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WO2005118610A3 - Macrocyclic compounds and methods of making and using the same - Google Patents

Macrocyclic compounds and methods of making and using the same

Info

Publication number
WO2005118610A3
WO2005118610A3 PCT/US2005/018733 US2005018733W WO2005118610A3 WO 2005118610 A3 WO2005118610 A3 WO 2005118610A3 US 2005018733 W US2005018733 W US 2005018733W WO 2005118610 A3 WO2005118610 A3 WO 2005118610A3
Authority
WO
WIPO (PCT)
Prior art keywords
making
methods
same
macrocyclic compounds
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/018733
Other languages
French (fr)
Other versions
WO2005118610A2 (en
Inventor
Yi Chen
Jay J Farmer
Joyce A Sutcliffe
Ashoke Bhattacharjee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Melinta Subsidiary Corp
Original Assignee
Rib X Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2005/006082 external-priority patent/WO2005085266A2/en
Application filed by Rib X Pharmaceuticals Inc filed Critical Rib X Pharmaceuticals Inc
Publication of WO2005118610A2 publication Critical patent/WO2005118610A2/en
Publication of WO2005118610A3 publication Critical patent/WO2005118610A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The present invention provides macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
PCT/US2005/018733 2004-06-01 2005-05-27 Macrocyclic compounds and methods of making and using the same Ceased WO2005118610A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US57594904P 2004-06-01 2004-06-01
US60/575,949 2004-06-01
PCT/US2005/006082 WO2005085266A2 (en) 2004-02-27 2005-02-25 Macrocyclic compounds and methods of making and using the same
USPCT/US2005/006082 2005-02-25

Publications (2)

Publication Number Publication Date
WO2005118610A2 WO2005118610A2 (en) 2005-12-15
WO2005118610A3 true WO2005118610A3 (en) 2006-10-19

Family

ID=35463422

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/018733 Ceased WO2005118610A2 (en) 2004-06-01 2005-05-27 Macrocyclic compounds and methods of making and using the same

Country Status (1)

Country Link
WO (1) WO2005118610A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005085266A2 (en) 2004-02-27 2005-09-15 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
US7247617B2 (en) 2004-07-13 2007-07-24 Kosan Biosciences Incorporated Sixteen-member macrolide antiinfective agents
EP1934237A2 (en) * 2005-08-24 2008-06-25 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same
HRP20171285T1 (en) 2005-08-24 2017-10-20 Melinta Therapeutics, Inc. Triazole compounds and methods of making and using the same
AU2012342548B2 (en) * 2011-11-25 2017-08-24 Elanco Animal Health Gmbh Antibacterial tylosin derivatives and methods for their preparation
SG11201504933WA (en) 2012-12-24 2015-07-30 Univ Ramot Agents for treating genetic diseases resulting from nonsense mutations, and methods for identifying the same
NO2999707T3 (en) 2013-05-23 2018-08-25
WO2015198329A1 (en) 2014-06-25 2015-12-30 Bio Blast Pharma Ltd. Injectable formulations for intrathecal administration of antibiotic agents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003011882A1 (en) * 2001-07-27 2003-02-13 Enanta Pharmaceuticals, Inc. 4'-substituted leucomycins
WO2004029066A2 (en) * 2002-09-26 2004-04-08 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003011882A1 (en) * 2001-07-27 2003-02-13 Enanta Pharmaceuticals, Inc. 4'-substituted leucomycins
WO2004029066A2 (en) * 2002-09-26 2004-04-08 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PHAN, LY T. ET AL: "Synthesis and Antibacterial Activity of a Novel Class of 4'-Substituted 16-Membered Ring Macrolides Derived from Tylosin", JOURNAL OF MEDICINAL CHEMISTRY , 47(12), 2965-2968 CODEN: JMCMAR; ISSN: 0022-2623, 2004, XP002376518 *
SANO, HIROSHI ET AL: "Chemical modification of spiramycins. V. Synthesis and antibacterial activity of 3'- or 4'''-de-N-methylspiramycin I and their N-substituted derivatives", JOURNAL OF ANTIBIOTICS , 38(2), 186-96 CODEN: JANTAJ; ISSN: 0021-8820, 1985, XP009064961 *

Also Published As

Publication number Publication date
WO2005118610A2 (en) 2005-12-15

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