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WO2005025498A3 - Substituted acetanilides and benzamides for the treatment of asthma and pulmonary inflammation - Google Patents

Substituted acetanilides and benzamides for the treatment of asthma and pulmonary inflammation Download PDF

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Publication number
WO2005025498A3
WO2005025498A3 PCT/US2004/028063 US2004028063W WO2005025498A3 WO 2005025498 A3 WO2005025498 A3 WO 2005025498A3 US 2004028063 W US2004028063 W US 2004028063W WO 2005025498 A3 WO2005025498 A3 WO 2005025498A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
benzamides
asthma
pulmonary inflammation
acetanilide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/028063
Other languages
French (fr)
Other versions
WO2005025498A2 (en
Inventor
William R Baker
Marcin Stasiak
David Macleod
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
Corus Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corus Pharma Inc filed Critical Corus Pharma Inc
Publication of WO2005025498A2 publication Critical patent/WO2005025498A2/en
Anticipated expiration legal-status Critical
Publication of WO2005025498A3 publication Critical patent/WO2005025498A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Substituted acetanilide or benzamide compositions or formulations for delivery by aerosolization are described. The formulation contains an efficacious amount of acetanilide or benzamide compound able to inhibit inflammation in asthmatic lungs. Compounds of the invention are formulated in 5 ml solution of a quarter normal saline having pH between 5.0 and 7.0. The method for treatment of respiratory tract inflammation by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5 µ, produced by nebulization or dry powder inhaler.
PCT/US2004/028063 2003-09-08 2004-08-26 Substituted acetanilides and benzamides for the treatment of asthma and pulmonary inflammation Ceased WO2005025498A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50113703P 2003-09-08 2003-09-08
US60/501,137 2003-09-08

Publications (2)

Publication Number Publication Date
WO2005025498A2 WO2005025498A2 (en) 2005-03-24
WO2005025498A3 true WO2005025498A3 (en) 2008-11-27

Family

ID=34312253

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/028063 Ceased WO2005025498A2 (en) 2003-09-08 2004-08-26 Substituted acetanilides and benzamides for the treatment of asthma and pulmonary inflammation

Country Status (1)

Country Link
WO (1) WO2005025498A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2911869B1 (en) * 2007-01-29 2011-05-20 Saint Gobain Ct Recherches PROCESS FOR PRODUCING A CERAMIC POROUS CORE BASED ON SIC
RU2494089C2 (en) 2007-04-20 2013-09-27 Акьюсела Инк. Compounds representing styrene derivatives for treating ophthalmic diseases and disorders
FR2926297B1 (en) 2008-01-10 2013-03-08 Centre Nat Rech Scient INHIBITORY CHEMICAL MOLECULES IN THE SPLICE MECHANISM FOR TREATING DISEASES RESULTING FROM SPLICE ANOMALIES.
WO2010007626A1 (en) * 2008-07-14 2010-01-21 Biocon Limited A method of synthesizing a substantially monodispersed mixture of oligomers
EP2505198A1 (en) 2011-04-01 2012-10-03 Société Splicos Compounds for use as therapeutic agents affecting p53 expression and/or activity
CA2907528A1 (en) * 2013-03-20 2014-09-25 Bayer Pharma Aktiengesellschaft Novel compounds
BR112017008809A2 (en) 2014-11-05 2017-12-19 Flexus Biosciences Inc immunoregulatory agents
UY36390A (en) 2014-11-05 2016-06-01 Flexus Biosciences Inc MODULATING COMPOUNDS OF INDOLAMINE ENZYME 2,3-DIOXYGENASE (IDO), ITS SYNTHESIS METHODS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AU2019322564A1 (en) 2018-08-15 2021-03-25 Pharmacyl Ab A new medical treatment for pathologic inflammation
MX2021001351A (en) * 2018-08-15 2021-04-13 Pharmacyl Ab Substituted benzamides and their use in therapy.
US11717500B2 (en) 2020-02-03 2023-08-08 Pharmacyl Ab Treatment of spondyloarthritis
CN112876414B (en) * 2021-01-29 2022-09-09 河南大学 A kind of naphthalimide conjugate based on polyamine modification, its preparation method and application
WO2023274258A1 (en) * 2021-06-29 2023-01-05 四川大学华西医院 Heteroatom-substituted aromatic compound, and preparation method therefor and use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029794A (en) * 1973-06-12 1977-06-14 Astra Pharmaceutical Products, Inc. Pharmaceutical local anesthetic composition
RU2105551C1 (en) * 1996-12-27 1998-02-27 Лариса Васильевна Дубинина Method of treatment of bronchial asthma and asthmatic bronchitis
WO1998037896A1 (en) * 1997-02-26 1998-09-03 Mayo Foundation For Medical Education And Research Treatment of eosinophil-associated pathologies, such as bronchial asthma, with synergistic combinations of glucocorticoids and a local anesthetics
WO2003099266A2 (en) * 2002-05-23 2003-12-04 Abbott Laboratories Acetamides and benzamides that are useful in treating sexual dysfunction

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029794A (en) * 1973-06-12 1977-06-14 Astra Pharmaceutical Products, Inc. Pharmaceutical local anesthetic composition
RU2105551C1 (en) * 1996-12-27 1998-02-27 Лариса Васильевна Дубинина Method of treatment of bronchial asthma and asthmatic bronchitis
WO1998037896A1 (en) * 1997-02-26 1998-09-03 Mayo Foundation For Medical Education And Research Treatment of eosinophil-associated pathologies, such as bronchial asthma, with synergistic combinations of glucocorticoids and a local anesthetics
WO2003099266A2 (en) * 2002-05-23 2003-12-04 Abbott Laboratories Acetamides and benzamides that are useful in treating sexual dysfunction

Non-Patent Citations (32)

* Cited by examiner, † Cited by third party
Title
COLL. CZECH. CHEM. COMMUN., vol. 53, no. 8, 1988, pages 1820 - 1844 *
DATABASE REGISTRY [online] BOKESCH ET AL., Database accession no. (RN 60108-67-0) *
DATABASE REGISTRY [online] Database accession no. (RN 21236-54-4) *
DATABASE REGISTRY [online] ERDTMAN ET AL., Database accession no. (RN 3213-15-8) *
DATABASE REGISTRY [online] HULINSKA ET AL., Database accession no. (RN 70060-41-2) *
DATABASE REGISTRY [online] IOVU ET AL., Database accession no. (RN 83471-40-3) *
DATABASE REGISTRY [online] MELLICK E TAL., Database accession no. (RN 200115-06-6) *
DATABASE REGISTRY [online] OKADA ET AL., Database accession no. (RN 70060-41-2) *
DATABASE REGISTRY [online] OKLODBZIJA ET AL., Database accession no. (RN 70060-41-2) *
DATABASE REGISTRY [online] PANTSURKIN ET AL., Database accession no. (RN 3213-14-7) *
DATABASE REGISTRY [online] ROSS ET AL., Database accession no. (RN 38838-29-8) *
DATABASE REGISTRY [online] SCHLEIFER ET AL., Database accession no. (RN 74634-66-5) *
DATABASE REGISTRY [online] SEARCEY ET AL., Database accession no. (RN 192071-10-6) *
DATABASE REGISTRY [online] SHANNON ET AL.: "Peptides: The Wave of the Future", Database accession no. (RN 3213-15-8) *
DATABASE REGISTRY [online] SHELDON ET AL., Database accession no. (RN 60108-67-0) *
DATABASE REGISTRY [online] TAHERI ET AL., Database accession no. (RN 97176-74-4) *
DATABASE REGISTRY [online] YANG ET AL., Database accession no. (RN 75549-58-5) *
J. HET. CHEM., vol. 20, no. 5, 1983, pages 1335 - 1338 *
J. MOLEC. CELL CARDIOL., vol. 15, no. 11, 1983, pages 749 - 757 *
J. PHARMACOL. & EXPERIM. THERAP., vol. 182, no. 2, 1972, pages 351 - 361 *
J. PHARMACOL. & EXPERIM. THERAP., vol. 237, no. 3, 1986, pages 773 - 781 *
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 304, no. 1, 2003, pages 71 - 80 *
JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 49, no. 10, 1997, pages 1008 - 1018 *
KHIMIKO-FARMATSEVTICHESKII ZHURNAL, vol. 27, no. 8, 1993, pages 34 - 36 *
MOLEC. PHARMACOL., vol. 39, no. 5, 1991, pages 609 - 614 *
PERKIN TRANS. 2: PHYS. ORG. CHEM., no. 3, 1997, pages 523 - 532 *
PHARMAZIE, vol. 53, no. 9, 1998, pages 596 - 602 *
PROCEED. 2ND INTERNTL. & 17TH AM. PEPTIDE SYMP., SAN DIEGO, CA, US, 9 June 2001 (2001-06-09) - 14 June 2001 (2001-06-14), pages 265 - 266 *
REVISTADE CHIMIE (BUCHAREST, ROMANIA), vol. 33, no. 7, 1982, pages 601 - 604 *
SVENSK KEM. TID., vol. 49, 1937, pages 163 - 174 *
YAKUGAKU ZASSHI, vol. 98, no. 12, 1978, pages 1619 - 1628 *
YAOXUE XUEBAO, vol. 15, no. 1, 1980, pages 18 - 26 *

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Publication number Publication date
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