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WO2005023848A3 - Adenoviral epitopes - Google Patents

Adenoviral epitopes Download PDF

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Publication number
WO2005023848A3
WO2005023848A3 PCT/GB2004/003861 GB2004003861W WO2005023848A3 WO 2005023848 A3 WO2005023848 A3 WO 2005023848A3 GB 2004003861 W GB2004003861 W GB 2004003861W WO 2005023848 A3 WO2005023848 A3 WO 2005023848A3
Authority
WO
WIPO (PCT)
Prior art keywords
adenoviral
fragment
epitope
region
molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2004/003861
Other languages
French (fr)
Other versions
WO2005023848A2 (en
Inventor
Niels Rudi Pedersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0321063A external-priority patent/GB0321063D0/en
Priority claimed from GB0321179A external-priority patent/GB0321179D0/en
Application filed by Individual filed Critical Individual
Priority to EP20040768408 priority Critical patent/EP1664099A2/en
Publication of WO2005023848A2 publication Critical patent/WO2005023848A2/en
Publication of WO2005023848A3 publication Critical patent/WO2005023848A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/235—Adenoviridae
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides a peptide comprising an adenoviral (Ad) penton base epitope for a human neutralising antibody; the epitope may be a fragment from within region 50-120, 191-233 or 310-408 of Ad5 or an equivalent region within another Ad serotype, or an immunologically equivalent variant of such a fragment; particularly preferred epitopes include GGRNSIRYSELA, TRVYLVDNKSTD, QTINLDDRSHWG, HYLKVGRQNGVL, FRLGFDPVTGLV, VTGLVMPGVYTN, SNSSGSGAEENS, DHAIRGDTFATR, DSTFTQYRSWYL, RRTCPYVYKALG; as well as the use of such peptides and corresponding nucleic acid molecules in therapy and formulations comprising these molecules, optionally together with an adenoviral vector.
PCT/GB2004/003861 2003-09-09 2004-09-09 Adenoviral epitopes Ceased WO2005023848A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20040768408 EP1664099A2 (en) 2003-09-09 2004-09-09 Adenoviral epitopes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0321063.0 2003-09-09
GB0321063A GB0321063D0 (en) 2003-09-09 2003-09-09 Adenoviral epitopes
GB0321179.4 2003-09-10
GB0321179A GB0321179D0 (en) 2003-09-10 2003-09-10 Adenoviral epitopes

Publications (2)

Publication Number Publication Date
WO2005023848A2 WO2005023848A2 (en) 2005-03-17
WO2005023848A3 true WO2005023848A3 (en) 2005-12-01

Family

ID=34276832

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/003861 Ceased WO2005023848A2 (en) 2003-09-09 2004-09-09 Adenoviral epitopes

Country Status (2)

Country Link
EP (1) EP1664099A2 (en)
WO (1) WO2005023848A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6576326B2 (en) 2013-03-14 2019-09-18 ソーク インスティテュート フォー バイオロジカル スタディーズ Oncolytic adenovirus composition
CL2016000164A1 (en) * 2016-01-21 2016-07-29 Pontificia Universidad Católica De Chile Monoclonal antibodies specific for the human adenovirus piii antigen (adv), produced and secreted by cellular hybridomas, useful for the detection and diagnosis of adv caused infection.
CA3013637A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
ES2933174T3 (en) 2016-02-23 2023-02-02 Salk Inst For Biological Studi Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics
JP2019536468A (en) 2016-12-12 2019-12-19 ソーク インスティテュート フォー バイオロジカル スタディーズ Synthetic adenovirus targeting tumors and uses thereof
KR20200140848A (en) 2018-04-09 2020-12-16 더 솔크 인스티튜트 포 바이올로지칼 스터디즈 Oncolytic adenovirus composition with improved replication properties
US11986536B2 (en) 2019-03-23 2024-05-21 Ablevia Biotech Gmbh Compound for the sequestration of undesirable antibodies in a patient
EP3715374A1 (en) 2019-03-23 2020-09-30 Ablevia biotech GmbH Compound for the sequestration of undesirable antibodies in a patient
EP4025599A4 (en) * 2019-09-04 2024-02-07 The Board of Trustees of the Leland Stanford Junior University Cross-reactive epitope for multiple sclerosis
IL301336A (en) 2020-09-23 2023-05-01 Ablevia Biotech Gmbh A compound to increase the efficiency of viral vectors
US20250213707A1 (en) 2022-03-24 2025-07-03 Ablevia Biotech Gmbh Compound for increasing efficacy of oncolytic viruses

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CHROBOCZEK ET AL: "THE SEQUENCE OF THE GENOME OF ADENOVIRUS TYPE 5 AND ITS COMPARISON WITH THE GENOME OF ADENOVIRUS TYPE 2", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 186, 1992, pages 280 - 285, XP002126551, ISSN: 0042-6822 *
DATABASE EMBL [online] 22 April 1989 (1989-04-22), "Adenovirus type 5 IIIa protein, 3' end; penton base protein gene, complete cds; and VIII protein, 5' end.", XP002341884, retrieved from EBI Database accession no. M22141 *
GAHERY-SEGARD H ET AL: "Immune reponse to recombinant capsid proteins of adenovirus in humans: Antifiber and anti-penton base antibodies have a synergistic effect on neutralizing activity", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 72, no. 3, March 1998 (1998-03-01), pages 2388 - 2397, XP002136355, ISSN: 0022-538X *
HABIB N ET AL: "Clinical trial of E1B-deleted adenovirus (dl1520) gene therapy for hepatocellular carcinoma", CANCER GENE THERAPY 2002 UNITED STATES, vol. 9, no. 3, 2002, pages 254 - 259, XP002337621, ISSN: 0929-1903 *
HABIB NAGY A ET AL: "E1B-deleted adenovirus (dl1520) gene therapy for patients with primary and secondary liver tumors", HUMAN GENE THERAPY, vol. 12, no. 3, 10 February 2001 (2001-02-10), pages 219 - 226, XP002337622, ISSN: 1043-0342 *
HONG SAW SEE ET AL: "Identification of adenovirus (Ad) penton base neutralizing epitopes by use of sera from patients who had received conditionally replicative Ad (Addl1520) for treatment of liver tumors.", JOURNAL OF VIROLOGY, vol. 77, no. 19, October 2003 (2003-10-01), pages 10366 - 10375, XP002341790, ISSN: 0022-538X *
NEUMANN R ET AL: "DETERMINATION OF THE NUCLEOTIDE SEQUENCE FOR THE PENTON-BASE GENE OF HUMAN ADENOVIRUS TYPE 5", GENE (AMSTERDAM), vol. 69, no. 1, 1988, pages 153 - 157, XP002341791, ISSN: 0378-1119 *
SAW SEE HONG ET AL: "IMMUNOREACTIVE DOMAINS AND INTEGRIN-BINDING MOTIFS IN ADENOVIRUS PENTON BASE CAPSOMER", VIRAL IMMUNOLOGY, MARY ANN LIEBERT, INC., NEW YORK, US, vol. 13, no. 3, 2000, pages 353 - 371, XP009041783, ISSN: 0882-8245 *

Also Published As

Publication number Publication date
EP1664099A2 (en) 2006-06-07
WO2005023848A2 (en) 2005-03-17

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