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WO2005108339A3 - High yield and rapid syntheses methods for producing metallo-organic salts - Google Patents

High yield and rapid syntheses methods for producing metallo-organic salts Download PDF

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Publication number
WO2005108339A3
WO2005108339A3 PCT/DK2005/000307 DK2005000307W WO2005108339A3 WO 2005108339 A3 WO2005108339 A3 WO 2005108339A3 DK 2005000307 W DK2005000307 W DK 2005000307W WO 2005108339 A3 WO2005108339 A3 WO 2005108339A3
Authority
WO
WIPO (PCT)
Prior art keywords
salts
high yield
organic salts
rapid
syntheses methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DK2005/000307
Other languages
French (fr)
Other versions
WO2005108339A2 (en
Inventor
Stephan Christgau
Jens E T Andersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Osteologix AS
Original Assignee
Osteologix AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK2004/000328 external-priority patent/WO2004098619A2/en
Priority claimed from PCT/DK2004/000327 external-priority patent/WO2004098618A2/en
Priority claimed from PCT/DK2004/000326 external-priority patent/WO2004098617A2/en
Priority to CN2005800226577A priority Critical patent/CN101010087B/en
Application filed by Osteologix AS filed Critical Osteologix AS
Priority to EP05734804A priority patent/EP1744770A2/en
Priority to AU2005240257A priority patent/AU2005240257B2/en
Priority to JP2007511865A priority patent/JP4954867B2/en
Priority to US11/579,773 priority patent/US7589235B2/en
Priority to KR1020067025206A priority patent/KR101203037B1/en
Priority to CA002565840A priority patent/CA2565840A1/en
Publication of WO2005108339A2 publication Critical patent/WO2005108339A2/en
Publication of WO2005108339A3 publication Critical patent/WO2005108339A3/en
Anticipated expiration legal-status Critical
Priority to US12/534,435 priority patent/US8183409B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/08—Malonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A new method for preparing salts of metal cations and organic acids, especially divalent salts of alkaline earth metal ions from group II of the periodic system and carboxylic acids. The method comprising the use of a high temperature (about 90° or more) and, optionally. high pressure, in order to obtain a higher yield, purity and faster reaction speed than obtained with known synthesis methods. In particular, the present invention relates to the production of strontium salts of carboxylic acids. Novel strontium salts are also provided by the present method.
PCT/DK2005/000307 2004-05-06 2005-05-05 High yield and rapid syntheses methods for producing metallo-organic salts Ceased WO2005108339A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA002565840A CA2565840A1 (en) 2004-05-06 2005-05-05 High yield and rapid syntheses methods for producing metallo-organic salts
KR1020067025206A KR101203037B1 (en) 2004-05-06 2005-05-05 High yield and rapid syntheses methods for producing metallo-organic salts
US11/579,773 US7589235B2 (en) 2004-05-06 2005-05-05 High yield and rapid synthesis methods for producing metallo-organic salts
CN2005800226577A CN101010087B (en) 2004-05-06 2005-05-05 High yield and rapid synthesis method for processing organic metal salt
EP05734804A EP1744770A2 (en) 2004-05-06 2005-05-05 High yield and rapid syntheses methods for producing metallo-organic salts
AU2005240257A AU2005240257B2 (en) 2004-05-06 2005-05-05 High yield and rapid syntheses methods for producing metallo-organic salts
JP2007511865A JP4954867B2 (en) 2004-05-06 2005-05-05 High-yield and rapid synthesis for the production of organometallic salts
US12/534,435 US8183409B2 (en) 2004-05-06 2009-08-03 High yield and rapid synthesis methods for producing metallo-organic salts

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
PCT/DK2004/000328 WO2004098619A2 (en) 2003-05-07 2004-05-06 Treating cartilage / bone conditions with water-soluble strontium salts
DKPCT/DK2004/000326 2004-05-06
PCT/DK2004/000326 WO2004098617A2 (en) 2003-05-07 2004-05-06 Controlled release composition containing a strontium salt
DKPCT/DK2004/000328 2004-05-06
PCT/DK2004/000327 WO2004098618A2 (en) 2003-05-07 2004-05-06 Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions
DKPCT/DK2004/000327 2004-05-06
DKPA200401708 2004-11-05
DKPA200401708 2004-11-05

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/579,773 A-371-Of-International US7589235B2 (en) 2004-05-06 2005-05-05 High yield and rapid synthesis methods for producing metallo-organic salts
US12/534,435 Division US8183409B2 (en) 2004-05-06 2009-08-03 High yield and rapid synthesis methods for producing metallo-organic salts

Publications (2)

Publication Number Publication Date
WO2005108339A2 WO2005108339A2 (en) 2005-11-17
WO2005108339A3 true WO2005108339A3 (en) 2005-12-29

Family

ID=37500238

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2005/000307 Ceased WO2005108339A2 (en) 2004-05-06 2005-05-05 High yield and rapid syntheses methods for producing metallo-organic salts

Country Status (8)

Country Link
US (2) US7589235B2 (en)
EP (1) EP1744770A2 (en)
JP (1) JP4954867B2 (en)
KR (1) KR20110124317A (en)
CN (1) CN101010087B (en)
AU (1) AU2005240257B2 (en)
CA (1) CA2565840A1 (en)
WO (1) WO2005108339A2 (en)

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AU2004237437B2 (en) * 2003-05-07 2011-01-20 Osteologix A/S Controlled release composition containing a strontium salt
CA2524610C (en) * 2003-05-07 2014-03-25 Osteologix A/S Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions
PL1745791T3 (en) 2003-05-07 2013-11-29 Osteologix As Treating cartilage/bone conditions with water-soluble strontium salts
AU2005216596B2 (en) 2004-02-26 2011-03-24 Osteologix A/S Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions
WO2006056794A1 (en) 2004-11-26 2006-06-01 Ucl Business Plc Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy
KR100878140B1 (en) * 2007-01-29 2009-01-12 한미약품 주식회사 Strontium salt of atorvastatin or a hydrate thereof, and pharmaceutical composition comprising the same
CN101327203B (en) * 2007-06-19 2011-03-30 惠州市昆泰精细化工有限公司 Gallic acid chelates composition and uses thereof
PL2413924T3 (en) 2009-04-03 2018-02-28 Ocera Therapeutics, Inc. L-ornithine phenyl acetate and methods of making thereof
NZ596916A (en) 2009-06-08 2013-09-27 Ucl Business Plc Treatment of portal hypertension and restoration of liver function using l-ornithine phenylacetate
FR2963837B1 (en) * 2010-08-10 2012-08-31 Air Liquide MULTI-LEVEL PROCESSING FOR OPTIMIZING ONE OR MORE FLUID SEPARATION UNITS
CN103502203B (en) 2010-10-06 2016-09-07 欧塞拉治疗有限公司 The method for preparing L-ornithine phenyl acetate
EP2530068A1 (en) 2011-05-31 2012-12-05 Lacer, S.A. New strontium salts, synthesis and use thereof in the treatment of osteoporosis
CN103173845B (en) * 2012-01-12 2015-06-03 江苏爱特恩高分子材料有限公司 Production method and application of terephthalic metal slat whisker
RU2564858C1 (en) * 2014-06-04 2015-10-10 Закрытое акционерное общество "ЭКОС-1" Method of producing anhydrous strontium formate
KR102487376B1 (en) 2014-11-24 2023-01-10 유씨엘 비즈니스 리미티드 Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies
JP6464475B2 (en) * 2015-03-02 2019-02-06 清水建設株式会社 Method for analyzing radioactive strontium
WO2017031131A1 (en) 2015-08-18 2017-02-23 Ocera Therapeutics, Inc. Treatment and prevention of muscle loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate
US10463636B2 (en) * 2016-09-30 2019-11-05 Deanna J. Nelson Pharmaceutical quality strontium L-lactate
CN106699781B (en) * 2016-12-16 2018-11-16 商丘师范学院 Based on itaconic acid-pyrazine mixed ligand zinc (II) fluorescent material and preparation method
US11066352B2 (en) 2017-05-11 2021-07-20 Ocera Therapeutics, Inc. Processes of making L-ornithine phenylacetate
CN114410396A (en) 2017-06-27 2022-04-29 埃科莱布美国股份有限公司 Phosphorus-free transition metal control in laundry applications
CN108047155A (en) * 2017-11-29 2018-05-18 浙江震元制药有限公司 A kind of orientation Preparation method and use of the isoxazole compound of double aryl substitutions
WO2019217790A1 (en) * 2018-05-11 2019-11-14 Premex, Inc. Process for quantification of metal amino acid chelates in solutions and solids
SG11202102204PA (en) * 2018-09-25 2021-04-29 Ponce De Leon Health Designated Activity Company Process of making calcium alpha-ketoglutarate
CN109444277B (en) * 2018-10-29 2021-05-11 郑州大学第一附属医院 Application of metabolic marker in preparation of glioma diagnostic kit
CN109622238B (en) * 2018-12-18 2020-07-17 商洛学院 Medicament combination for flotation and recovery of rutile from rutile gravity separation middling
CN110668934A (en) * 2019-10-14 2020-01-10 惠州市志海新威科技有限公司 Preparation method of zinc tartrate and application of zinc tartrate in stabilizer
CN114479098B (en) * 2021-12-17 2023-05-23 广东石油化工学院 Controllable micro mesoporous metal organic framework HKUST-1 material and preparation method and application thereof

Citations (5)

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Publication number Priority date Publication date Assignee Title
GB729376A (en) * 1952-04-29 1955-05-04 Bataafsche Petroleum Improvements in or relating to the preparation of basic metallic compounds of phenols
US3478073A (en) * 1966-05-06 1969-11-11 Astra Ab Preparation of anhydrous ferrous fumarate
US4056567A (en) * 1976-03-08 1977-11-01 Lever Brothers Company Chemical processes for preparing citric acid
US20040063972A1 (en) * 2002-09-24 2004-04-01 Lucile Vaysse-Ludot Process for the industrial synthesis of strontium ranelate and its hydrates
WO2004098619A2 (en) * 2003-05-07 2004-11-18 Osteologix A/S Treating cartilage / bone conditions with water-soluble strontium salts

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GB729376A (en) * 1952-04-29 1955-05-04 Bataafsche Petroleum Improvements in or relating to the preparation of basic metallic compounds of phenols
US3478073A (en) * 1966-05-06 1969-11-11 Astra Ab Preparation of anhydrous ferrous fumarate
US4056567A (en) * 1976-03-08 1977-11-01 Lever Brothers Company Chemical processes for preparing citric acid
US20040063972A1 (en) * 2002-09-24 2004-04-01 Lucile Vaysse-Ludot Process for the industrial synthesis of strontium ranelate and its hydrates
WO2004098619A2 (en) * 2003-05-07 2004-11-18 Osteologix A/S Treating cartilage / bone conditions with water-soluble strontium salts

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Also Published As

Publication number Publication date
KR20110124317A (en) 2011-11-16
AU2005240257B2 (en) 2011-11-24
AU2005240257A1 (en) 2005-11-17
CN101010087A (en) 2007-08-01
WO2005108339A2 (en) 2005-11-17
JP2007536288A (en) 2007-12-13
CN101010087B (en) 2012-06-27
EP1744770A2 (en) 2007-01-24
JP4954867B2 (en) 2012-06-20
US7589235B2 (en) 2009-09-15
US20090291926A1 (en) 2009-11-26
US8183409B2 (en) 2012-05-22
CA2565840A1 (en) 2005-11-17
US20070282127A1 (en) 2007-12-06

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