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WO2005037260A3 - Procede de traitement de symptomes vasomoteurs - Google Patents

Procede de traitement de symptomes vasomoteurs Download PDF

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Publication number
WO2005037260A3
WO2005037260A3 PCT/US2004/033754 US2004033754W WO2005037260A3 WO 2005037260 A3 WO2005037260 A3 WO 2005037260A3 US 2004033754 W US2004033754 W US 2004033754W WO 2005037260 A3 WO2005037260 A3 WO 2005037260A3
Authority
WO
WIPO (PCT)
Prior art keywords
antagonists
treatment
alphaze
adrenergic
vasomotor symptoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/033754
Other languages
English (en)
Other versions
WO2005037260A2 (fr
Inventor
Darlene Coleman Deecher
Chad Edward Beyer
Liza Leventhal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34468478&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2005037260(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US10/685,812 external-priority patent/US20040152710A1/en
Priority claimed from US10/962,897 external-priority patent/US20050130987A1/en
Priority to CA002539757A priority Critical patent/CA2539757A1/fr
Priority to BRPI0415280-8A priority patent/BRPI0415280A/pt
Priority to AU2004281750A priority patent/AU2004281750A1/en
Priority to EP04794977A priority patent/EP1846105A2/fr
Application filed by Wyeth LLC filed Critical Wyeth LLC
Priority to MXPA06003866A priority patent/MXPA06003866A/es
Priority to JP2006535623A priority patent/JP2007515395A/ja
Publication of WO2005037260A2 publication Critical patent/WO2005037260A2/fr
Anticipated expiration legal-status Critical
Publication of WO2005037260A3 publication Critical patent/WO2005037260A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne des antagonistes adrénergiquesα2B sélectifs, isolément, et ces mêmes antagonistes combinés avec des inhibiteurs de réabsorption de norépinéphrine (NRI) (en composé unique ou en combinaison avec deux ou plus de deux composés), ou bien ces mêmes antagonistes combinés avec des inhibiteurs doubles de réabsorption de norépinéphrine /sérotonine (NRI/SRI) (en composé unique ou en combinaison avec deux ou plus de deux composés), ainsi que des procédés d'utilisation correspondants pour le traitement des symptômes vasomoteurs.
PCT/US2004/033754 2003-10-14 2004-10-13 Procede de traitement de symptomes vasomoteurs Ceased WO2005037260A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2006535623A JP2007515395A (ja) 2003-10-14 2004-10-13 血管運動症状の治療方法
MXPA06003866A MXPA06003866A (es) 2003-10-14 2004-10-13 Metodos de tratamiento de sintomas vasomotores.
CA002539757A CA2539757A1 (fr) 2003-10-14 2004-10-13 Utilisation d'antagonistes de recepteurs alpha-2b-adrenergiques pour traiter les symptomes vasomoteurs
BRPI0415280-8A BRPI0415280A (pt) 2003-10-14 2004-10-13 métodos para o tratamento de sintomas vasomotores
AU2004281750A AU2004281750A1 (en) 2003-10-14 2004-10-13 Use of adrenergic alphaze antagonists for the treatment of vasomotor symptoms
EP04794977A EP1846105A2 (fr) 2003-10-14 2004-10-13 Utilisation d'antagonistes alpha-2b pour le traitement de symptomes vasomoteurs

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US51089703P 2003-10-14 2003-10-14
US10/685,812 US20040152710A1 (en) 2002-10-15 2003-10-14 Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms
US60/510,897 2003-10-14
US10/685,812 2003-10-14
PCT/US2003/032759 WO2004035058A1 (fr) 2002-10-15 2003-10-15 Utilisation de modulateurs du recaptage de la noradrenaline en prevention et traitement de symptomes vasomoteurs
USPCT/US03/32759 2003-10-15
US10/962,897 2004-10-12
US10/962,897 US20050130987A1 (en) 2003-10-14 2004-10-12 Methods of treating vasomotor symptoms

Publications (2)

Publication Number Publication Date
WO2005037260A2 WO2005037260A2 (fr) 2005-04-28
WO2005037260A3 true WO2005037260A3 (fr) 2007-08-16

Family

ID=34468478

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/033754 Ceased WO2005037260A2 (fr) 2003-10-14 2004-10-13 Procede de traitement de symptomes vasomoteurs

Country Status (4)

Country Link
EP (1) EP1846105A2 (fr)
AU (1) AU2004281750A1 (fr)
MX (1) MXPA06003866A (fr)
WO (1) WO2005037260A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1904059A2 (fr) * 2005-07-21 2008-04-02 Wyeth a Corporation of the State of Delaware Methode de traitement de troubles et d'affections du systeme nerveux

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2345422A1 (de) * 1973-09-08 1975-03-20 Thomae Gmbh Dr K Neue substituierte arylpiperazine, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu deren herstellung
US4302469A (en) * 1980-09-10 1981-11-24 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
US4310524A (en) * 1980-04-11 1982-01-12 Richardson-Merrell, Inc. TCA Composition and method for rapid onset antidepressant therapy
EP0303961A2 (fr) * 1987-08-14 1989-02-22 Merrell Dow Pharmaceuticals Inc. Antidépresseurs
WO2004035058A1 (fr) * 2002-10-15 2004-04-29 Wyeth Utilisation de modulateurs du recaptage de la noradrenaline en prevention et traitement de symptomes vasomoteurs
WO2004035036A1 (fr) * 2002-10-15 2004-04-29 Wyeth Methode de traitement des symptomes vasomoteurs comprenant un compose presentant une activite inhibitrice du recaptage de la noradrenaline et une activite antagoniste du recepteur 5-ht2a
WO2004035035A1 (fr) * 2002-10-15 2004-04-29 Wyeth Utilisation de modulateurs du recaptage de la noradrenaline en prevention et traitement de symptomes vasomoteurs

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2345422A1 (de) * 1973-09-08 1975-03-20 Thomae Gmbh Dr K Neue substituierte arylpiperazine, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu deren herstellung
US4310524A (en) * 1980-04-11 1982-01-12 Richardson-Merrell, Inc. TCA Composition and method for rapid onset antidepressant therapy
US4302469A (en) * 1980-09-10 1981-11-24 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
EP0303961A2 (fr) * 1987-08-14 1989-02-22 Merrell Dow Pharmaceuticals Inc. Antidépresseurs
WO2004035058A1 (fr) * 2002-10-15 2004-04-29 Wyeth Utilisation de modulateurs du recaptage de la noradrenaline en prevention et traitement de symptomes vasomoteurs
WO2004035036A1 (fr) * 2002-10-15 2004-04-29 Wyeth Methode de traitement des symptomes vasomoteurs comprenant un compose presentant une activite inhibitrice du recaptage de la noradrenaline et une activite antagoniste du recepteur 5-ht2a
WO2004035035A1 (fr) * 2002-10-15 2004-04-29 Wyeth Utilisation de modulateurs du recaptage de la noradrenaline en prevention et traitement de symptomes vasomoteurs

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANON: "IMILOXAN", DRUGS OF THE FUTURE, vol. 11, no. 2, 1986, pages 108 - 109, XP009044474, ISSN: 0377-8282 *
BARLOW D H: "Venlafaxine for hot flushes", LANCET, XX, XX, vol. 356, no. 9247, 16 December 2000 (2000-12-16), pages 2025 - 2026, XP004264301, ISSN: 0140-6736 *
SHANAFELT TAIT D ET AL: "Pathophysiology and treatment of hot flashes.", MAYO CLINIC PROCEEDINGS. NOV 2002, vol. 77, no. 11, November 2002 (2002-11-01), pages 1207 - 1218, XP009044403, ISSN: 0025-6196 *
SLOAN J A ET AL: "Methodologic lessons learned from hot flash studies.", JOURNAL OF CLINICAL ONCOLOGY : OFFICIAL JOURNAL OF THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY. 1 DEC 2001, vol. 19, no. 23, 1 December 2001 (2001-12-01), pages 4280 - 4290, XP002319050, ISSN: 0732-183X *

Also Published As

Publication number Publication date
WO2005037260A2 (fr) 2005-04-28
EP1846105A2 (fr) 2007-10-24
MXPA06003866A (es) 2006-07-03
AU2004281750A1 (en) 2005-04-28

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