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WO2005118067A1 - Dispositif d'emission d'impulsions lumineuses intermittentes destine au traitement de troubles de la memoire - Google Patents

Dispositif d'emission d'impulsions lumineuses intermittentes destine au traitement de troubles de la memoire Download PDF

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Publication number
WO2005118067A1
WO2005118067A1 PCT/EP2005/052376 EP2005052376W WO2005118067A1 WO 2005118067 A1 WO2005118067 A1 WO 2005118067A1 EP 2005052376 W EP2005052376 W EP 2005052376W WO 2005118067 A1 WO2005118067 A1 WO 2005118067A1
Authority
WO
WIPO (PCT)
Prior art keywords
timer
frequency
light
integrated circuit
circuit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2005/052376
Other languages
English (en)
Inventor
Adolfo Porro
Francesco Ferro Milone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2005118067A1 publication Critical patent/WO2005118067A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0618—Psychological treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645—Applicators worn by the patient
    • A61N2005/0647—Applicators worn by the patient the applicator adapted to be worn on the head
    • A61N2005/0648—Applicators worn by the patient the applicator adapted to be worn on the head the light being directed to the eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes

Definitions

  • the present invention is about a device for emission of intermittent light pulses to be used for treating memory troubles. Recent researches have led to believe that memory troubles, affecting people 5 starting from the age of 60-70, are originated by a gradual, inevitable and progressive loss of the contacts between cerebral cortex neurons, said contacts being called synapses in scientific terminology. It is known that the synapses generate an electrical activity In the brain, detectable through an electro-encephalogram (EEG).
  • EEG electro-encephalogram
  • the electro-encephalogram shows a basic rhythm in an awake adult person in psychosensorial rest conditions that is called ⁇ rhythm and that is shown in the electro-encephalogram by an essentially sinusoidal wave.
  • the electro-encephalogram analysis in volunteer persons 20 submitted to specific tests has led some researchers to demonstrate that particular functions of the explicit (semantic and episodic) memory are accompanied with specific modifications of the electro-encephalogram frequencies.
  • the specific cognitive functions and the ⁇ rhythm frequencies there is a precise relationship between the specific cognitive functions and the ⁇ rhythm frequencies: the lower band of the ⁇ rhythm (9,9-7,4 Hz) reflects cognitive functions not related to an objective, i.e. the expectation and attention functions, while the upper band (9,9-12,4 Hz) reflects cognitive processes related to an objective.
  • the neural bases of the memory can be summed up in two general principles, i.e.
  • memory comprises different stages and it is localized in different regions of the nervous system.
  • memory can be subdivided in implicit and explicit memory, according to the way the required information is stored and recalled, and this 35 involves the intervention of different neuronal circuits. More particularly, the explicit memory involves the intervention of the medial temporal lobe system, while the implicit memory involves the intervention of different perceptive and reflected channels which also comprise amygdale and cerebellum.
  • the effects of not configured stimulations to activate the electroencephalogram, like for instance the light stimulation, are known. This stimulation has been used up to now to make alterations in the ⁇ rhythms that allow to make diagnosis of particular pathologies, like for instance the light-sensitive epilepsy.
  • the ⁇ rhythm frequency has a well defined peak in a young and healthy person, for instance of 10 Hz at the age of 20, in aged persons the ⁇ frequency peak tends to be fragmented into more peaks always shifted downward, for instance near 7 Hz or 8 Hz.
  • the dominant peak is for instance of 8 Hz, lower but anyway relevant frequency peaks are present in the electro-encephalographic diagram of the ⁇ waves in the range of 8 Hz, for instance 7,5 Hz and 8,3 Hz.
  • the main object of the invention is thus to provide for a device for emission of light pulses, with preset switching on/switching off frequencies, able to treat memory troubles and to significantly modify the ⁇ rhythm amplitude in the electro-encephalographic diagram.
  • Another object is that the device of the invention is very simple, little expensive and feasibly usable by any person, even in the most different environmental conditions.
  • Still another object of the invention is to provide for a device as mentioned above which is able to prevent, as well as to treat, memory troubles, especially at the Alzheimer disease onset, and to allow a simple and easy treatment, even at home, for all those persons who want to be submitted to the light stimulation treatment.
  • a device for emission of intermittent light pulses to be used for treating memory troubles comprising a circuit consisting of:
  • said circuit being characterized in that said at least a light emitter works with intermittent switching on/switching off at a frequency comprised between 7 and 14 Hz, said emitted light waves interacting with the waves emitted by the brain neuronal activity.
  • the support for the circuit of the device of the invention is housed on a spectacle frame. It is a part of the invention too a spectacle frame which supports the device of the invention and has the front area, generally reserved to the sight, obscured.
  • the device of the invention can be easily used by the person under treatment, since it essentially consists of a pair of obscured spectacles having, instead of the lenses, an electronic device with at least two luminous LEDs disposed in front of the eyeballs when the spectacles are worn.
  • the device of the invention allows to select the switching on/switching off frequencies of the light sources in a variable range between 7,4 and 12,4 Hz.
  • the device is of the kind suitable for emitting a series of intermittent light pulses of different frequencies, each of said frequency being maintained for a prefixed time interval.
  • a treatment of the kind described above can be repeated several times, for instance two or three times a day for 10 or 20 days.
  • the device is efficient, especially as a preventive treatment, by operating with a series of preset frequencies emitted according to a predetermined sequence.
  • the device of the invention could be programmed to be switched on/switched off at the peak frequency only which, in any case, is always comprised in the interval between 7,4 and 12,4 Hz and it is maintained every time for a time interval considered to be optimal for the treatment.
  • FIG. 1 shows a circuit diagram of the device of the invention provided with a timer and a commutator
  • - Figure 2 shows the circuit of Figure 1 , provided as well with a counter to maintain the intermittency frequencies of the light pulses according to predetermined time intervals;
  • FIG. 3 shows a further embodiment of the diagram of the device of the invention, in which an integrated circuit is provided having the functions of remotely programmable counter and timer;
  • - Figure 4 shows a diagram of three frequencies which can be achieved with the device of the invention.
  • FIG. 5 shows a spectacle frame provided with the device of the invention.
  • the device for emission of intermittent light pulses of the invention comprises:
  • a battery 1 for example of 3 Volts nickel cadmium type,
  • the timer is connected to the LEDs 5, 6 and it is able to properly feed said LEDs with a switching on/switching off intermittent frequency which can be set through the commutator 4.
  • the commutator 4 in a certain selected position, activates the internal circuits of the timer 3, which is a component known per se, like for instance an astable multi-vibrator, enabling said timer to be switched on and switched off with an intermittent frequency, for example 7,4 Hz.
  • the timer 3 which is a component known per se, like for instance an astable multi-vibrator, enabling said timer to be switched on and switched off with an intermittent frequency, for example 7,4 Hz.
  • the connections in the timer 3 pins change too, so that the intermittence frequency to be set in the timer is modified, for instance from 7 to 10 or 12 Hz.
  • a counter which sets the activation time of a certain frequency rather than another is not present.
  • a counter 7 is present too, actuating for a certain prefixed time interval the commutator 4, which in its turn sets the intermittence frequency emitted by the timer 3.
  • the counter 7 causes the commutator 4 to be switched and the count of another time t2 starts, while the commutator changes its position so that the timer 3 emits a frequency f2 different from f1.
  • the counter can be of sequential type, with preset times, so that it can count, for instance, a time t1 at first, then a time t2 and then another time t3.
  • the current passes from the counter to the commutator, so that the latter trips and moves forward of one position, in order to activate the timer according to different frequencies ft, f2, f3 respectively. Since the timer feeds the LEDs 5, 6, these will be lighted at the frequency f1 for a time t1, at the frequency 2 for a time t2 and at the frequency f3 for a time t3.
  • the frequencies can be selected according to discrete steps (for instance from 7,4 Hz up to 12,4 Hz, with increments of 0,5 Hz, or they can vary with continuity).
  • the devices described above and shown in Figures 1 and 2, being able to sequentially emit different frequencies, are particularly suitable for treatments of preventive kind, with the purpose to avoid or to reduce the onset of memory troubles.
  • Said devices can be advantageously used by persons who have never been submitted to an electro-encephalogram, so that they don't know the ⁇ frequency of their own cerebral waves.
  • FIG. 3 A more advanced solution for the device of the invention is shown in Figure 3, where the counter, the commutator and the timer are replaced by an integrated circuit 8, programmable for instance through a computer 9.
  • the integrated circuit can also consist of a microprocessor. Therefore, through a proper software installed in the computer 9, the integrated circuit 8 can be set so that, according to the patient needs, the device emits light pulses at the peak frequency characteristic of the patient's ⁇ diagram.
  • the integrated circuit Once the integrated circuit has been programmed, it is able to perform its function, thus it is sufficient to operate the switch 2 in order to start the switching on/switching off sequence according to what has been set in the integrated circuit.
  • the LEDs 5, 6 are consequently activated, with the programmed intermittence frequencies and at the programmed times.
  • the frequency of the device could be modified by programming the integrated circuit 8, through the connection cable 91, with the computer 9 or with an equivalent means, in order to set the frequency at that having a more positive and stable response.
  • Figure 3 is a device programmable on the specific ⁇ rhythm frequency of the person to be submitted to the treatment.
  • said device can be customized according to the needs of every person, being sufficient to program the desired frequency on the integrated circuit 8.
  • Figure 4 is shown by way of example the diagram of a possible use of one of the devices of the invention, in which light pulses at the frequency of 7,5 Hz for a time t1 are initially emitted; pulses at 10 Hz for a time t2 and then at
  • the spectacles 10 comprise the support 11 for the electric circuit of the device of the invention.
  • Said support is essentially made of an insulating foil applied in place of the lenses and stably connected to the front part of the frame.
  • the support 11 of the circuit is provided with the battery 12, the switch 13 and the integrated circuit 14 from which the electric connections to feed the LEDs 5, 6 start.
  • the integrated circuit 14 is programmable through two pins 16, 17 that can be connected to a programming means, like the computer 9.
  • the integrated circuit is consequently programmed, setting the frequency as well as the duration time of each treatment.
  • the radiating energy of the LEDs should not exceed 200 mJoules, for evident reasons of a possible photo-stress in case of an uncontrolled radiation arises during the treatment.

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  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Social Psychology (AREA)
  • Developmental Disabilities (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

La présente invention concerne un dispositif d'émission d'impulsions lumineuses intermittentes comprenant un circuit constitué : d'au moins un générateur de tension directe (1,10), d'au moins un synchroniseur (3) destiné à émettre une onde de tension essentiellement par impulsions à une ou plusieurs fréquences préfixées, d'au moins un émetteur de lumière (5,6) alimenté par cette onde de tension essentiellement par impulsions, d'un commutateur (2) et d'un support (11) pour ce circuit. Cet émetteur de lumière (5,6) fonctionne avec une commutation allumée/commutation coupée intermittente à une fréquence comprise entre 7 et 2,4 Hz, de sorte que les ondes lumineuses émises interagissent avec une caractéristique d'onde de l'activité neuronale du cerveau. Dans un mode de réalisation de cette invention, ce dispositif est supporté par une monture de lunettes.
PCT/EP2005/052376 2004-05-26 2005-05-24 Dispositif d'emission d'impulsions lumineuses intermittentes destine au traitement de troubles de la memoire Ceased WO2005118067A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITVI2004A000131 2004-05-26
ITVI20040131 ITVI20040131A1 (it) 2004-05-26 2004-05-26 Dispositivo per l'emissione di impulsi luminosi intermittenti

Publications (1)

Publication Number Publication Date
WO2005118067A1 true WO2005118067A1 (fr) 2005-12-15

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IT (1) ITVI20040131A1 (fr)
WO (1) WO2005118067A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8025687B2 (en) 2003-01-24 2011-09-27 Photothera, Inc. Low level light therapy for enhancement of neurologic function
US8149526B2 (en) 2008-09-18 2012-04-03 Photothera, Inc. Single use lens assembly
US8308784B2 (en) 2006-08-24 2012-11-13 Jackson Streeter Low level light therapy for enhancement of neurologic function of a patient affected by Parkinson's disease
US9731092B2 (en) 2009-06-05 2017-08-15 Engelbert WINKLER Light treatment apparatus
US10188872B2 (en) 2006-01-30 2019-01-29 Pthera LLC Light-emitting device and method for providing phototherapy to the brain
US10342986B2 (en) 2012-04-06 2019-07-09 Kosivana Holdings Limited Frequency specific sensory stimulation
US10758743B2 (en) 2001-11-01 2020-09-01 Pthera LLC Method for providing phototherapy to the brain
WO2022216853A1 (fr) * 2021-04-07 2022-10-13 Into Technologies Inc. Systèmes et procédés de traitement d'indications médicales par l'administration de doses de lumière et de son

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3823402A1 (de) * 1988-07-09 1990-01-25 Lutz Mehlhorn Lern-entspannungsvorrichtung
EP0412629A1 (fr) * 1989-08-10 1991-02-13 Pioneer Electronic Corporation Système pour provoquer des signaux d'electro-encéphalogramme
US5092669A (en) * 1990-03-16 1992-03-03 Migra Limited Optical device and method for using same
US5242376A (en) * 1990-10-09 1993-09-07 21St Century Holdings, Inc. Relaxation device and method
US5409445A (en) * 1992-05-05 1995-04-25 Rubins; Tye Brain wave synchronizer
US5709645A (en) * 1996-01-30 1998-01-20 Comptronic Devices Limited Independent field photic stimulator
DE29720970U1 (de) * 1997-11-26 1998-02-05 Cheng Chun Chih Gehirnwellenanregungsgerät

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3823402A1 (de) * 1988-07-09 1990-01-25 Lutz Mehlhorn Lern-entspannungsvorrichtung
EP0412629A1 (fr) * 1989-08-10 1991-02-13 Pioneer Electronic Corporation Système pour provoquer des signaux d'electro-encéphalogramme
US5092669A (en) * 1990-03-16 1992-03-03 Migra Limited Optical device and method for using same
US5242376A (en) * 1990-10-09 1993-09-07 21St Century Holdings, Inc. Relaxation device and method
US5409445A (en) * 1992-05-05 1995-04-25 Rubins; Tye Brain wave synchronizer
US5709645A (en) * 1996-01-30 1998-01-20 Comptronic Devices Limited Independent field photic stimulator
DE29720970U1 (de) * 1997-11-26 1998-02-05 Cheng Chun Chih Gehirnwellenanregungsgerät

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10758743B2 (en) 2001-11-01 2020-09-01 Pthera LLC Method for providing phototherapy to the brain
US8167921B2 (en) 2003-01-24 2012-05-01 Jackson Streeter Low level light therapy for enhancement of neurologic function
US8025687B2 (en) 2003-01-24 2011-09-27 Photothera, Inc. Low level light therapy for enhancement of neurologic function
US9795803B2 (en) 2003-01-24 2017-10-24 Pthera LLC Low level light therapy for enhancement of neurologic function
US10188872B2 (en) 2006-01-30 2019-01-29 Pthera LLC Light-emitting device and method for providing phototherapy to the brain
US12303709B2 (en) 2006-01-30 2025-05-20 Pthera, Llc Light-emitting device and method for providing phototherapy to the brain
US11179572B2 (en) 2006-01-30 2021-11-23 Pthera LLC Light-emitting device and method for providing phototherapy to the brain
US8308784B2 (en) 2006-08-24 2012-11-13 Jackson Streeter Low level light therapy for enhancement of neurologic function of a patient affected by Parkinson's disease
US10071259B2 (en) 2008-09-18 2018-09-11 Pthera, Llc Optical assembly
US8149526B2 (en) 2008-09-18 2012-04-03 Photothera, Inc. Single use lens assembly
US9731092B2 (en) 2009-06-05 2017-08-15 Engelbert WINKLER Light treatment apparatus
US10342986B2 (en) 2012-04-06 2019-07-09 Kosivana Holdings Limited Frequency specific sensory stimulation
WO2022216853A1 (fr) * 2021-04-07 2022-10-13 Into Technologies Inc. Systèmes et procédés de traitement d'indications médicales par l'administration de doses de lumière et de son

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