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WO2005118584A3 - Saframycin analogs as therapeutic agents in the treatment of cancer - Google Patents

Saframycin analogs as therapeutic agents in the treatment of cancer Download PDF

Info

Publication number
WO2005118584A3
WO2005118584A3 PCT/US2005/018504 US2005018504W WO2005118584A3 WO 2005118584 A3 WO2005118584 A3 WO 2005118584A3 US 2005018504 W US2005018504 W US 2005018504W WO 2005118584 A3 WO2005118584 A3 WO 2005118584A3
Authority
WO
WIPO (PCT)
Prior art keywords
analogs
cancer
treatment
saframycin
therapeutic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/018504
Other languages
French (fr)
Other versions
WO2005118584A2 (en
Inventor
Hyunjin M Kim
Martin Sendzik
Jeffrey R Spencer
Penglie Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Axys Pharmaceuticals Inc
Original Assignee
Axys Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axys Pharmaceuticals Inc filed Critical Axys Pharmaceuticals Inc
Publication of WO2005118584A2 publication Critical patent/WO2005118584A2/en
Publication of WO2005118584A3 publication Critical patent/WO2005118584A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention is directed to saframcyin analogs that are useful in the treatment of cancer. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.
PCT/US2005/018504 2004-05-26 2005-05-26 Saframycin analogs as therapeutic agents in the treatment of cancer Ceased WO2005118584A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57470004P 2004-05-26 2004-05-26
US60/574,700 2004-05-26

Publications (2)

Publication Number Publication Date
WO2005118584A2 WO2005118584A2 (en) 2005-12-15
WO2005118584A3 true WO2005118584A3 (en) 2006-03-23

Family

ID=35004181

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/018504 Ceased WO2005118584A2 (en) 2004-05-26 2005-05-26 Saframycin analogs as therapeutic agents in the treatment of cancer

Country Status (1)

Country Link
WO (1) WO2005118584A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS50510B (en) 2004-10-29 2010-03-02 Pharma Mar S.A., Sociedad Unipersonal FORMULATIONS CONTAINING ECTEINASCIDINE AND DISAHARID
WO2006066183A2 (en) * 2004-12-16 2006-06-22 Axys Pharmaceuticals, Inc. Novel saframycin analogs as therapeutic agents
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
JP5313164B2 (en) 2007-11-19 2013-10-09 旭化成ケミカルズ株式会社 Method for producing isocyanate and aromatic hydroxy compound
JOP20190254A1 (en) 2017-04-27 2019-10-27 Pharma Mar Sa Antitumoral compounds
CN107759652B (en) * 2017-08-30 2019-10-29 大连理工大学 Cholesterol-containing coumarin derivatives and their synthesis and application
JPWO2019176732A1 (en) * 2018-03-16 2021-03-25 国立大学法人東京農工大学 Method for Producing Tetrahydroisoquinoline Ring-Containing Compound

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002040477A2 (en) * 2000-11-03 2002-05-23 President And Fellows Of Harvard College Saframycins, analogues and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002040477A2 (en) * 2000-11-03 2002-05-23 President And Fellows Of Harvard College Saframycins, analogues and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WERMUTH ET AL, PRACTICE OF MEDICINAL CHEMISTRY, 1996, pages 203 - 237, XP002190259 *

Also Published As

Publication number Publication date
WO2005118584A2 (en) 2005-12-15

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