WO2005103298B1 - Procede pour detecter ncrna - Google Patents
Procede pour detecter ncrnaInfo
- Publication number
- WO2005103298B1 WO2005103298B1 PCT/US2005/013247 US2005013247W WO2005103298B1 WO 2005103298 B1 WO2005103298 B1 WO 2005103298B1 US 2005013247 W US2005013247 W US 2005013247W WO 2005103298 B1 WO2005103298 B1 WO 2005103298B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- profile
- mir
- ncrna
- signature
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Abstract
L'invention concerne un nouveau procédé pour détecter des molécules ncRNA, ce procédé étant particulièrement utile pour la détection de miRNA et de siRNA. Ce procédé peut servir à générer un profil des molécules ncRNA présentes dans un échantillon. En outre, l'application des procédés de la présente invention permet de créer une signature ncRNA pour une maladie ou un trouble déterminé. La signature ncRNA peut être utile à l'établissement de diagnostics, à des fins thérapeutiques, pour la découverte de médicaments, entre autres.
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05736842A EP1745150A4 (fr) | 2004-04-20 | 2005-04-20 | Procede pour detecter ncrna |
| AU2005236044A AU2005236044B2 (en) | 2004-04-20 | 2005-04-20 | Method for detecting ncRNA |
| US11/568,065 US7811759B2 (en) | 2004-04-20 | 2005-04-20 | Method for detecting ncRNA |
| NZ551019A NZ551019A (en) | 2004-04-20 | 2005-04-20 | Method for detecting ncRNA |
| CA002585525A CA2585525A1 (fr) | 2004-04-20 | 2005-04-20 | Procede pour detecter ncrna |
| JP2007509556A JP2007533324A (ja) | 2004-04-20 | 2005-04-20 | ncRNAを検出する方法 |
| BRPI0509979-0A BRPI0509979A (pt) | 2004-04-20 | 2005-04-20 | método para detectar ncrna |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56387704P | 2004-04-20 | 2004-04-20 | |
| US60/563,877 | 2004-04-20 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| WO2005103298A2 WO2005103298A2 (fr) | 2005-11-03 |
| WO2005103298A3 WO2005103298A3 (fr) | 2005-12-15 |
| WO2005103298B1 true WO2005103298B1 (fr) | 2006-02-23 |
| WO2005103298A9 WO2005103298A9 (fr) | 2007-05-18 |
Family
ID=35197559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2005/013247 Ceased WO2005103298A2 (fr) | 2004-04-20 | 2005-04-20 | Procede pour detecter ncrna |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7811759B2 (fr) |
| EP (1) | EP1745150A4 (fr) |
| JP (1) | JP2007533324A (fr) |
| KR (1) | KR20070004957A (fr) |
| CN (1) | CN101056991A (fr) |
| AU (1) | AU2005236044B2 (fr) |
| BR (1) | BRPI0509979A (fr) |
| CA (1) | CA2585525A1 (fr) |
| NZ (1) | NZ551019A (fr) |
| WO (1) | WO2005103298A2 (fr) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2314688B1 (fr) | 2004-11-12 | 2014-07-16 | Asuragen, Inc. | Procédés et compositions impliquant l'ARNmi et des molécules inhibitrices de l'ARNmi |
| WO2006107826A2 (fr) | 2005-04-04 | 2006-10-12 | The Board Of Regents Of The University Of Texas System | Microarn regulant des cellules musculaires |
| US20060247503A1 (en) * | 2005-04-29 | 2006-11-02 | Sellers Orlando Ii | Method for predicting a transition to an increased probability of injury |
| CN103866018B (zh) | 2005-08-01 | 2016-05-25 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| CN103028120B (zh) | 2005-09-12 | 2015-08-12 | 俄亥俄州立大学研究基金会 | 用于诊断或治疗bcl2相关癌症的组合物和方法 |
| JP2007082436A (ja) * | 2005-09-20 | 2007-04-05 | Bioinformatics Institute For Global Good Inc | 機能性RNAが制御するターゲットmRNAの予測・同定方法及びその利用方法 |
| WO2007081720A2 (fr) | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Procédés et compositions basés sur des micro-arn et s'appliquant au diagnostic, au pronostic et au traitement du cancer du poumon |
| ES2524018T3 (es) * | 2006-01-05 | 2014-12-03 | The Ohio State University Research Foundation | Anomalías de la expresión de microARN en tumores pancreáticos endocrinos y acinares |
| EP2487260B1 (fr) | 2006-01-05 | 2015-07-08 | The Ohio State University Research Foundation | Procédés à base de micro ARN et compositions pour le diagnostic et le traitement des cancers solides |
| EP2369012A1 (fr) | 2006-03-20 | 2011-09-28 | The Ohio State University Research Foundation | Empreintes digitales micro-ARN pendant une mégacaryocytopoïese |
| KR101407707B1 (ko) * | 2006-04-03 | 2014-06-19 | 산타리스 팔마 에이/에스 | Anti-mirna 안티센스 올리고뉴클레오타이드를 함유하는 약학적 조성물 |
| US7955848B2 (en) | 2006-04-03 | 2011-06-07 | Trustees Of Dartmouth College | MicroRNA biomarkers for human breast and lung cancer |
| US8207325B2 (en) | 2006-04-03 | 2012-06-26 | Univ. of Copenhagen | MicroRNA biomarkers for human breast and lung cancer |
| AU2012216487B2 (en) * | 2006-04-03 | 2015-05-14 | Roche Innovation Center Copenhagen A/S | Pharmaceutical composition comprising anti-miRNA antisense oligonucleotides |
| US8163708B2 (en) | 2006-04-03 | 2012-04-24 | Santaris Pharma A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotide |
| CA2657030A1 (fr) | 2006-07-13 | 2008-01-17 | The Ohio State University Research Foundation, An Instrumentality Of The State Of Ohio | Procedes et compositions a base de micro-arn pour le diagnostic et le traitement de maladies apparentees au cancer du colon |
| US20080081330A1 (en) * | 2006-09-28 | 2008-04-03 | Helicos Biosciences Corporation | Method and devices for analyzing small RNA molecules |
| EP2407558A1 (fr) * | 2006-10-31 | 2012-01-18 | Noxxon Pharma AG | Procédés de détection d'une molécule d'acide nucléique à double ou simple brin |
| JP5501766B2 (ja) * | 2006-11-01 | 2014-05-28 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 肝細胞癌における生存および転移を予測するためのマイクロrna発現サイン |
| EP2094846B8 (fr) * | 2006-12-13 | 2013-10-16 | Roche Diagnostics GmbH | Utilisation de tde pour l'isolement d'acides nucléiques |
| US8034560B2 (en) | 2007-01-31 | 2011-10-11 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML) |
| US8053186B2 (en) | 2007-06-15 | 2011-11-08 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing |
| ES2496172T3 (es) | 2007-07-31 | 2014-09-18 | The Ohio State University Research Foundation | Métodos para invertir la metilación por selección dirigida de DNMT3A y DNMT3B |
| AU2008283997B2 (en) | 2007-08-03 | 2014-04-10 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
| CN101836112A (zh) | 2007-08-22 | 2010-09-15 | 俄亥俄州立大学研究基金会 | 用于在人急性白血病中诱导epha7和erk磷酸化的脱调节的方法和组合物 |
| US8288356B2 (en) | 2007-10-04 | 2012-10-16 | Santaris Pharma A/S | MicroRNAs |
| CA2703707A1 (fr) | 2007-10-26 | 2009-04-30 | The Ohio State University Research Foundation | Methodes pour identifier une interaction du gene "fragile histidine triad" (fhit) et utilisations associees |
| CA2716906A1 (fr) * | 2008-02-28 | 2009-09-03 | The Ohio State University Research Foundation | Procedes et compositions fondes sur microarn pour le diagnostic, le pronostic et le traitement du cancer de l'estomac |
| EP2268811A1 (fr) | 2008-03-07 | 2011-01-05 | Santaris Pharma A/S | Compositions pharmaceutiques pour le traitement de maladies associées aux microarn |
| CA2718520C (fr) | 2008-03-17 | 2020-01-07 | The Board Of Regents Of The University Of Texas System | Identification des micro-arn dans l'entretien et la regeneration de synapses neuromusculaires |
| AU2009257410B2 (en) | 2008-06-11 | 2014-03-06 | Fudan University | Use of miR-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
| WO2010012667A1 (fr) | 2008-08-01 | 2010-02-04 | Santaris Pharma A/S | Modulation à médiation par micro-arn de facteurs stimulateurs de colonies |
| WO2010033822A2 (fr) * | 2008-09-19 | 2010-03-25 | Immune Disease Institute, Inc | Stratégies thérapeutiques et diagnostiques |
| JP5773535B2 (ja) | 2009-04-24 | 2015-09-02 | ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブRoche Innovation Center Copenhagen A/S | インターフェロンに非応答性のhcv患者の治療のための医薬組成物 |
| WO2011060014A1 (fr) | 2009-11-13 | 2011-05-19 | Integrated Dna Technologies, Inc. | Essais de détection de petits arn |
| JP5960060B2 (ja) | 2009-11-23 | 2016-08-02 | ジ・オハイオ・ステート・ユニバーシティ | 腫瘍細胞の増殖、遊走および浸潤に影響を与えるために有用な物質および方法 |
| WO2012065049A1 (fr) | 2010-11-12 | 2012-05-18 | The Ohio State University Research Foundation | Matériaux et procédés relatifs aux microarn-21, réparation de désappariement et cancer colorectal |
| CA2817982C (fr) | 2010-11-15 | 2020-06-30 | The Regents Of The University Of Michigan | Systemes mucoadhesifs a liberation controlee |
| US8664192B2 (en) | 2011-03-07 | 2014-03-04 | The Ohio State University | Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer |
| DK3246416T3 (da) | 2011-04-15 | 2024-09-02 | Univ Johns Hopkins | Sikkert sekventeringssystem |
| EP2766500A4 (fr) | 2011-10-14 | 2015-10-14 | Univ Ohio State | Méthodes et matériaux relatifs au cancer des ovaires |
| CN104619353A (zh) | 2011-12-13 | 2015-05-13 | 俄亥俄州国家创新基金会 | 与miR-21和miR-29a相关的方法和组合物、外切体抑制和癌症转移 |
| JP2015511121A (ja) | 2012-01-20 | 2015-04-16 | ジ・オハイオ・ステート・ユニバーシティ | 浸潤性および予後に関する乳がんバイオマーカーシグネチャー |
| JP6146760B2 (ja) * | 2012-02-28 | 2017-06-14 | 国立研究開発法人産業技術総合研究所 | 序列化装置、序列化方法及びプログラム |
| WO2013153911A1 (fr) * | 2012-04-12 | 2013-10-17 | 国立大学法人東京大学 | Procédé de quantification d'acide nucléique, sonde de détection, jeu de sondes de détection, et procédé de détection d'acide nucléique |
| CN103146688B (zh) * | 2012-09-12 | 2015-05-13 | 上海长海医院 | 长链非编码rna作为疾病诊断血液分子标志物的应用 |
| ES2886507T5 (es) | 2012-10-29 | 2024-11-15 | Univ Johns Hopkins | Prueba de Papanicolaou para cánceres de ovario y de endometrio |
| US20160024565A1 (en) * | 2013-03-13 | 2016-01-28 | Tufts University | Fragment complementation of based assays |
| EP3105327A4 (fr) * | 2014-02-12 | 2017-10-18 | Thomas Jefferson University | Compositions et procédés d'utilisation d'inhibiteurs de micro-arn |
| EP2949759B1 (fr) | 2014-05-27 | 2017-07-26 | Université Paris Sud 11 | Détection multiplexe homogène d'oligonucléotides |
| WO2017027653A1 (fr) | 2015-08-11 | 2017-02-16 | The Johns Hopkins University | Analyse du fluide d'un kyste ovarien |
| MY202466A (en) * | 2016-12-05 | 2024-04-30 | Regulus Therapeutics Inc | Methods for treatment of polycystic kidney disease |
| CN111868260B (zh) | 2017-08-07 | 2025-02-21 | 约翰斯霍普金斯大学 | 用于评估和治疗癌症的方法和材料 |
| US20220275455A1 (en) * | 2019-07-08 | 2022-09-01 | Preferred Networks, Inc. | Data processing and classification for determining a likelihood score for breast disease |
| CN115516108A (zh) | 2020-02-14 | 2022-12-23 | 约翰斯霍普金斯大学 | 评估核酸的方法和材料 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4988617A (en) * | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
| WO1990001564A1 (fr) * | 1988-08-09 | 1990-02-22 | Microprobe Corporation | Procedes d'analyse a cibles multiples par hybridation d'acides nucleiques |
| WO1992008808A1 (fr) * | 1990-11-14 | 1992-05-29 | Siska Diagnostics, Inc. | Detection non isotopique d'acides nucleiques utilisant une technique d'hybridation en sandwich base sur des supports en polystyrene et compositions prevues a cet effet |
| AU9240898A (en) * | 1997-07-04 | 1999-01-25 | Gist-Brocades B.V. | Process for the modification of toxic and/or off-flavoured compounds |
| US6037130A (en) * | 1998-07-28 | 2000-03-14 | The Public Health Institute Of The City Of New York, Inc. | Wavelength-shifting probes and primers and their use in assays and kits |
| EP1208382B1 (fr) * | 1999-08-17 | 2006-04-26 | Luminex Corporation | Encapsulation de particules fluorescentes |
| JP4331476B2 (ja) * | 2000-08-03 | 2009-09-16 | エフ.ホフマン−ラ ロシュ アーゲー | プリン−2,6−ジアミンのピラゾロ[3,4−d]ピリミジンアナローグを含有する核酸結合性化合物およびそれらの使用 |
| US7189507B2 (en) * | 2001-06-18 | 2007-03-13 | Pdl Biopharma, Inc. | Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer |
| JP4537053B2 (ja) * | 2001-06-25 | 2010-09-01 | ジョージア テック リサーチ コーポレーション | 二重共鳴エネルギー転移核酸プローブ |
| WO2004083902A2 (fr) * | 2002-10-25 | 2004-09-30 | Georgia Tech Research Corporation | Sondes nanoparticulaires magnetiques multifonctionnelles pour l'imagerie moleculaire |
| CA2504443A1 (fr) * | 2002-10-30 | 2004-05-13 | Pointilliste, Inc. | Procedes de production de groupes marques par polypeptides et systemes de capture contenant ces polypeptides marques |
| CA2554818A1 (fr) * | 2004-02-09 | 2005-08-25 | Thomas Jefferson University | Diagnostic et traitement de cancers a l'aide de microarn present dans ou au voisinage de caracteristiques chromosomiennes liees aux cancers |
-
2005
- 2005-04-20 JP JP2007509556A patent/JP2007533324A/ja active Pending
- 2005-04-20 WO PCT/US2005/013247 patent/WO2005103298A2/fr not_active Ceased
- 2005-04-20 BR BRPI0509979-0A patent/BRPI0509979A/pt not_active IP Right Cessation
- 2005-04-20 AU AU2005236044A patent/AU2005236044B2/en not_active Expired - Fee Related
- 2005-04-20 EP EP05736842A patent/EP1745150A4/fr not_active Withdrawn
- 2005-04-20 CA CA002585525A patent/CA2585525A1/fr not_active Abandoned
- 2005-04-20 NZ NZ551019A patent/NZ551019A/en unknown
- 2005-04-20 KR KR1020067023408A patent/KR20070004957A/ko not_active Withdrawn
- 2005-04-20 US US11/568,065 patent/US7811759B2/en not_active Expired - Fee Related
- 2005-04-20 CN CNA2005800199103A patent/CN101056991A/zh active Pending
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