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WO2005023336A2 - Catheter convertible multi-lumiere - Google Patents

Catheter convertible multi-lumiere Download PDF

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Publication number
WO2005023336A2
WO2005023336A2 PCT/US2004/029313 US2004029313W WO2005023336A2 WO 2005023336 A2 WO2005023336 A2 WO 2005023336A2 US 2004029313 W US2004029313 W US 2004029313W WO 2005023336 A2 WO2005023336 A2 WO 2005023336A2
Authority
WO
WIPO (PCT)
Prior art keywords
lumen
catheter
obturator
lumens
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/029313
Other languages
English (en)
Other versions
WO2005023336A3 (fr
Inventor
Scott O. Trerotola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Publication of WO2005023336A2 publication Critical patent/WO2005023336A2/fr
Anticipated expiration legal-status Critical
Publication of WO2005023336A3 publication Critical patent/WO2005023336A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
    • A61M1/3659—Cannulae pertaining to extracorporeal circulation
    • A61M1/3661—Cannulae pertaining to extracorporeal circulation for haemodialysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0074—Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
    • A61M25/0075—Valve means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A61M25/003—Multi-lumen catheters with stationary elements characterized by features relating to least one lumen located at the distal part of the catheter, e.g. filters, plugs or valves
    • A61M2025/0031—Multi-lumen catheters with stationary elements characterized by features relating to least one lumen located at the distal part of the catheter, e.g. filters, plugs or valves characterized by lumina for withdrawing or delivering, i.e. used for extracorporeal circuit treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A61M25/0032—Multi-lumen catheters with stationary elements characterized by at least one unconventionally shaped lumen, e.g. polygons, ellipsoids, wedges or shapes comprising concave and convex parts

Definitions

  • the invention described herein relates to a multi-lumen catheter that has an obturator for permanently or semi-permanently blocking an unused lumen while treatment continues in another lumen, thereby minimizing risk of infection and eliminating the need to remove the catheter until all treatments are completed.
  • a patient in need of such a device receives a catheter consisting of one or more lumens where the catheter configuration is chosen based on the patient's needs at the time of catheter placement. For example, a patient needing infusion of two incompatible medications will need at least two lumens.
  • Patients undergoing hemodialysis need at least two lumens for hemodialysis but may need additional lumens for medications as the hemodialysis lumens are dedicated for that purpose.
  • One problem with this approach is that patients' needs may vary from the time of catheter placement to a later time. Typically, patients need more lumens during an acute phase of their illness and fewer lumens during a later phase. For example, a patient with cancer may need multiple incompatible drugs for induction chemotherapy and therefore multiple lumens, but later needs a fewer number of lumens for chronic maintenance therapy. [0003] In addition to these considerations, it is highly desirable to keep the number of lumens in a catheter to the minimum number required for sufficient therapy.
  • none of these systems reduces the risk of infection by blocking off the unused lumen when it is not in use.
  • a multi-lumen catheter is thus desired that permits one or more lumens to be used for acute treatments and selectively blocked when not needed, while allowing use of the other lumens to continue.
  • the present invention has been designed to address this pressing need in the art.
  • the obturator may be removable so that its lumen may be used to inject fluids and the like as needed in more acute settings.
  • the obturator is preferably made of a biocompatible plastic of sufficient stiffness for insertion into a lumen and may also have a locking mechanism, such as a luer lock, on a distal end that removably connects the obturator to the catheter.
  • the locking mechanism is configured such that the distal end of the obturator is flush with a distal end of catheter when the locking mechanism is engaged.
  • the obturator may extend the length of the lumen or may extend partially into the lumen. In the latter case, the obturator may have a mark thereon at a predetermined point so as to identify an amount of dead space in the lumen remaining when the obturator is fully inserted into the lumen. If it is desired to permanently block the lumen, a biocompatible adhesive may be injected into the dead space of the lumen prior to insertion of the obturator, thereby bonding the obturator to the catheter.
  • a convertible multi-lumen catheter assembly in accordance with the invention may also include a hub attached to a distal end of the catheter.
  • the hub may include a marking identifying the amount of dead space in the lumen and a fitting that communicates with the lumen that is configured to match a syringe containing an amount of the adhesive sufficient to fill the amount of dead space in the lumen.
  • the convertible multi-lumen catheter of the invention has at least two lumens, a first lumen for inserting fluids into a patient and a second lumen for inserting fluids into a patient. Either lumen or both may be adapted to accept the obturator.
  • the convertible multi-lumen catheter of the invention has at least three lumens, a first lumen adapted to insert antibiotics into a patient or for accepting a guide wire, a second lumen for inserting fluids into the patient, and a third lumen for removing fluids from the patient.
  • the obturator may be accepted in any one or all of the lumens to selectively block the lumens as desired.
  • the lumen into which the obturator is inserted is adapted to collapse when not in use and the obturator is not inserted.
  • the invention also encompasses a method of treating a patient with a catheter having at least two lumens.
  • Such a method in accordance with the invention includes the steps of inserting the catheter into the patient, applying a first treatment to the patient via a first lumen of the catheter, applying a second treatment to the patient via a second lumen of the catheter, and sealing one of the lumens when it is not in use while treatment continues in the other lumen.
  • the sealing may be performed by inserting an obturator into the lumen when it is not in use.
  • Such a method in accordance with the invention also includes the further step of removably locking a distal end of the obturator in the lumen using a locking mechanism.
  • the locking mechanism is configured such that the distal end of the obturator is flush with a distal end of the catheter when the locking mechanism is engaged.
  • the obturator leaves a dead space in the lumen when the obturator is fully inserted.
  • This method may include the further step of inserting a biocompatible adhesive into the dead space of the lumen prior to insertion of the obturator in the inserting step.
  • the adhesive permanently bonds the obturator to the catheter to prevent further usage of the blocked lumen and any further risk of infection.
  • the method of permanently blocking a lumen in accordance with the invention may also include the further step of attaching a hub to a distal end of the catheter, where the hub identifies the amount of dead space in the lumen and has a fitting that communicates with the lumen.
  • the fitting is preferably configured to match a syringe containing an amount of the adhesive sufficient to fill the amount of dead space in the lumen.
  • the method of the invention may be used for catheters with two or more lumens.
  • the first treatment applying step may comprise the step of inserting fluids into the patient via the first lumen
  • the second treatment applying step may comprise the step of inserting fluids into the patient via the second lumen.
  • the first treatment applying step may comprise the step of inserting antibiotics or a guide wire into the first lumen for insertion into the patient and the second treatment applying step may comprise the step of inserting fluids into the patient via the second lumen.
  • the obturator inserting step includes the step of inserting the obturator into the first lumen after cessation of the application of the antibiotics or the removal of the guide wire from the first lumen.
  • Figures 1(A) and 1(B) illustrate a cross-section of a three lumen catheter including a guide wire in the third lumen ( Figure 1(A)) and the same three lumen catheter with the guide wire removed from the third lumen leaving a dead space ( Figure 1(B)).
  • Figures 2(A) and 2(B) illustrate a cross-section of a four lumen catheter including guide wires in the third and fourth lumens ( Figure 2(A)) and the same four lumen catheter with the guide wires removed from the third and fourth lumens leaving dead spaces ( Figure 2(B)).
  • Figures 3(A) and 3(B) illustrate a cross-section of a catheter including a center lumen for accepting a guide wire (Figure 3(A)) and the same catheter with the guide wire removed so that the common adjacent walls of the remaining lumens retttrn to their initial position, thereby closing off the space that held the guide wire (Figure 3(B)).
  • Figures 4(A) and 4(B) illustrate the proximal end of a multi-lumen catheter in accordance with an embodiment of the invention with the obturator partially inserted ( Figure 4(A)) and fully inserted ( Figure 4(B)).
  • Figures 5(A) and 5(B) illustrate the distal end of a multi-lumen catheter in accordance with an embodiment of the invention with the obturator inserted ( Figure 5(A)) and removed ( Figure 5(B)).
  • Figures 6(A) through 6(C) illustrate the proximal end of the multi-lumen catheter in accordance with an embodiment of the invention where the obturator extends the length of the lumen
  • Figure 6(A) illustrates the proximal end of the locked obturator
  • Figure. 6(B) illustrates a cross-section of the catheter of Figure 6(A)
  • Figure 6(C) illustrates the extension of the obturator through the lumen.
  • Figure 6(D) illustrates the obturator of the embodiment of Figures 6(A) through 6(C).
  • Figures 7(A) and 7(B) illustrate the proximal end of the multi-lumen catheter in accordance with an embodiment of the invention where the obturator extends partially into the lumen so as to leave a dead space, where Figure 7(A) illustrates the catheter prior to insertion of the obturator and Figure 7(B) illustrates the catheter with the obturator fully inserted and glued into place.
  • Figure 8 illustrates the proximal end of the multi-lumen catheter in accordance with an embodiment of the invention where the hub of the lumen for accepting the obturator has a non-luer fitting such as (a) or (b) designed to mate with a matching syringe or other delivery system containing biocompatible adhesive for injection into the dead space of the lumen.
  • a non-luer fitting such as (a) or (b) designed to mate with a matching syringe or other delivery system containing biocompatible adhesive for injection into the dead space of the lumen.
  • Figures 1 (A) and 1 (B) illustrate a cross-section of a three lumen catheter 10 including two fixed lumens 12, 14 and a guide wire 16 in a third lumen 18 (Fig. 1(A)).
  • Figure 1(B) dead space
  • Figures 2(A) and 2(B) illustrate a cross-section of a four lumen catheter 20 including two fixed lumens 22, 24 with guide wires 25, 26 in the third and fourth lumens 27, 28, respectively. As shown in Figure 2(B), dead spaces 29, 30 remain in the catheter
  • Figures 3(A) and 3(B) illustrate a cross-section of a catheter 34 including a center lumen 32 for accepting a guide wire 33 (Figure 3(A)). As shown in Figure 3(B), when the guide wire 33 is removed from the catheter 34, the lumen 32 collapses and the remauTing lumens 36, 38 conform to fill the dead space.
  • This embodiment might be desirable for mamtaining the highest possible flow rates through the remajriing lumens 36, 38, such as is desirable in hemodialysis and apheresis.
  • a significant consideration is how to maintain hemostasis and aerostasis once the additional lumens have been removed. This may be accomplished by means of hemostasis valves such as are found in vascular sheaths or more permanently through the use of adhesives such as silicone or other medical grade adhesive.
  • Figures 4(A) and 4(B) illustrate the proximal end of a multi-lumen catheter in accordance with a first embodiment of the invention with the obturator 40 partially inserted (Figure 4(A)) through a luer hub assembly 42 into the lumen and fully inserted into the lumen ( Figure 4(B)).
  • luer connections 44 may be included for communication with each lumen.
  • the obturator 40 may also have a luer lock mechanism 46 for locking the obturator to the catheter via the luer hub assembly 42.
  • Tip configuration for the catheters 10, 20, or 34 would depend on the medical use anticipated.
  • This may include step and/or split tip multi side hole configurations for hemodialysis, or more conventional trimmable tips as used in oncology catheters.
  • One possible configuration is shown in Figure 5, with an obturator in place in a third lumen (Figure 5 A) and after removal (Figure 5B) with closed slit valve 50.
  • Figure 5 A an obturator in place in a third lumen
  • Figure 5B after removal
  • Figure 5B With closed slit valve 50.
  • Figures 6(A) through 6(C) illustrate the proximal end of the multi-lumen catheter of Figure 4 where the obturator 40 extends the length of the lumen and is locked at the proximal end of the catheter assembly (Figure 6(A)).
  • Figure 6(B) illustrates a cross-section of the catheter of Fig. 6(A) with the solid obturator 40 blocking the unused lumen.
  • Figure 6(C) illustrates the extension of the obturator 40 through the lumen, while Figure 6(D) illustrates the obturator 40.
  • obturator 40 is made of a biocompatible plastic of sufficient stiffness to easily pass into the catheter as shown.
  • the locking mechanism 46 may be a luer lock, which connects the obturator 40 to the catheter hub 42, filling the unused lumen as shown in Figure 6(B) and rendering the tip portion flush as shown in Figure 6(C).
  • a luer lock which connects the obturator 40 to the catheter hub 42, filling the unused lumen as shown in Figure 6(B) and rendering the tip portion flush as shown in Figure 6(C).
  • Figures 7(A) and 7(B) illustrate the proximal end of the multi-lumen catheter in accordance with an embodiment of the invention where the obturator 40 extends partially into the lumen so as to leave a dead space 70 beyond the point 72 where the obturator 40 ends when fully inserted.
  • Figure 7(A) illustrates the catheter prior to insertion of the obturator 40
  • Figure 7(B) illustrates the catheter with the obturator 40 fully inserted and glued into place by adhesive 74.
  • a combination of obturator 40 and biocompatible adhesive 74 are preferred if it is desired to permanently block the lumen.
  • the adhesive 74 could be delivered using a blunt cannula and syringe similar to that found in commercially available Hickman catheter repair ldts or by other means.
  • the combination of hemostasis valves and medical grade adhesive also may be desirable, but it is not necessarily desirable or required to completely fill the lumen with adhesive 74 as a blood clot would rapidly form in and occlude any remaking dead space.
  • the obturator 40 may have markings on it at a predetermined point 76 with the rema ⁇ ing dead space of the lumen indicated at 78.
  • Figure 8 illustrates the proximal end of the multi-lumen catheter in accordance with an embodiment of the invention where the hub 42 of the lumen for accepting the obturator 40 has a non-luer fitting such as fitting 80 (a) or fitting 82 (b) designed to mate with a matching syringe or other delivery system containing biocompatible adhesive for injection into the dead space of the lumen.
  • a non-luer fitting such as fitting 80 (a) or fitting 82 (b) designed to mate with a matching syringe or other delivery system containing biocompatible adhesive for injection into the dead space of the lumen.
  • the dead space volume may be written on the fitting of the hub 42 and a matching syringe or other delivery system attached to the fitting whereby the appropriate volume of biocompatible adhesive is injected to fill and permanently occlude the lumen.
  • a short obturator or cap may be attached to the fitting 80, 82 to cover the lumen once the adhesive is injected.
  • the obturator may be threaded at its proximal end so that it may be screwed into place.
  • the techniques of the invention may be used with catheters having any number of lumens and any tip and hub arrangement. Further, the methods described herein are intended as specific implementations only and are not intended to delimit the scope of the invention, which should instead be understood with reference to the following claims.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • External Artificial Organs (AREA)

Abstract

L'invention concerne un cathéter convertible multi-lumière utilisé pour une hémodialyse ou d'autres indications impliquant une perfusion et/ou un retrait de fluides corporels. A la différence des cathéters existant comprenant un certain nombre de lumières qui peuvent limiter leur utilisation à la fois dans des dispositifs vasculaires veineux à court terme et à long terme, le cathéter de l'invention permet d'ajouter une ou plusieurs lumière(s) pendant la phase aiguë de l'utilisation du cathéter avec retrait de ces lumière (c'est-à-dire, conversion) lorsqu'il s'agit d'un usage plus permanent. Un exemple typique de cathéter serait un dispositif à trois lumières utilisé pour une hémodialyse et une thérapie antibiotique pendant une infection aiguë avec conversion en cathéter d'hémodialyse chronique à deux lumières après un traitement réussi de ladite infection. La lumière est bloquée de manière permanente et semi-permenente à l'aide d'un obturateur en plastique biocompatible qui est introduit dans la lumière non utilisée et verrouillée et/ou collé en place.
PCT/US2004/029313 2003-09-09 2004-09-09 Catheter convertible multi-lumiere Ceased WO2005023336A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56864703A 2003-09-09 2003-09-09
US10/568,647 2003-09-09

Publications (2)

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WO2005023336A2 true WO2005023336A2 (fr) 2005-03-17
WO2005023336A3 WO2005023336A3 (fr) 2006-08-17

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Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2092943A1 (fr) 2008-02-21 2009-08-26 Universität Bern Accès implantable pour le retrait et/ou le retour de fluides
EP2286849A1 (fr) 2009-08-21 2011-02-23 Cendres & Métaux S.A. Accès vasculaire implantable
US8092415B2 (en) 2007-11-01 2012-01-10 C. R. Bard, Inc. Catheter assembly including triple lumen tip
US8206371B2 (en) 2003-05-27 2012-06-26 Bard Access Systems, Inc. Methods and apparatus for inserting multi-lumen split-tip catheters into a blood vessel
US8292841B2 (en) 2007-10-26 2012-10-23 C. R. Bard, Inc. Solid-body catheter including lateral distal openings
US8454565B2 (en) 2006-09-28 2013-06-04 Covidien Lp Low profile catheter assembly
US8500939B2 (en) 2007-10-17 2013-08-06 Bard Access Systems, Inc. Manufacture of split tip catheters
US8597258B2 (en) 2009-08-31 2013-12-03 Covidien Lp Valved catheter
US8696614B2 (en) 2007-10-26 2014-04-15 C. R. Bard, Inc. Split-tip catheter including lateral distal openings
US8808227B2 (en) 2003-02-21 2014-08-19 C. R. Bard, Inc. Multi-lumen catheter with separate distal tips
US8864724B2 (en) 2008-05-14 2014-10-21 Covidien Lp Catheter with valve
US8986263B2 (en) 2011-03-08 2015-03-24 Covidien Lp Catheter with valve
US8992454B2 (en) 2004-06-09 2015-03-31 Bard Access Systems, Inc. Splitable tip catheter with bioresorbable adhesive
US9005154B2 (en) 2008-09-26 2015-04-14 Covidien Lp Valved hemodialysis catheter
US9072867B2 (en) 2011-09-30 2015-07-07 Covidien Lp Catheter with external flow channel
US9168355B2 (en) 2006-09-29 2015-10-27 Covidien Lp Acute hemodialysis catheter assembly
US9174037B2 (en) 2010-06-04 2015-11-03 Cendres + Mataux SA Implanted access port
USD748252S1 (en) 2013-02-08 2016-01-26 C. R. Bard, Inc. Multi-lumen catheter tip
US9333331B2 (en) 2010-11-08 2016-05-10 Cendres+Metaux Sa Method for implanting an access port
US9526861B2 (en) 2012-09-28 2016-12-27 Covidien Lp Symmetrical tip acute catheter
US9579485B2 (en) 2007-11-01 2017-02-28 C. R. Bard, Inc. Catheter assembly including a multi-lumen configuration
US10058676B2 (en) 2009-09-30 2018-08-28 Covidien Lp Medical catheter having a design providing low recirculation and reversibility
US10143822B2 (en) 2012-07-05 2018-12-04 Covidien Lp Valved tip catheters
WO2019050673A1 (fr) * 2017-09-06 2019-03-14 Becton, Dickinson And Company Ensemble obturateur à trajet d'écoulement de fluide sélectivement contrôlable
US10258768B2 (en) 2014-07-14 2019-04-16 C. R. Bard, Inc. Apparatuses, systems, and methods for inserting catheters having enhanced stiffening and guiding features
GB2572852A (en) * 2018-02-28 2019-10-16 Spiration Inc D/B/A Olympus Respiratory America Orientation pins for device using radial ultrasound

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US5984908A (en) * 1997-04-10 1999-11-16 Chase Medical Inc Venous return catheter having integral support member

Cited By (61)

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Publication number Priority date Publication date Assignee Title
US9387304B2 (en) 2003-02-21 2016-07-12 C.R. Bard, Inc. Multi-lumen catheter with separate distal tips
US8808227B2 (en) 2003-02-21 2014-08-19 C. R. Bard, Inc. Multi-lumen catheter with separate distal tips
US10806895B2 (en) 2003-05-27 2020-10-20 Bard Access Systems, Inc. Methods and apparatus for inserting multi-lumen split-tip catheters into a blood vessel
US9572956B2 (en) 2003-05-27 2017-02-21 Bard Access Systems, Inc. Methods and apparatus for inserting multi-lumen split-tip catheters into a blood vessel
US8206371B2 (en) 2003-05-27 2012-06-26 Bard Access Systems, Inc. Methods and apparatus for inserting multi-lumen split-tip catheters into a blood vessel
US10105514B2 (en) 2003-05-27 2018-10-23 Bard Access Systems, Inc. Methods and apparatus for inserting multi-lumen split-tip catheters into a blood vessel
US8597275B2 (en) 2003-05-27 2013-12-03 Bard Access Systems, Inc. Methods and apparatus for inserting multi-lumen split-tip catheters into a blood vessel
US9669149B2 (en) 2004-06-09 2017-06-06 Bard Access Systems, Inc. Splitable tip catheter with bioresorbable adhesive
US8992454B2 (en) 2004-06-09 2015-03-31 Bard Access Systems, Inc. Splitable tip catheter with bioresorbable adhesive
US9782535B2 (en) 2004-06-09 2017-10-10 Bard Access Systems, Inc. Splitable tip catheter with bioresorbable adhesive
US8454565B2 (en) 2006-09-28 2013-06-04 Covidien Lp Low profile catheter assembly
US9713694B2 (en) 2006-09-28 2017-07-25 Covidien Lp Low profile catheter assembly
US9168355B2 (en) 2006-09-29 2015-10-27 Covidien Lp Acute hemodialysis catheter assembly
US8500939B2 (en) 2007-10-17 2013-08-06 Bard Access Systems, Inc. Manufacture of split tip catheters
US8292841B2 (en) 2007-10-26 2012-10-23 C. R. Bard, Inc. Solid-body catheter including lateral distal openings
US10207043B2 (en) 2007-10-26 2019-02-19 C. R. Bard, Inc. Solid-body catheter including lateral distal openings
US9233200B2 (en) 2007-10-26 2016-01-12 C.R. Bard, Inc. Split-tip catheter including lateral distal openings
US8696614B2 (en) 2007-10-26 2014-04-15 C. R. Bard, Inc. Split-tip catheter including lateral distal openings
US10258732B2 (en) 2007-10-26 2019-04-16 C. R. Bard, Inc. Split-tip catheter including lateral distal openings
US11260161B2 (en) 2007-10-26 2022-03-01 C. R. Bard, Inc. Solid-body catheter including lateral distal openings
US11338075B2 (en) 2007-10-26 2022-05-24 C. R. Bard, Inc. Split-tip catheter including lateral distal openings
US8540661B2 (en) 2007-10-26 2013-09-24 C. R. Bard, Inc. Solid-body catheter including lateral distal openings
US9174019B2 (en) 2007-10-26 2015-11-03 C. R. Bard, Inc. Solid-body catheter including lateral distal openings
US12076475B2 (en) 2007-10-26 2024-09-03 C. R. Bard, Inc. Split-tip catheter including lateral distal openings
US10518064B2 (en) 2007-11-01 2019-12-31 C. R. Bard, Inc. Catheter assembly including a multi-lumen configuration
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