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WO2005020881A3 - Compositions of flavonoids and flavonoid-containing extracts and the treatment of diseases - Google Patents

Compositions of flavonoids and flavonoid-containing extracts and the treatment of diseases Download PDF

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Publication number
WO2005020881A3
WO2005020881A3 PCT/IB2004/003998 IB2004003998W WO2005020881A3 WO 2005020881 A3 WO2005020881 A3 WO 2005020881A3 IB 2004003998 W IB2004003998 W IB 2004003998W WO 2005020881 A3 WO2005020881 A3 WO 2005020881A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
flavonoid
flavonoids
containing extracts
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2004/003998
Other languages
French (fr)
Other versions
WO2005020881A2 (en
Inventor
Bang Qiang Gong
Ren Jin
Han Xin Chun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHANGHAI COMMAN PHARMACEUTICAL CO
SHANGHAI COMMAN PHARMACEUTICAL
Original Assignee
SHANGHAI COMMAN PHARMACEUTICAL CO
SHANGHAI COMMAN PHARMACEUTICAL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CNB031507026A external-priority patent/CN1266144C/en
Application filed by SHANGHAI COMMAN PHARMACEUTICAL CO, SHANGHAI COMMAN PHARMACEUTICAL filed Critical SHANGHAI COMMAN PHARMACEUTICAL CO
Publication of WO2005020881A2 publication Critical patent/WO2005020881A2/en
Publication of WO2005020881A3 publication Critical patent/WO2005020881A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

In this invention we describe a group of flavonoids and flavonoid-containing extracts that have pharmaceutical properties which are useful in the medicinal therapy of fibrotic diseases for the treatment or reparation and prevention of fibrotic lesional tissues. Representative flavonoids and flavonoid-containing extracts have the active compositions of the below formula (I). Those compositions can be extracted and purified from the botanicals, including Scutellaria baicalensis Georgi, Scutellaria scordifolia Fish, Oroxylum indicum (L.) Vent, Plantago major L. The compositions of the invention are novel as an anti-fibrotic drugs, as agents for treating fibrosis.
PCT/IB2004/003998 2003-09-01 2004-08-31 Compositions of flavonoids and flavonoid-containing extracts and the treatment of diseases Ceased WO2005020881A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CNB031507026A CN1266144C (en) 2003-09-01 2003-09-01 Compound of flavonoid as well as application and dosage form of extract product of the compound
CN03150702.6 2003-09-01
US10/746,632 US20050049206A1 (en) 2003-09-01 2003-12-23 Compositions of flavonoids and flavonoid-containing extracts and the treatment of diseases
US10/746,632 2003-12-23

Publications (2)

Publication Number Publication Date
WO2005020881A2 WO2005020881A2 (en) 2005-03-10
WO2005020881A3 true WO2005020881A3 (en) 2005-07-28

Family

ID=34276299

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/003998 Ceased WO2005020881A2 (en) 2003-09-01 2004-08-31 Compositions of flavonoids and flavonoid-containing extracts and the treatment of diseases

Country Status (1)

Country Link
WO (1) WO2005020881A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101040760B1 (en) 2005-11-30 2011-06-10 한국과학기술연구원 Novel flavone derivatives, preparation methods thereof, and compositions for preventing and treating cerebral nervous system diseases, including the same
CA2677892A1 (en) * 2007-02-14 2008-12-04 Mars, Incorporated Neurogenic compounds
WO2022080846A1 (en) * 2020-10-13 2022-04-21 서울대학교병원 Composition for preventing or treating fibrosis, comprising flavone
US20240300913A1 (en) * 2023-03-09 2024-09-12 A-Chembio Co., Ltd Flavone derivative and use thereof for improving pulmonary fibrosis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972995A (en) * 1997-10-16 1999-10-26 Children's Hospital Medical Center Of Northern California Compositions and methods for cystic fibrosis therapy
CN1526389A (en) * 2003-03-03 2004-09-08 张俊平 Application of 5,7,4'-substituted flavone in preparing medicine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972995A (en) * 1997-10-16 1999-10-26 Children's Hospital Medical Center Of Northern California Compositions and methods for cystic fibrosis therapy
CN1526389A (en) * 2003-03-03 2004-09-08 张俊平 Application of 5,7,4'-substituted flavone in preparing medicine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
XU D.H. ET AL: "Effect of the Rice Flavone on Experimental Rat Hepatic Fibrosis.", JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY., vol. 33, no. 3, 2002, pages 234 - 237 *

Also Published As

Publication number Publication date
WO2005020881A2 (en) 2005-03-10

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