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WO2005034840A3 - Identification of kinase inhibitors - Google Patents

Identification of kinase inhibitors Download PDF

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Publication number
WO2005034840A3
WO2005034840A3 PCT/US2003/029870 US0329870W WO2005034840A3 WO 2005034840 A3 WO2005034840 A3 WO 2005034840A3 US 0329870 W US0329870 W US 0329870W WO 2005034840 A3 WO2005034840 A3 WO 2005034840A3
Authority
WO
WIPO (PCT)
Prior art keywords
identification
kinase inhibitors
inhibitors
protein kinase
inactive conformation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/029870
Other languages
French (fr)
Other versions
WO2005034840A8 (en
WO2005034840A2 (en
Inventor
John C Prescott
Andrew Braisted
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Viracta Therapeutics Inc
Original Assignee
Sunesis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunesis Pharmaceuticals Inc filed Critical Sunesis Pharmaceuticals Inc
Priority to AU2003270848A priority Critical patent/AU2003270848A1/en
Priority to CA002539064A priority patent/CA2539064A1/en
Priority to EP03752561A priority patent/EP1670422A4/en
Priority to PCT/US2003/029870 priority patent/WO2005034840A2/en
Publication of WO2005034840A2 publication Critical patent/WO2005034840A2/en
Anticipated expiration legal-status Critical
Publication of WO2005034840A8 publication Critical patent/WO2005034840A8/en
Publication of WO2005034840A3 publication Critical patent/WO2005034840A3/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G01N33/6815—Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention concerns the identification of protein kinase inhibitors that preferentially bind to the inactive conformation of a target protein kinase. The inhibitors are identified by locking the target protein kinase in an inactive conformation, and using Tethering to identify inhibitors preferentially targeting the inactive conformation.
PCT/US2003/029870 2003-09-17 2003-09-17 Identification of kinase inhibitors Ceased WO2005034840A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2003270848A AU2003270848A1 (en) 2003-09-17 2003-09-17 Identification of kinase inhibitors
CA002539064A CA2539064A1 (en) 2003-09-17 2003-09-17 Identification of kinase inhibitors
EP03752561A EP1670422A4 (en) 2003-09-17 2003-09-17 IDENTIFICATION OF KINASE INHIBITORS
PCT/US2003/029870 WO2005034840A2 (en) 2003-09-17 2003-09-17 Identification of kinase inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2003/029870 WO2005034840A2 (en) 2003-09-17 2003-09-17 Identification of kinase inhibitors

Publications (3)

Publication Number Publication Date
WO2005034840A2 WO2005034840A2 (en) 2005-04-21
WO2005034840A8 WO2005034840A8 (en) 2006-04-20
WO2005034840A3 true WO2005034840A3 (en) 2006-10-05

Family

ID=34434214

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/029870 Ceased WO2005034840A2 (en) 2003-09-17 2003-09-17 Identification of kinase inhibitors

Country Status (4)

Country Link
EP (1) EP1670422A4 (en)
AU (1) AU2003270848A1 (en)
CA (1) CA2539064A1 (en)
WO (1) WO2005034840A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7572914B2 (en) 2003-12-19 2009-08-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
JP2008510734A (en) 2004-08-18 2008-04-10 タケダ サン ディエゴ インコーポレイテッド Kinase inhibitor
ATE479687T1 (en) 2004-10-15 2010-09-15 Takeda Pharmaceutical KINASE INHIBITORS
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
SG175609A1 (en) 2006-10-09 2011-11-28 Takeda Pharmaceutical Kinase inhibitors
NZ598705A (en) * 2009-09-16 2014-06-27 Celgene Avilomics Res Inc Protein kinase conjugates and inhibitors
CN102812167A (en) 2009-12-30 2012-12-05 阿维拉制药公司 Ligand-directed Covalent Modification Of Protein
EA028080B1 (en) * 2010-06-09 2017-10-31 Дана-Фарбер Кэнсер Инститьют, Инк. Mek1 mutation conferring resistance to raf and mek inhibitors
GB201614152D0 (en) 2016-08-18 2016-10-05 Imp Innovations Ltd Assay
US12440494B2 (en) * 2019-02-25 2025-10-14 Albert Einstein College Of Medicine Compounds useful for inhibiting RAF dimers
CN116434828B (en) * 2023-04-17 2024-03-26 深圳新锐基因科技有限公司 Method and device for introducing dynamic disulfide bonds of protein molecules based on computational structure biology

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002042773A2 (en) * 2000-11-21 2002-05-30 Sunesis Pharmaceuticals, Inc. An extended tethering approach for rapid identification of ligands
EP1421379A2 (en) * 2001-08-07 2004-05-26 Sunesis Pharmaceuticals, Inc. Cysteine mutants and methods for detecting ligand binding to biological molecules
CA2478981A1 (en) * 2002-03-21 2003-10-02 Sunesis Pharmaceuticals, Inc. Identification of kinase inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ERLANSON D.A., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 97, no. 17, August 2000 (2000-08-01), XP002199107 *
See also references of EP1670422A4 *

Also Published As

Publication number Publication date
WO2005034840A8 (en) 2006-04-20
WO2005034840A2 (en) 2005-04-21
AU2003270848A1 (en) 2005-04-27
EP1670422A2 (en) 2006-06-21
CA2539064A1 (en) 2005-04-21
EP1670422A4 (en) 2007-08-01

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