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WO2005017505A3 - Diagnosis of atopic disorder - Google Patents

Diagnosis of atopic disorder Download PDF

Info

Publication number
WO2005017505A3
WO2005017505A3 PCT/GB2004/003518 GB2004003518W WO2005017505A3 WO 2005017505 A3 WO2005017505 A3 WO 2005017505A3 GB 2004003518 W GB2004003518 W GB 2004003518W WO 2005017505 A3 WO2005017505 A3 WO 2005017505A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnosis
atopic disorder
subject
atopic
disorder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2004/003518
Other languages
French (fr)
Other versions
WO2005017505A2 (en
Inventor
William Osmond Charles Cookson
Miriam Fleur Moffat
Michael Richard Hill
James Arnold Traherne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Publication of WO2005017505A2 publication Critical patent/WO2005017505A2/en
Publication of WO2005017505A3 publication Critical patent/WO2005017505A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Detecting whether a subject has or is predisposed to an atopic disorder can be carried out by determining whether the subject has any of the identified genetic polymorphisms located in the MS4A2 gene.
PCT/GB2004/003518 2003-08-14 2004-08-16 Diagnosis of atopic disorder Ceased WO2005017505A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0319135.0 2003-08-14
GB0319135A GB0319135D0 (en) 2003-08-14 2003-08-14 Assay

Publications (2)

Publication Number Publication Date
WO2005017505A2 WO2005017505A2 (en) 2005-02-24
WO2005017505A3 true WO2005017505A3 (en) 2005-06-16

Family

ID=28052526

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/003518 Ceased WO2005017505A2 (en) 2003-08-14 2004-08-16 Diagnosis of atopic disorder

Country Status (2)

Country Link
GB (1) GB0319135D0 (en)
WO (1) WO2005017505A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006107031A1 (en) 2005-04-04 2006-10-12 Asubio Pharma Co., Ltd. Method of relative risk for the onset of atopic dermatitis by gene single nucleotide polymorphism analysis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997008338A1 (en) * 1995-08-29 1997-03-06 Isis Innovation Limited Atopy: diagnosis and therapy
WO2001014588A1 (en) * 1999-08-24 2001-03-01 Genaissance Pharmaceuticals, Inc. Drug target isogenes: polymorphisms in the immunoglobulin e receptor beta chain gene

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997008338A1 (en) * 1995-08-29 1997-03-06 Isis Innovation Limited Atopy: diagnosis and therapy
WO2001014588A1 (en) * 1999-08-24 2001-03-01 Genaissance Pharmaceuticals, Inc. Drug target isogenes: polymorphisms in the immunoglobulin e receptor beta chain gene

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
COX H E ET AL: "ASSOCIATION OF ATOPIC DERMATITIS TO THE BETA SUBUNIT OF THE HIGH AFFINITY IMMUNOGLOBULIN E RECEPTOR", BRITISH JOURNAL OF DERMATOLOGY, XX, XX, vol. 138, 1998, pages 182 - 187, XP002933012, ISSN: 0007-0963 *
DATABASE DBSNP 27 July 2000 (2000-07-27), XP002302000, retrieved from NCBI Database accession no. RS513986 *
HILL M R ET AL: "A NEW VARIANT OF THE BETA SUBUNIT OF THE HIGH-AFFINITY RECEPTOR FORIMMUNOGLOBULIN E (FCEPSILONRI-BETA E237G): ASSOCIATIONS WITH MEASURES OF ATOPY AND BRONCHIAL HYPER-RESPONSIVENESS", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 5, no. 7, 1 July 1996 (1996-07-01), pages 959 - 962, XP000616300, ISSN: 0964-6906 *
HIZAWA NOBUYUKI ET AL: "A common FCER1B gene promoter polymorphism influences total serum IgE levels in a Japanese population", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 161, no. 3 part 1, March 2000 (2000-03-01), pages 906 - 909, XP002301997, ISSN: 1073-449X *
PALMER L J ET AL: "FC-epsilon-R1-beta polymorphism and total serum IgE levels in endemically parasitized Australian Aborigines", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 61, no. 1, 1997, pages 182 - 188, XP001203480, ISSN: 0002-9297 *
ROHRBACH M ET AL: "Screening of the Fc epsilon RI-beta-gene in a Swiss population of asthmatic children: no association with E237G and identification of new sequence variations.", DISEASE MARKERS. NOV 1998, vol. 14, no. 3, November 1998 (1998-11-01), pages 177 - 186, XP009038510, ISSN: 0278-0240 *
SHIRAKAWA T ET AL: "ASSOCIATION BETWEEN ATOPY AND VARIANTS OF THE BETA SUBUNIT OF THE HIGH-AFFINITY IMMUNOGLOBULIN E RECEPTOR", NATURE GENETICS, NEW YORK, NY, US, vol. 7, 1 June 1994 (1994-06-01), pages 125 - 130, XP000198191, ISSN: 1061-4036 *
TRAHERNE JAMES A ET AL: "LD mapping of maternally and non-maternally derived alleles and atopy in FcepsilonRI-beta.", HUMAN MOLECULAR GENETICS, vol. 12, no. 20, 15 October 2003 (2003-10-15), pages 2577 - 2585, XP002301999, ISSN: 0964-6906 *

Also Published As

Publication number Publication date
GB0319135D0 (en) 2003-09-17
WO2005017505A2 (en) 2005-02-24

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