[go: up one dir, main page]

WO2005013945A3 - Medicament pour inhalation comprenant des steroides et un betamimetique - Google Patents

Medicament pour inhalation comprenant des steroides et un betamimetique Download PDF

Info

Publication number
WO2005013945A3
WO2005013945A3 PCT/EP2004/008023 EP2004008023W WO2005013945A3 WO 2005013945 A3 WO2005013945 A3 WO 2005013945A3 EP 2004008023 W EP2004008023 W EP 2004008023W WO 2005013945 A3 WO2005013945 A3 WO 2005013945A3
Authority
WO
WIPO (PCT)
Prior art keywords
betamimetic
steroids
medicaments
inhalation
steroid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2004/008023
Other languages
English (en)
Other versions
WO2005013945A2 (fr
Inventor
Christopher John Montagu Meade
Michel Pairet
Michael P Pieper
Ingo Konetzki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim International GmbH
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH, Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim International GmbH
Priority to EP04741127A priority Critical patent/EP1654001A2/fr
Priority to JP2006522264A priority patent/JP2007501194A/ja
Priority to CA002534693A priority patent/CA2534693A1/fr
Publication of WO2005013945A2 publication Critical patent/WO2005013945A2/fr
Publication of WO2005013945A3 publication Critical patent/WO2005013945A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne de nouvelles compositions pharmaceutiques comprenant un ou plusieurs composés, de préférence un stéroïde 1 et un bêtamimétique représentés par la formule (2), des processus de préparation et d'utilisation de ces compositions dans le traitement de douleurs respiratoires.
PCT/EP2004/008023 2003-08-05 2004-07-17 Medicament pour inhalation comprenant des steroides et un betamimetique Ceased WO2005013945A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP04741127A EP1654001A2 (fr) 2003-08-05 2004-07-17 Medicament pour inhalation comprenant des steroides et un betamimetique
JP2006522264A JP2007501194A (ja) 2003-08-05 2004-07-17 ステロイドとβ模倣薬を含む吸入用薬剤
CA002534693A CA2534693A1 (fr) 2003-08-05 2004-07-17 Medicament pour inhalation comprenant des steroides et un betamimetique

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03017814 2003-08-05
EP03017814.9 2003-08-05

Publications (2)

Publication Number Publication Date
WO2005013945A2 WO2005013945A2 (fr) 2005-02-17
WO2005013945A3 true WO2005013945A3 (fr) 2005-06-23

Family

ID=34130070

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/008023 Ceased WO2005013945A2 (fr) 2003-08-05 2004-07-17 Medicament pour inhalation comprenant des steroides et un betamimetique

Country Status (4)

Country Link
EP (1) EP1654001A2 (fr)
JP (1) JP2007501194A (fr)
CA (1) CA2534693A1 (fr)
WO (1) WO2005013945A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20060159A1 (es) * 2004-03-24 2006-04-04 Chiesi Farma Spa Monoclorhidrato de 8-hidroxi-5-[(1r)-1-hidroxi-2-{[(1r)-2-(4-metoxifenil)-1-metiletil]amino}etil]-2-(1h)-quinolinona en forma cristalina y el proceso para su preparacion
DE102005007654A1 (de) * 2005-02-19 2006-08-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue langwirksame Betamimetika zur Behandlung von Atemwegserkrankungen
DE102005030733A1 (de) * 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
PE20081788A1 (es) * 2007-02-19 2008-12-18 Cipla Ltd Combinaciones farmaceuticas

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0147719A2 (fr) * 1983-12-24 1985-07-10 Tanabe Seiyaku Co., Ltd. Dérivé de carbostyrile et procédé pour sa préparation
WO1998041193A1 (fr) * 1997-03-20 1998-09-24 Schering Corporation Preparation d'agglomerats de poudre
WO2001089480A1 (fr) * 2000-05-22 2001-11-29 Chiesi Farmaceutici S.P.A. Preparation en solution pharmaceutique stable pour aerosols-doseurs sous pression
US20040023935A1 (en) * 2002-08-02 2004-02-05 Dey, L.P. Inhalation compositions, methods of use thereof, and process for preparation of same
WO2004028545A1 (fr) * 2002-09-25 2004-04-08 Astrazeneca Ab Combinaison d'un agoniste $g(b)2 a action prolongee et d'un glucocorticosteroide dans le traitement de maladies fibrotiques
EP1452179A1 (fr) * 2003-02-27 2004-09-01 CHIESI FARMACEUTICI S.p.A. Nouveau combination d'un puissant agoniste beta 2 de longue duree et un corticosteroid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9804001D0 (sv) * 1998-11-23 1998-11-23 Astra Ab New process
GB0123951D0 (en) * 2001-10-05 2001-11-28 Glaxo Group Ltd Therapies for treating respiratory diseases

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0147719A2 (fr) * 1983-12-24 1985-07-10 Tanabe Seiyaku Co., Ltd. Dérivé de carbostyrile et procédé pour sa préparation
WO1998041193A1 (fr) * 1997-03-20 1998-09-24 Schering Corporation Preparation d'agglomerats de poudre
WO2001089480A1 (fr) * 2000-05-22 2001-11-29 Chiesi Farmaceutici S.P.A. Preparation en solution pharmaceutique stable pour aerosols-doseurs sous pression
US20040023935A1 (en) * 2002-08-02 2004-02-05 Dey, L.P. Inhalation compositions, methods of use thereof, and process for preparation of same
WO2004028545A1 (fr) * 2002-09-25 2004-04-08 Astrazeneca Ab Combinaison d'un agoniste $g(b)2 a action prolongee et d'un glucocorticosteroide dans le traitement de maladies fibrotiques
EP1452179A1 (fr) * 2003-02-27 2004-09-01 CHIESI FARMACEUTICI S.p.A. Nouveau combination d'un puissant agoniste beta 2 de longue duree et un corticosteroid

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
IZEBOUD, C. A. ET AL: "Stereoselectivity at the .beta.2-adrenoceptor on macrophages is a major determinant of the anti-inflammatory effects of .beta.2-agonists", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY , 362(2), 184-189 CODEN: NSAPCC; ISSN: 0028-1298, 2000, XP002300185 *
KIKKAWA, HIDEO ET AL: "Tracheal relaxing effects and .beta.2-selectivity of TA-2005, a newly developed bronchodilating agent, in isolated guinea pig tissues", JAPANESE JOURNAL OF PHARMACOLOGY , 57(2), 175-85 CODEN: JJPAAZ; ISSN: 0021-5198, 1991, XP008045059 *

Also Published As

Publication number Publication date
EP1654001A2 (fr) 2006-05-10
CA2534693A1 (fr) 2005-02-17
JP2007501194A (ja) 2007-01-25
WO2005013945A2 (fr) 2005-02-17

Similar Documents

Publication Publication Date Title
MXPA03011515A (es) Nuevas composiciones de medicamentos sobre la base de agentes anticolinergicos, corticoesteroides y agentes betamimeticos.
UA85708C2 (ru) Лекарственные комбинации, содержащие бензоксазины, для лечения заболеваний дыхательных путей
WO2002047667A3 (fr) Nouvelles compositions medicamenteuses a base d'anticholinergiques et d'un steroide
WO2005102431A3 (fr) Appareil d'administration en aerosol, methodes et compositions pour systemes de respiration assistee en pression
WO2004037768A3 (fr) Composes a usage medicinal
WO2003020253A3 (fr) Compositions pharmaceutiques pour le traitement de l'asthme
WO2004037773A8 (fr) Derive de phenethanolamine utilise dans le traitement de maladies respiratoires
CA2436540A1 (fr) Composition pharmaceutique a base d'anticholinergiques et de corticosteroides
SG167657A1 (en) Novel medicament compositions based on tiotropium salts and on salmeterol salts
WO2003084539A3 (fr) Nouvelles compositions pharmaceutiques a base d'anticholinergiques et d'inhibiteurs de la kinase p38
TW200505483A (en) New medicament compositions based on anticholinergically-effective compounds and β-mimetics
IL204947A0 (en) Phenylacetamido-thiazole derivatives, process for their preparation and their use in the manufacture of medicaments, pharmaceutical compositions and kits comprising them
EP1803469A3 (fr) Médicaments déstinés à l'inhalation, contenant un agent anticholinergique et un béta-mimétique
MY145166A (en) Novel tiotropium salts, process for the preparation and pharmaceutical compositions thereof
TW200731975A (en) Novel combinations of medicaments for the treatment of respiratory diseases
TWI347845B (en) Pharmaceutical compositions,combinations,and kits for the treatment of respiratory diseases and use of the same
WO2005013945A3 (fr) Medicament pour inhalation comprenant des steroides et un betamimetique
AU2003259986A1 (en) Pharmaceutical compositions
WO2005041922A3 (fr) Composition
IL168308A (en) Compositions containing roflumilast and formoterol
WO2005011616A3 (fr) Association de dehydroepiandrosterone ou de sulfate de dehydroepiandrosterone et de cromone dans le traitement de l'asthme ou de la maladie pulmonaire obstructive chronique
WO2004004725A3 (fr) Nouvelles compositions pharmaceutiques a base de nouveaux anticholinergiques et d'inhibiteurs de la kinase p38
TW200500066A (en) New tiotropium containing powder formulation for inhalation
WO2004105759A3 (fr) Nouvelles combinaisons medicamenteuses a action prolongee utilisees pour traiter des maladies des voies respiratoires
WO2002069944A3 (fr) Nouvelles compositions medicamenteuses a base d'anticholinergiques et d'antagonistes de recepteurs nk1

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2004741127

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2534693

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2006522264

Country of ref document: JP

WWP Wipo information: published in national office

Ref document number: 2004741127

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2004741127

Country of ref document: EP