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WO2005110046A3 - Method of enhancing uptake of keratinocyte growth factor - Google Patents

Method of enhancing uptake of keratinocyte growth factor Download PDF

Info

Publication number
WO2005110046A3
WO2005110046A3 PCT/US2005/016220 US2005016220W WO2005110046A3 WO 2005110046 A3 WO2005110046 A3 WO 2005110046A3 US 2005016220 W US2005016220 W US 2005016220W WO 2005110046 A3 WO2005110046 A3 WO 2005110046A3
Authority
WO
WIPO (PCT)
Prior art keywords
growth factor
keratinocyte growth
enhancing uptake
cells
uptake
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/016220
Other languages
French (fr)
Other versions
WO2005110046A2 (en
Inventor
Edward C Shinal
Robert G Ii Petit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aesgen Inc
Original Assignee
Aesgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aesgen Inc filed Critical Aesgen Inc
Publication of WO2005110046A2 publication Critical patent/WO2005110046A2/en
Publication of WO2005110046A3 publication Critical patent/WO2005110046A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Provided is a composition and a method for increasing cellular uptake of bioactive agents, particularly those compounds termed “small molecules” into the cells of mammalian tissue, such as the epithelial cells of the mucosa.
PCT/US2005/016220 2004-05-10 2005-05-09 Method of enhancing uptake of keratinocyte growth factor Ceased WO2005110046A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56970404P 2004-05-10 2004-05-10
US60/569,704 2004-05-10

Publications (2)

Publication Number Publication Date
WO2005110046A2 WO2005110046A2 (en) 2005-11-24
WO2005110046A3 true WO2005110046A3 (en) 2006-02-09

Family

ID=35394605

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/016220 Ceased WO2005110046A2 (en) 2004-05-10 2005-05-09 Method of enhancing uptake of keratinocyte growth factor

Country Status (1)

Country Link
WO (1) WO2005110046A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580856A (en) * 1994-07-15 1996-12-03 Prestrelski; Steven J. Formulation of a reconstituted protein, and method and kit for the production thereof
WO2000069470A2 (en) * 1999-05-17 2000-11-23 Aesgen, Inc. Improved cellular uptake of bioactive agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580856A (en) * 1994-07-15 1996-12-03 Prestrelski; Steven J. Formulation of a reconstituted protein, and method and kit for the production thereof
WO2000069470A2 (en) * 1999-05-17 2000-11-23 Aesgen, Inc. Improved cellular uptake of bioactive agents
US20020147156A1 (en) * 1999-05-17 2002-10-10 Petit Robert G. Cellular uptake of bioactive agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CANCER RESEARCH, vol. 58, no. 5, 1 March 1998 (1998-03-01), pages 933 - 939, ISSN: 0008-5472 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1 March 1998 (1998-03-01), FARRELL CATHERINE L ET AL: "Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality", XP002358560, Database accession no. PREV199800168875 *

Also Published As

Publication number Publication date
WO2005110046A2 (en) 2005-11-24

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