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WO2005115088A2 - Generateur de nanoparticules et procede de production de nanoparticules au moyen dudit generateur - Google Patents

Generateur de nanoparticules et procede de production de nanoparticules au moyen dudit generateur Download PDF

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Publication number
WO2005115088A2
WO2005115088A2 PCT/IL2005/000548 IL2005000548W WO2005115088A2 WO 2005115088 A2 WO2005115088 A2 WO 2005115088A2 IL 2005000548 W IL2005000548 W IL 2005000548W WO 2005115088 A2 WO2005115088 A2 WO 2005115088A2
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WO
WIPO (PCT)
Prior art keywords
aerosol
particles
nano
sleeve
generator
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Ceased
Application number
PCT/IL2005/000548
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English (en)
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WO2005115088A3 (fr
Inventor
Dror Halevi
Dimitry Dobson
Arik Ran
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Individual
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Individual
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Publication of WO2005115088A2 publication Critical patent/WO2005115088A2/fr
Anticipated expiration legal-status Critical
Publication of WO2005115088A3 publication Critical patent/WO2005115088A3/fr
Ceased legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops

Definitions

  • the present invention generally relates to a nano particle generator and to a method for generating nano particles by said device.
  • Micro particle manufacturing is currently provided by various solvent-ousting techniques, some of them are known as "wet technology". These techniques are of only limited use in the preparation of sub-micron and nano-particles, due to filtration problems and agglomeration of the colloid systems.
  • Air, electric field, and ultrasound sputtering are commonly used to obtain finely dispersed aerosols.
  • Air dispersion involves with a vigorous mixing of a thin liquid jet and a high-energy gas flow. This cost effective and high capacity technique can be implemented for the sputtering of relatively viscous liquids.
  • the aerosol is widely dispersed and hence rarely provided thus for nano-particle manufacture.
  • Ultrasound (i.e., US) technique for dispersion of liquids is being widely used in various engineering branches, including air humidity control in premises, painting, mass spectrometric devices, etc. Aerosol US generators are being large-scale manufactured, and possess wide capacity and particle size range.
  • WO Pat. Appl. No. 02056866 to Watanabe et al. discloses a method for the preparation of nano-particles an aerosol ultrasound generator, hereinafter denoted by the term 'nebulizer', which is equipped with aerosol drying system, having optimal configuration and temperature field intensity.
  • this method and means is characterized by an insufficient capacity and resulted with only inadequate yield of particle size of the nano range.
  • ultrasonic dispersion provides for an aerosol of low bipolar electric charge, characterized by a Coulomb interaction, coagulation, and thus by a wide dispersion of the particle size.
  • US Pat. No. 5,247,842 to Kaufman et al. introduces an electro-spray nebulizer generates an aerosol comprised of sub micron and uniform droplets.
  • a liquid sample is supplied at a controlled rate to a capillary needle of the nebulizer, and droplets are formed due to an electrical field in the region about the needle discharge.
  • the tendency of the droplets to disintegrate due to Coulomb forces is counteracted by sources of ionizing radiation within the nebulizer.
  • the ions reduce the charge in each droplet while solvent evaporation reduces the diameter of the droplet.
  • a controlled air sheath was introduced to the nebulizer for transporting droplets more rapidly downstream.
  • the particle size comprising a known liquid composition is determined by the electric field applied on said particle and by stabilizing forces, such as the particle's surface tension etc.
  • stabilizing forces such as the particle's surface tension etc.
  • Fig. 1 schematically shows a lateral cross section one of the embodiments of nano particle generation device, wherein the ultrasound nebulizer is used as the aerosol source;
  • Fig. 2 displays an alternative device embodiment with a modified charging unit
  • FIG. 3 displays alternative device embodiment with a modified charging unit and aerosol source; and, Figure 4 schematically presents a design of the setup comprising two parallel operating nano-particle generators.
  • a cost effective and highly efficient nano-particle generator comprising an aerosol generation unit comprising an ultrasonic nebulizer adapted to generate an aerosol from gas feed; and an aerosol charging unit comprising a porous, gas-permeable, electrically conductive sleeve, and at least one corona electrode; said sleeve is grounded and barriered in its both sides by a plurality of insulation rings and contact discs connected to a high-voltage source; said electrode is adapted to be electrically communicated with a high-voltage source via said contact discs.
  • the generator is provided in the manner that when the setup is energized, gas flow and/or gas flow enriched with solvent fumes enters said charging unit so that large aerosol drops are deposited and returned to the stock solution, an efficient corona discharge is generated between said corona electrode and the walls of said sleeve, generated ions are combined with the particles of the aerosol in the manner that a homogeneously dispersed aerosol are obtained. Moreover, wherein interactions between said charged aerosol particles and the applied electric field are resulted by the drift of the obtained nano particles towards said sleeve walls; gas- solvent mixture that filters through the porous walls of said sleeve creates an air dynamic barrier, which prevents particle sedimentation.
  • the gas fed to the nebulizer is enriched with solution-constituent solvent fumes; and/or wherein the sleeve is made of materials selected from sintered stainless steel, bronze, metal-covered polymers or any combination thereof.
  • the aforesaid corona electrode may be a needle.
  • the hereto-defined generator additionally comprising an aerosol-drying unit comprising a heat source.
  • the drying unit is possibly made of materials selected from aluminum or aluminum-containing alloys.
  • the heat source is selected in a non-limiting manner from a heated gas stream; an ohmic heat module or any combination thereof.
  • means for encapsulating nano or micro particles comprising a mixing chamber in communication with a first nano- particle generator and a second nano-particle generator; said first generator is adapted for the preparation of aerosol particles with relatively large diameter and negative charge and comprising a aerosol generation unit and a aerosol charging unit; said second generator is adapted to produce dry positively charged nano-particles with respectively smaller diameter, and it comprising a aerosol generation unit, a aerosol charging unit and an aerosol drying unit; wherein particle fluxes obtained from said first and second generator are directed to said mixing chamber in the manner that particles of reciprocal surface charges are forced to merge together so that liquid particles comprising polymer solution are incorporated with solid particles.
  • It is another object of the present invention to present a novel method for generating nano-particles comprising the steps of generating an aerosol by means of a an aerosol generation unit comprising an ultrasonic nebulizer adapted to generate an aerosol from gas feed; charging the aerosol obtained in the previous step by a means of an aerosol charging unit comprising a porous, gas-permeable, electrically conductive sleeve, and at least one corona electrode, wherein said sleeve is grounded and barriered in its both sides by a plurality of insulation rings and contact discs connected to a high-voltage source, and wherein said electrode is adapted to be electrically communicated with a high-voltage source via said contact discs.
  • the aforesaid method for generating nanoparticles is especially preferably provided by means of the aerosol generator as defined in any of the above.
  • the method may additionally comprise of the step of drying the charged aerosol by a means of an aerosol-drying unit comprising a heat source.
  • a method for encapsulating nano or micro particles is hereto provided useful by a means of a device comprising a mixing chamber in communication with a first nano-particle generator and a second nano-particle generator; said first generator is adapted for the preparation of aerosol particles with relatively large diameter and negative charge and comprising a aerosol generation unit and a aerosol charging unit; said second generator is adapted to produce dry positively charged nano-particles with respectively smaller diameter, and it comprising a aerosol generation unit, a aerosol charging unit and an aerosol drying unit.
  • the method hence mat comprise of the steps of directing particle fluxes obtained from the first and second generator towards the mixing chamber so that particles of reciprocal surface charges are forced to merge together so that liquid particles comprising polymer solution are incorporated with solid particles.
  • Aerosol obtained in this manner is generally characterized by significant wide fraction size distribution, wherein average particle size is relatively large. Narrow distribution is obtained however, when maximal charging level is introduced for a sufficient long period and particles are of a single charge density.
  • Equation (] shows that the diffusion mechanism predominates over impact mechanism, provided that D grad n » n k E.
  • FIG 1 wherein the device according to one embodiment of the present invention is schematically presented in its lateral cross section view.
  • Aforesaid elongated and typically rounded tube-like assembly comprises inter alia the following three functional segments: aerosol generation unit 10, aerosol charging unit 20, and aerosol drying unit 30. All above specified elements are preferentially cylindrical and are situated consecutively inside common housing 40.
  • Aforementioned drying unit (30) outlet aperture comprising a circular electrode 50 adapted to generate external electric field.
  • Electrode 50 may alternatively be knife-like or needle-shaped and is under positive or negative polarity potential.
  • Aerosol generation unit 10 comprises disc-shaped US nebulizer 1 1 mounted on sealed membrane 12, which may be an integrated part of housing 40.
  • Nebulizer 1 1 forms aerosol at chamber 13 that comprises a plurality (e.g., two) of lateral orifices.
  • Orifice 14 serves for solution feeding inlet and is in communication with a feeder.
  • a pump may be used, wherein syringe pump, peristaltic pump or hydrostatic feeder are applicable.
  • Orifice 15 is the gas-feeding inlet of chamber 13. Air, nitrogen, or any alternative inert gases can be used, preferably at ambient temperature. It is in the scope of the present invention wherein a gas, e.g., nitrogen, is enriched with solution- constituent solvent fumes.
  • a nebulizer is thus an aerosol generation of high capacity and admissible disperse phase features; nevertheless, alternative solutions are acceptable.
  • Fig. 3 presents the device comprising electrostatic atomizer 16 with corona capillary 17. Electrical sputtering with pre-charging, air sputtering, etc. can be implemented as well.
  • Aerosol charging unit 20 comprises cylindrical sleeve 21 made of porous, gas- permeable, electrically conductive, and chemically resistant to organic-solvent-fume- medium agents. Sintered stainless steel, bronze and/or metal-covered polymers are preferable.
  • Sleeve 21 is grounded and barriered in its both sides by insulation rings 22 and contact discs 23 connected to high-voltage source.
  • Contact discs 23 are shaped as a ring comprising one or more thin diameter and centered ribs. Thus, contact discs 23 have wide central orifice and exhibit low air dynamic resistance to aerosol flow but at the same time they can be used for corona electrode 24 mounting between them, its location coinciding with sleeve 21 longitudinal symmetry axis.
  • Corona electrode 24 is preferably made of thin metal wire, platinum for example, and connected to the high-voltage source via contact discs.
  • the surfaces of sleeve 21 , housing 40, and insulation discs 22 form a supercharge chamber 25 having an inlet 26 for gas feeding.
  • Drying unit 30 comprises inter alia tube 31 which is a metal thin-walled, i.e., aluminum or aluminum-containing alloys.
  • the exterior surface of tube 31 is comprised of a plurality of ribs 32 adapted to form a spiral-shaped heat exchange chamber 33 in housing wall 40.
  • Heat exchange chamber comprising inlet 34 and outlet 35 for hot air passage, the air being heat carrier.
  • gas flow enriched with solvent fumes is fed via orifice 15 and enters the charging unit 20.
  • large aerosol drops are deposited and returned to the stock solution.
  • a strong corona discharge is generated between the electrode and the walls of grounded cylinder sleeve 21 as voltage of about 10 kW is supplied to corona electrode 24.
  • Generated ions are combined with the particles of the aerosol in the manner that a homogeneously dispersed aerosol is obtained.
  • the medium is saturated with solvent fumes so the drops are not dried. Interactions between charged aerosol particles and the applied electric field are resulted by the drift of the particles towards sleeve 21 walls.
  • Gas-solvent mixture that filters through the porous walls of sleeve 21 creates an air dynamic barrier, which prevents particle sedimentation, and carries them, together with the gas supplied from chamber 13, into the drying chamber 30 inner volumes.
  • a 10-fold to 100-fold decrease in particle sizes usually occurs during drying, and the disperse phase dry fraction is produced.
  • the excessive electric charge ionizes air-gas mixture and subsequently removed outside.
  • the particles obtained can be of immediate use in coating of diversified surfaces, or can be trapped by different-design filters, cyclones, scrubbers, electrostatic graders, etc.
  • Fig. 4 is schematically presenting a setup comprising two parallel operating nano- particle generators.
  • One of the generators (A) is adapted for the preparation of aerosol particles with relatively large diameter and negative charge out of polymer solution (e.g., cellulose acetate phthalate).
  • Generator does not include a drying unit.
  • a second generator (B) produces dry positively charged nano-particles (e.g., paracetamol) with respectively smaller diameter. Both particle fluxes are directed to a mixing chamber so that flux tabulation and curving by means of deflectors are obtained.

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

L'invention concerne un générateur de nanoparticules comprenant une unité génératrice d'aérosol pourvue d'un nébuliseur à ultrasons, permettant de générer un aérosol à partir d'une charge gazeuse, et une unité de charge d'aérosol comprenant une manchon poreux conducteur d'électricité, perméable au gaz, et au moins une électrode à effet couronne. Le manchon est mis à la masse, et isolé des deux côtés par une pluralité d'anneaux isolants et des disques de contact raccordés à une source haute tension. L'électrode est conçue pour être raccordée électriquement à la source par l'intermédiaire des disques de contact. Lorsque l'ensemble est mis sous tension, un flux gazeux éventuellement enrichi par des vapeurs de solvant pénètre dans l'unité de charge, de manière à provoquer le dépôt des gouttelettes d'aérosol de grande taille, qui sont renvoyées dans la réserve de solution. Une décharge en couronne efficace est produite entre l'électrode et la solution. Les ions générés sont combinés aux particules d'aérosol de manière à permettre l'obtention de nanoparticules d'aérosol à dispersion homogène. Sous l'effet des interactions entre les nanoparticules d'aérosol chargées et le champ électrique appliqué, les nanoparticules produites sont entraînées vers les parois du manchon. Un mélange gaz-solvant passant à travers les parois poreuses dudit manchon, crée une barrière d'air dynamique empêchant la sédimentation des particules.
PCT/IL2005/000548 2004-05-27 2005-05-29 Generateur de nanoparticules et procede de production de nanoparticules au moyen dudit generateur Ceased WO2005115088A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL16219504A IL162195A0 (en) 2004-05-27 2004-05-27 Nano particle generator and a method for generating nano particles by said device
IL162195 2004-05-27

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WO2005115088A2 true WO2005115088A2 (fr) 2005-12-08
WO2005115088A3 WO2005115088A3 (fr) 2007-01-18

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2364783A1 (fr) * 2010-03-10 2011-09-14 Msp Corporation Ioniseur électrique pour conditionnement et mesure de charge d'aérosol
WO2012001210A1 (fr) * 2010-06-29 2012-01-05 Beneq Oy Appareil et procédé de charge de nanoparticules
CN102703316A (zh) * 2012-05-28 2012-10-03 天津开发区合普工贸有限公司 细胞暴露在纳米颗粒气溶胶中的实验设备
WO2014010803A1 (fr) * 2012-07-13 2014-01-16 서울대학교산학협력단 Élément optique utilisant une structure tridimensionnelle assemblée ayant des nanoparticules
WO2014186783A1 (fr) * 2013-05-17 2014-11-20 Birmingham Joseph G Laminage par électropulvérisation de dépôts de nanograins
WO2015048904A1 (fr) * 2013-10-03 2015-04-09 Ebed Holdings Inc. Solutions liquides contenant des nanobulles
US9222190B2 (en) 2012-07-13 2015-12-29 Snu R&Db Foundation 3-dimensional nanoparticle assembly structure and gas sensor using same
US9321633B2 (en) 2012-07-13 2016-04-26 Global Frontier Center For Multiscale Energy Systems Process for producing 3-dimensional structure assembled from nanoparticles
US9349976B2 (en) 2012-07-13 2016-05-24 Snu R&Db Foundation Process for preparing nanoparticle embedded electronic device
CN107715789A (zh) * 2017-10-23 2018-02-23 中国石油大学(北京) 一种制备聚合物颗粒的新方法及装置

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2701764A (en) * 1951-05-02 1955-02-08 Chester F Carlson Electrophotographic apparatus and methods
US5196171A (en) * 1991-03-11 1993-03-23 In-Vironmental Integrity, Inc. Electrostatic vapor/aerosol/air ion generator
US5247842A (en) * 1991-09-30 1993-09-28 Tsi Incorporated Electrospray apparatus for producing uniform submicrometer droplets

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2364783A1 (fr) * 2010-03-10 2011-09-14 Msp Corporation Ioniseur électrique pour conditionnement et mesure de charge d'aérosol
EP2589436A1 (fr) * 2010-03-10 2013-05-08 Msp Corporation Ioniseur électrique pour conditionner et mesurer une charge d'aérosol
EP3766585A1 (fr) * 2010-03-10 2021-01-20 Msp Corporation Ioniseur électrique pour conditionner et mesurer une charge d'aérosol
EP3305411A1 (fr) * 2010-03-10 2018-04-11 Msp Corporation Ioniseur électrique pour conditionner et mesurer une charge d'aérosol
US9764333B2 (en) 2010-03-10 2017-09-19 Msp Corporation Electrical ionizer for aerosol charge conditioning and measurement
WO2012001210A1 (fr) * 2010-06-29 2012-01-05 Beneq Oy Appareil et procédé de charge de nanoparticules
CN102985186A (zh) * 2010-06-29 2013-03-20 Beneq有限公司 将纳米颗粒充电的设备和方法
CN102703316A (zh) * 2012-05-28 2012-10-03 天津开发区合普工贸有限公司 细胞暴露在纳米颗粒气溶胶中的实验设备
CN103930364B (zh) * 2012-07-13 2015-12-09 首尔大学校产学协力团 采用3d纳米微粒结构体的光学装置
US9222190B2 (en) 2012-07-13 2015-12-29 Snu R&Db Foundation 3-dimensional nanoparticle assembly structure and gas sensor using same
US9321633B2 (en) 2012-07-13 2016-04-26 Global Frontier Center For Multiscale Energy Systems Process for producing 3-dimensional structure assembled from nanoparticles
US9349976B2 (en) 2012-07-13 2016-05-24 Snu R&Db Foundation Process for preparing nanoparticle embedded electronic device
CN103930364A (zh) * 2012-07-13 2014-07-16 首尔大学校产学协力团 采用3d纳米微粒结构体的光学装置
KR101349976B1 (ko) * 2012-07-13 2014-01-16 재단법인 멀티스케일 에너지시스템 연구단 나노입자로 조립된 3차원 구조물을 이용한 광학소자
WO2014010803A1 (fr) * 2012-07-13 2014-01-16 서울대학교산학협력단 Élément optique utilisant une structure tridimensionnelle assemblée ayant des nanoparticules
WO2014186783A1 (fr) * 2013-05-17 2014-11-20 Birmingham Joseph G Laminage par électropulvérisation de dépôts de nanograins
WO2015048904A1 (fr) * 2013-10-03 2015-04-09 Ebed Holdings Inc. Solutions liquides contenant des nanobulles
US10814290B2 (en) 2013-10-03 2020-10-27 Ebed Holdings Inc. Nanobubble-containing liquid solutions
CN107715789A (zh) * 2017-10-23 2018-02-23 中国石油大学(北京) 一种制备聚合物颗粒的新方法及装置
CN107715789B (zh) * 2017-10-23 2023-10-03 中国石油大学(北京) 一种制备聚合物颗粒的新方法及装置

Also Published As

Publication number Publication date
IL162195A0 (en) 2005-11-20
WO2005115088A3 (fr) 2007-01-18

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