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WO2005012901A3 - Procede de mesure de l'activite de l'aromatase - Google Patents

Procede de mesure de l'activite de l'aromatase Download PDF

Info

Publication number
WO2005012901A3
WO2005012901A3 PCT/GB2004/003341 GB2004003341W WO2005012901A3 WO 2005012901 A3 WO2005012901 A3 WO 2005012901A3 GB 2004003341 W GB2004003341 W GB 2004003341W WO 2005012901 A3 WO2005012901 A3 WO 2005012901A3
Authority
WO
WIPO (PCT)
Prior art keywords
aromatase activity
measuring
measuring aromatase
activity
screening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2004/003341
Other languages
English (en)
Other versions
WO2005012901A2 (fr
Inventor
John Gerard Whateley
Rahman Aziz Ismail
Peter Gordon Laughton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare UK Ltd
Original Assignee
Amersham Biosciences UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Biosciences UK Ltd filed Critical Amersham Biosciences UK Ltd
Priority to US10/561,817 priority Critical patent/US7829714B2/en
Priority to AU2004262130A priority patent/AU2004262130A1/en
Priority to JP2006521676A priority patent/JP5037127B2/ja
Priority to EP04767965.9A priority patent/EP1649283B1/fr
Priority to CA2529669A priority patent/CA2529669C/fr
Publication of WO2005012901A2 publication Critical patent/WO2005012901A2/fr
Publication of WO2005012901A3 publication Critical patent/WO2005012901A3/fr
Anticipated expiration legal-status Critical
Priority to US12/892,202 priority patent/US8334387B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Steroid Compounds (AREA)

Abstract

L'invention concerne des composés utilisés pour mesurer l'activité de l'aromatase. L'invention concerne en outre des procédés permettant de mesurer l'activité de l'aromatase et de trier des agents de référence qui modulent l'activité de l'aromatase. L'invention concerne également un nécessaire permettant de mettre lesdits procédés en oeuvre.
PCT/GB2004/003341 2003-07-30 2004-07-30 Procede de mesure de l'activite de l'aromatase Ceased WO2005012901A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US10/561,817 US7829714B2 (en) 2003-07-30 2004-07-30 Method for measuring aromatase activity
AU2004262130A AU2004262130A1 (en) 2003-07-30 2004-07-30 Method for measuring aromatase activity
JP2006521676A JP5037127B2 (ja) 2003-07-30 2004-07-30 アロマターゼ活性の測定方法
EP04767965.9A EP1649283B1 (fr) 2003-07-30 2004-07-30 Procede de mesure de l'activite de l'aromatase
CA2529669A CA2529669C (fr) 2003-07-30 2004-07-30 Procede de mesure de l'activite de l'aromatase
US12/892,202 US8334387B2 (en) 2003-07-30 2010-09-28 Method for measuring aromatase activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0317743.3 2003-07-30
GBGB0317743.3A GB0317743D0 (en) 2003-07-30 2003-07-30 Method for measuring aromatase activity

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/561,817 A-371-Of-International US7829714B2 (en) 2003-07-30 2004-07-30 Method for measuring aromatase activity
US12/892,202 Division US8334387B2 (en) 2003-07-30 2010-09-28 Method for measuring aromatase activity

Publications (2)

Publication Number Publication Date
WO2005012901A2 WO2005012901A2 (fr) 2005-02-10
WO2005012901A3 true WO2005012901A3 (fr) 2005-07-28

Family

ID=27799411

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/003341 Ceased WO2005012901A2 (fr) 2003-07-30 2004-07-30 Procede de mesure de l'activite de l'aromatase

Country Status (7)

Country Link
US (2) US7829714B2 (fr)
EP (1) EP1649283B1 (fr)
JP (1) JP5037127B2 (fr)
AU (1) AU2004262130A1 (fr)
CA (1) CA2529669C (fr)
GB (1) GB0317743D0 (fr)
WO (1) WO2005012901A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO20034351D0 (no) * 2003-09-29 2003-09-29 Amersham Health As Optisk avbilding av endometrose
CN103149186B (zh) * 2013-02-06 2015-09-23 中国药科大学 一种基于荧光检测原理的芳香化酶抑制剂高通量筛选模型
CN107311927B (zh) * 2017-08-04 2019-11-22 福建医科大学 一种双光子荧光探针10-甲基-2-氨基-吖啶酮及其制备方法和应用
CN111217820B (zh) * 2020-02-25 2022-04-22 广西中医药大学 香豆素-吖啶酮荧光探针及其制备方法和应用
US11636870B2 (en) 2020-08-20 2023-04-25 Denso International America, Inc. Smoking cessation systems and methods
US11760170B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Olfaction sensor preservation systems and methods
US11881093B2 (en) 2020-08-20 2024-01-23 Denso International America, Inc. Systems and methods for identifying smoking in vehicles
US12251991B2 (en) 2020-08-20 2025-03-18 Denso International America, Inc. Humidity control for olfaction sensors
US11932080B2 (en) 2020-08-20 2024-03-19 Denso International America, Inc. Diagnostic and recirculation control systems and methods
US12377711B2 (en) 2020-08-20 2025-08-05 Denso International America, Inc. Vehicle feature control systems and methods based on smoking
US11828210B2 (en) 2020-08-20 2023-11-28 Denso International America, Inc. Diagnostic systems and methods of vehicles using olfaction
US11813926B2 (en) 2020-08-20 2023-11-14 Denso International America, Inc. Binding agent and olfaction sensor
US12017506B2 (en) 2020-08-20 2024-06-25 Denso International America, Inc. Passenger cabin air control systems and methods
US12269315B2 (en) 2020-08-20 2025-04-08 Denso International America, Inc. Systems and methods for measuring and managing odor brought into rental vehicles
US11760169B2 (en) 2020-08-20 2023-09-19 Denso International America, Inc. Particulate control systems and methods for olfaction sensors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002099424A2 (fr) * 2001-06-04 2002-12-12 Amersham Biosciences Uk Limited Derives d'acridone utilises comme etiquettes dans la detection par fluorescence de materiaux cibles
WO2003020294A1 (fr) * 2001-08-28 2003-03-13 Alfred Schmidt Marquage d'aromatase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07228593A (ja) * 1993-12-22 1995-08-29 Senju Pharmaceut Co Ltd ステロイド誘導体
JP2003507466A (ja) 1999-08-19 2003-02-25 ジェンテスト・コーポレーション ハイスループットチトクロームｐ４５０阻害アッセイにおけるフルオレセインアリールエーテル類の使用
US6207404B1 (en) * 1999-09-30 2001-03-27 Gentest Corporation Coumarin-based CYP3A fluorescent assay reagents
GB0113434D0 (en) * 2001-06-04 2001-07-25 Amersham Pharm Biotech Uk Ltd Quinacridone derivatives as labels for fluorescence detection of biological materials
BR0214373A (pt) 2001-11-21 2004-10-13 Sterix Ltd Derivados de 1,2,4-triazol contendo um grupo sulfamato como inibidores de aromatase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002099424A2 (fr) * 2001-06-04 2002-12-12 Amersham Biosciences Uk Limited Derives d'acridone utilises comme etiquettes dans la detection par fluorescence de materiaux cibles
WO2003020294A1 (fr) * 2001-08-28 2003-03-13 Alfred Schmidt Marquage d'aromatase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
STRESSER D M ET AL: "A HIGH-THROUGHPUT SCREEN TO IDENTIFY INHIBITORS OF AROMATASE (CYP19)", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 284, no. 2, 2000, pages 427 - 430, XP000979096, ISSN: 0003-2697 *

Also Published As

Publication number Publication date
CA2529669C (fr) 2011-04-19
EP1649283B1 (fr) 2014-06-18
AU2004262130A1 (en) 2005-02-10
US7829714B2 (en) 2010-11-09
WO2005012901A2 (fr) 2005-02-10
US20070184429A1 (en) 2007-08-09
GB0317743D0 (en) 2003-09-03
US8334387B2 (en) 2012-12-18
CA2529669A1 (fr) 2005-02-10
JP5037127B2 (ja) 2012-09-26
JP2007500182A (ja) 2007-01-11
EP1649283A2 (fr) 2006-04-26
US20110014641A1 (en) 2011-01-20

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