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WO2005028506A3 - Structure cristalline de la tyrosine kinase semblable a fms - Google Patents

Structure cristalline de la tyrosine kinase semblable a fms Download PDF

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Publication number
WO2005028506A3
WO2005028506A3 PCT/US2004/030358 US2004030358W WO2005028506A3 WO 2005028506 A3 WO2005028506 A3 WO 2005028506A3 US 2004030358 W US2004030358 W US 2004030358W WO 2005028506 A3 WO2005028506 A3 WO 2005028506A3
Authority
WO
WIPO (PCT)
Prior art keywords
fms
tyrosine kinase
relates
protein
flt3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/030358
Other languages
English (en)
Other versions
WO2005028506A2 (fr
Inventor
James Paul Griffith
James Roger Black
Carlos H Faerman
Lovorka Lora Swenson
Michael Andrew Wynn
Fan Lu
Judith A Lippke
Kumkum Saxena
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of WO2005028506A2 publication Critical patent/WO2005028506A2/fr
Publication of WO2005028506A3 publication Critical patent/WO2005028506A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne une tyrosine kinase semblable à FMS (FLT3), des poches de fixation de FLT3 ou des poches de fixation semblables à FLT3. L'invention concerne également un ordinateur comprenant un support de stockage de données codé avec les coordonnées de structure de ces poches de fixation. L'invention concerne également des procédés utilisant ces coordonnées de structure pour résoudre la structure de protéines homologues ou de complexes protéinés. L'invention concerne également des procédés d'utilisation de ces coordonnées de structure pour cribler et désigner des composés qui se fixent à la protéine tyrosine kinase semblable à FMS, des complexes de la protéine tyrosine kinase semblable à FMS, des homologues de cette protéine, ou une protéines semblable à FLT3 ou des complexes protéinés. L'invention concerne également des compositions cristallisables et des cristaux comprenant le domaine cytoplasmique de la tyrosine kinase semblable à FMS ou des homologues de cette dernière. L'invention concerne également des procédés d'identification d'inhibiteurs du domaine cytoplasmique de la protéine tyrosine kinase semblable à FMS.
PCT/US2004/030358 2003-09-15 2004-09-15 Structure cristalline de la tyrosine kinase semblable a fms Ceased WO2005028506A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US50327003P 2003-09-15 2003-09-15
US60/503,270 2003-09-15
US54039104P 2004-01-29 2004-01-29
US60/540,391 2004-01-29

Publications (2)

Publication Number Publication Date
WO2005028506A2 WO2005028506A2 (fr) 2005-03-31
WO2005028506A3 true WO2005028506A3 (fr) 2005-09-15

Family

ID=34381067

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/030358 Ceased WO2005028506A2 (fr) 2003-09-15 2004-09-15 Structure cristalline de la tyrosine kinase semblable a fms

Country Status (2)

Country Link
US (1) US7494795B2 (fr)
WO (1) WO2005028506A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7270987B1 (en) * 2004-11-30 2007-09-18 Takeda San Diego, Inc. Crystallization of FMS-like tyrosine kinase 3
US7572614B2 (en) * 2006-02-24 2009-08-11 Academia Sinica Crystal structure of soluble glutaminyl cyclase
WO2012084895A2 (fr) * 2010-12-20 2012-06-28 Universiteit Gent Structure cristalline du complexe ligand-récepteur flt3
EP3902836A4 (fr) 2018-12-18 2022-08-31 Boehringer Ingelheim IO Canada Inc. Anticorps agonistes de flt3 et utilisations associées

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886646A (en) * 1988-03-23 1989-12-12 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Hanging drop crystal growth apparatus and method
US5096676A (en) * 1989-01-27 1992-03-17 Mcpherson Alexander Crystal growing apparatus
US5130105A (en) * 1990-10-23 1992-07-14 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Protein crystal growth tray assembly
US5221410A (en) * 1991-10-09 1993-06-22 Schering Corporation Crystal forming device
US5884230A (en) * 1993-04-28 1999-03-16 Immunex Corporation Method and system for protein modeling
US5400741A (en) * 1993-05-21 1995-03-28 Medical Foundation Of Buffalo, Inc. Device for growing crystals

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
GILLILAND D GARY ET AL: "The roles of FLT3 in hematopoiesis and leukemia", BLOOD, vol. 100, no. 5, 1 September 2002 (2002-09-01), pages 1532 - 1542, XP002333635, ISSN: 0006-4971 *
GRIFFITH JAMES ET AL: "The structural basis for autoinhibition of FLT3 by the juxtamembrane domain.", MOLECULAR CELL, vol. 13, no. 2, 30 January 2004 (2004-01-30), pages 169 - 178, XP002333638, ISSN: 1097-2765 *
MCTIGUE M A ET AL: "Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: A key enzyme in angiogenesis", STRUCTURE, CURRENT BIOLOGY LTD., PHILADELPHIA, PA, US, vol. 7, no. 3, 15 March 1999 (1999-03-15), pages 319 - 330, XP002238334, ISSN: 0969-2126 *
MOHAMMADI M ET AL: "Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 86, 1996, pages 577 - 587, XP002219716, ISSN: 0092-8674 *
MOL CLIFFORD D ET AL: "Structure of a c-Kit product complex reveals the basis for kinase transactivation.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 34, 22 August 2003 (2003-08-22), pages 31461 - 31464, XP002333636, ISSN: 0021-9258 *
SAVVIDES SAVVAS N ET AL: "Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots", NATURE STRUCTURAL BIOLOGY, vol. 7, no. 6, June 2000 (2000-06-01), pages 486 - 491, XP002333637, ISSN: 1072-8368 *

Also Published As

Publication number Publication date
US20050181975A1 (en) 2005-08-18
US7494795B2 (en) 2009-02-24
WO2005028506A2 (fr) 2005-03-31

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