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WO2005115338A3 - Macromolecular gsh-activated glyoxylase i inhibitors - Google Patents

Macromolecular gsh-activated glyoxylase i inhibitors Download PDF

Info

Publication number
WO2005115338A3
WO2005115338A3 PCT/US2005/013361 US2005013361W WO2005115338A3 WO 2005115338 A3 WO2005115338 A3 WO 2005115338A3 US 2005013361 W US2005013361 W US 2005013361W WO 2005115338 A3 WO2005115338 A3 WO 2005115338A3
Authority
WO
WIPO (PCT)
Prior art keywords
gsh
activated
macromolecular
glyoxylase
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/013361
Other languages
French (fr)
Other versions
WO2005115338A2 (en
Inventor
Donald J Creighton
Zhe-Bin Zheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Maryland Baltimore County UMBC
University of Maryland College Park
Original Assignee
University of Maryland Baltimore County UMBC
University of Maryland College Park
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Maryland Baltimore County UMBC, University of Maryland College Park filed Critical University of Maryland Baltimore County UMBC
Priority to US11/587,160 priority Critical patent/US20070287672A1/en
Publication of WO2005115338A2 publication Critical patent/WO2005115338A2/en
Publication of WO2005115338A3 publication Critical patent/WO2005115338A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface

Landscapes

  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

This invention relates to macromolecular prodrugs having antitumor activity when activated by GSH, and methods for synthesizing and administering these to patients. More particularly, this invention relates to, inter alia, the synthesis and use of polyacrylamide carriers to target anticancer prodrugs to tumors, and to release active antitumor agents selectively in tumor cells. These active antitumor agents target the active site of the methylglyoxal-detoxifying enzyme glyoxalase I to thereby cause tumor regression.
PCT/US2005/013361 2004-04-20 2005-04-20 Macromolecular gsh-activated glyoxylase i inhibitors Ceased WO2005115338A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/587,160 US20070287672A1 (en) 2004-04-20 2005-04-20 Macromolecular Gsh-Activiated Glyoxylase I Inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56386404P 2004-04-20 2004-04-20
US60/563,864 2004-04-20

Publications (2)

Publication Number Publication Date
WO2005115338A2 WO2005115338A2 (en) 2005-12-08
WO2005115338A3 true WO2005115338A3 (en) 2006-02-16

Family

ID=35451372

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/013361 Ceased WO2005115338A2 (en) 2004-04-20 2005-04-20 Macromolecular gsh-activated glyoxylase i inhibitors

Country Status (1)

Country Link
WO (1) WO2005115338A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106146612B (en) * 2015-04-17 2019-09-27 成都大学 A class of glyoxalase I irreversible inhibitors and their preparation methods and uses
CN113101278B (en) * 2021-04-14 2023-05-26 中山大学附属第七医院(深圳) Targeting nanoparticle with GSH and esterase tumor microenvironment dual response and preparation method and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616563A (en) * 1992-12-07 1997-04-01 University Of Maryland Baltimore Campus Glutathione N-hydroxycarbamoyl thioesters and method of inhibiting neoplastic growth
US5969174A (en) * 1998-01-07 1999-10-19 University Of Maryland At Baltimore County Competitive inhibitors of glyoxalase I and method of generating such competitive inhibitors inside tumor cells

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616563A (en) * 1992-12-07 1997-04-01 University Of Maryland Baltimore Campus Glutathione N-hydroxycarbamoyl thioesters and method of inhibiting neoplastic growth
US5969174A (en) * 1998-01-07 1999-10-19 University Of Maryland At Baltimore County Competitive inhibitors of glyoxalase I and method of generating such competitive inhibitors inside tumor cells

Also Published As

Publication number Publication date
WO2005115338A2 (en) 2005-12-08

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