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WO2005120529A1 - Polyphyto-composition agissant comme agent anti-inflammatoire - Google Patents

Polyphyto-composition agissant comme agent anti-inflammatoire Download PDF

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Publication number
WO2005120529A1
WO2005120529A1 PCT/IN2004/000148 IN2004000148W WO2005120529A1 WO 2005120529 A1 WO2005120529 A1 WO 2005120529A1 IN 2004000148 W IN2004000148 W IN 2004000148W WO 2005120529 A1 WO2005120529 A1 WO 2005120529A1
Authority
WO
WIPO (PCT)
Prior art keywords
panekure
inflammation
herbs
polyherbal
reduces
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2004/000148
Other languages
English (en)
Inventor
Tapan Kumar Chatterjee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2005120529A1 publication Critical patent/WO2005120529A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead

Definitions

  • Rheumatoid arthritis is an auto-immune disease.
  • the immune system of human body fights bacteria and viruses by producing millions of cells called antibodies that specially match and attack the individual bacteria or virus.
  • the system becomes confused and produces antibodies to collagen.
  • Collagen forms the building blocks of cartilage which represents the bearings of joints.
  • the persons suffering from rheumatoid arthritis lose their bearings and that's why deformity in fingers, hands etc are seen.
  • the disorganization of joints strains tendons, ligaments and muscles, and inflames them, thereby producing pain.
  • Osteoarthritis is a degenerative disease and is mostly related to ageing. Osteoarthritis commonly affects the hands, feet, spine and large weight-bearing joints, such as the hips and knees.
  • Cartilage is a protein substance that serves as the cushion between the bones of the joints. With ageing, the water content of the cartilage increases and the protein makeup of the cartilage degenerates. Repetitive use of the joints over the years irritates and inflames the cartilage, causing pain and swelling. Osteoarthritis is also caused by another disease or condition like obesity, surgery to the joint structures, gout, diabetis and other hormone disorders.
  • NSADDs non-steroidal anti-inflammatory drugs
  • the conventional treatment for both kinds of painful arthritic conditions and musculo-skeletal disorders is non-steroidal anti-inflammatory drugs (NSADDs) to relieve symptoms of pain and inflammation in the affected areas.
  • NSADDs non-steroidal anti-inflammatory drugs
  • the most common side effects of NSADDs involve gastrointestinal distress like stomach upset, cramping, ulcer and even bleeding.
  • the prolonged usage of NSADDs also affect kidneys. Cortisone injections are applied in acute painful conditions, but such application can be harmful to the tissue and bones, if used frequently.
  • Panekure a poly herbal medicine is an invention which addresses all the cardinal signs of inflammation - rwb ⁇ r(redness), c ⁇ Z ⁇ r(heat), twm ⁇ r(swelling), d ⁇ Z ⁇ r(pain) and function laesa (lost function) without having any adverse effects on GI tract and kidneys and thus, treats both kinds of arthritis and musculo skeletal disorders.
  • the standard orthodox treatment of rheumatoid and osteoarthritis is to prescribe non-steroidal anti- inflammatory drugs (NSADDs) which offer a degree of relief, but all of which cause stomach irritation and other gastrointestinal disrorders.
  • NSADDs non-steroidal anti- inflammatory drugs
  • the goal of available treatment in arthritis is to reduce joint pain and inflammation while improving and maintaining joint function.
  • weight reduction and avoiding activities that exert excessive stress on the joint cartilage there is no specific treatment so far to halt cartilage degeneration or to repair damaged cartilage in arthritic disorders.
  • Some may benefit from conservative measures such as rest, exercise, physical and occupational therapy, and mechanical support devices. When all such known measures fail, surgery is considered.
  • the drawback of all such drugs and medical devices is that they provide symptomatic relief only and do not protect cartilage from degeneration.
  • Panekure is of hyaluronic acid - thus helps protect viscosity of the synovial fluid in the joints, and it also significantly inhibits xanthine oxydase enzyme and reduces uric acid production - thus becomes effective against gout.
  • Panekure has the scavenging ability of ROS and therefore, prevents the damaging side effects of inflammation.
  • treatment with Panekure is absolutely safe. It does not cause any gastric irritation and damage to kidneys. It also reduces the C-Reactive Protein which is considered as the potent blood marker to cause inflammation.
  • Phanekure is a poly herbal research formulation containing five herbs, Hemidesmus indicus, Ricinus communis, Moringa pterygosperma, Tinospora cordifolia and Boerhaavia diffusa.
  • Hemidesmus indicus contains essential oils, coumarin, hemidosterol and hemidesmol which are effective in chronic rheumatism.
  • Ricinus communis contains glycerides of ricinoleic, isoricinoleic, stearic and dihydroxystearic acids which provide soothing effect on joint pains and inflammations.
  • Moringa pterygosperma also contains an essential oil called pterygospermin having strong anti-biotic activity.
  • Tinospora cordifolia contains tinosporin, tinosporidin, beta-sitosterol which are very effective in rheumatism and arthritis and Boerhaavia diffusa containing boerhaavic acid, low tannins, phlobaphenes give soothing effect on severe joint pains.
  • Boerhaavia diffusa containing boerhaavic acid, low tannins, phlobaphenes give soothing effect on severe joint pains.
  • the bio-synthesis of all these herbal extracts with controlled mixture provides anti-inflammatory, analgesic and anti-pyretic effect which is unique and first of its kind
  • Extracts of the five herbs are prepared and the extracts are kept at 4°C for use in PANEKURE capsule preparation.
  • the sieved five powdered herb extracts e.g. Anantamul, Shetverenda, Sajina, Gulancha, Rakta Punarnaba
  • the sieved five powdered herb extracts are separately weighed as per specifications and mixed thoroughly in a Double Cone Mixture for 15 minutes (20 -24 rotation /min). Properly mixed material is then collected in a closed container to avoid humidification from the environment. The room temperature is to be maintained at 24 ⁇ 1°C.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Polyphyto-médicament à base de Hemidesmus indicus, Ricinus communis, Moringa pterygorpoma, Tinosperma cardifolia et Boerhaavia diffusa, qui convient pour tous les symptômes majeurs d'inflammation rougeur, chaleur, tuméfaction, douleur et lésion fonctionnelle ou perte de fonction sans effets contraires d'aucune sorte sur l'appareil gastro-intestinal ou les reins et permet donc de traiter tous les types d'arthrite et de troubles musculo-squelettiques. Cette composition, qui inhibe la dépolymérisation de l'acide hyalouronique, contribue à maintenir la viscosité de la synovie dans les articulations: De plus, elle inhibe sensiblement l'enzyme xanthine oxydase et réduit la production d'acide urique, ce qui en fait un médicament efficace contre la goutte. Avec sa capacité de décomposition des espèces oxygénées radicalaires, elle prévient les effets secondaires dommageables de l'inflammation. Elle ne provoque pas d'irritation gastrique et ménage les reins. De plus, elle réduit la protéine C-réactive, laquelle est considérée comme un marqueur sanguin puissant dans la cause de l'inflation.
PCT/IN2004/000148 2004-05-20 2004-05-31 Polyphyto-composition agissant comme agent anti-inflammatoire Ceased WO2005120529A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN262/KOL/2004 2004-05-20
IN262KO2004 2004-05-20

Publications (1)

Publication Number Publication Date
WO2005120529A1 true WO2005120529A1 (fr) 2005-12-22

Family

ID=35502820

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2004/000148 Ceased WO2005120529A1 (fr) 2004-05-20 2004-05-31 Polyphyto-composition agissant comme agent anti-inflammatoire

Country Status (1)

Country Link
WO (1) WO2005120529A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008184439A (ja) * 2007-01-30 2008-08-14 B & C Laboratories Inc 活性酸素種細胞障害改善用皮膚外用剤
WO2008117230A1 (fr) * 2007-03-23 2008-10-02 Ranbaxy Laboratories Limited Extraits végétaux bioactifs standardisés
CN102920754A (zh) * 2012-11-26 2013-02-13 北京盈良安生物科技有限公司 辣木叶片提取物及其对癌症在化疗或放疗的增效减毒应用
CN103980291A (zh) * 2014-04-29 2014-08-13 天津大学 从辣木根部提取辣木素的方法
CN104725400A (zh) * 2013-12-18 2015-06-24 刘福利 一种从辣木根部提取辣木素的方法
WO2022135882A1 (fr) * 2020-12-25 2022-06-30 Unilever Ip Holdings B.V. Composition de soins personnels

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Note of the FDA.", 21 February 2003 (2003-02-21), pages 1, Retrieved from the Internet <URL:http://www.fda.gov/ohrms/dockets/dailys/03/Mar03/031403/80055e23.pdf> *
"Product specification of Panekure.", 2002, Retrieved from the Internet <URL:http://www.herbicureindia.com/panekure_prod.html> *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008184439A (ja) * 2007-01-30 2008-08-14 B & C Laboratories Inc 活性酸素種細胞障害改善用皮膚外用剤
WO2008117230A1 (fr) * 2007-03-23 2008-10-02 Ranbaxy Laboratories Limited Extraits végétaux bioactifs standardisés
CN102920754A (zh) * 2012-11-26 2013-02-13 北京盈良安生物科技有限公司 辣木叶片提取物及其对癌症在化疗或放疗的增效减毒应用
CN104725400A (zh) * 2013-12-18 2015-06-24 刘福利 一种从辣木根部提取辣木素的方法
CN104725400B (zh) * 2013-12-18 2018-03-09 刘福利 一种从辣木根部提取辣木素的方法
CN103980291A (zh) * 2014-04-29 2014-08-13 天津大学 从辣木根部提取辣木素的方法
WO2022135882A1 (fr) * 2020-12-25 2022-06-30 Unilever Ip Holdings B.V. Composition de soins personnels
CN116669689A (zh) * 2020-12-25 2023-08-29 联合利华知识产权控股有限公司 个人护理组合物
JP2024504571A (ja) * 2020-12-25 2024-02-01 ユニリーバー・アイピー・ホールディングス・ベスローテン・ヴェンノーツハップ パーソナルケア組成物

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