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WO2005118485A1 - Amorçage de machine de dialyse polyvalente et dispositif de distribution d'une solution - Google Patents

Amorçage de machine de dialyse polyvalente et dispositif de distribution d'une solution Download PDF

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Publication number
WO2005118485A1
WO2005118485A1 PCT/US2005/018650 US2005018650W WO2005118485A1 WO 2005118485 A1 WO2005118485 A1 WO 2005118485A1 US 2005018650 W US2005018650 W US 2005018650W WO 2005118485 A1 WO2005118485 A1 WO 2005118485A1
Authority
WO
WIPO (PCT)
Prior art keywords
accessory
accessory device
conduit
interlocking
cartridge
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/018650
Other languages
English (en)
Inventor
James Summerton
Gregory R. Collins
Edward Spence
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nephros Inc
Original Assignee
Nephros Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nephros Inc filed Critical Nephros Inc
Publication of WO2005118485A1 publication Critical patent/WO2005118485A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A61M1/1656—Apparatus for preparing dialysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A61M1/1656—Apparatus for preparing dialysates
    • A61M1/1666—Apparatus for preparing dialysates by dissolving solids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A61M1/1656—Apparatus for preparing dialysates
    • A61M1/1668—Details of containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3643—Priming, rinsing before or after use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3643—Priming, rinsing before or after use
    • A61M1/3644—Mode of operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3643—Priming, rinsing before or after use
    • A61M1/3644—Mode of operation
    • A61M1/3649—Mode of operation using dialysate as priming or rinsing liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/20—Accessories; Auxiliary operations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1414—Hanging-up devices
    • A61M5/1418—Clips, separators or the like for supporting tubes or leads

Definitions

  • the present invention relates generally to blood, cleansing systems and
  • BACKGROUND Hemodialysis is a common blood cleansing operation, wherein blood to be
  • a physiologic solution e.g., a physiologic solution
  • dialysate flows on the other side of the membrane, whereby toxins in the blood are transferred from one side to the other.
  • the primary driving force in this treatment is
  • One of the functions of a hemodialysis system is to prepare a physiologic equivalent dialysate fluid and deliver it to the dialysis machine where it enters and flows through a compartment (e.g., a dialysate compartment of a hemodialysis cartridge).
  • a compartment e.g., a dialysate compartment of a hemodialysis cartridge.
  • dialysate is made of a suitable quality water to which a number of concentrates are added.
  • a suitable quality water for example, an acid concentrate and a sodium bicarbonate concentrate are typically
  • concentrate is often in a powdered form that is stored in a container into which the water flows to form a sodium bicarbonate solution that is then introduced back into a water feed stream.
  • the containers that hold the powered material are often in the form of single use cartridges and , ⁇ . . ⁇ . ⁇ j ⁇ j( j ⁇ ⁇ _ ⁇ , f ⁇ ⁇ ⁇ ⁇
  • the cartridge is only capable of delivering one type of concentrate solution.
  • a multi-use accessory device for use with a hemodialysis system, wherein the accessory device is designed to be compatible with a number of available hemodialysis machines and is configured to perform a number of functions in such dialysis system.
  • the accessory device for use with a hemodialysis system is provided.
  • the accessory device is configured so that it can perform more than one function related to the
  • the accessory device is constructed as
  • a funnel-like member having a generally conical shaped body having a first open end and an opposing second open end.
  • the open first end has an outer circumferential edge and an inner circumferential edge with a circumferential track being formed between the outer and inner
  • the circumferential track is configured to receive a sealing element
  • an O-ring to provide a seal between two accessory devices that are mated with one
  • the open first end further includes a plurality of interlocking tabs that permit one accessory device to be releasably interlocked with another
  • the first end also includes other features for holding tubing conduits and the
  • Solution is introduced into the accessory device at the open first end and flows toward the open second end.
  • the accessory device Proximate to the open second end, the accessory device includes a particulate filter for filtering the solution.
  • the solution then flows through a nozzle like part of the accessory device to the open second end.
  • the accessory device can be formed of any number of different types of materials, including plastic materials.
  • the accessory device is used in an extracorporeal priming operation.
  • the inlet (i.e., the open first end) of the accessory device is attached to a bloodline outlet, while the outlet (i.e., the open second end) of the accessory device is attached to a machine drain pump.
  • the accessory device essentially functions as a bottomless container during the priming cycle, thereby eliminating the need for the technician to continuously empty a limited volume bucket that receives the priming solution.
  • two accessory devices are mated with one another in a releasably interlocked manner to form a cartridge.
  • the cartridge is arranged so that the two open first ends face another.
  • one accessory device is inverted relative to the
  • the open second end of the inverted accessory device acts as an inlet of the cartridge and the open second end of the other accessory device
  • the cartridge can hold a concentrate, such as sodium
  • bicarbonate that is used to form the physiologic dialysate fluid or it can hold a w ⁇ a ⁇ S ⁇ »s JL SO
  • the cartridge When the cartridge contains a concentrate, it is arranged within a fluid flow path for generating the dialysate fluid (i.e., a concentrated solution delivery flow path) and when the cartridge contains the disinfectant/cleaning solution, it is arranged within a
  • the sealing element disposed between the two accessory devices within the circumferential track ensures that a fluid seal is formed between the two
  • FIG. 1 is a perspective view of a multi-use accessory device according to one
  • FIG. 2 is a top plan view of the multi-use accessory device of Fig. 1 ;
  • Fig. 3 is cross-sectional view of the multi-use accessory device of Fig. 1 taken
  • Fig. 4 is a schematic illustration of a dialysis system including the multi-use
  • accessory device of Fig. 1 being used as a cartridge for holding a concentrate that is added to an aqueous stream to generate a dialysate fluid that is fed to a dialysis machine;
  • Fig. 5 is a schematic illustration of a dialysis system which is configured in a dialysis machine disinfection/cleaning cycle, wherein the accessory device of Fig. 1 is
  • FIG. 6 is a schematic illustration of a dialysis system illustrating a manual priming operation for a dialysis machine, wherein the multi-use accessory device is used as a waste collection vessel;
  • Fig. 7 is a schematic illustration of a dialysis system illustrating an automated priming operation for a dialysis machine, wherein the multi-use accessory device is used as a waste collection vessel.
  • DETAD ED DESCRD7TION OF EMBODIMENTS Referring to Figs. 1 through 3, an accessory device 10 is provided for use in a dialysis system to perform a variety of functions as will be described in detail hereinafter.
  • the accessory device 10 is a funnel-like member having an open first end 12 and an open second end 14. Due to its funnel shape, the accessory device 10 has a generally conically-shaped body that tapers inwardly from the open first end 12 towards the open second end 14.
  • the accessory device 10 can be formed of any number of suitable materials, including a variety of plastic materials.
  • At the open first end 12, a plurality of interlocking tabs 20 are formed. The first end 12, a plurality of interlocking tabs 20 are formed.
  • interlocking tabs 20 are arranged around the circumference of the open first end 12 and extend upwardly from the open first end 12. In one exemplary embodiment, some of the interlocking
  • tabs 20 have a post 22 that extends upwardly from a peripheral edge of the open first end 12
  • the interlocking body part 24 is preferably orientated substantially
  • part 24 form an "L-shaped” locking member. Others of the interlocking tabs 20 are formed so that the interlocking body part 24 is not “L-shaped” but rather is a generally rectangular tab
  • one accessory device 10 can mate with another accessory device, as will be described and illustrated hereinafter, to form an interlocked
  • the open first end 12 has an outer circumferential edge 30 and an inner circumferential edge 32 spaced therefrom with a circumferential track 40 being formed therebetween.
  • the edges 30, 32 extend above the circumferential track 40 so as to define walls of the track 40.
  • the circumferential track 40 is configured to receive a sealing element (not shown), such as an O-ring, for producing a seal between two accessory devices 10 that are arranged to form the interlocked structure described above.
  • a sealing element not shown
  • one O-ring is provided in one track 40 and then when the other accessory device 10 is mated thereto, the O-ring will likewise be received in the other track 40 because
  • the open first end 12 also includes at least one external conduit clip 50 and at
  • the accessory device 10 has a pair of external conduit clips 50.
  • the pair of external conduit clips 50 are arranged in spaced relationship with respect to one another and in the illustrated embodiment, the external conduit clips 50 are arranged opposite one another along the circumference of the first end 12 (i.e., arranged 180° apart).
  • Each external conduit clip 50 is connected to the outer circumferential edge 30 (between a pair of interlocking tabs 20) and extends outwardly therefrom.
  • the external conduit clip 50 is a yoke-like member that has a pair of spaced fingers 52 that define an opening 54 therebetween.
  • the external conduit clip 50 is configured so that a flexible conduit, i.e., tubing member, is frictionally received in the opening 54 and securely held in place by frictional engagement with the spaced fingers 52.
  • a pair of internal conduit clips 60 arranged in spaced relationship with respect to one another (e.g., arranged 180° apart).
  • the internal conduit clip 60 is connected to the inner circumferential edge 32 and extends inwardly therefrom toward the center of the accessory device 10.
  • the internal conduit clip 60 is preferably orientated substantially perpendicular to the inner circumferential edge 32.
  • the internal conduit clips 60 are offset from the external conduit clips 50.
  • Each internal conduit clip 60 is a tab-like member having an opening 62 formed therein.
  • opening 62 defines a pair of opposing fingers 64 that frictionally hold a conduit (e.g., a tubing
  • the accessory device 10 is in a priming operation for a dialysis machine and in this operation, the external conduit clips 50 hook onto main bloodline tubing (not shown) to thereby stabilize (i.e., keep upright) the accessory device 10.
  • the internal conduit clips 60 are configured to hold a tubing member, such as a saline line or a main bloodline, in place so that the priming outflow remains directed downwardly into the accessory device 10 toward the open second end 14 that serves as an outlet.
  • the volume capacity of the accessory device 10 is sufficient to accommodate typical priming volume flow rates.
  • the accessory device 10 includes an internal seat 70 formed proximate to the open second end 14.
  • the seat 70 has a generally annular shape and receives a particulate filter 80. It will be appreciated that the particulate filter 80 has a complementary shape relative to the seat 70 and the shape of the seat 70 is not limited to an annular shape.
  • the particulate filter 80 is fitted within the seat 70 to filter fluid that is introduced into the accessory device 10 through the open first end 12.
  • the seat 70 forms a neck portion of the accessory device 10 such that the fluid filtered therethrough is collected into and flows through a tube-like outlet member to the second end 14.
  • Fig. 4 is a schematic illustration of a conventional UF controlled dialysis system, generally indicated at 100.
  • the system 100 includes a conduit 102 that carries water of a quality that permits the water to be used to form a physiologic equivalent dialysate fluid.
  • the water is of AAMI (Association for Advancement of Medical Instrumentation) quality.
  • the conduit 102 is connected at one end to a heat exchanger 104 with an inlet valve iD r irT' i i ⁇ T'"-'' " ! '' ' "i a Pi " ⁇ " ⁇ ⁇ ' f
  • the inlet valve 106 can be any number of types of valves that are configured to permit or prevent water flow through the conduit 102 to the heat exchanger 104.
  • the heat exchanger 104 is of a
  • the flow balancing system 110 can include suitable devices in the art, for example, volumetric balance chambers as used in a Fresenius 2008 dialysis machine, available from Fresenius, Lexington, MA, U.S.A., or dual flow meters as used in a Baxter 1550 dialysis machine, available from Baxter, Deerfield, IL, U.S.A.
  • the two concentrates are added upstream of the flow balancing system 110; however, it will be understood that the two concentrates can be added downstream of the flow balancing system as long as a UF pump 112 removes a specified volume of the dialysate fluid. More specifically, the UF pump 112 removes the equivalent
  • the acid concentrate is provided in liquid form and is disposed in
  • the storage container 114 is in fluid
  • volumetrically controlled pump 120 that is disposed along the conduit 118.
  • the sodium bicarbonate can come in a variety of forms including a liquid form and a solid form. When the sodium bicarbonate comes in liquid form, it is delivered the same way as the liquid acid concentrate is delivered. When the sodium bicarbonate comes in solid form, the sodium bicarbonate is stored in some type of container and is released at a predetermined rate to permit proper mixing with the water. According to one embodiment, the sodium bicarbonate is disposed in a disposable cartridge 130 that is filled with a predetermined amount of sodium bicarbonate powder. In the embodiment of Fig. 1 , the cartridge 130 is constructed of two interlocking accessory devices 10. Each of the accessory devices 10 is a funnel type member with the cartridge 130 being formed by arranging and interlocking the two inlet ends of the funnel type members against one another.
  • the cartridge 130 thus assumes an elongated diamond like shape as shown in Fig. 1 and a seal is formed between the two devices 10 as will be described.
  • the cartridge 130 is filled with sodium bicarbonate powder.
  • the inlet connector 132 is connected to
  • conduit 136 which carries water from the main water conduit 102 (prior
  • the cartridge 130 also includes a conduit 138 that is connected to the outlet connector 134 at one end and to the conduit 102 at the other
  • a pump 140 is disposed along the conduit 138 for drawing the water through the conduit 136 into the cartridge 130, where the water mixes with sodium bicarbonate powder to form a bicarbonate solution that is withdrawn from the cartridge 130 and delivered through the conduit 138 to the main water conduit 102.
  • the pump 140 infuses the correct proportion of sodium bicarbonate to make the physiologic equivalent dialysate fluid. While in Fig. 1 , the conduit 138 is connected to the conduit 102 downstream of the conduit 118, it will be understood that the conduit 138 may be positioned upstream of the conduit 118 so long as both are orientated upstream of the flow balancing system 110 (according to this embodiment).
  • the cartridge 130 can be disassembled by removing the two funnel type members (the accessory devices) 10 and then additional sodium bicarbonate powder can be added to one or more of the funnel type members 10 before reassembling the members 10 to form the cartridge 130 that is
  • dialysate conduit 150 to a dialysate inlet port 152 of a dialyzer
  • the dialyzer 160 is in the form of a dialyzer cartridge containing a semi-permeable
  • dialysate fluid that enters the inlet port 152 flows through the dialysate compartment 166
  • the dialyzer cartridge 160 may of any type suitable for hemodialysis, hemodiafiltration, hemofiltration, or hemoconcentration, for example, the Fresenius F60, available from Fresenius Medical Care, Lexington, Massachusetts; the Baxter CT 110, available from Baxter Health Care, Baxter Health Care, Deerfield, Illinois, the Minntech Hemocor HPH 1000, available from Minntech Corporation, Minneapolis, Minnesota, or the Hospal Filtral 16, available from Hospal A.G., Switzerland.
  • the Fresenius F60 available from Fresenius Medical Care, Lexington, Massachusetts
  • the Baxter CT 110 available from Baxter Health Care, Baxter Health Care, Deerfield, Illinois
  • Minntech Hemocor HPH 1000 available from Minntech Corporation, Minneapolis, Minnesota
  • Hospal Filtral 16 available from Hospal A.G., Switzerland.
  • the semi-permeable membrane 162 is preferably a medium to high flux membrane, for example, the polysulfone, cellulose triacetate or acrylonitrile membranes available from Fresenius Medical Care, Lexington, Massachusetts; Minntech Corporation, Minneapolis, Minnesota; Baxter Health Care, Deerfield, Illinois; or Hospal A.G., Switzerland.
  • a conduit 170 is connected to the dialysate outlet port 168 for carrying spent dialysate fluid from the dialysate compartment 166 of the dialyzer 160.
  • the conduit 170 is
  • a dialysate pump 181 is provided along the conduit 170 prior to the flow balancing system 110 for drawing the fresh dialysate fluid through the dialysate conduit 150 into the dialyzer 160 and then through the
  • conduit 170 as spent dialysate fluid after transfer of the toxins into the dialysate fluid.
  • the spent dialysate fluid flows through the conduit 170 to the
  • heat exchanger 104 before eventually being delivered to a drain or the like, generally indicated i iCr ' T / i. P S S / fi 5 Or
  • a drain outlet valve 179 is disposed in the conduit 170 upstream of the drain 180.
  • This valve 179 can be any number of types of valves and is configured to either permit fluid flow through the conduit 170 to the drain 180 or permit fluid flow through the conduit 170 to
  • Fig. 5 illustrates the accessory device 10 being used in a dialysis system that is configured to perform a machine disinfection/cleaning cycle operation. As in the dialysis mode illustrated in Fig. 1, two accessory devices 10 are arranged to form a cartridge 190. The two accessory devices 10 are interlocked by manipulation of the interlocking tabs 20 (Fig. 2) and are sealed by an O-ring 192.
  • the cartridge 190 is filled with a disinfectant/cleaning agent.
  • this agent comes in a powder form and in one exemplary embodiment, the agent is citric acid.
  • the agent can be supplied in liquid form so long as the lowermost accessory device 10 forming the cartridge 190 has an auto-shut off feature at an outlet portion thereof when it is not connected to a prime connector
  • the conduit 118 is connected to a rinse block port 196 that is in communication with the conduit 102. This results in the conduit 118 being a closed loop that only carries water that is flowing through the conduit 102.
  • the connectors 132, 134 are connected so as to form a closed water loop.
  • the cartridge 130 of Fig. 1 is removed and the inlet and outlet connectors 132, 134, respectively, are mated with one another so as to define a closed loop that carries water from the conduit 102 and then returns it thereto.
  • the dialyzer 160 (Fig. 1) is also taken off line and removed from the fluid flow path by fluidly connecting the dialysate conduit 150 with the conduit 170 so to bypass the dialyzer 160.
  • the dialysate conduit 150 can be connected to the conduit 170 using any number of techniques, including using connector 197, 198. As with the other modifications, .the fluid coupling of the conduits 150, 170 defines a closed loop where the
  • a recirculation conduit 196 is fluidly connected between the conduit 102 and the conduit 170 as shown. One end is fluidly connected to the conduit 102 upstream of the heat exchanger 104, while the other end is fluidly connected to the conduit 170 downstream of the heat exchanger 104 but upstream of the drain outlet valve 179.
  • a shut valve 199 is disposed within the recirculation conduit 197 such that in an open position, fluid can communicate
  • the cartridge 190 is disposed within a closed loop that is P S UaftJ - ⁇ 3 'tfSI ⁇ J
  • 01508/200H653-WO0 connected to the conduit 170 at both ends of the loop. More specifically and according to the exemplary embodiment shown in Fig. 5, an inlet end of the cartridge 190 is fluidly connected
  • a rinse connector 201 that is in fluid communication with the conduit 170 downstream of the heat exchanger 104 but upstream of the drain outlet valve 179.
  • An outlet end of the cartridge 190 is fluidly connected to the prime connector 200 which is itself connected to a conduit 210 that is connected at its other end to the conduit 170 downstream of where the rinse connector 201 connects to the conduit 170.
  • the conduit 210 must connect to the conduit 170 upstream of the recirculation conduit 197.
  • a pump 220 is disposed in the conduit 210 for withdrawing a disinfectant/cleaning solution from the cartridge 190. The operation of the disinfectmg/cleaning mode is now described.
  • the cleaning solution runs through and is in contact with the various components of the system.
  • the cleaning solution is recirculated through the entire system for a sufficient period of time for all of the components to be disinfected and/or cleaned.
  • the system can be disassembled and then reconfigured to perform a different mode, e.g., dialysis mode of Fig. 4.
  • the amount of cleaning agent in the cartridge 190 can be measured out so that for a given fluid path volume of the machine, a desired amount of cleaner/disinfectant can be dispensed.
  • the cartridge 190 is reusable and refillable.
  • Figs. 6 and 7 illustrate the accessory device 10 being used as a waste collection vessel with Fig.
  • Fig. 6 illustrating an arrangement for performing a manual primping operation
  • Fig. 7 illustrates an arrangement for performing an automated priming operation.
  • the system of Fig. 6 is very similar to the dialysis system of Fig. 1 and therefore only differences will be described in any detail.
  • the system of Fig. 6 illustrates the sodium bicarbonate being introduced in liquid form from a container or other storage medium 220.
  • the physiologic equivalent dialysate fluid flows through the dialysate conduit 150 to the dialysate inlet port 152
  • the fresh dialysate flowing through conduit 150 is the fresh dialysate flowing through conduit 150.
  • dialyzer 160 needs to be primed to remove the air or disinfectant.
  • the dialysate fluid is pumped through the
  • dialysate compartment 166 by operation of the pump 181 and is delivered through the conduit 170 eventually to the drain 180.
  • a saline bag or the like 230 is connected
  • a blood pump 241 is run at low speed to prime the first section 232 and a venous bloodline 236 and the blood compartment 164.
  • the first section 232 is primed by gravity since the saline solution is free to flow by gravity through the saline conduit 237 to the first section 232.
  • a second section 235 of the arterial bloodline 234 (i.e. , post pump section) is primed by operation of the pump 241.
  • the first section 232 of the arterial bloodline 234 has an arterial line patient connector 238 and one end of the venous bloodline 236 has a venous line patient connector 240.
  • the arterial connector 238 and the venous connector 240 are in fluid communication with the open first end 12 of the accessory device 10 so that the priming solution drains into the accessory device 10.
  • a connector 242 is provided and is in fluid communication with a drain conduit 250 that fluidly connects to the conduit 170.
  • a waste pump 251 is disposed within the drain conduit 250 for withdrawing the priming solution from the accessory device 10 and then transporting the priming solution from the accessory device 10 to the conduit 170 where it is then delivered to the drain 180.
  • the waste pump 251 is operated at a higher speed than the rate of the saline infusion into the arterial bloodline 234 to keep the accessory device 10 from overflowing.
  • the shunt valve 199 remains closed while the drain outlet valve 179 remains open
  • Fig. 7 illustrates a system that is similar to the system of Fig. 6 except for the r 1 S ⁇ / ,,f , CsS- S O "
  • the arterial and venous bloodlines 234, 236 are connected to one another using a recirculation connector 260.
  • the blood pump 240 is operated in reverse at low speed. This causes dialysate fluid to be back-filtered across the semi-permeable membrane 162 into the blood compartment 164. In this manner, both the blood compartment 164 and the dialysate compartment 166 are filled with dialysate fluid.
  • the saline conduit 237 extending from the first section 232 is undamped from the saline bag (not shown) and is placed in fluid communication with the open first end 12 of the accessory device 10. If there is a vented cap on the end of the saline conduit 237, it can remain in place since it will allow passage of fluid but helps to keep the blood circuit sterile.
  • the accessory device 10 and the waste pump 251 drain the priming fluid as shown and described with reference to Fig. 6.
  • the advantage of the configuration illustrated in Fig. 7 is the automation aspect. A virtually unlimited supply of priming fluid can be pumped through the accessory device 10 without requiring any user monitoring. It will be appreciated by persons skilled in the art that the present invention is not limited to the embodiments described thus far with reference to the accompanying drawing. Rather the present invention is limited only by the following claims.

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  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Water Supply & Treatment (AREA)
  • External Artificial Organs (AREA)

Abstract

L'invention concerne un dispositif auxiliaire utilisé dans un système pour hémodialyse, qui est conçu de façon à exécuter plusieurs fonctions en relation avec le fonctionnement d'une machine d'hémodialyse, y compris comme cartouche-amorce.
PCT/US2005/018650 2004-05-28 2005-05-23 Amorçage de machine de dialyse polyvalente et dispositif de distribution d'une solution Ceased WO2005118485A1 (fr)

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US60/576,073 2004-05-28

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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008125893A1 (fr) 2007-04-12 2008-10-23 Gambro Lundia Ab Procédé et dispositif d'amorçage d'un circuit sanguin extracorporel
JPWO2014024972A1 (ja) * 2012-08-09 2016-07-25 日機装株式会社 血液浄化装置及びそのプライミング方法
WO2018036859A1 (fr) * 2016-08-20 2018-03-01 Fresenius Medical Care Deutschland Gmbh Dispositif et procédé pour préparer un liquide de dialyse et dispositif de dialyse
EP3290068A1 (fr) * 2016-08-30 2018-03-07 B. Braun Avitum AG Dispositif de filtration du type tamis pour un contenant en forme de cartouche
US10195336B2 (en) 2013-11-11 2019-02-05 Nikkiso Company Limited Blood purification apparatus and priming method thereof
CN109562218A (zh) * 2016-08-09 2019-04-02 日机装株式会社 血液净化装置和预充方法
US10610634B2 (en) 2015-05-21 2020-04-07 Nikkiso Company Limited Blood purification apparatus
US10625007B2 (en) 2015-06-24 2020-04-21 Nikkiso Company Limited Blood purification apparatus and blood purification system
WO2021067247A1 (fr) * 2019-09-30 2021-04-08 Fresenius Medical Care Holdings, Inc. Appareil de drainage pour machines d'hémodialyse
US11123463B2 (en) 2015-06-24 2021-09-21 Nikkiso Company Limited Blood purification apparatus
US11278655B2 (en) 2016-01-25 2022-03-22 Nikkiso Company Limited Blood purification apparatus
US11413387B2 (en) 2016-09-23 2022-08-16 Nikkiso Company Limited Blood purification apparatus
US11590334B2 (en) 2016-08-09 2023-02-28 Nikkiso Co., Ltd. Blood circuit adapter set and blood circuit
US11690942B2 (en) 2016-09-12 2023-07-04 Nikkiso Company Limited Blood purification apparatus with a bypass line that bypasses an ultrafiltration pump

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2694515A (en) * 1952-03-26 1954-11-16 United States Steel Corp Funnel device for filling containers
US5676185A (en) * 1996-05-14 1997-10-14 New Pig Corporation Vented drum funnel
US6103200A (en) * 1998-06-17 2000-08-15 Babashak; John Adapter assembly for scientific glassware

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2694515A (en) * 1952-03-26 1954-11-16 United States Steel Corp Funnel device for filling containers
US5676185A (en) * 1996-05-14 1997-10-14 New Pig Corporation Vented drum funnel
US6103200A (en) * 1998-06-17 2000-08-15 Babashak; John Adapter assembly for scientific glassware

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008125893A1 (fr) 2007-04-12 2008-10-23 Gambro Lundia Ab Procédé et dispositif d'amorçage d'un circuit sanguin extracorporel
AU2007350967B2 (en) * 2007-04-12 2012-04-12 Gambro Lundia Ab Method and apparatus for priming an extracorporeal blood circuit.
KR101148716B1 (ko) 2007-04-12 2012-07-04 감브로 룬디아 아베 체외 혈액 회로의 프라이밍 방법 및 장치
US8529487B2 (en) 2007-04-12 2013-09-10 Gambro Lundia Ab Method and apparatus for priming an extracorporeal blood circuit
US9186450B2 (en) 2007-04-12 2015-11-17 Gambro Lundia Ab Method and apparatus for priming an extracorporeal blood circuit
JP2019055267A (ja) * 2012-08-09 2019-04-11 日機装株式会社 血液浄化装置及びそのプライミング方法
US9872951B2 (en) 2012-08-09 2018-01-23 Nikkiso Company Limited Blood purification apparatus and priming method for the same
JPWO2014024972A1 (ja) * 2012-08-09 2016-07-25 日機装株式会社 血液浄化装置及びそのプライミング方法
US10195336B2 (en) 2013-11-11 2019-02-05 Nikkiso Company Limited Blood purification apparatus and priming method thereof
US10610634B2 (en) 2015-05-21 2020-04-07 Nikkiso Company Limited Blood purification apparatus
US10625007B2 (en) 2015-06-24 2020-04-21 Nikkiso Company Limited Blood purification apparatus and blood purification system
US11123463B2 (en) 2015-06-24 2021-09-21 Nikkiso Company Limited Blood purification apparatus
US11278655B2 (en) 2016-01-25 2022-03-22 Nikkiso Company Limited Blood purification apparatus
US11590334B2 (en) 2016-08-09 2023-02-28 Nikkiso Co., Ltd. Blood circuit adapter set and blood circuit
US11351293B2 (en) 2016-08-09 2022-06-07 Nikkiso Co., Ltd. Blood purification device and priming method
CN109562218A (zh) * 2016-08-09 2019-04-02 日机装株式会社 血液净化装置和预充方法
CN109562218B (zh) * 2016-08-09 2021-08-27 日机装株式会社 血液净化装置和预充方法
EP3498317A4 (fr) * 2016-08-09 2020-03-04 Nikkiso Co., Ltd. Dispositif de purification du sang et procédé d'amorçage
WO2018036859A1 (fr) * 2016-08-20 2018-03-01 Fresenius Medical Care Deutschland Gmbh Dispositif et procédé pour préparer un liquide de dialyse et dispositif de dialyse
US11305042B2 (en) 2016-08-20 2022-04-19 Fresenius Medical Care Deutschland Gmbh Device and method for preparing dialysis fluid and dialysis device
US10569235B2 (en) 2016-08-30 2020-02-25 B. Braun Avitum Ag Sieve-like filter unit for cartridge-shaped receptacle
CN107789869A (zh) * 2016-08-30 2018-03-13 B·布莱恩·阿维图姆股份公司 筒状容器的筛状过滤器单元
EP3290068A1 (fr) * 2016-08-30 2018-03-07 B. Braun Avitum AG Dispositif de filtration du type tamis pour un contenant en forme de cartouche
US11690942B2 (en) 2016-09-12 2023-07-04 Nikkiso Company Limited Blood purification apparatus with a bypass line that bypasses an ultrafiltration pump
US11413387B2 (en) 2016-09-23 2022-08-16 Nikkiso Company Limited Blood purification apparatus
WO2021067247A1 (fr) * 2019-09-30 2021-04-08 Fresenius Medical Care Holdings, Inc. Appareil de drainage pour machines d'hémodialyse
CN114450044A (zh) * 2019-09-30 2022-05-06 费森尤斯医疗保健控股公司 用于血液透析机器的排出设备
US11596721B2 (en) 2019-09-30 2023-03-07 Fresenius Medical Care Holdings, Inc. Drain apparatus for hemodialysis machines
US12070538B2 (en) 2019-09-30 2024-08-27 Fresenius Medical Care Holdings, Inc. Drain apparatus for hemodialysis machines
CN114450044B (zh) * 2019-09-30 2025-12-05 费森尤斯医疗保健控股公司 用于血液透析机器的排出设备

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