[go: up one dir, main page]

WO2005123964A3 - Gene de susceptibilite pour les accidents vasculaires cerebraux chez l'humain et procedes de traitement - Google Patents

Gene de susceptibilite pour les accidents vasculaires cerebraux chez l'humain et procedes de traitement Download PDF

Info

Publication number
WO2005123964A3
WO2005123964A3 PCT/US2005/021211 US2005021211W WO2005123964A3 WO 2005123964 A3 WO2005123964 A3 WO 2005123964A3 US 2005021211 W US2005021211 W US 2005021211W WO 2005123964 A3 WO2005123964 A3 WO 2005123964A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
methods
susceptibility gene
human stroke
stroke
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/021211
Other languages
English (en)
Other versions
WO2005123964A2 (fr
Inventor
Solveig Gretarsdottir
Gudmar Thorleifsson
Jeffrey R Gulcher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Decode Genetics ehf
Original Assignee
Decode Genetics ehf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/067,514 external-priority patent/US20030054531A1/en
Priority claimed from US10/419,723 external-priority patent/US20040014099A1/en
Priority claimed from PCT/US2003/029906 external-priority patent/WO2004028341A2/fr
Priority claimed from US10/868,397 external-priority patent/US20050164220A1/en
Application filed by Decode Genetics ehf filed Critical Decode Genetics ehf
Publication of WO2005123964A2 publication Critical patent/WO2005123964A2/fr
Publication of WO2005123964A3 publication Critical patent/WO2005123964A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne un rôle du gène PDE4D humain ainsi que des procédés de diagnostic, de prévision de l'évolution clinique et de traitement des accidents vasculaires cérébraux au moyen de polymorphismes du gène PDE4D.
PCT/US2005/021211 2001-03-19 2005-06-14 Gene de susceptibilite pour les accidents vasculaires cerebraux chez l'humain et procedes de traitement Ceased WO2005123964A2 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US81135201A 2001-03-19 2001-03-19
US10/067,514 US20030054531A1 (en) 2001-03-19 2002-02-04 Human stroke gene
US10/255,120 US20040091865A1 (en) 2001-03-19 2002-09-25 Human stroke gene
US10/419,723 US20040014099A1 (en) 2001-03-19 2003-04-18 Susceptibility gene for human stroke; methods of treatment
US65012003A 2003-08-27 2003-08-27
PCT/US2003/029906 WO2004028341A2 (fr) 2001-03-19 2003-09-25 Gene de predisposition pour l'attaque chez l'homme, et procedes de traitement
US10/868,397 2004-06-14
US10/868,397 US20050164220A1 (en) 2001-03-19 2004-06-14 Susceptibility gene for human stroke: method of treatment

Publications (2)

Publication Number Publication Date
WO2005123964A2 WO2005123964A2 (fr) 2005-12-29
WO2005123964A3 true WO2005123964A3 (fr) 2006-05-26

Family

ID=56290696

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/021211 Ceased WO2005123964A2 (fr) 2001-03-19 2005-06-14 Gene de susceptibilite pour les accidents vasculaires cerebraux chez l'humain et procedes de traitement

Country Status (1)

Country Link
WO (1) WO2005123964A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2723590A1 (fr) * 1994-08-09 1996-02-16 Inst Nat Sante Rech Med Procede de detection et trousse de diagnostic in vitro d'une predisposition a l'infarctus du myocarde
WO2004028341A2 (fr) * 2001-03-19 2004-04-08 Decode Genetics Ehf. Gene de predisposition pour l'attaque chez l'homme, et procedes de traitement

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2723590A1 (fr) * 1994-08-09 1996-02-16 Inst Nat Sante Rech Med Procede de detection et trousse de diagnostic in vitro d'une predisposition a l'infarctus du myocarde
WO2004028341A2 (fr) * 2001-03-19 2004-04-08 Decode Genetics Ehf. Gene de predisposition pour l'attaque chez l'homme, et procedes de traitement

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DOMINICZAK ANNA F ET AL: "Genetics of common polygenic stroke.", NATURE GENETICS. OCT 2003, vol. 35, no. 2, October 2003 (2003-10-01), pages 116 - 117, XP002354559, ISSN: 1061-4036 *
GRETARSDOTTIR SOLVEIG ET AL: "The gene encoding phosphodiesterase 4D confers risk of ischemic stroke.", NATURE GENETICS, vol. 35, no. 2, October 2003 (2003-10-01), pages 131 - 138, XP002354558, ISSN: 1061-4036 *

Also Published As

Publication number Publication date
WO2005123964A2 (fr) 2005-12-29

Similar Documents

Publication Publication Date Title
WO2004028341A3 (fr) Gene de predisposition pour l'attaque chez l'homme, et procedes de traitement
WO2002074992A3 (fr) Gene humain implique dans l'accident vasculaire cerebral
AU2002255248A1 (en) Diagnosis, treatment and research of mental disorders
AU2002327792A1 (en) Diagnosis and treatment of diseases caused by mutations in cd72
AU2003293460A1 (en) Novel application of biosensors for diagnosis and treatment of disease
AU2002323258A1 (en) Diagnosis and treatment of vascular disease
AU2002367535A1 (en) Diagnosis and treatment of vascular disease
AU2002309750A1 (en) Screening, diagnostic and therapeutic methods relating to riz
AU2002330215A1 (en) Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of alzheimer's disease
WO2002022871A3 (fr) Gene humain de l'osteoporose
AU2003291536A1 (en) Method for the diagnosis and treatment of vascular disease
AU2002326813A1 (en) Diagnosis and treatment of vascular disease
AU2002219137A1 (en) Diagnosis kit, dna chip, and methods for diagnosing or supervising the treatment of testicular cancer
AU2002341880A1 (en) Diagnosis and treatment of vascular disease
AU2002341604A1 (en) Diagnosis and treatment of vascular disease
WO2005123964A3 (fr) Gene de susceptibilite pour les accidents vasculaires cerebraux chez l'humain et procedes de traitement
WO2003065979A3 (fr) Procedes de diagnostic, de controle et de traitement de la sterilite
WO2003062469A3 (fr) Gene lie a l'arthrose
EP1461351A4 (fr) Methodes et reactifs pour le diagnostic et le traitement du diabete
AU2002319591A1 (en) Diagnosis and treatment of vascular disease
AU2002364889A1 (en) Methods for diagnosis and treatment of diseases associated with altered expression of nrf2
WO2004065938A3 (fr) Gene humain de l'osteoporose
AU2002240745A1 (en) Diagnosis and treatment of blood disorders
AU2003278877A1 (en) Susceptibility gene for human stroke; methods of treatment
AU2002330715A1 (en) Methods for diagnosis and treatment of diseases associated with altered expression of jak1

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

122 Ep: pct application non-entry in european phase