.
  • active principles they may be either lipophilic or hydrophilic, for example, seaweeds, a combination of palmitoyl hydroxypropyl trimonium aminopectin, glycerin crosspolymer, lecithin and grape-seed extract, bisabolol (anti-inflammatory active), D-pantenol (conditioning active), tocopherol (vitamin E), retinol (vitamin A), ascorbic acid (vitamin C), erocalcipherol (vitamin D) and sunscreen commonly added to compositions of products for topical or hair use;
  • lipophilic or hydrophilic for example, seaweeds, a combination of palmitoyl hydroxypropyl trimonium aminopectin, glycerin crosspolymer, lecithin and grape-seed extract, bisabolol (anti-inflammatory active), D-pantenol (conditioning active), tocopherol (vitamin E), retinol (vitamin A), ascorbic acid (vitamin C),
  • bacteriostatics bactericides or antimicrobials, as for example, lrgasan DP300;
  • chelating agent as ethylenediaminotetraacetic acid (EDTA) and salts thereof;
  • plant extract chamomile, rosemary, thyme, calendula, carrot extract, common juniper extract, gentian extract, cucumber extract; • skin conditioning agent;
  • antioxidant agent like butyl hydroxytoluene (BHT), butyl hydroxyanisol (BHA); and
  • Example 1 cupuassu butter milk
  • example 1 illustrated above may also contain carap-nut oil and Para nut to replace cupuassu butter. These compositions were used to carry out the tests described later.
  • Triethanolamine pH adjusting agent Triethanolamine pH adjusting agent
  • the nanoemulsion of the present invention may be prepared by the process described below, the phases cited therein being as follows:
  • Phase A may comprise any oil commonly used in oil-in-water emulsion compositions known and further butter(s) or mixtures of oil(s) and butter(s).
  • Step I Preparation of the emulsion a - Mixing the components of the emulsifying system (phase A) in an auxiliary equipment and heat up to 75 0 C; b - adding water (Phase B) to a main equipment and stirring at 1500 rpm for 30 minutes, while keeping the temperature between 7O 0 C - 75 0 C; and c - adding cooling water (Phase C) and stirring for 15 minutes at 1500 rpm.
  • Said stirring should preferably occur in rotor-stator homogenizers.
  • Step Il Preparation of the nanoemulsion from the prepared emulsion a - transferring the composition obtained in Step I to a high- pressure equipment having preferably 1 to 3 pistons; this equipment has two chambers, the first one with pressure of 1200 bar and the second one with pressure of 120 bar; i. - the nanoemulsion of the present invention is automatically transferred from the first chamber that is under a pressure of 1200 bar to the second chamber that is under a pressure of 120 bar, completing the cycle; b - in order to obtain the average particle size of 50 to 200 nm, repeat, if necessary, the above substep, totalizing three cycles, at most.
  • Step I a - adding the components of phase A in an auxiliary equipment and heating up to 75 0 C; b - adding the components of phase B in a main equipment and heating up to 75 0 C; c - adding the phase A in the main equipment under stirring of about 1500 rpm for 30 minutes, while keeping the temperature between 7O 0 C and 75 0 C; d - adding cooling water (phase C) and stirring for 15 minutes at 1500 rpm; e - adding the phase D and stirring for 5 minutes; f - adding the phase E and stirring for 5 minutes; g - adding the phase F and stirring for 5 minutes; h - adding the phase G and stirring for 5 minutes; Step Il a - inserting the emulsion obtained in step (h) into the high- pressure equipment and the product will pass through two chambers: the first chamber being under a pressure of 1200 bar and the second chamber being under a pressure of 120 bar, totalizing a cycle to obtain the average particle size between 50 and 200 nm.
  • the irritation potential of a product depends on a number of variables: the components of the composition, the concentration of each of the components, absorption thereof by the skin, the amount applied onto the skin, the state in which the skin at the time of application, the manner and frequency of application of the product onto the skin and the inherent cumulative effect of the product.
  • Patch test is the main tool used in diagnosing a reaction caused by a cosmetic and in researching allergenicity.
  • the following clinical tests are involved: primary and accumulated dermal irritability, cutaneous sensitization, phototoxicity and photoallergy. These consist in repeated applications of the product onto the skin and have the function of detecting possible irritations or induction of sensitization. It is indicated to carry out use tests after approval of the product in patch tests. With the use tests one may evaluate, in addition to allergenicity, sensorial characteristics of the products, that is, their performance.
  • hypoallergenic adhesive card for patch test with duly identified filter paper discs of 1.0 cm 2 , semipermeable hypoallergenic adhesive plaster for occlusion, saline solution and samples of the cosmetic composition.
  • 0.05g of the cosmetic composition was applied to each area of 1 cm 2 of the filter paper disc, and the saline solution was applied onto the control disc. These discs were fixed onto the back of the volunteers with adhesive plaster. The following clinical researches were also carried out.
  • the test method used was the patch test.
  • the place of application of the tests was the back of the volunteers, duly protected.
  • the patch test was removed by the researches after 48 hours of contact with the skin, and the reactions were written down, 30 minutes after removal.
  • the sample was always applied in the same region, on the back, duly protected.
  • the applications were all made on the same day, the patch test remaining 72 hours in the end of the week, for 4 consecutive weeks, in a total of 20 applications.
  • the sample was reapplied onto the skin always on the same spot and the reactions were written down. After 20 consecutive applications, a rest period of 10 followed, when no patch was applied. After this rest interval, a simple patch of sample was applied onto the back of the volunteers in a virgin area, that is to say, a place where no patch had been applied.
  • the test was removed by the researchers after 48 hours of contact with the skin and the reactions were written 30 minutes after removal.
  • the sample was always applied in the same region on the back, duly protected.
  • the applications were made 3 times per week for 3 consecutive weeks, on alternate days, resulting in a total of 9 applications.
  • the patch test was removed by the researches 24 hours after application thereof. After a series of 9 consecutive applications, a rest period of 20 days followed, when no patch was applied. Then, a simple patch of the sample was applied onto the back of the volunteers, in the virgin area. The patch test was removed by the researchers after 48 hours of contact with the skin and the reactions were written down 30 minutes after removal. IV - Research on Photoallergy
  • the test was carried out as follows: the nanoemulsion was applied onto the back of the volunteers at a concentration of 0.05g/cm 2 in an always protected region. The applications were made twice a week for 3 weeks resulting in a total of 6 applications.
  • the patch test was removed by the researchers 24 hours after application, the area being immediately evaluated and irradiated with an A and B ultraviolet lamp. The non-irradiated back areas and the eyes were duly protected from light incidence. The sample was always reapplied on the same place. After 6 consecutive applications and irradiations, a rest period of 10 days followed, when no patch and no irradiation were made. The tests were removed by the researchers after 24 hours of application. After removal, the test areas were irradiated with an UVA lamp. The volunteers were instructed to protect the irradiated area against sunlight. Evaluations were made 24, 48 and 72 hours after the last irradiation and written down on a form for this purpose. V - Research on Phototoxicity
  • the nanoemulsion was applied onto the back of the volunteers at a concentration of 0.05g/cm in an always protected region. The application was made only once.
  • the patch test was removed by the researchers 24 hours after application, the area being immediately evaluated and irradiated with an A ultraviolet lamp. The non-irradiated areas of the back and the eyes were duly protected against light incidence. Then, a patch was applied onto the back of the volunteers with saline solution, in the virgin area, and irradiated. The volunteers were instructed to protect the irradiated area against sunlight. Evaluations were made 24, 48 and 72 hours after the last irradiation and written down on a form for this purpose.
  • the objective of this test is to determine the prevalence of adverse reactions in real conditions of use of the products that comprise the nanoemulsion of the present invention, used in the three sets of test.
  • Second set for this test, 25 female volunteers were selected, with age ranging from 18 to 64 years.
  • Third set for this test 29 female volunteers were selected, with age ranging fro 20 to 57 years.
  • the volunteers were guided to use the product for 3 weeks, being supervised by dermatologists.
  • First set for this test, 18 female volunteers were selected, with age ranging fro 18 to 60 years.
  • the readings were made by applying the probe to the test area, with the pressure permitted by the spring.
  • the measurement area was of 49mm 2 . 20 measurements were made in each area.
  • the reading indicated the degree of moisture of the skin surface based in variations of electric capacity.
  • the scale of the apparatus is arbitrary, the highest reading values indicating greatest moisturizing.
  • the tested product was applied in the amount of 50 ⁇ l in the demarcated region of each volunteer.
  • This study aims at evaluating the skin moisturizing power of the nanoemulsion of the present invention.
  • Second set for this test, 20 female volunteers were selected, with age ranging from 28 to 58 years.
  • Third set for this test, 20 female volunteers were selected, with age ranging from 28 to 58 years.
  • Fourth set for this test, 20 female volunteers were selected, with age ranging from 28 to 58 years. A composition in cream form (ordinary oil- in-water emulsion) with carap oil was used.
  • a Corneometer CM 820 which measures the water contents in the skin, specifying the degree of moisturizing of the skin surface.
  • the product was applied to determined areas with 25 cm 2 of the legs. A third area is kept without product (control).
  • the measurements of the corneometer area carried out in the beginning of the test and after application of the product onto the skin in determined periods of time of 24 hours. All these measurements are effected in a specific room (moisturizing room), where the temperature and the moisture are monitored (maximal temperature of 22 0 C and maximal relative humidity of 55%). With the measurements, one determines the electric capacity of these regions.
  • the stock bacterium cultures were chopped in tubes containing "Tryptic Soy” Agar or Nutrient Agar slants and incubated at 35 0 C for 24 hours. The residues (bulks) containing the analyzed samples were identified.
  • the inoculated saline solution will serve as a control for obtaining the initial number of microorganism in the zero-contact time, and for evaluating the feasibility of the microorganisms after 7 and 28 days from the incubation; diluting the inoculated saline solution down to the dilution of 10-6, by using 9 ml of sterile saline solution at 0.85% per flask; pipetting 1 ml of each dilution to sterile Petri plates;
  • the objective of this analysis is to determine the distribution of particle sizes in products through laser ray diffraction, by using the equipment Mastersizer Plus MAF 5001 - Malvem.
  • the particles dispersed in the dispersing liquid are transported through an optical cell, onto which a laser beam having a wavelength equal to 630nm falls. Upon passing through the optical cell, the particles cause the light to spread in several angles. The values of these angles are inversely proportional to the particle sizes.
  • the spread light is detected by sensors positioned below the angles, and the analysis of the diffraction pattern enables the calculation of the particle size of the sample.
  • the objective of this evaluation is to normalize the procedures of operation of the equipment Zetasizer 3000 (Malvern) for carrying out the analysis of particle size.
  • the particles of the compositions analyzed exhibited an average diameter ranging from 50 to 200 nm (nanometers).

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Abstract

L'invention concerne une émulsion d'huile dans l'eau à usage cosmétique. Les particules d'huile ont un diamètre moyen compris entre 50 et 200 nm (nanomètres). La nanoémulsion comprend un système émulsifiant ayant des composants tels que cétéareth-20, cétéareth-12, stéarate de glycéryle, alcool cétéarylique et palmitate de cétyle. Cette composition confère à la nanoémulsion une coloration opaque, outre le fait de donner à la peau des propriétés inhérentes de la nanoémulsion, par exemple une meilleure absorption des composants par la peau, conférant à celle-ci douceur, lissé et hydratation pendant 24 heures; on peut également l'ajouter aux produits destinés au soins capillaires. La composition de la nanoémulsion sans adjonction d'agents conservateurs possède également une action bactéricide. La nanoémulsion est, de préférence, utilisée dans des applications cosmétiques pour le corps, le visage et les cheveux sous forme de lait, de lotions et de gels. L'invention concerne enfin les compositions et produits cosmétiques qui renferment ladite nanoémulsion, ainsi qu'un procédé de préparation associé.
PCT/BR2005/000222 2004-10-26 2005-10-25 Nanoemulsion d'huile dans l'eau, composition et produit cosmetiques la renfermant, procede de preparation de ladite nanoemulsion Ceased WO2006045170A2 (fr)

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US11/577,931 US8956597B2 (en) 2004-10-26 2005-08-25 Oil-in-water nanoemulsion, a cosmetic composition and a cosmetic product comprising it, a process for preparing said nanoemulsion
CA 2585259 CA2585259C (fr) 2004-10-26 2005-08-25 Nanoemulsion d'huile dans l'eau, composition et produit cosmetiques la renfermant, procede de preparation de ladite nanoemulsion
EP05800456.5A EP1817045B1 (fr) 2004-10-26 2005-10-25 Nanoemulsion d'huile dans l'eau, composition et produit cosmetiques la renfermant, procede de preparation de ladite nanoemulsion

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BRPI0404595 BRPI0404595A (pt) 2004-10-26 2004-10-26 nanoemulsão óleo-em-água, composição cosmética e produto cosmético compreendendo a mesma, processo para preparação da dita nanoemulsão
BRPI0404595-5 2004-10-26

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WO2006045170A3 WO2006045170A3 (fr) 2006-07-27

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US20090208541A1 (en) 2009-08-20
WO2006045170A3 (fr) 2006-07-27
EP1817045A2 (fr) 2007-08-15
US8956597B2 (en) 2015-02-17
EP1817045B1 (fr) 2017-12-27
CA2585259A1 (fr) 2006-05-04
CA2585259C (fr) 2013-08-06
BRPI0404595A (pt) 2006-06-13

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